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1. 发明授权

US10487046B1 Dihydroxytyrosol hexamethylene-1,6-dicarbamate having antioxidant activity and a method of preparing the same 有权
公开(公告)号：US10487046B1
公开(公告)日：2019-11-26
申请号：US16510906
申请日：2019-07-13
申请人： Han Li , Yuzhi Liu , Xingke Ju , Lei Tian , Juan Li , Nan Hui , Guaiping Qiao , Ning Liu , Liuyi Yang , Xuefeng Chen
发明人： Han Li , Yuzhi Liu , Xingke Ju , Lei Tian , Juan Li , Nan Hui , Guaiping Qiao , Ning Liu , Liuyi Yang , Xuefeng Chen
IPC分类号： C07C233/09 , C07C231/06
CPC分类号： C07C233/09 , C07C231/06
摘要： A compound having the following formula I:

is disclosed. A method of preparing the compound of formula (I) is also disclosed.

2. 发明授权

US10618911B2 1-O-acetylbritannilatone spiro aryl isoxazoline compounds 有权
公开(公告)号：US10618911B2
公开(公告)日：2020-04-14
申请号：US16167598
申请日：2018-10-23
申请人： Han Li , Yuzhi Liu , Nan Qin , Juan Xia , Shaomeng Pei , Chengyuan Liang , Lei Tian
发明人： Han Li , Yuzhi Liu , Nan Qin , Juan Xia , Shaomeng Pei , Chengyuan Liang , Lei Tian
IPC分类号： C07D498/10 , A61P11/06 , A61P29/00 , C07D495/04
CPC分类号： C07D498/10 , A61P11/06 , A61P29/00 , C07D495/04
摘要： A compound of chemical formula I:

or formula II:

or a pharmaceutical acceptable salt thereof is disclosed. R1 is OH or OAc; X is C or N; and R2 is H, alkyl, alkoxy, benzyloxy, haloalkyl, OH, CN, NO2, or halogen, provided that when X is N, R2 is nil.

3. 发明授权

US11306076B2 Silibinin lipoic acid ester with hepatoprotective activity and a method of preparing the same 有权
公开(公告)号：US11306076B2
公开(公告)日：2022-04-19
申请号：US16871354
申请日：2020-05-11
申请人： Yonghong Tang , Huafeng Qi , Peiyu Zhou , Xingke Ju , Chengyuan Liang , Yuzhi Liu , Bin Tian , Lei Tian , Gennian Mao , Limei Wang , Yuanyuan He , Yongbo Wang , Jingwen Xu , Dan Yang , Liang Qi , Wenbo Yao , Qianqian Zhao , Han Li
发明人： Yonghong Tang , Huafeng Qi , Peiyu Zhou , Xingke Ju , Chengyuan Liang , Yuzhi Liu , Bin Tian , Lei Tian , Gennian Mao , Limei Wang , Yuanyuan He , Yongbo Wang , Jingwen Xu , Dan Yang , Liang Qi , Wenbo Yao , Qianqian Zhao , Han Li
IPC分类号： C07D409/14 , B01J27/24
摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

4. 发明授权

US10729675B2 Gossypol isatin schiff base compounds with antitumor activities and a method of preparing the same 有权
公开(公告)号：US10729675B2
公开(公告)日：2020-08-04
申请号：US16270567
申请日：2019-02-07
申请人： Chengyuan Liang , Xingke Ju , Shunjun Ding , Lei Tian , Yuzhi Liu , Xiaolin Xie , Dezhu Zhang , Wenbo Yao , Dan Yang
发明人： Chengyuan Liang , Xingke Ju , Shunjun Ding , Lei Tian , Yuzhi Liu , Xiaolin Xie , Dezhu Zhang , Wenbo Yao , Dan Yang
IPC分类号： A61K31/404 , A61P35/00 , G01N33/50
摘要： A gossypol isatin Schiff base compound with antitumor activities represented by formula I: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

5. 发明申请

US20200147042A1 GOSSYPOL ISATIN SCHIFF BASE COMPOUNDS WITH ANTITUMOR ACTIVITIES AND A METHOD OF PREPARING THE SAME 审中-公开
公开(公告)号：US20200147042A1
公开(公告)日：2020-05-14
申请号：US16270567
申请日：2019-02-07
申请人： Chengyuan LIANG , Lei TIAN , Shunjun DING , Xingke JU , Yuzhi LIU , Xiaolin XIE , Dezhu ZHANG
发明人： Chengyuan LIANG , Lei TIAN , Shunjun DING , Xingke JU , Yuzhi LIU , Xiaolin XIE , Dezhu ZHANG
IPC分类号： A61K31/404 , A61P35/00 , G01N33/50
摘要： A gossypol isatin Schiff base compound with antitumor activities represented by formula I: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkoxy, nitro, halogen, unsubstituted or substituted phenyl, or unsubstituted or substituted benzyl. A method of preparing the compound of formula I is also disclosed.

6. 发明授权

US10377702B1 Hydroxytyrosol isophorone diisocyannate derivative with antioxidant activity and a method of preparing the same 有权
公开(公告)号：US10377702B1
公开(公告)日：2019-08-13
申请号：US16426560
申请日：2019-05-30
申请人： Chengyuan Liang , Yuzhi Liu , Xingke Ju , Yonghong Tang , Gennian Mao , Qianqian Zhao , Bin Tian , Jian Zha , Chunyang Shi , Yongbo Wang , Huayin Pu , Yanghan Liu
发明人： Chengyuan Liang , Yuzhi Liu , Xingke Ju , Yonghong Tang , Gennian Mao , Qianqian Zhao , Bin Tian , Jian Zha , Chunyang Shi , Yongbo Wang , Huayin Pu , Yanghan Liu
IPC分类号： C07C269/02 , B01J31/02 , B01D15/16
摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

7. 发明授权

US09422699B2 Toilet inlet valve and control method thereof 有权
标题翻译：马桶入口阀及其控制方法
公开(公告)号：US09422699B2
公开(公告)日：2016-08-23
申请号：US13884847
申请日：2011-11-07
申请人： Feiyu Li , Dongsheng Yao , Yuzhi Liu
发明人： Feiyu Li , Dongsheng Yao , Yuzhi Liu
IPC分类号： F16K31/18 , E03D1/32 , F16K21/18 , F16K31/22 , F16K31/34
CPC分类号： E03D1/32 , F16K21/18 , F16K31/22 , F16K31/34 , Y10T137/0318 , Y10T137/7442
摘要： A toilet inlet valve and control method thereof, the inlet valve comprises a valve body, an inlet pipe, a water stop device with a water stop rubber gasket, a float bowl device, a raising rod device and an outlet pipe, wherein, the water stop device also comprises a water stop seat, a tray, a needle valve and a back pressure cavity; the water stop seat is located at the front end of the outlet pipe, and of which the opening is coupling with the end face of the water stop rubber gasket; the tray is connected to the water stop rubber gasket, and is located at the side of the water stop seat that is opposite to the water stop rubber gasket; the needle valve is fixed to the tray, and is located at the side of the water stop rubber gasket that is opposite to the tray.
摘要翻译：一种马桶入口阀及其控制方法，入口阀包括阀体，入口管，具有止水橡胶垫圈的止水装置，浮筒装置，升高杆装置和出口管，其中，水停止装置还包括止水座，托盘，针阀和背压腔; 止水座位于出口管的前端，其开口与止水橡胶垫圈的端面相连; 托盘连接到止水橡胶垫圈，位于止水垫座的与止水垫橡胶垫圈相对的一侧; 针阀固定在托盘上，位于与托盘相对的止水橡胶垫圈的一侧。

8. 发明申请

US20130227774A1 INLET STRUCTURE OF WATER-STORING KEG FLOAT 有权
标题翻译：水储罐入口结构
公开(公告)号：US20130227774A1
公开(公告)日：2013-09-05
申请号：US13884894
申请日：2011-11-07
申请人： Feiyu Li , Dongsheng Yao , Yuzhi Liu
发明人： Feiyu Li , Dongsheng Yao , Yuzhi Liu
IPC分类号： E03D1/30
CPC分类号： E03D1/304 , E03D1/32 , F16K21/165 , F16K21/18
摘要： The present invention discloses an inlet structure of water-storing keg float, comprises an inlet, an outlet pipe and a water-storing keg float with a storage tank, and the inlet is provided with a channel passing through the outlet pipe, and the channel is provided with a water-storing cavity and a guide hole, and the guide hole is communicated with the water-storing cavity and the outside wall of the outlet pipe. Because water-storing cavity is present, part of water from the inlet can be stored in the water-storing cavity because of gravity, and this part of water fully enters the storage tank of the keg float through the guide hole, and the keg float can be balanced effectively under different water pressure conditions, and the stability of the keg float is enhanced.
摘要翻译：本发明公开了一种储水桶浮子的入口结构，包括入口，出口管和带有储罐的储水桶浮子，入口设有通过出口管的通道，通道设有储水腔和引导孔，引导孔与储水腔和出水管的外壁连通。由于存在储水腔，所以入口处的一部分水由于重力而可以储存在储水腔中，这部分水通过导孔完全进入小桶浮球的储罐，小桶浮子可以在不同的水压条件下有效平衡，提高小桶浮球的稳定性。

9. 发明申请

US20210347767A1 SILIBININ LIPOIC ACID ESTER WITH HEPATOPROTECTIVE ACTIVITY AND A METHOD OF PREPARING THE SAME 有权
公开(公告)号：US20210347767A1
公开(公告)日：2021-11-11
申请号：US16871354
申请日：2020-05-11
申请人： Xingke JU , Chengyuan LIANG , Yuzhi LIU , Bin TIAN , Lei TIAN , Gennian MAO , Limei WANG , Yuanyuan HE , Yongbo WANG , Jingwen XU , Dan YANG , Liang QI , Wenbo YAO , Qianqian ZHAO , Han LI
发明人： Xingke JU , Chengyuan LIANG , Yuzhi LIU , Bin TIAN , Lei TIAN , Gennian MAO , Limei WANG , Yuanyuan HE , Yongbo WANG , Jingwen XU , Dan YANG , Liang QI , Wenbo YAO , Qianqian ZHAO , Han LI
IPC分类号： C07D409/14 , B01J27/24
摘要： A compound having the formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

10. 发明授权

US10995053B1 Hydroxytyrosol ursolic acid ester with antioxidant activity and methods of preparing the same 有权
公开(公告)号：US10995053B1
公开(公告)日：2021-05-04
申请号：US16826045
申请日：2020-03-20
申请人： Han Li , Nan Hui , Bin Tian , Xingke Ju , Yuzhi Liu , Dan Yang , Jingwen Xu , Liang Qi , Qianqian Zhao , Yongbo Wang
发明人： Han Li , Nan Hui , Bin Tian , Xingke Ju , Yuzhi Liu , Dan Yang , Jingwen Xu , Liang Qi , Qianqian Zhao , Yongbo Wang
IPC分类号： C07C67/08 , B01J20/291 , B01J31/02
摘要： A compound having the formula (I): is disclosed. Methods of preparing the compound of formula (I) are also disclosed. The compound of formula (I) can be prepared by reacting a compound of formula (II) with a compound of formula (III) in an organic solvent with EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide). The compound of formula (I) can also be prepared by reacting the compound of formula (II) with the compound of formula (III) in 1-ethyl-3-methylimidazolium hexafluorophosphate as a solvent with silicomolybdic acid as a catalyst.

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