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1. 发明授权

US5234665A Apparatus for measuring aggregation patterns on a microplate 失效
标题翻译：用于测量麦克风上的聚集图案的装置
公开(公告)号：US5234665A
公开(公告)日：1993-08-10
申请号：US700567
申请日：1991-05-15
申请人： Masato Ohta , Yasuhiko Yokomori , Toshiyuki Furuta , Hideo Suda , Naoki Ozawa , Shogo Kida
发明人： Masato Ohta , Yasuhiko Yokomori , Toshiyuki Furuta , Hideo Suda , Naoki Ozawa , Shogo Kida
IPC分类号： G01N21/17 , G01N21/25 , G01N21/59 , G01N21/82 , G01N33/543
CPC分类号： G01N21/253 , G01N21/82 , G01N2021/5957 , G01N2201/0446
摘要： An aggregation pattern detecting apparatus includes a microplate having a plurality of reactive vessels in which aggregation patterns are formed, a light source arranged above the microplate, and a light sensor arrangement positioned below the microplate. The microplate is removably fastened to a main body, and a movable frame is movably supported on the main body. The light source and light sensor arrangement are carried on the movable frame for movement therewith. A driving mechanism effects movement of the movable frame and is controlled by a main control section. A reference plate is provided separately from the microplate, and has a plurality of through holes therein which correspond to the reactive vessels of the microplate. The reference plate is removably fastenable to the main body at the normal operative position of the microplate. With the reference plate in this position, the distance from a starting point of the driving mechanism to the through holes of the reference plate is measured and stored in the main control section. Based on these stored distances, the main control section determines appropriate operational positions for the light sensor.
摘要翻译：聚集图案检测装置包括具有形成聚集图案的多个反应性血管的微孔板，布置在微孔板上方的光源和位于微板下方的光传感器装置。微板可拆卸地固定在主体上，可移动的框架可移动地支撑在主体上。光源和光传感器装置承载在可移动框架上以与其一起运动。驱动机构实现可动框架的移动，由主控制部控制。参考板与微孔板分开设置，并且在其中具有多个对应于微孔板的反应性容器的通孔。参考板可移除地在微板的正常操作位置处紧固到主体。在该位置的参考板上，测量从驱动机构的起点到参考板的通孔的距离并将其存储在主控制部分中。基于这些存储的距离，主控制部分确定光传感器的适当操作位置。

2. 发明授权

US5230026A Apparatus for discriminating particle aggregation pattern 失效
标题翻译：用于分离颗粒聚集图案的装置
公开(公告)号：US5230026A
公开(公告)日：1993-07-20
申请号：US700618
申请日：1991-05-15
申请人： Masato Ohta , Yasuhiko Yokomori , Toshiyuki Furuta , Hideo Suda , Naoki Ozawa , Shogo Kida
发明人： Masato Ohta , Yasuhiko Yokomori , Toshiyuki Furuta , Hideo Suda , Naoki Ozawa , Shogo Kida
IPC分类号： G01N21/17 , G01N21/59 , G01N21/82 , G01N33/543 , G06K9/38 , G06T5/00
CPC分类号： G01N21/82 , G06K9/38 , G06T7/0081 , G01N2021/5957 , G06T2207/20144 , G06T2207/30072
摘要： An apparatus for discriminating a particle aggregation pattern includes a memory circuit for storing line data output from a CCD line sensor, which line data represents the aggregation pattern. A maximum value is obtained for each set of line data, and thereafter a further maximum value is obtained from the afore-mentioned previously obtained maximum values. A threshold value is determined on the basis of the further maximum value, and is then applied to the line data in order to extract therefrom information regarding the shape and area of the aggregation pattern. In another embodiment, the threshold value is determined on the basis of minimum values obtained from the line data.
摘要翻译：用于鉴别粒子聚集图案的装置包括存储电路，用于存储从CCD行传感器输出的行数据，该行数据表示聚集图案。对于每组行数据获得最大值，然后从上述获得的最大值获得另一最大值。基于另外的最大值确定阈值，然后将其应用于线数据，以从其中提取关于聚集模式的形状和面积的信息。在另一个实施例中，基于从线数据获得的最小值来确定阈值。

3. 发明授权

US5233668A Method and apparatus for discriminating aggregation pattern 失效
标题翻译：用于分辨聚集图案的方法和装置
公开(公告)号：US5233668A
公开(公告)日：1993-08-03
申请号：US700568
申请日：1991-05-15
申请人： Yasuhiko Yokomori , Toshiyuki Furuta , Naoki Ozawa , Masato Ohta , Hideo Suda , Shogo Kida , Ryohei Matsumoto , Kunio Kurata , Yoshinobu Kubo , Yoshiharu Matsuoka , Masahiro Kato
发明人： Yasuhiko Yokomori , Toshiyuki Furuta , Naoki Ozawa , Masato Ohta , Hideo Suda , Shogo Kida , Ryohei Matsumoto , Kunio Kurata , Yoshinobu Kubo , Yoshiharu Matsuoka , Masahiro Kato
IPC分类号： G01N21/17 , G01N21/59 , G01N21/82 , G01N33/543 , G06K9/38 , G06T5/00
CPC分类号： G06K9/38 , G01N21/82 , G06T7/0081 , G01N2021/5957 , G06T2207/20144 , G06T2207/30072
摘要： A method and apparatus for discriminating aggregation patterns includes detection of an image of the aggregation pattern and dividing the image into a plurality of image line data using a photoelectric element. The image line data defines an image waveform and includes a maximum image value. High and low image levels are defined based on the maximum image value. These high and low image levels are used to determine first and second areas of the aggregation pattern image, which first and second areas respectively include image values at least as large as the high and low image levels. An area difference between the first and second areas and a level difference between the high and low image levels are then calculated, along with a ratio of the area difference to the level difference. The calculated area difference and ratio are then compared with a predetermined reference value to discriminate whether or not the aggregation pattern is positive.
摘要翻译：用于识别聚集模式的方法和装置包括使用光电元件检测聚集图案的图像并将图像划分为多个图像行数据。图像线数据定义图像波形并且包括最大图像值。基于最大图像值定义高和低图像级别。这些高和低图像级别用于确定聚集图案图像的第一和第二区域，第一和第二区域分别包括至少与高和低图像水平一样大的图像值。然后计算第一和第二区域之间的区域差和高和低图像水平之间的水平差，以及面积差与水平差的比率。然后将计算的面积差和比率与预定参考值进行比较，以鉴别聚集模式是否为正。

4. 发明授权

US5210612A Circuit for reading a plurality of CCD sensors during respective non-overlapping output periods 失效
标题翻译：在相关非重叠输出期间读取大量CCD传感器的电路
公开(公告)号：US5210612A
公开(公告)日：1993-05-11
申请号：US705637
申请日：1991-05-24
申请人： Toshiyuki Furuta , Yasuhiko Yokomori , Masato Ohta , Hideo Suda , Naoki Ozawa , Shogo Kida
发明人： Toshiyuki Furuta , Yasuhiko Yokomori , Masato Ohta , Hideo Suda , Naoki Ozawa , Shogo Kida
IPC分类号： H04N1/028 , H04N1/19 , H04N5/335 , H04N5/341 , H04N5/353 , H04N5/372 , H04N5/376 , H04N5/378
CPC分类号： H04N5/335
摘要： A CCD driving circuit for reading and outputting data from a plurality of CCD sensors, each CCD sensor being actuable to convert an image into data by first optically sensing the image during a first time period and thereafter converting the optically-sensed image into data during a second time period, including a driving arrangement for actuating the CCD sensors such that the first time periods associated therewith are staggered so that the second time periods associated therewith do not overlap each other. A multiplexing arrangement is provided for multiplexing and outputting the data read from each of the CCD sensors.
摘要翻译：一种用于从多个CCD传感器读取和输出数据的CCD驱动电路，每个CCD传感器可致动以通过在第一时间段期间首先光学地感测图像将图像转换成数据，然后将光学感测图像在第二时间段，包括用于致动CCD传感器的驱动装置，使得与其相关联的第一时间段交错，使得与其相关联的第二时间段彼此不重叠。提供多路复用装置，用于复用和输出从每个CCD传感器读取的数据。

5. 发明授权

US5265169A Method of discriminating particle aggregation pattern 失效
标题翻译：鉴别粒子聚集图案的方法
公开(公告)号：US5265169A
公开(公告)日：1993-11-23
申请号：US775809
申请日：1991-10-11
申请人： Masato Ohta , Yasuhiko Yokomori , Toshiyuki Furuta
发明人： Masato Ohta , Yasuhiko Yokomori , Toshiyuki Furuta
IPC分类号： G01N21/17 , G01N21/75 , G01N21/82 , G01N33/543 , G06K9/00
CPC分类号： G01N21/82 , G01N2021/755 , G01N2201/0407 , G01N2201/0446 , G01N2201/127
摘要： A method for identifying the presence or absence of an aggregation of particles distributed on a translucent surface includes the steps of providing a light sensing device for sensing light incident thereon and producing an output value which represents the intensity of the incident light, and identifying a first output value which is produced by the light sensing device when there is no light incident thereon. The method also identifies a second output value which is produced by the light sensing means when, with no particles present on the translucent surface, light is directed through the translucent surface onto the light sensing device. With a distribution of particles deposited on the translucent surface, light is directed through the translucent surface and onto the light sensing device, causing the light sensing device to produce a third output value. A final output value is then determined as a function of said first, second and third output values.
摘要翻译：用于识别分布在半透明表面上的颗粒的聚集的存在或不存在的方法包括以下步骤：提供用于感测入射在其上的光的光感测装置，并产生表示入射光强度的输出值，并且识别第一当没有光入射时由光检测装置产生的输出值。该方法还识别由光感测装置产生的第二输出值，当在半透明表面上没有颗粒存在时，光被引导通过透光表面到光感测装置上。随着沉积在半透明表面上的颗粒的分布，光被引导通过半透明表面并且到达光感测装置，使光感测装置产生第三输出值。然后确定最终输出值作为所述第一，第二和第三输出值的函数。

6. 发明授权

US5169601A Immunological agglutination detecting apparatus with separately controlled supplementary light sources 失效
标题翻译：具有单独控制的辅助光源的免疫凝集检测装置
公开(公告)号：US5169601A
公开(公告)日：1992-12-08
申请号：US516101
申请日：1990-04-27
申请人： Masato Ohta , Naoki Ozawa , Yasuhiko Yokomori
发明人： Masato Ohta , Naoki Ozawa , Yasuhiko Yokomori
IPC分类号： B01L3/00 , G01N21/82 , G01N33/53
CPC分类号： B01L3/5085 , G01N21/82 , G01N33/5302
摘要： An immunological agglutination detecting apparatus including an agglutination examination plate having one or more reaction vessels each provided with a bottom face of which at least a part is slanted. A light emitting source is arranged at one side of the agglutination examination plate. A light receiver is situated on the other side thereof. Respective images of the agglutination patterns formed on the bottom faces of the reaction vessels are focussed on the light receiver through individual lenses in order to detect, by an electrical device, the agglutination patterns which are formed by the shining light from the light emitting source. In the preferred embodiment, the light emitting source is one or more rows of primary point sources, each corresponding to a particular vessel in the plate, and one or more supplementary point sources adjacent the ends of the row or rows. The intensity of the primary and supplementary light sources can be separately adjusted.
摘要翻译：一种免疫凝集检测装置，其包括具有一个或多个反应容器的凝集检查板，每个反应容器的底面至少部分倾斜。发光源布置在凝集检查板的一侧。光接收器位于其另一侧。形成在反应容器的底面上的凝集图案的各图像通过各个透镜聚焦在光接收器上，以便通过电子装置检测由来自发光源的发光光形成的凝集图案。在优选实施例中，发光源是一行或多行主要点源，每一个源点对应于板中的特定容器，以及一个或多个与行或行的端部相邻的补充点源。主光源和辅助光源的强度可以单独调整。

7. 发明授权

US5096835A Method of discriminating particle aggregation pattern 失效
标题翻译：分离粒子聚集图案的方法
公开(公告)号：US5096835A
公开(公告)日：1992-03-17
申请号：US520093
申请日：1990-05-07
申请人： Yasuhiko Yokomori , Masato Ohta , Masahide Kimura , Kunio Kurata , Yoshinobu Kubo , Yoshiharu Matsuoka
发明人： Yasuhiko Yokomori , Masato Ohta , Masahide Kimura , Kunio Kurata , Yoshinobu Kubo , Yoshiharu Matsuoka
IPC分类号： G01N33/543 , G01N21/17 , G01N21/59 , G01N21/82
CPC分类号： G01N21/82 , G01N2021/5957 , G01N2201/04 , Y10S436/805
摘要： The aggregation pattern of particles is determined by obtaining luminous intensity curves representative of the particle aggregation pattern, obtaining a first threshold face by cutting the curves with a plane positioned at a first given height, obtaining a second threshold face by cutting the curves with a plane positioned at a second given height and determining the particle aggregation pattern by calculating the ratio of the area of the first threshold face to the area of the second threshold face.
摘要翻译：通过获得表示颗粒聚集图案的亮度曲线来确定颗粒的聚集图案，通过用位于第一给定高度的平面切割曲线获得第一阈值面，通过用平面切割曲线获得第二阈值面定位在第二给定高度，并通过计算第一阈值面积的面积与第二阈值面积的面积的比率来确定粒子聚集模式。

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