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1. 发明申请

US20090148519A1 PULSED-RELEASE PREPARATION HAVING IMPROVED DISINTEGRATION PROPERTIES IN VIVO 审中-公开
标题翻译：在体内具有改善的消毒特性的脉冲释放制剂
公开(公告)号：US20090148519A1
公开(公告)日：2009-06-11
申请号：US12088080
申请日：2006-09-27
申请人： Yasuhiro Zaima , Takayuki Owaki
发明人： Yasuhiro Zaima , Takayuki Owaki
IPC分类号： A61K9/48 , A61K9/00 , A61K31/435 , A61K9/30 , A61K9/14
CPC分类号： A61K9/2886 , A61K9/2846 , A61K9/2866 , A61K31/4439 , A61K31/444
摘要： An object of the present invention is to provide a pulsed-release preparation that achieves pulsed-release by coating the exterior of a core that contains a physiologically active substance and a disintegrant, with a controlled-release coating that contains a water-insoluble polymer and an enteric polymer, or a water-insoluble polymer and a water-soluble polymer, wherein a satisfactory pulsed-release can be achieved without increasing the amount of disintegrant in the core, in particular even in the low-water environment in the lower part of the digestive tract. The present invention provides a pulsed-release preparation comprising: 1) a core containing a physiologically active substance and a disintegrant; 2) an enteric coating that covers the core; and 3) a controlled-release coating that covers the enteric coating applied on the core and that contains a water-insoluble polymer and an enteric polymer or water-soluble polymer.
摘要翻译：本发明的目的是提供一种脉冲释放制剂，其通过涂覆含有生理活性物质和崩解剂的核心的外部来实现脉冲释放，其中包含含有水不溶性聚合物的控释包衣和肠溶性聚合物或水不溶性聚合物和水溶性聚合物，其中可以实现令人满意的脉冲释放，而不增加芯中的崩解剂的量，特别是甚至在下部的低水环境中消化道。本发明提供一种脉冲释放制剂，其包括：1）含有生理活性物质和崩解剂的核心; 2）覆盖核心的肠溶衣; 和3）覆盖施加在芯上并含有水不溶性聚合物和肠溶性聚合物或水溶性聚合物的肠溶衣的控释包衣。

2. 发明申请

US20090123665A1 Fluidized Bed Device 审中-公开
标题翻译：流化床装置
公开(公告)号：US20090123665A1
公开(公告)日：2009-05-14
申请号：US11793425
申请日：2005-12-21
申请人： Yasuhiro Zaima
发明人： Yasuhiro Zaima
IPC分类号： B01J8/42 , H05F3/00 , B01J2/16 , G21K5/00
CPC分类号： B01J8/1854 , B01J2/16 , B01J4/002 , B01J8/006 , B01J8/1827 , B01J8/42 , B01J19/125 , B01J19/26 , B01J2219/0886
摘要： The present invention provides a fluidized bed device for handling fine particles as a fluidized bed in a medicine manufacturing process, a cosmetic manufacturing process, a food manufacturing process, a chemical manufacturing process and the like, wherein influence of static electricity is suppressed, and a method for neutralizing the static electricity using that device. The fluidized bed device includes an X-ray irradiation unit for irradiating fine particles in the fluidized bed device with X-rays.
摘要翻译：本发明提供了一种用于在药物制造工艺，化妆品制造工艺，食品制造工艺，化学制造工艺等中处理细颗粒作为流化床的流化床装置，其中静电的影响被抑制，并且使用该装置中和静电的方法。流化床装置包括用于以X射线照射流化床装置中的微粒的X射线照射单元。

3. 发明申请

US20100105738A1 EXTENDED RELEASE FORMULATIONS OF A PROTON PUMP INHIBITOR 审中-公开
标题翻译：原子泵抑制剂的扩展释放配方
公开(公告)号：US20100105738A1
公开(公告)日：2010-04-29
申请号：US12443804
申请日：2007-10-04
申请人： Mitsuru Mizuno , Shigeru Aoki , Kiyoshi Iwamoto , Kenji Moroshima , Yasuhiro Zaima , Manabu Murakami , Yukio Horai , Takashi Seno , Norihiro Ueda
发明人： Mitsuru Mizuno , Shigeru Aoki , Kiyoshi Iwamoto , Kenji Moroshima , Yasuhiro Zaima , Manabu Murakami , Yukio Horai , Takashi Seno , Norihiro Ueda
IPC分类号： A61K31/4439
CPC分类号： A61K9/4808 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K9/4891 , A61K9/5078 , A61K31/4439
摘要： The invention provides extended release formulations of proton pump inhibitor, such as an extended release formulation of rabeprazole, comprising an amount of rabeprazole between 30 and 90 mg rabeprazole and having an AUC of between 900 and 1750 ng*hr/mL and other properties.
摘要翻译：本发明提供质子泵抑制剂的延长释放制剂，例如雷贝拉唑的延长释放制剂，其包含一定量的雷贝拉唑，其在30至90mg雷贝拉唑之间，AUC为900至1750ng * hr / mL和其它性质。

4. 发明申请

US20100009003A1 PHARMACEUTICAL PREPARATION TO BE DISPERSED BEFORE ADMINISTRATION 审中-公开
标题翻译：在管理之前要分配的药物制剂
公开(公告)号：US20100009003A1
公开(公告)日：2010-01-14
申请号：US12561776
申请日：2009-09-17
申请人： Koji UKAI , Yasuyuki Asai , Yoshiteru Kato , Takayuki Ohwaki , Shigeru Aoki , Yasuhiro Zaima , Takehiro Yamaguchi
发明人： Koji UKAI , Yasuyuki Asai , Yoshiteru Kato , Takayuki Ohwaki , Shigeru Aoki , Yasuhiro Zaima , Takehiro Yamaguchi
IPC分类号： A61K31/4439 , A61K9/14
CPC分类号： A61K9/0095 , A61K9/5078 , A61K31/717 , A61K45/06
摘要： The present invention provides a pharmaceutical preparation to be dispersed before administration which has an adequate viscosity and a suitable flowability even when dispersed in a small amount of water and can be easily administered through an NG tube is provided. Specifically, the pharmaceutical preparation to be dispersed before administration contains active granules containing a pharmaceutically active substance having an average particle diameter of 5 mm or less and a thickening agent, and can be administered through an NG tube by dispersing in water before administration.
摘要翻译：本发明提供了即使分散在少量的水中也可以容易地通过NG管施用的具有足够的粘度和合适的流动性的在给药前分散的药物制剂。具体地说，给药前待分散的药物制剂含有含有平均粒径为5mm以下的药物活性物质和增稠剂的活性颗粒，并且可以通过NG管通过在给药前在水中分散来给药。

5. 发明授权

US07611078B2 Method of producing powered medicine multi-dose administering device and apparatus thereof 有权
标题翻译：动力药物多剂量给药装置及其制造方法
公开(公告)号：US07611078B2
公开(公告)日：2009-11-03
申请号：US10489662
申请日：2004-03-16
申请人： Yasuhiro Zaima , Masahiko Dohi , Seiji Mochizuki , Hiroshi Kuroda
发明人： Yasuhiro Zaima , Masahiko Dohi , Seiji Mochizuki , Hiroshi Kuroda
IPC分类号： F23D11/10
CPC分类号： G01G17/00 , A61M15/0066 , A61M2202/064 , Y10T29/49826
摘要： Parts of a powdered medicine multi-dose administering device are assembled, powdered medicine is filled and assembly that is obtained is inspected all on an automatic production line to increase productivity while preventing the production of defective products. The powdered medicine multi-dose administering device is produced through automated steps of inserting a filter (12) in a filter-fitting portion (11a) of a container (10), inserting an inner cylinder (15) in the container body (10), filling the container with the powdered medicine through a ring-like opening between an opening in the upper part of the container and the inner cylinder, fitting an inner closure (19) to the container and to the inner cylinder, fitting a nozzle (20) to the container while coupling it to the inner cylinder, and inspecting the thus obtained assembly.
摘要翻译：组装粉末药物多剂量给药装置的部件，填充粉末药物，并且在自动生产线上检查所有的组装，以提高生产率，同时防止缺陷产品的生产。通过将过滤器（12）插入容器（10）的过滤器配合部（11a）中的自动化步骤，将内筒（15）插入容器主体（10）中，通过自动化步骤来生产粉末状药物多剂量给药装置，通过容器上部的开口与内筒之间的环形开口将粉末药物填充到容器中，将内盖（19）装配到容器和内筒上，将喷嘴（20））连接到容器，同时将其联接到内筒，并检查由此获得的组件。

6. 发明授权

US07119288B2 Method and apparatus for weighing easily chargeable measured object 有权
标题翻译：容易充电的测量对象称重的方法和装置
公开(公告)号：US07119288B2
公开(公告)日：2006-10-10
申请号：US10489677
申请日：2003-07-17
申请人： Yasuhiro Zaima , Masahiko Dohi , Seiji Mochizuki , Akemi Kitada
发明人： Yasuhiro Zaima , Masahiko Dohi , Seiji Mochizuki , Akemi Kitada
IPC分类号： G01G13/00 , G01G23/00
CPC分类号： G01G23/00
摘要： A method of weighing an easily chargeable measured object able to remove the effects of static electricity to weigh a measured object by an accuracy of about 0.3 mg continuously with a good work efficiency. When using an electronic scale (10) provided with a weighing platform (11) and a weighing pan (12) able to move vertically by a very small distance with respect to the weighing platform to weight an easily chargeable measured object (14), the measured object is weighed in the state with a conductive frame (13) of a suitable size set on the weighing platform (11) around the weighing pan so as to surround the measured object placed on the weighing pan.
摘要翻译：称量容易计量的测量对象的方法，其能够以良好的工作效率连续地测量能够消除静电效应的重量，测量对象的精度为约0.3mg。当使用设置有称重平台（11）的电子秤（10）和能够相对于称重平台垂直移动非常小距离的称重盘（12）以对容易计量的测量对象（14）进行加重时，在具有设置在称重平台（11）上的合适尺寸的导电框架（13）的状态下称量被测物体围绕称重盘，以便围绕放置在称重盘上的被测物体。

7. 发明申请

US20050123021A1 Method and device for weighing easily charged weighed object 有权
标题翻译：称重物体称重的方法和装置
公开(公告)号：US20050123021A1
公开(公告)日：2005-06-09
申请号：US10489677
申请日：2003-07-17
申请人： Yasuhiro Zaima , Masahiko Dohi , Seiji Mochizuki , Akemi Kitada
发明人： Yasuhiro Zaima , Masahiko Dohi , Seiji Mochizuki , Akemi Kitada
IPC分类号： G01G7/00 , G01G23/00 , G01K7/00 , G01K1/08 , G01K1/14 , G01K13/00
CPC分类号： G01G23/00
摘要： A method of weighing an easily chargeable measured object able to remove the effects of static electricity to weigh a measured object by an accuracy of about 0.3 mg continuously with a good work efficiency. When using an electronic scale (10) provided with a weighing platform (11) and a weighing pan (12) able to move vertically by a very small distance with respect to the weighing platform to weight an easily chargeable measured object (14), the measured object is weighed in the state with a conductive frame (13) of a suitable size set on the weighing platform (11) around the weighing pan so as to surround the measured object placed on the weighing pan.
摘要翻译：称量容易计量的测量对象的方法，其能够以良好的工作效率连续地测量能够消除静电效应的重量，测量对象的精度为约0.3mg。当使用设置有称重平台（11）的电子秤（10）和能够相对于称重平台垂直移动非常小距离的称重盘（12）以对容易计量的测量对象（14）进行加重时，在具有设置在称重平台（11）上的合适尺寸的导电框架（13）的状态下称量被测物体围绕称重盘，以便围绕放置在称重盘上的被测物体。

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