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1. 发明授权

US08541468B2 Ophthalmic composition for treating tear dysfunction 有权
标题翻译：用于治疗眼泪功能障碍的眼用组合物
公开(公告)号：US08541468B2
公开(公告)日：2013-09-24
申请号：US10574615
申请日：2004-09-30
申请人： Yuzuru Umeda , Hideo Nakashima , Michiko Shibuya , Yasukazu Saitoh , Shoji Okada , Shigeru Nakamura
发明人： Yuzuru Umeda , Hideo Nakashima , Michiko Shibuya , Yasukazu Saitoh , Shoji Okada , Shigeru Nakamura
IPC分类号： A01N37/00
CPC分类号： A61K31/19 , A61K9/0048
摘要： There are provided an ophthalmic composition that comprises 3-hydroxybutyric acid and/or salts thereof as active ingredients and is used to prevent desiccation of eyes and an ophthalmic composition that is used to treat tear dysfunction. By use of the ophthalmic compositions of the present invention, desiccation of the eyes can be inhibited and tear dysfunction can be treated. Therefore, by use of the compositions, discomforts caused by tear dysfunction, such as desiccation of the eyes, foreign-body sensation, feeling of discomfort on the eyes and eye strain, can be improved. Further, the ophthalmic compositions of the present invention can inhibit diseases caused by tear dysfunction, exemplified by development of dry eye and suspected dry eye which are dysfunctions related to desiccation of the eyes, particularly, development of diseases caused by tear dysfunction without injuries on the keratoconjunctive.
摘要翻译：提供了一种眼科组合物，其包含3-羟基丁酸和/或其盐作为活性成分，并用于防止眼睛干燥和用于治疗泪液功能障碍的眼用组合物。通过使用本发明的眼用组合物，可以抑制眼睛的干燥并且可以治疗眼泪功能障碍。因此，通过使用组合物，可以提高由泪液功能障碍引起的不适，例如眼睛干燥，异物感觉，眼睛不适感和眼睛疲劳感。此外，本发明的眼用组合物可以抑制由泪液功能障碍引起的疾病，例如发展与眼睛干燥有关的功能障碍的干眼症和怀疑干眼症，特别是由泪液功能障碍引起的疾病的发展，角膜结膜

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