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1. 发明申请

US20110015142A1 METHOD FOR PREPARING GYNOSTEMMA PENTAPHYLLUM EXTRACT WITH INCREASING DAMULIN A AND DAMULIN B CONTENTS, AND PHARMACEUTICAL COMPOSITIONS OF THE SAME FOR TREATING METABOLIC DISEASE 有权
标题翻译：用于制备具有增加大黄酸A和大豆B含量的GYNOSTEMMA PENTAPHLLUM提取物的方法及其药代动力学组合物用于治疗代谢疾病
公开(公告)号：US20110015142A1
公开(公告)日：2011-01-20
申请号：US12696362
申请日：2010-01-29
申请人： Tae Lin HUH , He Bok SONG , Ji Eun KIM , So Young JOON , Won Keun OH
发明人： Tae Lin HUH , He Bok SONG , Ji Eun KIM , So Young JOON , Won Keun OH
IPC分类号： A61K31/58 , C07J17/00 , A61P3/06 , A61P3/10 , A61P3/04
CPC分类号： A61K36/424 , A23L33/105 , A23V2002/00 , A23V2250/21
摘要： Disclosed is an AMPK activating material used for improving and treating metabolic syndrome, in which AMPK (AMP-activated protein kinase) is a main enzyme for regulating an energy sensor and lipid/glucose metabolism in the body. The activation of AMPK inhibits the synthesis of fat and cholesterol, and accelerates the reduction of body fat and blood glucose, thereby improving obesity, diabetes, and hyperlipidaemia. The disclosed AMPK activating material contains, as active ingredients having an improving and treating effect on metabolic syndrome, including obesity, diabetes, and hyperlipidaemia, a novel compound 2α,3β,12β-trihydroxydammar-20(22)-E,24-diene-3-O-[β-D-glucopyranosyl-(1→)-β-D-glucopyranoside], named Damulin A, and a novel compound 2α,3β,12β-trihydroxydammara-20,24-diene-3-O-[β-D-glucopyranosyl-(1→)-β-D-glucopyranoside], named Damulin B. Herein, the contents of damulin A and damulin B (as active indicator ingredients for AMPK activation) can be increased by treating a Gynostemma pentaphyllum extract with high temperature/high pressure. Accordingly, the novel Gynostemma pentaphyllum extract with a significantly increased AMPK activating capability can be used for improving or treating metabolic syndrome, such as obesity, diabetes, and hyperlipidaemia.
摘要翻译：公开了用于改善和治疗代谢综合征的AMPK活化材料，其中AMPK（AMP激活的蛋白激酶）是调节体内能量传感器和脂质/葡萄糖代谢的主要酶。 AMPK的激活抑制脂肪和胆固醇的合成，并加速体脂肪和血糖的降低，从而改善肥胖，糖尿病和高脂血症。所公开的AMPK活化材料含有作为对代谢综合征（包括肥胖症，糖尿病和高脂血症）具有改善和治疗作用的活性成分，新型化合物2α，3β，12β-三氢羟基-20（22）-E 24- 二烯-3-O- [[b] -D-吡喃葡萄糖基 - （1→） - ＆bgr-D-吡喃葡萄糖苷]，命名为Damulin A，和新化合物2α，3＆bgr，12b-三氢羟基-20,24-二烯 -3-O- [＆bgr-D-吡喃葡萄糖基 - （1→） - ＆bgr-D-吡喃葡萄糖苷]，命名为Damulin B.本文中，damulin A和damulin B（作为AMPK活化的活性指标成分）的含量可以通过用高温/高压处理绞股蓝五叶萃取物来增加。因此，具有显着增加的AMPK活化能力的新型绞股蓝五叶萃取物可用于改善或治疗代谢综合征，例如肥胖症，糖尿病和高脂血症。

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