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1. 发明授权

US09494568B2 Passive microfluidic device and a method of forming the same 有权
标题翻译：被动微流体装置及其形成方法
公开(公告)号：US09494568B2
公开(公告)日：2016-11-15
申请号：US14376279
申请日：2012-02-03
申请人： Soon Chye Ng , Swee Lian Liow , Naiqing Chen , Yen Wah Tong , Saif Abdul Kadir Khan , Boon Sing Fang
发明人： Soon Chye Ng , Swee Lian Liow , Naiqing Chen , Yen Wah Tong , Saif Abdul Kadir Khan , Boon Sing Fang
IPC分类号： G01N33/00 , C12N5/076 , G01N33/483 , C12M1/00 , B01L3/00 , G01N33/487 , G01N15/14 , C12M3/06 , C12N5/071 , A61D19/00
CPC分类号： G01N33/4833 , A61D19/00 , B01L3/5027 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2300/0861 , B01L2300/087 , C12M23/16 , C12M47/04 , C12N5/061 , C12N5/0612 , G01N15/147 , G01N33/487 , G01N2015/149 , Y10T29/49826
摘要： According to embodiments of the present invention, a passive counter flow free microfluidic device for sorting a sample of flagellated cells is provided. The passive counter flow free microfluidic device includes an input reservoir configured to receive the sample of flagellated cells, an output reservoir positioned downstream of the input reservoir, the output reservoir configured to collect the flagellated cells that are sorted, and a plurality of microchannel sections arranged sequentially and in fluid communication with each other between the input reservoir and the output reservoir, and designed to define a closed microchannel system between the input reservoir and the output reservoir, wherein each microchannel section comprises at least one microchannel, wherein an inlet of the microchannel of a first microchannel section of the plurality of microchannel sections is connected to the input reservoir, wherein an outlet of the microchannel of a last microchannel section of the plurality of microchannel sections is connected to the output reservoir, and wherein, for each microchannel section, the total volume of the microchannels of one microchannel section of the plurality of microchannel sections is larger than that of the respective in said downstream direction subsequent microchannel section of the plurality of microchannel sections for sorting the flagellated cells when the flagellated cells move from the input reservoir to the output reservoir.
摘要翻译：根据本发明的实施例，提供了一种用于对鞭毛细胞样品进行分选的无源逆流微流体装置。被动无逆流微流体装置包括：输入储存器，其构造成接收鞭毛细胞的样品;位于输入储存器下游的输出储存器，输出储存器，被配置成收集被分类的鞭毛细胞，以及多个微通道部分排列顺序地并且在输入储存器和输出储存器之间彼此流体连通，并被设计为在输入储存器和输出储存器之间限定封闭的微通道系统，其中每个微通道部分包括至少一个微通道，其中微通道的入口所述多个微通道部分中的第一微通道部分连接到所述输入储存器，其中所述多个微通道部分中的最后微通道部分的所述微通道的出口连接到所述输出储存器，并且其中，对于每个微通道部分，微通道的总体积所述多个微通道部分中的一个微通道部分大于所述多个微通道部分中的所述下游方向的相应的微通道部分，当所述鞭毛状细胞从所述输入储存器移动到所述输出储存器时，用于分选所述鞭毛细胞。

2. 发明申请

US20150072374A1 PASSIVE MICROFLUIDIC DEVICE AND A METHOD OF FORMING THE SAME 有权
标题翻译：被动微流体装置及其形成方法
公开(公告)号：US20150072374A1
公开(公告)日：2015-03-12
申请号：US14376279
申请日：2012-02-03
申请人： Soon Chye Ng , Swee Lian Liow , Naiqing Chen , Yen Wah Tong , Saif Abdul Kadir Khan , Boon Sing Fang
发明人： Soon Chye Ng , Swee Lian Liow , Naiqing Chen , Yen Wah Tong , Saif Abdul Kadir Khan , Boon Sing Fang
IPC分类号： G01N33/483
CPC分类号： G01N33/4833 , A61D19/00 , B01L3/5027 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2300/0861 , B01L2300/087 , C12M23/16 , C12M47/04 , C12N5/061 , C12N5/0612 , G01N15/147 , G01N33/487 , G01N2015/149 , Y10T29/49826
摘要： According to embodiments of the present invention, a passive counter flow free microfluidic device for sorting a sample of flagellated cells is provided. The passive counter flow free microfluidic device includes an input reservoir configured to receive the sample of flagellated cells, an output reservoir positioned downstream of the input reservoir, the output reservoir configured to collect the flagellated cells that are sorted, and a plurality of microchannel sections arranged sequentially and in fluid communication with each other between the input reservoir and the output reservoir, and designed to define a closed microchannel system between the input reservoir and the output reservoir, wherein each microchannel section comprises at least one microchannel, wherein an inlet of the microchannel of a first microchannel section of the plurality of microchannel sections is connected to the input reservoir, wherein an outlet of the microchannel of a last microchannel section of the plurality of microchannel sections is connected to the output reservoir, and wherein, for each microchannel section, the total volume of the microchannels of one microchannel section of the plurality of microchannel sections is larger than that of the respective in said downstream direction subsequent microchannel section of the plurality of microchannel sections for sorting the flagellated cells when the flagellated cells move from the input reservoir to the output reservoir.
摘要翻译：根据本发明的实施例，提供了一种用于对鞭毛细胞样品进行分选的无源逆流微流体装置。被动无逆流微流体装置包括：输入储存器，其构造成接收鞭毛细胞的样品;位于输入储存器下游的输出储存器，输出储存器，被配置成收集被分类的鞭毛细胞，以及多个微通道部分排列顺序地并且在输入储存器和输出储存器之间彼此流体连通，并被设计为在输入储存器和输出储存器之间限定封闭的微通道系统，其中每个微通道部分包括至少一个微通道，其中微通道的入口所述多个微通道部分中的第一微通道部分连接到所述输入储存器，其中所述多个微通道部分中的最后微通道部分的所述微通道的出口连接到所述输出储存器，并且其中，对于每个微通道部分，微通道的总体积所述多个微通道部分中的一个微通道部分大于所述多个微通道部分中的所述下游方向的相应的微通道部分，当所述鞭毛状细胞从所述输入储存器移动到所述输出储存器时，用于分选所述鞭毛细胞。

3. 发明申请

US20100291224A1 NANOSTRUCTURES, METHODS OF PREPARING AND USES THEREOF 审中-公开
标题翻译：纳米结构，其制备方法及其用途
公开(公告)号：US20100291224A1
公开(公告)日：2010-11-18
申请号：US12811690
申请日：2009-01-05
申请人： Yen Wah Tong , Chau Jin Tan , Hong Gap Chua , Kwee Hong Ker , Niranjani Sankarakumar
发明人： Yen Wah Tong , Chau Jin Tan , Hong Gap Chua , Kwee Hong Ker , Niranjani Sankarakumar
IPC分类号： A61K9/16 , G01N33/53 , G01N33/538 , G01N33/545 , B05D7/00 , C12Q1/70
CPC分类号： G01N33/587 , C08F263/00 , C08F265/00 , G01N33/54346 , G01N2600/00
摘要： The present invention provides a core-shell nanostructure comprising: a hydrophobic polymeric core; and a hydrophobic polymeric shell on the core, wherein the shell comprises at least one binding site for binding at least one target agent. In particular, the nanostructure has a red-blood cell morphology. The present invention also provides a method for preparing the nanostructure and uses of the nanostructure.
摘要翻译：本发明提供一种核 - 壳纳米结构，包括：疏水聚合物芯; 和核心上的疏水聚合物壳，其中所述壳包含用于结合至少一种目标试剂的至少一个结合位点。特别地，纳米结构具有红细胞形态。本发明还提供了纳米结构的制备方法和纳米结构的用途。

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