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1. 发明申请

US20120228520A1 Photoregulated Reversible Hydrogels for Delivery and Releasing of Drugs and Other Therapeutical Reagents 审中-公开
标题翻译：用于递送和释放药物和其他治疗试剂的光调节的可逆水凝胶
公开(公告)号：US20120228520A1
公开(公告)日：2012-09-13
申请号：US13390754
申请日：2010-08-12
申请人： Weihong Tan , Huaizhi Kang
发明人： Weihong Tan , Huaizhi Kang
IPC分类号： G21K5/04 , A61K47/32
CPC分类号： A61K9/06 , A61K9/0009 , A61K41/0028 , A61K47/34
摘要： A novel hydrogel delivery systems useful for encapsulating and releasing pharmaceuticals or chemicals is disclosed where water soluble polymers containing crosslinker repeating units that associate or dissociate with complementary crosslinking repeating units or separate linkers to reversibly crosslink the hydrogel. In an exemplary embodiment, a DNA crosslinked hydrogel displays photoreversibility. An exemplary hydrogel delivery system comprises DNA polymer conjugates, wherein complementary DNA sequences are crosslinked with polymer chains and hybridization of the DNA sequences is controlled by photoresponsive moieties. Such hydrogels can be used to release drug molecules and/or other therapeutic reagents. The exemplary hydrogel employs photosensitive azobenzene moieties that are incorporated into the DNA crosslinker units. The azobenzene moieties respond to different wavelengths of light so that the state of azobenzene isomerization is induced by the proportion of visible and UV light irradiated. The isomer state of the azobenzene dictates whether the complementary DNA sequences hybridize to cross link the DNA polymer conjugates. Thus, irradiation of light (visible or UV) can transform the hydrogel network between a sol and any of multiple gel states to regulate the degree of crosslinking between complementary DNA sequences and, therefore, provide a profile of release of a hydrogel encapsulated pharmaceutical or other chemical.
摘要翻译：公开了一种用于包封和释放药物或化学物质的新型水凝胶递送系统，其中含有交联剂重复单元的水溶性聚合物与互补的交联重复单元或分离的连接体缔合或解离以可逆地交联水凝胶。在示例性实施方案中，DNA交联的水凝胶显示出光可逆性。示例性的水凝胶递送系统包含DNA聚合物缀合物，其中互补DNA序列与聚合物链交联，DNA序列的杂交由光响应部分控制。这种水凝胶可用于释放药物分子和/或其它治疗试剂。示例性的水凝胶使用掺入到DNA交联剂单元中的光敏偶氮苯部分。偶氮苯部分响应于不同波长的光，使得偶氮苯异构化的状态由照射的可见光和UV光的比例引发。偶氮苯的异构体状态指示互补DNA序列是否杂交以交联DNA聚合物缀合物。因此，光的照射（可见或UV）可以将溶胶和多种凝胶状态中的任何一种之间的水凝胶网络转化，以调节互补DNA序列之间的交联程度，因此提供水凝胶包封的药物或其它的释放曲线化学品。

2. 发明申请

US20090117549A1 Aptamer-based methods for identifying cellular biomarkers 审中-公开
标题翻译：用于鉴定细胞生物标志物的基于探针的方法
公开(公告)号：US20090117549A1
公开(公告)日：2009-05-07
申请号：US11880013
申请日：2007-07-18
申请人： Weihong Tan , Dihua Shangguan
发明人： Weihong Tan , Dihua Shangguan
IPC分类号： C12Q1/68 , G01N33/566 , B01D59/44
CPC分类号： C12N15/115 , C12N15/111 , C12N2310/16 , C12N2320/11
摘要： In this invention, a biomarker discovery method has been developed using specific biotin-labeled oligonucleotide ligands and magnetic streptavidin beads. In one embodiment, the oligonucleotide ligands are firstly generated by whole-cell based SELEX technique. Such ligands can recognize target cells with high affinity and specificity and can distinguish cells that are closely related to target cells even in patient samples. The targets of these oligonucleotide ligands are significant biomarkers for certain cells. These important biomarkers can be captured by forming complexes with biotin-labeled oligonucleotide ligands and collecting the complexes using magnetic streptavidin beads, whereupon the captured biomarkers are analyzed to identify the biomarkers. Analysis of biomarkers include HPLC-Mass Spectroscopy analysis, polyacrylamide gel electrophoresis, flow cytometry, and the like. The identified biomarkers can be used for pathological diagnosis and therapeutic applications. Using the disclosed methods, highly specific biomarkers of any kinds of cells, in particular cancer cells, can easily be identified without prior knowledge of the existence of such biomarkers.
摘要翻译：在本发明中，已经开发了使用特定生物素标记的寡核苷酸配体和磁性链亲和素珠子的生物标志物发现方法。在一个实施方案中，寡核苷酸配体首先通过基于全细胞的SELEX技术产生。这样的配体可以高亲和力和特异性识别靶细胞，并且即使在患者样品中也能区分与靶细胞密切相关的细胞。这些寡核苷酸配体的靶标是某些细胞的重要生物标志物。可以通过与生物素标记的寡核苷酸配体形成复合物并使用磁性链亲和素珠来收集复合物来捕获这些重要的生物标志物，然后分析捕获的生物标志物以鉴定生物标志物。生物标志物的分析包括HPLC-质谱分析，聚丙烯酰胺凝胶电泳，流式细胞术等。鉴定的生物标志物可用于病理诊断和治疗应用。使用所公开的方法，可以容易地鉴定任何种类的细胞，特别是癌细胞的高度特异性生物标志物，而无需存在这样的生物标志物。

3. 发明授权

US07524630B2 Functionalized nanoparticles and methods of use 失效
标题翻译：官能化纳米粒子和使用方法
公开(公告)号：US07524630B2
公开(公告)日：2009-04-28
申请号：US10421491
申请日：2003-04-22
申请人： Weihong Tan , Jin Shouguang , Xiaojun Zhao , Rovelyn Tapec Dytioco , Timothy James Drake , Lisa Renee Hilliard
发明人： Weihong Tan , Jin Shouguang , Xiaojun Zhao , Rovelyn Tapec Dytioco , Timothy James Drake , Lisa Renee Hilliard
IPC分类号： G01N33/552 , G01N33/553
CPC分类号： G01N33/54346 , B82Y15/00 , C12Q1/6816 , G01N33/54393 , G01N33/552 , G01N33/588 , C12Q2563/155
摘要： Silica-coated nanoparticles functionalized with biologically active molecules such as antibodies and nucleotides are used to label cells, to detect and isolate nucleic acid molecules having specific nucleotide sequences, and to separate a mixture of different nucleic acid molecules.
摘要翻译：用生物活性分子（如抗体和核苷酸）功能化的二氧化硅包被的纳米粒子用于标记细胞，以检测和分离具有特定核苷酸序列的核酸分子，并分离不同核酸分子的混合物。

4. 发明申请

US20080311590A1 Portable Materials and Methods for Ultrasensitive Detection of Pathogen and Bioparticles 审中-公开
标题翻译：便携式材料和方法用于超敏感检测病原体和生物颗粒
公开(公告)号：US20080311590A1
公开(公告)日：2008-12-18
申请号：US11994962
申请日：2006-10-10
申请人： Weihong Tan , Shelly John Mechery
发明人： Weihong Tan , Shelly John Mechery
IPC分类号： G01N33/53 , C12M1/34 , B01J19/00 , G01N21/00 , G01N21/76
CPC分类号： G01N21/6428 , G01N15/1459 , G01N2015/1486
摘要： The present invention provides systems for ultrasensitive detection of pathogens and bioparticles. One embodiment of the system comprises an optical detection scheme that allows for the detection of the fluorescence signal of bacteria or other bioparticles in less than about 20 minutes. A microflow channel allows for an assay probing volume of as little as a few picoliters. In one embodiment, the system uses RuBpy dye-doped silica nanoparticles bioconjugated with specific monoclonal antibodies of the target bioparticles. The system allows for the rapid and highly sensitive and specific detection of bacteria or other bioparticles without the need for amplification or enrichment of the sample.
摘要翻译：本发明提供了用于病原体和生物颗粒的超敏感检测的系统。该系统的一个实施例包括允许在少于约20分钟内检测细菌或其他生物颗粒的荧光信号的光学检测方案。微流通道允许少至几微摩尔的测定探测体积。在一个实施方案中，该系统使用与靶生物颗粒的特异性单克隆抗体生物缀合的RuBpy染料掺杂二氧化硅纳米颗粒。该系统允许对细菌或其他生物颗粒的快速和高灵敏度和特异性检测，而不需要扩增或富集样品。

5. 发明申请

US20080176263A1 Materials and Methods for Efficient and Accurate Detection of Analytes 审中-公开
标题翻译：用于有效和准确检测分析物的材料和方法
公开(公告)号：US20080176263A1
公开(公告)日：2008-07-24
申请号：US11952943
申请日：2007-12-07
申请人： Gregory Schultz , John I. Azeke , Daniel J. Gibson , Olajompo Busola Moloye , Priscilla Lorraine Phillips , Weihong Tan , Christopher D. Batich
发明人： Gregory Schultz , John I. Azeke , Daniel J. Gibson , Olajompo Busola Moloye , Priscilla Lorraine Phillips , Weihong Tan , Christopher D. Batich
IPC分类号： C12Q1/37 , C12M1/34 , G01N21/75
CPC分类号： G01N33/54386
摘要： The present invention provides diagnostic methods and devices that can be used to assay a medium, such as tissue in vivo or a sample in vitro (e.g. biological sample or environmental sample), in order to determine the presence, quantity, and/or concentration ratio of one or more target analytes.
摘要翻译：本发明提供了可用于测定培养基（例如体内组织或体外样品（例如生物样品或环境样品））的诊断方法和装置，以便确定存在，数量和/或浓度比的一种或多种目标分析物。

6. 发明申请

US20060228554A1 Method of making nanoparticles 失效
标题翻译：纳米颗粒的制备方法
公开(公告)号：US20060228554A1
公开(公告)日：2006-10-12
申请号：US11188459
申请日：2005-07-25
申请人： Weihong Tan , Swadeshmukul Santra , Peng Zhang , Rovelyn Tapec , Jon Dobson
发明人： Weihong Tan , Swadeshmukul Santra , Peng Zhang , Rovelyn Tapec , Jon Dobson
IPC分类号： B32B1/00
CPC分类号： G01N33/54346 , A61K49/183 , A61K49/1875 , B01J13/18 , B82Y5/00 , B82Y25/00 , B82Y30/00 , C09B67/0005 , G01N33/54326 , G01N33/552 , G01N33/569 , G01N33/587 , G01N2446/20 , H01F1/0054 , Y10T428/2982 , Y10T428/2984 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995
摘要： Disclosed are silica-coated nanoparticles and a process for producing silica-coated nanoparticles. Silica-coated nanoparticles are prepared by precipitating nano-sized cores from reagents dissolved in the aqueous compartment of a water-in-oil microemulsion. A reactive silicate is added to coat the cores with silica. Also disclosed are methods for functionalizing silica-coated nanoparticles for use in a variety of applications.
摘要翻译：公开了二氧化硅涂覆的纳米颗粒和用于生产二氧化硅涂覆的纳米颗粒的方法。通过从溶解在油包水微乳液的水性隔室中的试剂中沉淀纳米尺寸的核来制备二氧化硅涂覆的纳米颗粒。加入反应性硅酸盐以用二氧化硅涂覆芯。还公开了用于在各种应用中使用的二氧化硅涂覆的纳米颗粒的官能化方法。

7. 发明授权

US06924116B2 Method for identifying cells 失效
标题翻译：识别细胞的方法
公开(公告)号：US06924116B2
公开(公告)日：2005-08-02
申请号：US10010807
申请日：2001-11-13
申请人： Weihong Tan , Swadeshmukul Santra , Peng Zhang , Rovelyn Tapec , Jon Dobson
发明人： Weihong Tan , Swadeshmukul Santra , Peng Zhang , Rovelyn Tapec , Jon Dobson
IPC分类号： G01N33/53 , A61K49/18 , B82B3/00 , G01N33/543 , G01N33/552 , G01N33/58 , H01F1/00
CPC分类号： G01N33/54346 , A61K49/183 , A61K49/1875 , B01J13/18 , B82Y5/00 , B82Y25/00 , B82Y30/00 , C09B67/0005 , G01N33/54326 , G01N33/552 , G01N33/569 , G01N33/587 , G01N2446/20 , H01F1/0054 , Y10T428/2982 , Y10T428/2984 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995
摘要： Disclosed are silica-coated nanoparticles and a process for producing silica-coated nanoparticles. Silica-coated nanoparticles are prepared by precipitating nano-sized cores from reagents dissolved in the aqueous compartment of a water-in-oil microemulsion. A reactive silicate is added to coat the cores with silica. Also disclosed are methods for functionalizing silica-coated nanoparticles for use in a variety of applications.
摘要翻译：公开了二氧化硅涂覆的纳米颗粒和用于生产二氧化硅涂覆的纳米颗粒的方法。通过从溶解在油包水微乳液的水性隔室中的试剂中沉淀纳米尺寸的核来制备二氧化硅涂覆的纳米颗粒。加入反应性硅酸盐以用二氧化硅涂覆芯。还公开了用于在各种应用中使用的二氧化硅涂覆的纳米颗粒的官能化方法。

8. 发明授权

US5361314A Micro optical fiber light source and sensor and method of fabrication thereof 失效
标题翻译：微光纤光源和传感器及其制造方法
公开(公告)号：US5361314A
公开(公告)日：1994-11-01
申请号：US941879
申请日：1992-09-04
申请人： Raoul Kopelman , Weihong Tan , Zhong-You Shi
发明人： Raoul Kopelman , Weihong Tan , Zhong-You Shi
IPC分类号： G01Q60/18 , G02B6/24 , G02B6/255 , G02B6/36 , G02B6/00 , B05D5/06 , H01J5/16
CPC分类号： G02B6/241 , B82Y20/00 , B82Y35/00 , G01Q60/22 , G02B6/2552 , G02B6/3624
摘要： This invention relates generally to the development of and a method of fabricating a micro optical fiber light source. An optical fiber micro-light source is presented whose aperture is extremely small yet able to act as an intense light source. Light sources of this type have wide ranging applications, including use as micro-sensors in NSOM. Micro-sensor light sources have excellent detection limits as well as photo stability, reversibility, and millisecond response times. Furthermore, a method for manufacturing a micro optical fiber light source is provided. It involves the photo-chemical attachment of an optically active material onto the end surface of an optical fiber cable which has been pulled to form an end with an extremely narrow aperture. More specifically, photopolymerization has been applied as a means to photo-chemically attach an optically active material. This process allows significant control of the size of the micro light source. Furthermore, photo-chemically attaching an optically active material enables the implementation of the micro-light source in a variety of sensor applications.
摘要翻译：本发明一般涉及微型光纤光源的制造和制造方法。提出了一种光纤微光源，其光圈非常小，但能够充当强光源。这种光源具有广泛的应用，包括在NSOM中用作微型传感器。微传感器光源具有优异的检测限以及光稳定性，可逆性和毫秒响应时间。此外，提供了一种用于制造微型光纤光源的方法。它涉及光学活性材料的光化学附着到光纤电缆的端面上，该光缆被拉动以形成具有非常窄的孔径的端部。更具体地，已经应用光聚合作为光学化学连接光学活性材料的手段。该过程允许显着控制微光源的尺寸。此外，光学化学地附着光学活性材料使得能够在各种传感器应用中实现微光源。

9. 发明申请

US20120087949A1 OLIGONUCLEOTIDE MICELLES 审中-公开
标题翻译：寡核苷酸
公开(公告)号：US20120087949A1
公开(公告)日：2012-04-12
申请号：US13141027
申请日：2009-12-18
申请人： Weihong Tan , Liu Haipeng , Yanrong Wu
发明人： Weihong Tan , Liu Haipeng , Yanrong Wu
IPC分类号： A61K31/7088 , C12Q1/02 , C12N5/00 , A61K9/00
CPC分类号： A61K31/7088 , A61K9/0019 , A61K9/1075 , C12N15/111 , C12N2310/3515 , C12N2320/32
摘要： The present invention provides homogenous populations of micelles, methods for preparing these populations, methods for treating or preventing a disease or disorder using the population of micelles of the invention.
摘要翻译：本发明提供了均匀的胶束群，制备这些种群的方法，使用本发明的胶束群治疗或预防疾病或病症的方法。

10. 发明申请

US20090258382A1 Novel devices for the detection of the presence and/or activity of proteases in biological samples 有权
标题翻译：用于检测生物样品中蛋白酶的存在和/或活性的新型装置
公开(公告)号：US20090258382A1
公开(公告)日：2009-10-15
申请号：US12316705
申请日：2008-12-15
申请人： Gregory S. Schultz , John I. Azeke , Daniel J. Gibson , Olajompo B. Moloye , Priscilla Lorraine Phillips , Weihong Tan , Christopher D. Batich
发明人： Gregory S. Schultz , John I. Azeke , Daniel J. Gibson , Olajompo B. Moloye , Priscilla Lorraine Phillips , Weihong Tan , Christopher D. Batich
IPC分类号： C12Q1/37 , C12M1/34
CPC分类号： C12Q1/37 , G01N33/542 , G01N2333/96494
摘要： The subject invention provides novel devices and methods for the detection of the presence and/or activity of proteases in biological samples.
摘要翻译：本发明提供了用于检测生物样品中蛋白酶的存在和/或活性的新颖的装置和方法。

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