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1. 发明授权

US10722500B2 Gossypol 7-N-isatin Schiff base compounds with antitumor activities and a method of preparing the same 有权
公开(公告)号：US10722500B2
公开(公告)日：2020-07-28
申请号：US16270563
申请日：2019-02-07
申请人： Xiaolin Xie , Dezhu Zhang , Shunjun Ding , Chengyuan Liang
发明人： Xiaolin Xie , Dezhu Zhang , Shunjun Ding , Chengyuan Liang
IPC分类号： A61K31/437 , A61P35/00 , G01N33/50
摘要： A gossypol 7-N-isatin Schiff base compounds compound with antitumor activities represented by formula I: is disclosed. In formula I, R is hydrogen, alkyl, cycloalkyl, alkoxy, unsubstituted or substituted phenyl, or substituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

2. 发明授权

US09753431B2 Visible light photoinitiating system for preparing high diffraction efficiency hologram optical polymer material 有权
$Visible light photoinitiating system for preparing high diffraction efficiency hologram optical polymer material$
公开(公告)号：US09753431B2
公开(公告)日：2017-09-05
申请号：US14131676
申请日：2012-05-25
申请人： Xiaolin Xie , Haiyan Peng , Xingping Zhou , Chengfu Zheng , Hongwei Ge
发明人： Xiaolin Xie , Haiyan Peng , Xingping Zhou , Chengfu Zheng , Hongwei Ge
IPC分类号： C08F2/52 , C08F2/42 , G03H1/04 , C08F2/50 , G03F7/00 , G03F7/029 , G03F7/031 , G11B7/24044 , G11B7/245 , G03H1/18
CPC分类号： G03H1/04 , C08F2/50 , G03F7/001 , G03F7/029 , G03F7/031 , G03H1/181 , G03H2260/12 , G11B7/24044 , G11B7/245
摘要： The present invention provides a visible light photoinitiating system for preparing a holographic photopolymer material with high-diffraction efficiency. The photoinitiating system comprises a photosensitizer and a co-initiator, and its mechanism is that the photosensitizer transforms from ground state to excited state after absorbing photons, and then interacts with the co-initiator through transfer of electrons and protons, which produces an alkyl (or aryl) free radical R and a ketyl radical K; wherein the free radical R initiates the addition polymerization of monomers that are capable of free radical polymerization, whereas the radical K inhibits the chain propagation of the macromolecular free radicals to a certain degree due to the steric hindrance effect, and thus delays the gelation time of the photopolymerization, which helps to increase the phase separation between the polymer and the functional components. A holographic photopolymer material with high-diffraction efficiency can be obtained by employing this visible light photoinitiating system.

3. 发明申请

US20110104606A1 COLOR TONER AND METHOD FOR PREPARING THE SAME 有权
标题翻译：彩色调色剂及其制备方法
公开(公告)号：US20110104606A1
公开(公告)日：2011-05-05
申请号：US12832100
申请日：2010-07-08
申请人： Xiaolin XIE , Guilin XIAO , Wenbu LI , Zeguan LAN
发明人： Xiaolin XIE , Guilin XIAO , Wenbu LI , Zeguan LAN
IPC分类号： G03G9/08
CPC分类号： G03G9/0804 , G03G9/0806 , G03G9/0812 , G03G9/08711 , G03G9/08782 , G03G9/09335 , G03G9/09357 , G03G9/09378 , G03G9/09385 , G03G9/09392 , G03G9/09716 , G03G9/09725
摘要： A method of preparing a color toner by: a) preparing an anionic polymer composite emulsion comprising wax with a wax particle and nanosilica as core by in situ emulsion polymerization; b) preparing a cationic polymer composite emulsion comprising colorant with a colorant and nanosilica as core by in situ emulsion polymerization; c) agglutinating the anionic polymer composite emulsion comprising wax and the cationic polymer composite emulsion comprising colorant; and d) filtering, washing, and drying the product obtained in c). The color toner prepared by this method. The color toner has high development density, high resolution, low bottom ash, low waste rate, and low consumption, and is easy to recover and recycle.
摘要翻译：一种通过以下步骤制备彩色调色剂的方法：a）通过原位乳液聚合制备包含蜡与蜡颗粒和纳米二氧化硅作为核心的阴离子聚合物复合乳液; b）通过原位乳液聚合制备包含着色剂和纳米二氧化硅作为核的着色剂的阳离子聚合物复合乳液; c）将包含蜡的阴离子聚合物复合乳液和包含着色剂的阳离子聚合物复合乳液凝结; 和d）过滤，洗涤和干燥c）中获得的产物。通过该方法制备的彩色调色剂。彩色调色剂具有高显影密度，高分辨率，低灰分，低废物率，低消耗，易于回收和回收利用。

4. 发明申请

US20110047060A1 APPARATUSES, METHODS AND SYSTEMS FOR A MARGINAL CONTRIBUTION TO PERFORMANCE PLATFORM 审中-公开
标题翻译：性能平台的标准贡献的装置，方法和系统
公开(公告)号：US20110047060A1
公开(公告)日：2011-02-24
申请号：US12705270
申请日：2010-02-12
申请人： DOUGLAS LAWRENCE BORDEN , Oliver Hansch , Youxun Shen , Xiaolin Xie
发明人： DOUGLAS LAWRENCE BORDEN , Oliver Hansch , Youxun Shen , Xiaolin Xie
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04
摘要： The APPARATUSES, METHODS AND SYSTEMS FOR A MARGINAL CONTRIBUTION TO PERFORMANCE PLATFORM (“MCP PLATFORM”) brings about significant advances in the utility and efficacy of algorithmic trading. In one embodiment, the MCP Platform facilitates optimized trading of financial instruments by employing an optimization framework that extends down to the order-placement level. The MCP Platform may minimize a total, generalized cost associated with a trade by separating the overall optimization problem into current order placement decisions and future order placement decisions. Future order placement decisions may then be evaluated analytically and the current order placement decisions evaluated numerically to effectively reduce the dimensionality of the optimization problem and allow optimization to be performed in a relatively short period of time.
摘要翻译： “性能平台”（“MCP PLATFORM”）对设备，方法和系统的贡献，在算法交易的效用和效用方面取得了显着进步。在一个实施例中，MCP平台通过采用延伸到订单放置级别的优化框架来促进金融工具的优化交易。 MCP平台可以通过将整体优化问题分解为当前订单放置决策和未来订单放置决策来最大限度地减少与交易相关的总体广义成本。然后可以分析地评估未来订单放置决策，并且以数字方式评估当前订单放置决策，以有效地降低优化问题的维度，并允许在相对较短的时间段内执行优化。

5. 发明授权

US11712457B2 有权
公开(公告)号：US11712457B2
公开(公告)日：2023-08-01
申请号：US17173622
申请日：2021-02-11
申请人： Qianqian Zhao , Jialin Li , Dan Yang , Jingyi Li , Liang Xin , Chunyang Shi , Xiaolin Xie , Dezhu Zhang , Ruina Bian , Xingke Ju , Chengyuan Liang , Yanjun Li , Qiao Zeng
发明人： Qianqian Zhao , Jialin Li , Dan Yang , Jingyi Li , Liang Xin , Chunyang Shi , Xiaolin Xie , Dezhu Zhang , Ruina Bian , Xingke Ju , Chengyuan Liang , Yanjun Li , Qiao Zeng
IPC分类号： A61K36/63 , A61P31/04 , A61K47/44 , A61K31/7034 , A61K31/7048
CPC分类号： A61K36/63 , A61K31/7034 , A61K31/7048 , A61K47/44 , A61P31/04 , A61K2236/15 , A61K2236/333 , A61K2236/35 , A61K2236/37 , A61K2236/51 , A61K2236/53
摘要： A Syringa microphylla seed extract includes the following components by weight based on a total weight of the Syringa microphylla seed extract: 0.4944-0.7142 mg/g of echinacoside, 6.624-7.617 mg/g of oleuropein, 0.4276-0.6309 mg/g of verbascoside, 3.927-4.684 mg/g of syringin, and 4.505-5.250 mg/g of forsythiaside B. A method of preparing the Syringa microphylla seed extract is disclosed. A composition for treating antibiotic-resistant infections that includes the Syringa microphylla seed extract is also disclosed.

6. 发明申请

US20220160805A1 SYRINGA PUBESCENS SEED EXTRACT, ITS PREPARATION AND APPLICATION IN ANTIBIOTIC-RESISTANT INFECTIONS 有权
公开(公告)号：US20220160805A1
公开(公告)日：2022-05-26
申请号：US17173622
申请日：2021-02-11
申请人： Dan YANG , Jingyi LI , Liang XIN , Chunyang SHI , Xiaolin XIE , Dezhu ZHANG , Ruina BIAN , Xingke JU , Chengyuan LIANG , Yanjun LI , Qiao ZENG
发明人： Dan YANG , Jingyi LI , Liang XIN , Chunyang SHI , Xiaolin XIE , Dezhu ZHANG , Ruina BIAN , Xingke JU , Chengyuan LIANG , Yanjun LI , Qiao ZENG
IPC分类号： A61K36/63 , A61K31/7034 , A61K31/7048 , A61K47/44 , A61P31/04
摘要： A Syringa microphylla seed extract includes the following components by weight based on a total weight of the Syringa microphylla seed extract: 0.4944-0.7142 mg/g of echinacoside, 6.624-7.617 mg/g of oleuropein, 0.4276-0.6309 mg/g of verbascoside, 3.927-4.684 mg/g of syringin, and 4.505-5.250 mg/g of forsythiaside B. A method of preparing the Syringa microphylla seed extract is disclosed. A composition for treating antibiotic-resistant infections that includes the Syringa microphylla seed extract is also disclosed.

7. 发明授权

US10729675B2 Gossypol isatin schiff base compounds with antitumor activities and a method of preparing the same 有权
公开(公告)号：US10729675B2
公开(公告)日：2020-08-04
申请号：US16270567
申请日：2019-02-07
申请人： Chengyuan Liang , Xingke Ju , Shunjun Ding , Lei Tian , Yuzhi Liu , Xiaolin Xie , Dezhu Zhang , Wenbo Yao , Dan Yang
发明人： Chengyuan Liang , Xingke Ju , Shunjun Ding , Lei Tian , Yuzhi Liu , Xiaolin Xie , Dezhu Zhang , Wenbo Yao , Dan Yang
IPC分类号： A61K31/404 , A61P35/00 , G01N33/50
摘要： A gossypol isatin Schiff base compound with antitumor activities represented by formula I: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

8. 发明申请

US20200147042A1 GOSSYPOL ISATIN SCHIFF BASE COMPOUNDS WITH ANTITUMOR ACTIVITIES AND A METHOD OF PREPARING THE SAME 审中-公开
公开(公告)号：US20200147042A1
公开(公告)日：2020-05-14
申请号：US16270567
申请日：2019-02-07
申请人： Chengyuan LIANG , Lei TIAN , Shunjun DING , Xingke JU , Yuzhi LIU , Xiaolin XIE , Dezhu ZHANG
发明人： Chengyuan LIANG , Lei TIAN , Shunjun DING , Xingke JU , Yuzhi LIU , Xiaolin XIE , Dezhu ZHANG
IPC分类号： A61K31/404 , A61P35/00 , G01N33/50
摘要： A gossypol isatin Schiff base compound with antitumor activities represented by formula I: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

9. 发明授权

US09758486B1 Edaravone-gossypol derivatives with antitumor activities and a method of preparing the same 有权
公开(公告)号：US09758486B1
公开(公告)日：2017-09-12
申请号：US15489713
申请日：2017-04-17
申请人： Chengyuan Liang , Danni Tian , Minyi Jia , Xiaolin Xie , Dezhu Zhang , Weihui Ju , Shunjun Ding , Xuechuan Wang
发明人： Chengyuan Liang , Danni Tian , Minyi Jia , Xiaolin Xie , Dezhu Zhang , Weihui Ju , Shunjun Ding , Xuechuan Wang
IPC分类号： C07D231/36 , C07D231/22 , C07D231/26
CPC分类号： C07D231/36 , C07D231/22 , C07D231/26
摘要： A compound with antitumor activities represented by formula I: In formula I, R1 is alkyl, alkoxy, or ethenyl; and R2 is alkyl, alkoxy, or halogen.

10. 发明授权

US10336689B1 Gossypol eflornithine Schiff base compound with antitumor activities and a method of preparing the same 有权
公开(公告)号：US10336689B1
公开(公告)日：2019-07-02
申请号：US16359963
申请日：2019-03-20
申请人： Chengyuan Liang , Shunjun Ding , Nan Hui , Juan Li , Dezhu Zhang , Xiaolin Xie
发明人： Chengyuan Liang , Shunjun Ding , Nan Hui , Juan Li , Dezhu Zhang , Xiaolin Xie
IPC分类号： C07C251/24 , A61P35/00 , C07C249/02
摘要： A gossypol eflornithine Schiff base compound having the following Formula I: is disclosed. A method of preparing the compound of Formula I is also disclosed.

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