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1. 发明申请

US20070015506A1 Synchronization matrix process for total emergency management 审中-公开
标题翻译：全面应急管理同步矩阵过程
公开(公告)号：US20070015506A1
公开(公告)日：2007-01-18
申请号：US11182567
申请日：2005-07-15
申请人： Paul Hewett , Jacques Mitrani , William Metz , Christopher Jones , William Metz
发明人： Paul Hewett , Jacques Mitrani , William Metz , Christopher Jones , William Metz
IPC分类号： H04Q7/20
CPC分类号： G06Q10/00 , G06Q50/26
摘要： A proactive and unifying systems-based method for total emergency management supported by an information technology architecture. The use of an embedded process for collaboration among a myriad of agencies fulfills newly recognized critical needs for interconnectivity and coordinated relationships among the public, private, nonprofit, and not-for-profit sectors in community preparedness, improved camaraderie among members of separate agencies, and a coordinated, integrated, and synchronized emergency response. Knowing and agreeing upon the actions that precede and succeed an integrating action among entities is the critical output of the synchronization matrix process for the present invention. The concept of tying these integrating actions to hazard actions and to decision points, so that timing of alert and notification, population protection, and response actions can be assessed against what needs to be initiated and when, serves to minimize community impacts from routine and catastrophic emergencies. A software tool implementing the present invention results in a collaborative set of relationship-centric activities (inter-agency planning) and a relationship-centric familiarization among participants (inter-agency coordination and camaraderie).
摘要翻译：一种主动和统一的基于系统的全面应急管理方法，由信息技术架构支持。使用嵌入式过程在各种机构之间进行协作，满足新认可的公共，私营，非营利和非营利部门在社区准备中的互联关系和协调关系的关键需求，改进独立机构成员之间的友谊，以及协调，综合和同步的应急响应。了解和同意实体之间的集成动作之前和之后的动作是本发明的同步矩阵处理的关键输出。将这些整合行动与危害行为和决策点结合在一起的概念，从而可以根据需要启动的时间和时间来评估警戒和通知的时间安排，人口保护和应对行动，以减少常规和灾难性社区的影响紧急情况。实施本发明的软件工具产生了一组以关系为中心的活动（机构间规划）和参与者之间以关系为中心的熟悉（机构间协调和友情）。

2. 发明授权

US10350141B2 Syringe holding assembly 有权
公开(公告)号：US10350141B2
公开(公告)日：2019-07-16
申请号：US15792243
申请日：2017-10-24
申请人： William Metz
发明人： William Metz
IPC分类号： A61M5/178 , A61J1/20 , B65B3/00 , A61J1/16
摘要： A syringe holding assembly for filling a syringe with medication includes a block that has a first well therein to insertably receive a medication bottle. The block has a second well therein to insertably receive a syringe. The first well is aligned with the second well to align the syringe with the medication bottle. In this way a user with limited hand dexterity is assisted to fill the syringe with medication. An adapter is provided to receive a vial. The adapter is removably positioned in the first well thereby facilitating the vial to be aligned with the syringe.

3. 发明申请

US20080027124A1 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I 有权
标题翻译： 3-取代的5-和6-氨基烷基吲哚-2-羧酸和作为CASEIN KINASE I的抑制剂的相关模拟物
公开(公告)号：US20080027124A1
公开(公告)日：2008-01-31
申请号：US11674385
申请日：2007-02-13
申请人： William METZ , Fa-Xiang DING
发明人： William METZ , Fa-Xiang DING
IPC分类号： A61K31/404 , A61P25/00 , A61P25/24 , C07D209/42
CPC分类号： C07D491/10 , C07D209/42 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14
摘要： The present invention discloses and claims compounds of formula (I) and formula (II) as inhibitors of human casein kinase Iε, and methods of using said compounds of formula (I) and formula (II) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. The R-group substituents are defined herein and pharmaceutical compositions comprising compounds of formula (I) or formula (II) are also disclosed and claimed.
摘要翻译：本发明公开并要求作为人酪蛋白激酶Iepsilon抑制剂的式（I）和式（II）化合物，以及使用所述式（I）和式（II）化合物治疗中枢神经系统疾病和病症的方法，包括情绪障碍和睡眠障碍。 R基取代基在本文中定义，并且还公开并要求保护包含式（I）或式（II）化合物的药物组合物。

4. 发明申请

US20080045561A1 Novel Bis-Azaindole Derivatives, Preparation And Pharmaceutical Use Thereof As Kinase Inhibitors 失效
标题翻译：新型双 - 阿魏那衍生物，其制备和药物用途作为激酶抑制剂
公开(公告)号：US20080045561A1
公开(公告)日：2008-02-21
申请号：US11692321
申请日：2007-03-28
申请人： Conception NEMECEK , William METZ , Sylvie WENTZLER , Dominique LESUISSE , Youssef EL-AHMAD
发明人： Conception NEMECEK , William METZ , Sylvie WENTZLER , Dominique LESUISSE , Youssef EL-AHMAD
IPC分类号： A61K31/5375 , A61K31/435 , A61P35/00 , C07D413/14 , C07D471/02
CPC分类号： C07D519/00
摘要： Disclosed are compounds of formula (I): wherein R1, R2, R3, R4, and R5 have the meanings given in the description, and to salts thereof, pharmaceutical compositions comprising said compounds and the use thereof as protein kinase inhibitors.
摘要翻译：公开了式（I）化合物：其中R1，R2，R3，R4和R5具有说明书中给出的含义及其盐，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。

5. 发明申请

US20050131012A1 Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon 有权
标题翻译：取代的1H-吡咯并[3,2-b，3,2-c和2,3-c]吡啶-2-甲酰胺和相关类似物作为酪蛋白激酶lepsilon的抑制剂
公开(公告)号：US20050131012A1
公开(公告)日：2005-06-16
申请号：US11001533
申请日：2004-12-01
申请人： William Metz , Frank Halley , Gilles Dutruc-Rosset , Yong Choi-Sledeski , Gregory Bernard Poli , David Fink , Gilles Doerflinger , Bao-Guo Huang , Ann Gelormini , Juan Gamboa , Andrew Giovanni , Joachim Roehr , Joseph Tsay , Fernando Camacho , William Hurst , Stephen Harnish , Yulin Chiang
发明人： William Metz , Frank Halley , Gilles Dutruc-Rosset , Yong Choi-Sledeski , Gregory Bernard Poli , David Fink , Gilles Doerflinger , Bao-Guo Huang , Ann Gelormini , Juan Gamboa , Andrew Giovanni , Joachim Roehr , Joseph Tsay , Fernando Camacho , William Hurst , Stephen Harnish , Yulin Chiang
IPC分类号： A61K31/437 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention discloses and claims compounds of formula (I) as inhibitors of human casein kinase IF, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
摘要翻译：本发明公开并要求作为人酪蛋白激酶IF抑制剂的式（I）化合物，以及使用所述式（I）化合物治疗中枢神经系统疾病和病症（包括情绪障碍和睡眠障碍）的方法。还公开并要求保护包含式（I）化合物和制备式（I）化合物的方法的药物组合物。

6. 发明授权

US06382943B1 Multiple insert tire mold and assembly method 失效
标题翻译：多重轮胎模具和装配方法
公开(公告)号：US06382943B1
公开(公告)日：2002-05-07
申请号：US09806806
申请日：2001-04-03
申请人： Joseph William Metz , Lloyd Glenn Whiteman , Samuel Eubanks Reckley , William John Dormer
发明人： Joseph William Metz , Lloyd Glenn Whiteman , Samuel Eubanks Reckley , William John Dormer
IPC分类号： B29C3502
CPC分类号： B29D30/0606 , B29C33/301 , B29D2030/0609 , B29D2030/0612 , Y10S425/812 , Y10T29/49826
摘要： A multiple insert tire mold (10) has inserts (26) with radially extending ribs (28) for sliding engagement in a slot (22) in the outer ring back (12) of the mold and abutting surfaces (48) for venting exhaust gases from the mold (10).
摘要翻译：多个插入轮胎模具（10）具有插入件（26），其具有径向延伸的肋（28），用于在模具的外环背部（12）中的槽（22）中滑动接合，并且用于排出排气的邻接表面（48）从模具（10）。

7. 发明申请

US20070142454A1 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE I 有权
标题翻译： 3-ARYLTHIOINDOLE-2-羧酰胺衍生物及其作为CASEIN KINASE I的抑制剂的模拟物
公开(公告)号：US20070142454A1
公开(公告)日：2007-06-21
申请号：US11675230
申请日：2007-02-15
申请人： William METZ
发明人： William METZ
IPC分类号： A61K31/404
CPC分类号： A61K31/404
摘要： The present invention relates to methods for treating a patient suffering from a disease or disorder of the central nervous system associated with the disturbance of the human circadian clock that are ameliorated by inhibition of casein kinase Iε activity such as, for example, mood disorders including major depressive disorder, bipolar I disorder and bipolar II disorder, and sleep disorders including circadian rhythm sleep disorders such as, for example, shift work sleep disorder, jet lag syndrome, advanced sleep phase syndrome and delayed sleep phase syndrome, comprising administering to said patient a therapeutically effective amount of a compound of formula I. its stereoisomer, enantiomer, racemate, tautomer or pharmaceutically acceptable salt thereof,
摘要翻译：本发明涉及治疗患有与人类昼夜节律钟紊乱相关的中枢神经系统疾病或病症的患者的方法，其通过抑制酪蛋白激酶Iepsilon活性而改善，例如包括主要的情绪障碍抑郁障碍，双相性精神障碍和双相II障碍，以及睡眠障碍，包括昼夜节律性睡眠障碍，例如转移工作睡眠障碍，时差综合征，晚期睡眠期综合征和延迟睡眠期综合征，包括对所述患者施用治疗有效量的式I化合物。其立体异构体，对映异构体，外消旋物，互变异构体或其药学上可接受的盐，

8. 发明申请

US20190117516A1 Syringe Holding Assembly 审中-公开
公开(公告)号：US20190117516A1
公开(公告)日：2019-04-25
申请号：US15792243
申请日：2017-10-24
申请人： William Metz
发明人： William Metz
IPC分类号： A61J1/20 , A61J1/16 , B65B3/00
CPC分类号： A61J1/2096 , A61J1/16 , A61J1/2048 , A61M5/008 , A61M5/1782 , B65B3/003
摘要： A syringe holding assembly for filling a syringe with medication includes a block that has a first well therein to insertably receive a medication bottle. The block has a second well therein to insertably receive a syringe. The first well is aligned with the second well to align the syringe with the medication bottle. In this way a user with limited hand dexterity is assisted to fill the syringe with medication. An adapter is provided to receive a vial. The adapter is removably positioned in the first well thereby facilitating the vial to be aligned with the syringe.

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