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    • 1. 发明申请
    • SYSTEMS AND METHODS FOR MULTI-SPECTRAL BIOLUMINESCENCE TOMOGRAPHY
    • 多光谱生物荧光光谱的系统与方法
    • US20070244395A1
    • 2007-10-18
    • US11619495
    • 2007-01-03
    • Ge WangAlexander CongWeimin HanMing JiangHaiou ShenWenxiang Cong
    • Ge WangAlexander CongWeimin HanMing JiangHaiou ShenWenxiang Cong
    • A61B5/00
    • A61B5/0059A61B5/0077A61B6/03A61B6/4488A61B6/482A61B6/508A61B6/5247A61B2503/40
    • Bioluminescent imaging has proven to be a valuable tool for monitoring physiological and pathological activities at cellular and molecular levels in living small animals. Using biological techniques, target cells can be tagged with reporters which generate characteristic photons in a wide spectrum covering the infra-red range. Part of the diffused light can reach the body surface of a subject/specimen (e.g., a small animal), be separated into several spectral bands using optical means, and collected by a sensitive camera. Systems and methods are disclosed herein for multi-spectral bioluminescence tomography (MBLT), in which an image of an underlying 3D bioluminescent source distribution is synergistically reconstructed from spectrally resolved datasets externally measured. This MBLT process involves two or multiple imaging modalities that produce structural information of the object and optical properties of the object as well to enable and improve the quality of MBLT.
    • 已经证明生物发光成像是监测活的小动物细胞和分子水平的生理和病理活动的有价值的工具。 使用生物学技术,靶细胞可以用记录器进行标记,记者在覆盖红外范围的广谱中产生特征光子。 扩散光的一部分可以到达对象/标本(例如,小动物)的身体表面,使用光学装置分离成若干光谱带,并由敏感摄像机收集。 本文公开了用于多光谱生物发光断层摄影(MBLT)的系统和方法,其中底层3D生物发光源分布的图像从外部测量的光谱解析数据集协同地重建。 该MBLT过程涉及产生物体的结构信息和对象的光学性质的两个或多个成像模态,以及实现和提高MBLT的质量。
    • 3. 发明授权
    • Systems and methods for multi-spectral bioluminescence tomography
    • 多光谱生物发光断层扫描的系统和方法
    • US08676302B2
    • 2014-03-18
    • US11619495
    • 2007-01-03
    • Ge WangAlexander X. CongWeimin HanMing JiangHaiou ShenWenxiang Cong
    • Ge WangAlexander X. CongWeimin HanMing JiangHaiou ShenWenxiang Cong
    • A61B6/00
    • A61B5/0059A61B5/0077A61B6/03A61B6/4488A61B6/482A61B6/508A61B6/5247A61B2503/40
    • Bioluminescent imaging has proven to be a valuable tool for monitoring physiological and pathological activities at cellular and molecular levels in living small animals. Using biological techniques, target cells can be tagged with reporters which generate characteristic photons in a wide spectrum covering the infra-red range. Part of the diffused light can reach the body surface of a subject/specimen (e.g., a small animal), be separated into several spectral bands using optical means, and collected by a sensitive camera. Systems and methods are disclosed herein for multi-spectral bioluminescence tomography (MBLT), in which an image of an underlying 3D bioluminescent source distribution is synergistically reconstructed from spectrally resolved datasets externally measured. This MBLT process involves two or multiple imaging modalities that produce structural information of the object and optical properties of the object as well to enable and improve the quality of MBLT.
    • 已经证明生物发光成像是监测活的小动物细胞和分子水平的生理和病理活动的有价值的工具。 使用生物学技术,靶细胞可以用记录器进行标记,记者在覆盖红外范围的广谱中产生特征光子。 扩散光的一部分可以到达对象/标本(例如,小动物)的身体表面,使用光学装置分离成若干光谱带,并由敏感摄像机收集。 本文公开了用于多光谱生物发光断层摄影(MBLT)的系统和方法,其中底层3D生物发光源分布的图像从外部测量的光谱解析数据集协同地重建。 该MBLT过程涉及产生物体的结构信息和对象的光学性质的两个或多个成像模态,以及实现和提高MBLT的质量。