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1. 发明授权

US11414427B2 Solid forms of stemospironine and its salts 有权
公开(公告)号：US11414427B2
公开(公告)日：2022-08-16
申请号：US16646694
申请日：2018-09-07
申请人： Yang Ye , Sheng Yao , Hui-Yin Li , Qun Li
发明人： Yang Ye , Sheng Yao , Hui-Yin Li , Qun Li
IPC分类号： C07D491/20 , C07C59/255 , C07C309/04 , C07C309/05 , C07C309/19
摘要： Disclosed are stemospironine salts of Formula 1: wherein HX represents HCl, HBr, L-tartaric acid, D-tartaric acid, sulfuric acid, (+)-(1S)-10-camphorsulfonic acid, ethanesulfonic acid and ethane-1,2-disulfonic acid. This invention also provides crystalline polymorph forms of the compound of Formula 1 wherein HX is HCl, stemospironine hydrochloride. This invention also provides a new crystalline form of the compound of Formula 2, stemospironine free base: Also disclosed are compositions containing one or more compounds of Formula 1, methods for controlling cough comprising administering a therapeutically effective amount of a compound of Formula 1, and methods for preparing compounds of Formula 1. Also disclosed is a method for preparing crystalline stemospironine hydrochloride polymorph Form II from stemospironine hydrochloride polymorph Form I.

2. 发明授权

US08299054B2 Cyclic 11-beta hydroxysteroid dehydrogenase type 1 inhibitors 有权
标题翻译：环状11-β羟基类固醇脱氢酶1型抑制剂
公开(公告)号：US08299054B2
公开(公告)日：2012-10-30
申请号：US12759867
申请日：2010-04-14
申请人： Xiang-Yang Ye , Jeffrey A. Robl , Ronald L. Hanson , Zhiwei Guo , Ramesh N. Patel
发明人： Xiang-Yang Ye , Jeffrey A. Robl , Ronald L. Hanson , Zhiwei Guo , Ramesh N. Patel
IPC分类号： A61K31/397 , C07D206/00
CPC分类号： C07C61/40 , C07B2200/07 , C07C57/50 , C07C57/62 , C07C59/54 , C07C59/56 , C07C59/72 , C07C59/88 , C07C61/39 , C07C62/38 , C07C2603/66 , C07C2603/74 , C07D203/18 , C07D205/04 , C07D205/06 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/42 , C07D211/46 , C07D213/40 , C07D217/02 , C07D241/08 , C07D257/04 , C07D261/02 , C07D261/08 , C07D263/04 , C07D277/04 , C07D277/46 , C07D277/64 , C07D277/82 , C07D285/135 , C07D295/185 , C07D295/205 , C07D401/12 , C07D403/04 , C07D407/06 , C07D413/04 , C07D471/04 , C07D493/08
摘要： Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-Beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: enantiomers, diastereomers, solvates, or salts thereof, wherein A, W, X and Z are defined herein.
摘要翻译：提供了新的化合物，其为11-β-羟基类固醇脱氢酶I型抑制剂。 11-β-羟基类固醇脱氢酶I型抑制剂可用于治疗，预防或减缓需要11-β-羟基类固醇脱氢酶I型抑制剂治疗的疾病进展。这些新化合物具有以下结构：其中A，W，X和Z如本文所定义，其对映异构体，非对映体，溶剂合物或其盐。

3. 发明授权

US07951793B2 Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method 有权
标题翻译：用作抗糖尿病和抗肥胖剂的取代的杂环衍生物和方法
公开(公告)号：US07951793B2
公开(公告)日：2011-05-31
申请号：US11779319
申请日：2007-07-18
申请人： Peter T. W. Cheng , Sean Chen , Pratik Devasthale , Charles Z. Ding , Timothy F. Herpin , Shung Wu , Hao Zhang , Wei Wang , Xiang-Yang Ye
发明人： Peter T. W. Cheng , Sean Chen , Pratik Devasthale , Charles Z. Ding , Timothy F. Herpin , Shung Wu , Hao Zhang , Wei Wang , Xiang-Yang Ye
IPC分类号： A61K31/397 , C07D205/08 , A01N43/00
CPC分类号： C07D413/12 , C07D413/14
摘要： Compounds are provided which have the structure wherein Z1 is (CH2)q or C═O; Z2 is (CH2)p or C═O; D is —CH═ or C═O or (CH2)m where m is 0, 1, 2 or 3; n=0, 1 or 2; p=1 or 2; q=0, 1 or 2; Q is C or N; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4 X5 and X6 is C; and A, B, R1, R2, R2a, R4, R3, E, Z and Y are as defined herein, which compounds are useful in treating diabetes and related diseases.
摘要翻译：提供具有其中Z 1是（CH 2）q或C = O的结构的化合物; Z2是（CH2）p或C = O; D是-CH =或C = O或（CH 2）m，其中m为0,1,2或3; n = 0,1或2; p = 1或2; q = 0,1或2; Q是C或N; X是CH或N; X2是C，N，O或S; X3为C，N，O或S; X4为C，N，O或S; X5为C，N，O或S; X6为C，N，O或S; 条件是X 2，X 3，X 4 X 5和X 6中的至少一个为N; X2，X3，X4，X5和X6中的至少一个为C; 并且A，B，R1，R2，R2a，R4，R3，E，Z和Y如本文所定义，该化合物可用于治疗糖尿病和相关疾病。

4. 发明申请

US20110012607A1 METHOD AND APPARATUS FOR GENERALIZED AC AND DC ARC FAULT DETECTION AND PROTECTION 失效
标题翻译：用于通用交流和直流电弧故障检测和保护的方法和装置
公开(公告)号：US20110012607A1
公开(公告)日：2011-01-20
申请号：US12890861
申请日：2010-09-27
申请人： HASSAN ALI KOJORI , YANG YE
发明人： HASSAN ALI KOJORI , YANG YE
IPC分类号： G01R31/08
CPC分类号： H02H1/0015 , H02H3/0935
摘要： According to the features discussed herein, through a single generalized arc-fault detection algorithm, various types of series and/or parallel arc faults can be detected without any nuisance trip for either AC or DC Electric Power Systems. Running Discrete Fourier Series (RDFS) formulation for nuisance-free operation and cost-effective implementation is developed. Unlike other methods which require numerous source and load-side current and voltage measurements, only source side current is required. An arc detector may include a first detector to monitor variations of a magnitude of a fundamental component of a current, and a second detector to monitor an overload condition based in an i2t calculation. A method may include obtaining a first cycle of a fundamental component of a current, obtaining a second cycle of the fundamental component of the current, and comparing the first cycle of the fundamental component of the current and the second cycle of the fundamental component of the current to determine if a difference of the first cycle and the second cycle is greater than a threshold amount.
摘要翻译：根据本文所讨论的特征，通过单一的广义电弧故障检测算法，可以检测各种类型的串联和/或并联电弧故障，而无需任何AC或DC电力系统的扰动跳闸。开发了运行离散傅立叶级数（RDFS）制定无障碍操作和成本效益实施。与需要大量源极和负载侧电流和电压测量的其他方法不同，仅需要源极侧电流。电弧检测器可以包括第一检测器，用于监测电流的基波分量的幅度的变化，以及第二检测器，用于监测基于i2t计算的过载状况。一种方法可以包括获得电流的基波分量的第一周期，获得电流的基波分量的第二周期，以及比较电流的基波分量的当前和第二周期的基波分量的第一周期电流以确定第一周期和第二周期的差是否大于阈值量。

5. 发明申请

US20100171482A1 METHOD AND APPARATUS OF A MAXIMUM POWER POINT TRACKING CIRCUIT FOR SOLAR POWER GENERATION 审中-公开
标题翻译：用于太阳能发电的最大功率点跟踪电路的方法和装置
公开(公告)号：US20100171482A1
公开(公告)日：2010-07-08
申请号：US12350252
申请日：2009-01-08
申请人： YANG YE , Sheng Tao
发明人： YANG YE , Sheng Tao
IPC分类号： G05F5/00
CPC分类号： G05F1/67
摘要： A circuit that tracks the maximum power point of the solar cell is disclosed in the present invention. Unlikely conventional way of maximum power point tracking (maximum power point is referred to as MPP hereinafter; maximum power point tracking is referred to as MPPT hereinafter) which tracks MPP in the time frame of second or minutes, in the disclosed invention, MPP is tracked within the switching cycle, using the natural current ripple of the downstream converter circuit. The switching cycle is in the order of 10s of micro-seconds. Within the switching cycle of the converter, there is a natural current ripple which will result in the power change. The MPPT circuit tracks the power change and adjusts the current reference value accordingly to operate at MPP of the solar cell.
摘要翻译：在本发明中公开了跟踪太阳能电池的最大功率点的电路。在所公开的发明中，不寻常的最大功率点跟踪方法（最大功率点在下文中称为MPP，下文称为MPPT，称为MPPT），其在第二或分钟的时间帧内跟踪MPP，在MPP中被跟踪在开关周期内，使用下游转换电路的自然电流纹波。开关周期为10秒的微秒级。在转换器的开关周期内，有一个自然的电流纹波会导致电源变化。 MPPT电路跟踪功率变化并相应地调整电流参考值以在太阳能电池的MPP处工作。

6. 发明申请

US20090228223A1 POWER LINE COMMUNICATION BASED AIRCRAFT POWER DISTRIBUTION SYSTEM WITH REAL TIME WIRING INTEGRITY MONITORING CAPABILITY 有权
标题翻译：基于电力线通信的飞机功率分配系统，具有实时的线性一体化监控能力
公开(公告)号：US20090228223A1
公开(公告)日：2009-09-10
申请号：US12041941
申请日：2008-03-04
申请人： ZHENNING LIU , Randy J. Fuller , Wenjiang Yu , Yang Ye , Guangjun G. Liu
发明人： ZHENNING LIU , Randy J. Fuller , Wenjiang Yu , Yang Ye , Guangjun G. Liu
IPC分类号： H02H3/00 , G01R31/02
CPC分类号： G01R31/008 , G01R31/025 , G01R31/086 , G01R31/11 , H04B3/546 , H04B2203/5445 , H04B2203/5458 , H04B2203/5495
摘要： A power line communication-based aircraft power distribution system may allow for both power line communication (PLC) technology and spread spectrum time domain reflectometry (SSTDR) technology to be utilized in aircraft power distribution systems to achieve key maintenance functions. Unlike conventional power distribution systems, which may, for example, use only SSTDR for fault detection, the present invention includes a hardware platform that may allow both the PLC and the SSTDR to be utilized in aircraft power distribution systems to achieve key maintenance functions, such as real time wire fault location, and cost and weight savings. Further, unlike conventional power distribution systems, which may only detect and locate damage in feeder conductor wire sections before the power is applied to the load, the power distribution system of the present invention may permit real time wire fault location.
摘要翻译：基于电力线通信的飞机配电系统可以允许在飞机配电系统中利用电力线通信（PLC）技术和扩频时域反射计（SSTDR）技术来实现关键维护功能。与常规配电系统不同，传统配电系统可能例如仅使用SSTDR进行故障检测，本发明包括硬件平台，其可以允许PLC和SSTDR在飞机配电系统中使用以实现关键维护功能，例如作为实时线路故障定位，并节省成本和重量。此外，与在功率施加到负载之前只能检测和定位馈线导线部分中的损坏的常规配电系统不同，本发明的配电系统可以允许实时线路故障定位。

7. 发明申请

US20090122454A1 AUGMENTATION OF AMBIENT TEMPERATURE AND FREE CONVECTION EFFECTS IN THERMAL CIRCUIT BREAKER TRIP CURVE APPROXIMATIONS 有权
标题翻译：环境温度的增加和热断路器中的自由对流效应TRIP曲线逼近
公开(公告)号：US20090122454A1
公开(公告)日：2009-05-14
申请号：US11938693
申请日：2007-11-12
申请人： Ted J. Gayowsky , Yang Ye , Zhenning Z. Liu , Randy J. Fuller
发明人： Ted J. Gayowsky , Yang Ye , Zhenning Z. Liu , Randy J. Fuller
IPC分类号： H02H5/04
CPC分类号： H02H6/005 , H02H3/093 , H02H7/222
摘要： An electrical overload protection system may be based on a solid state control system. A solid state switch may open responsively to commands for a solid-state controller. The controller may perform calculations to determine accumulated energy in a protected conductor. The calculations may be based, in part, on samplings of current in the protected conductor and ambient temperature to which the conductor may be exposed.
摘要翻译：电气过载保护系统可以基于固态控制系统。固态开关可以响应于固态控制器的命令而打开。控制器可以执行计算以确定受保护导体中的累积能量。计算可以部分地基于受保护导体中的电流采样和导体可能暴露于的环境温度。

8. 发明申请

US20070014066A1 Method and apparatus applying virtual at trip criterion in power distribution 有权
标题翻译：在配电中应用虚拟跳闸标准的方法和装置
公开(公告)号：US20070014066A1
公开(公告)日：2007-01-18
申请号：US11480450
申请日：2006-07-05
申请人： Yang Ye
发明人： Yang Ye
IPC分类号： H02H3/00
CPC分类号： H02H6/005 , H02H3/0935 , H02H6/00 , H02H7/228
摘要： A virtual ΔT trip criterion is implemented in an electrical power distribution system to provide current-based tripping for a solid state power switching device. A first-order system model is implemented either by hardware or software to represent a rise in temperature of the electrical wire through which power is supplied. When the simulated temperature exceeds a threshold, the solid state power switching device may be tripped.
摘要翻译：在配电系统中实现虚拟的DeltaT跳闸标准，以为固态功率开关装置提供基于电流的跳闸。通过硬件或软件来实现一阶系统模型，以表示通过其供电的电线的温度升高。当模拟温度超过阈值时，固态电源开关装置可能跳闸。

9. 发明授权

US11953078B1 Low speed gear module 有权
公开(公告)号：US11953078B1
公开(公告)日：2024-04-09
申请号：US18234864
申请日：2023-08-16
申请人： SHA YANG YE INDUSTRIAL CO., LTD.
发明人： Feng-Chun Tsai , Ming-Han Tsai , Chin-Fa Lu , Kai-Hsien Wang
IPC分类号： F16H1/46 , F02C7/06 , F16H48/42 , F16H57/021 , F16H57/08
CPC分类号： F16H1/46 , F16H57/082 , F02C7/06 , F16H48/42 , F16H2048/423 , F16H2048/426 , F16H57/021 , F16H2057/085
摘要： A gear module includes a rotating cylinder, a first planetary gear set, a second planetary gear set, a concave-convex structure, and a limit bearing set. The first planetary gear set is accommodated in the rotating cylinder and includes a driven gear; the second planetary gear set includes a positioning frame, second planetary gears pivoted to a positioning frame, a driven gear engaged with the second planetary gears, and the positioning frame has a through hole; the concave-convex structure includes a convex column extended from the rotating cylinder and a concave hole formed on the positioning frame, the convex column is plugged into the concave hole; the limit bearing set includes a first ball bearing sheathing the driven gear and mounted between the driven gear and the through hole, and a second ball bearing sheathing the convex column and mounted between the convex column and the concave hole.

10. 发明授权

US10704651B2 Low rotational speed gear module 有权
公开(公告)号：US10704651B2
公开(公告)日：2020-07-07
申请号：US15976657
申请日：2018-05-10
申请人： Sha Yang Ye Industrial Co. Ltd.
发明人： Feng-Chun Tsai , Ming-Han Tsai , Chin-Fa Lu , Kai-Hsien Wang
IPC分类号： F16H1/46 , F16H57/021 , F16H57/031
摘要： A low rotational speed gear module includes a fixed tube member, a rotational sleeve, a first planetary gear set, a sun gear, and a second planetary gear set. The fixed tube member includes a first inner gear. The rotational sleeve includes a second inner gear. The first planetary gear set includes a fixing plate, first planetary gears fixed to one side of the fixing plate, and a driven gear fixed to the other side of the fixing plate. The first planetary gear is engaged at one side with the sun gear and engaged at another side with the first inner gear. The second planetary gear set includes second planetary gears. The second planetary gears is engaged at one side with the driven gear and engaged at another side with the first inner gear and the second inner gear.

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