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1. 发明授权

US08357786B2 Method for preparing Gynostemma pentaphyllum extract with increasing damulin A and damulin B contents, and pharmaceutical compositions of the same for treating metabolic disease 有权
标题翻译：制备绞股蓝五味子提取物的方法，增加抗菌素A和damulin B的含量，以及用于治疗代谢疾病的药物组合物
公开(公告)号：US08357786B2
公开(公告)日：2013-01-22
申请号：US12696362
申请日：2010-01-29
申请人： Tae Lin Huh , He Bok Song , Ji Eun Kim , So Young Joon , Won Keun Oh
发明人： Tae Lin Huh , He Bok Song , Ji Eun Kim , So Young Joon , Won Keun Oh
IPC分类号： C07G3/00 , C07H17/00 , A01N45/00
CPC分类号： A61K36/424 , A23L33/105 , A23V2002/00 , A23V2250/21
摘要： Disclosed is an AMPK activating material used for improving and treating metabolic syndrome, in which AMPK (AMP-activated protein kinase) is a main enzyme for regulating an energy sensor and lipid/glucose metabolism in the body. The activation of AMPK inhibits the synthesis of fat and cholesterol, and accelerates the reduction of body fat and blood glucose, thereby improving obesity, diabetes, and hyperlipidaemia. The disclosed AMPK activating material contains, as active ingredients having an improving and treating effect on metabolic syndrome, including obesity, diabetes, and hyperlipidaemia, a novel compound 2α,3β,12β-trihydroxydammar-20(22)-E,24-diene-3-O-[β-D-glucopyranosyl-(1→)-β-D-glucopyranoside], named Damulin A, and a novel compound 2α,3β,12β-trihydroxydammara-20,24-diene-3-O-[β-D-glucopyranosyl-(1→)-β-D-glucopyranoside], named Damulin B. Herein, the contents of damulin A and damulin B (as active indicator ingredients for AMPK activation) can be increased by treating a Gynostemma pentaphyllum extract with high temperature/high pressure. Accordingly, the novel Gynostemma pentaphyllum extract with a significantly increased AMPK activating capability can be used for improving or treating metabolic syndrome, such as obesity, diabetes, and hyperlipidaemia.
摘要翻译：公开了用于改善和治疗代谢综合征的AMPK活化材料，其中AMPK（AMP激活的蛋白激酶）是调节体内能量传感器和脂质/葡萄糖代谢的主要酶。 AMPK的激活抑制脂肪和胆固醇的合成，并加速体脂肪和血糖的降低，从而改善肥胖，糖尿病和高脂血症。所公开的AMPK活化材料含有作为对代谢综合征（包括肥胖症，糖尿病和高脂血症）具有改善和治疗作用的活性成分，新型化合物2α，3β，12β-三氢羟基-20（22）-E 24- 二烯-3-O- [[b] -D-吡喃葡萄糖基 - （1→） - ＆bgr-D-吡喃葡萄糖苷]，命名为Damulin A，和新化合物2α，3＆bgr，12b-三氢羟基-20,24-二烯 -3-O- [＆bgr-D-吡喃葡萄糖基 - （1→） - ＆bgr-D-吡喃葡萄糖苷]，命名为Damulin B.本文中，damulin A和damulin B（作为AMPK活化的活性指标成分）的含量可以通过用高温/高压处理绞股蓝五叶萃取物来增加。因此，具有显着增加的AMPK活化能力的新型绞股蓝五叶萃取物可用于改善或治疗代谢综合征，例如肥胖症，糖尿病和高脂血症。

2. 发明申请

US20120083525A1 COMPOSITION FOR PREVENTING OR TREATING OBESITY-RELATED DISEASES MEDIATED BY THE ACTIVATION OF AMPK AND INCLUDING 2,5-BIS-ARYL-3,4-DIMETHYLTETRAHYDROFURAN LIGNANS AS ACTIVE INGREDIENTS 审中-公开
标题翻译：用于预防或治疗由AMPK激活引起的与相关疾病相关的疾病的组合物，包括2,5-BIS-ARYL-3,4-DIMETHYLTETRAHYDROFURAN LIGNANS作为活性成分
公开(公告)号：US20120083525A1
公开(公告)日：2012-04-05
申请号：US13375446
申请日：2009-06-26
申请人： Won Keun Oh , Phi Hung Nguyen , Thi Van Thu Le , Hu Won Kang , Eui Seok Shin , Jin Kyu Chio , Dae Bang Seo , Sang Jun Lee
发明人： Won Keun Oh , Phi Hung Nguyen , Thi Van Thu Le , Hu Won Kang , Eui Seok Shin , Jin Kyu Chio , Dae Bang Seo , Sang Jun Lee
IPC分类号： A61K31/341 , A61P3/04 , A61P3/00 , C07D307/12
摘要： The present invention relates to a 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan compound which activates nutmeg-derived AMP-activated protein kinase (AMPK), and to a composition including same as active ingredients for preventing and treating metabolic syndromes such as obesity. More particularly, the present invention relates to an AMPK-activating compound comprising one of the 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignan-based compounds produced by extracting Myristica fragrans with a solution of 30% or less of ethanol and separating and purifying the extracts using chromatography, as expressed in chemical formula 1 below, and to a composition comprising same as an active ingredient for preventing and treating metabolic syndrome caused by AMPK enzyme activation, such as obesity, diabetes, high cholesterol and cardiopulmonary diseases.
摘要翻译：本发明涉及活化肉豆蔻衍生的AMP活化蛋白激酶（AMPK）的2,5-双 - 芳基-3,4-二甲基四氢呋喃木脂素化合物，以及包含其作为预防和治疗代谢综合征的活性成分的组合物如肥胖。更具体地说，本发明涉及一种AMPK活化化合物，其包含通过用30％或更少乙醇的溶液提取肉豆蔻酸所制备的2,5-双 - 芳基-3,4-二甲基四氢呋喃木酚素基化合物之一和使用如下述化学式1所示的色谱法分离纯化提取物，以及包含其作为活性成分的组合物，用于预防和治疗由AMPK酶活化引起的代谢综合征，如肥胖症，糖尿病，高胆固醇和心肺疾病。

3. 发明申请

US20110015142A1 METHOD FOR PREPARING GYNOSTEMMA PENTAPHYLLUM EXTRACT WITH INCREASING DAMULIN A AND DAMULIN B CONTENTS, AND PHARMACEUTICAL COMPOSITIONS OF THE SAME FOR TREATING METABOLIC DISEASE 有权
标题翻译：用于制备具有增加大黄酸A和大豆B含量的GYNOSTEMMA PENTAPHLLUM提取物的方法及其药代动力学组合物用于治疗代谢疾病
公开(公告)号：US20110015142A1
公开(公告)日：2011-01-20
申请号：US12696362
申请日：2010-01-29
申请人： Tae Lin HUH , He Bok SONG , Ji Eun KIM , So Young JOON , Won Keun OH
发明人： Tae Lin HUH , He Bok SONG , Ji Eun KIM , So Young JOON , Won Keun OH
IPC分类号： A61K31/58 , C07J17/00 , A61P3/06 , A61P3/10 , A61P3/04
CPC分类号： A61K36/424 , A23L33/105 , A23V2002/00 , A23V2250/21
摘要： Disclosed is an AMPK activating material used for improving and treating metabolic syndrome, in which AMPK (AMP-activated protein kinase) is a main enzyme for regulating an energy sensor and lipid/glucose metabolism in the body. The activation of AMPK inhibits the synthesis of fat and cholesterol, and accelerates the reduction of body fat and blood glucose, thereby improving obesity, diabetes, and hyperlipidaemia. The disclosed AMPK activating material contains, as active ingredients having an improving and treating effect on metabolic syndrome, including obesity, diabetes, and hyperlipidaemia, a novel compound 2α,3β,12β-trihydroxydammar-20(22)-E,24-diene-3-O-[β-D-glucopyranosyl-(1→)-β-D-glucopyranoside], named Damulin A, and a novel compound 2α,3β,12β-trihydroxydammara-20,24-diene-3-O-[β-D-glucopyranosyl-(1→)-β-D-glucopyranoside], named Damulin B. Herein, the contents of damulin A and damulin B (as active indicator ingredients for AMPK activation) can be increased by treating a Gynostemma pentaphyllum extract with high temperature/high pressure. Accordingly, the novel Gynostemma pentaphyllum extract with a significantly increased AMPK activating capability can be used for improving or treating metabolic syndrome, such as obesity, diabetes, and hyperlipidaemia.
摘要翻译：公开了用于改善和治疗代谢综合征的AMPK活化材料，其中AMPK（AMP激活的蛋白激酶）是调节体内能量传感器和脂质/葡萄糖代谢的主要酶。 AMPK的激活抑制脂肪和胆固醇的合成，并加速体脂肪和血糖的降低，从而改善肥胖，糖尿病和高脂血症。所公开的AMPK活化材料含有作为对代谢综合征（包括肥胖症，糖尿病和高脂血症）具有改善和治疗作用的活性成分，新型化合物2α，3β，12β-三氢羟基-20（22）-E 24- 二烯-3-O- [[b] -D-吡喃葡萄糖基 - （1→） - ＆bgr-D-吡喃葡萄糖苷]，命名为Damulin A，和新化合物2α，3＆bgr，12b-三氢羟基-20,24-二烯 -3-O- [＆bgr-D-吡喃葡萄糖基 - （1→） - ＆bgr-D-吡喃葡萄糖苷]，命名为Damulin B.本文中，damulin A和damulin B（作为AMPK活化的活性指标成分）的含量可以通过用高温/高压处理绞股蓝五叶萃取物来增加。因此，具有显着增加的AMPK活化能力的新型绞股蓝五叶萃取物可用于改善或治疗代谢综合征，例如肥胖症，糖尿病和高脂血症。

4. 发明授权

US07060714B2 Fungal strain acremonium sp.MT70646(KCTC 0916BP), novel compounds produced by this strain and their use 失效
标题翻译：真菌菌株顶孢菌MTP70646（KCTC 0916BP），该菌株产生的新化合物及其用途
公开(公告)号：US07060714B2
公开(公告)日：2006-06-13
申请号：US10168807
申请日：2000-12-19
申请人： Jong Seog Ahn , Bo Yeon Kim , Won Keun Oh , Tae Ick Mheen , Dae Ook Kang , Hack Ryong Ko
发明人： Jong Seog Ahn , Bo Yeon Kim , Won Keun Oh , Tae Ick Mheen , Dae Ook Kang , Hack Ryong Ko
IPC分类号： A01N43/16 , C12P19/58 , C12N1/14
CPC分类号： C07H15/203 , C12P19/46 , C12R1/645
摘要： The invention is aimed at discovering a new type of anti-cancer compound which can exert an excellent inhibitory activity against the heparanase. A fungal strain Acremonium sp. MT70646 (KCTC 8973P) was isolated from the soil. From the culture of the isolated fungal strain, novel compounds that can inhibit both heparinase and heparanase was purified. Therefore, the present invention regards to provide a newly isolated fungal strain Acremonium sp. MT70646 (KCTC 8973P), its new products, and pharmaceutical agents such as a heparinase inhibitor, a heparanase inhibitor, a metastasis inhibitor and an angeiogenesis inhibitor all of which contain the above new compounds produced by the fungal strain as an active ingredient.
摘要翻译：本发明旨在发现能够对乙酰肝素酶发挥优异抑制活性的新型抗癌化合物。真菌菌株Acremonium sp。从土壤中分离出MT70646（KCTC8973P）。从分离的真菌菌株的培养物中纯化可抑制肝素酶和乙酰肝素酶的新型化合物。因此，本发明提供了一种新分离的真菌菌株Acremonium sp。 MT70646（KCTC8973P）及其新产品，以及诸如肝素酶抑制剂，乙酰肝素酶抑制剂，转移抑制剂和血管发生抑制剂等药剂，均含有上述由真菌菌株生产的新化合物作为活性成分。

5. 发明申请

US20120046353A1 CLEISTOCALYX OPERCULATUS-DERIVED COMPOUNDS HAVING INHIBITORY ACTIVITIES AGAINST AVIAN AND SWINE INFLUENZA VIRUSES OR NOVEL INFLUENZA VIRUS 审中-公开
标题翻译：具有抗AVIAN和SWINE INVRENZA病毒或新型流感病毒的抑制活性的CLEISTOCALYX操作化合物
公开(公告)号：US20120046353A1
公开(公告)日：2012-02-23
申请号：US12954331
申请日：2010-11-24
申请人： Injoong YOON , Eunhee KIM , Hwan-won CHOI , Won Keun OH , Trong Tuan DAO , Phuong Thien THUONG
发明人： Injoong YOON , Eunhee KIM , Hwan-won CHOI , Won Keun OH , Trong Tuan DAO , Phuong Thien THUONG
IPC分类号： A61K31/353 , C07D311/38 , C07C49/835 , A61P31/16 , A01N43/16 , A01N35/04 , A01P1/00 , C07D311/32 , A61K31/12
CPC分类号： C07D311/32 , A01N35/04 , A01N43/16 , A01N65/00 , A01N65/28 , C07D311/38
摘要： The present invention relates to a Cleistocalyx operculatus-derived compound having inhibitory activity against neuraminidase and to a composition for preventing and treating diseases caused by avian and swine influenza viruses and novel influenza viruses, comprising the compound as an active ingredient.
摘要翻译：本发明涉及具有对神经氨酸酶的抑制活性的Cleistocalyx operculatus衍生化合物和用于预防和治疗禽流感病毒和猪流感病毒和新型流感病毒引起的疾病的组合物，其包含该化合物作为活性成分。

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