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1. 发明授权

US06410014B1 Redirection of cellular immunity by protein-tyrosine kinase chimeras 失效
公开(公告)号：US06410014B1
公开(公告)日：2002-06-25
申请号：US09333636
申请日：1999-06-15
申请人： Brian Seed , Charles Romeo , Waldemar Kolanus
发明人： Brian Seed , Charles Romeo , Waldemar Kolanus
IPC分类号： A61K4800
CPC分类号： A61K35/17 , A61K35/13 , A61K35/15 , A61K35/28 , A61K38/00 , C07K14/705 , C07K14/70503 , C07K14/7051 , C07K14/70514 , C07K14/70535 , C07K19/00 , C07K2319/00 , C12N9/1205
摘要： Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. The chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent, and (b) an intracellular portion of a protein-tyrosine kinase which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.

2. 发明授权

US06753162B1 Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells 失效
标题翻译：通过嵌合CD4受体细胞对HIV感染细胞的靶向细胞溶解
公开(公告)号：US06753162B1
公开(公告)日：2004-06-22
申请号：US08394388
申请日：1995-02-24
申请人： Brian Seed , Babak Banapour , Charles Romeo , Waldemar Kolanus
发明人： Brian Seed , Babak Banapour , Charles Romeo , Waldemar Kolanus
IPC分类号： C12P2106
CPC分类号： A61K35/17 , A61K35/15 , A61K38/00 , C07K14/705 , C07K14/70503 , C07K14/7051 , C07K14/70514 , C07K14/70535 , C07K19/00 , C07K2319/00 , C12N9/1205 , C12N2799/023
摘要： Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed is a second method of treating HIV in a mammal involving administering to the mammal an effective amount of therapeutic cells expressing a membrane-bound, proteinaceous chimeric receptor comprising an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.
摘要翻译：公开了一种在哺乳动物中引导针对HIV感染细胞的细胞免疫应答的方法，包括向哺乳动物施用有效量的表达膜结合蛋白质嵌合受体的治疗细胞，所述受体细胞包含（a）细胞外部分，其包括能够特异性识别和结合HIV感染细胞但不介导HIV感染的CD4片段，和（b）能够发信号通知治疗细胞破坏受体结合的HIV感染细胞的细胞内部分。还公开了治疗哺乳动物HIV的第二种方法，其涉及向哺乳动物施用有效量的表达膜结合的蛋白质嵌合受体的治疗细胞，其包含细胞外部分，其包括能够特异性识别和结合的CD4片段艾滋病毒感染细胞，但不介导艾滋病毒感染。还公开了表达嵌合受体的细胞和编码嵌合受体的DNA和载体。

3. 发明授权

US08163788B2 Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors 失效
标题翻译：细胞毒素家族鸟嘌呤核苷酸交换因子的低分子抑制剂
公开(公告)号：US08163788B2
公开(公告)日：2012-04-24
申请号：US11667046
申请日：2005-11-18
申请人： Michael Famulok , Waldemar Kolanus , Markus Hafner , Imke Grune , Barbara Tappertzhofen , Mirko Theis
发明人： Michael Famulok , Waldemar Kolanus , Markus Hafner , Imke Grune , Barbara Tappertzhofen , Mirko Theis
IPC分类号： A61K31/4196
CPC分类号： A61K31/427 , A61K31/4196 , A61K31/506 , G01N2500/02
摘要： The invention relates to a pharmaceutical composition and the use thereof, wherein the pharmaceutical composition contains compounds selected from a group of general formulas (5), (6), (7) and (8) and/or enantiomers, diastereomers or the pharmaceutically acceptable salts thereof. The pharmaceutical composition is used for treating autoimmune and tumoral diseases and/or for immunosuppresion.
摘要翻译：本发明涉及药物组合物及其用途，其中药物组合物含有选自通式（5），（6），（7）和（8）的化合物和/或对映异构体，非对映异构体或药学上可接受的的盐。药物组合物用于治疗自身免疫性和肿瘤性疾病和/或用于免疫抑制。

4. 发明授权

US07320787B2 Redirection of cellular immunity by protein tyrosine kinase chimeras 有权
标题翻译：蛋白酪氨酸激酶嵌合体细胞免疫的重定向
公开(公告)号：US07320787B2
公开(公告)日：2008-01-22
申请号：US10151193
申请日：2002-05-20
申请人： Brian Seed , Charles Romeo , Waldemar Kolanus
发明人： Brian Seed , Charles Romeo , Waldemar Kolanus
IPC分类号： A61K48/00 , C12N15/63 , C12N5/08
CPC分类号： C12N9/1205 , C07K14/705 , C07K14/70503 , C07K14/7051 , C07K14/70514 , C07K14/70535 , C07K19/00 , C07K2319/00
摘要： Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. The chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent, and (b) an intracellular portion of a protein-tyrosine kinase which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.
摘要翻译：公开了一种通过在哺乳动物细胞中表达嵌合受体来引导细胞反应的方法，所述嵌合受体导致细胞特异性识别和破坏感染剂，感染了感染剂，肿瘤或癌细胞的细胞，或自身免疫产生的细胞。嵌合受体包括能够特异性识别和结合靶细胞或靶感染剂的细胞外部分，和（b）蛋白质 - 酪氨酸激酶的细胞内部分，其能够表达治疗细胞以破坏受体结合靶细胞或受体结合的靶感染剂。还公开了表达嵌合受体的细胞和编码嵌合受体的DNA。

5. 发明申请

US20070287153A1 Methods for the identification and validation of functional intracellular targets with intramers or in vivo selection 审中-公开
公开(公告)号：US20070287153A1
公开(公告)日：2007-12-13
申请号：US11440907
申请日：2006-05-25
申请人： Michael Blind , Michael Famulok , Waldemar Kolanus
发明人： Michael Blind , Michael Famulok , Waldemar Kolanus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897 , C12N15/1034 , C12Q1/6809
摘要： Described are methods for the identification and validation of (1) functional intracellular targets and (2) nucleic acids (intramers) which are capable of binding to and modifying the function of said intracellular targets. These nucleic acids or, alternatively, compounds showing the same or a similar target specificity and/or effect are useful for the preparation of therapeutics, particularly for gene therapy.

6. 发明授权

US07094599B2 Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells 有权
公开(公告)号：US07094599B2
公开(公告)日：2006-08-22
申请号：US09939537
申请日：2001-08-24
申请人： Brian Seed , Babak Banapour , Charles Romeo , Waldemar Kolanus
发明人： Brian Seed , Babak Banapour , Charles Romeo , Waldemar Kolanus
IPC分类号： C12N5/16
CPC分类号： A61K35/15 , A61K35/13 , A61K35/17 , A61K35/545 , A61K38/00 , C07K14/705 , C07K14/70503 , C07K14/7051 , C07K14/70514 , C07K14/70535 , C07K19/00 , C07K2319/00 , C12N9/1205 , C12N2799/023
摘要： Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.

7. 发明授权

US07049136B2 Redirection of cellular immunity by receptor chimeras 有权
标题翻译：受体嵌合体细胞免疫的重定向
公开(公告)号：US07049136B2
公开(公告)日：2006-05-23
申请号：US09243008
申请日：1999-02-02
申请人： Brian Seed , Charles Romeo , Waldemar Kolanus
发明人： Brian Seed , Charles Romeo , Waldemar Kolanus
IPC分类号： C12N5/02
CPC分类号： C12N9/1205 , A61K35/13 , A61K35/15 , A61K35/17 , A61K35/545 , A61K38/00 , A61K47/6901 , A61K48/00 , A61K2039/5156 , C07K14/705 , C07K14/70503 , C07K14/7051 , C07K14/70514 , C07K14/70535 , C07K16/28 , C07K19/00 , C07K2319/00 , C12N2799/023
摘要： Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.
摘要翻译：公开了一种通过在哺乳动物细胞中表达嵌合受体来引导细胞反应的方法，所述嵌合受体导致细胞特异性识别和破坏感染剂，感染了感染剂，肿瘤或癌细胞的细胞，或自身免疫产生的细胞。还公开了表达嵌合受体的细胞和编码嵌合受体的DNA。

8. 发明授权

US06573362B1 Cythohesin-PH peptides that affect the ability of integrins to adhere 失效
标题翻译：影响整联蛋白粘附能力的Cythohesin-PH肽
公开(公告)号：US06573362B1
公开(公告)日：2003-06-03
申请号：US08708573
申请日：1996-09-05
申请人： Waldemar Kolanus , Britta Ostner
发明人： Waldemar Kolanus , Britta Ostner
IPC分类号： C07K14705
CPC分类号： C07K14/4705 , A61K38/00 , C07K2319/00 , C12N2799/023 , Y10S435/81
摘要： Isolated cytohesin-PH peptides that can inhibit the beta-2 integrins from adhering, wherein the cytohesin-PH peptide has an amino acid sequence that comprises about a 140 amino acid domain from cytohesin-2. Assay kits comprising the peptides also are provided.
摘要翻译：可以抑制β-2整联蛋白粘附的分离的细胞毒素-PH肽，其中细胞色素-PH肽具有包含来自细胞毒素-2的约140个氨基酸结构域的氨基酸序列。还提供了包含肽的测定试剂盒。

9. 发明申请

US20110224279A1 ANTICANCER AGENT 审中-公开
标题翻译： ANTICANCER代理
公开(公告)号：US20110224279A1
公开(公告)日：2011-09-15
申请号：US12920167
申请日：2009-02-27
申请人： Waldemar Kolanus , Michael Karl Hoch , Joachim L. Schultze , Birgit Loeer
发明人： Waldemar Kolanus , Michael Karl Hoch , Joachim L. Schultze , Birgit Loeer
IPC分类号： A61K31/713 , C07H21/02 , C07K7/08 , C12N15/12 , C07K16/00 , C07K9/00 , C12Q1/00 , C12Q1/68 , A61P35/00
CPC分类号： A61K38/1709 , A61K38/10 , C07K14/47
摘要： The present invention relates to a nucleic acid molecule and a pharmaceutical or diagnostic composition for the therapeutic and/or prophylactic treatment or diagnosis of cancer and/or metastasis thereof, comprising a nucleic acid molecule, or an amino acid sequence related to Trim71 and/or its mammalian and non mammalian orthologs and/or a nucleic acid sequence of the gene encoding for Trim71 and/or its mammalian and non mammalian orthologs.
摘要翻译：本发明涉及用于治疗和/或预防治疗或诊断其癌症和/或转移的核酸分子和药物或诊断组合物，其包含核酸分子或与Trim71相关的氨基酸序列和/或其哺乳动物和非哺乳动物直系同源物和/或编码Trim71和/或其哺乳动物和非哺乳动物直系同源物的基因的核酸序列。

10. 发明授权

US06392013B1 Redirection of cellular immunity by protein tyrosine kinase chimeras 失效
标题翻译：蛋白酪氨酸激酶嵌合体细胞免疫的重定向
公开(公告)号：US06392013B1
公开(公告)日：2002-05-21
申请号：US08889712
申请日：1997-07-07
申请人： Brian Seed , Charles Romeo , Waldemar Kolanus
发明人： Brian Seed , Charles Romeo , Waldemar Kolanus
IPC分类号： C12P2102
CPC分类号： C12N9/1205 , C07K14/705 , C07K14/70503 , C07K14/7051 , C07K14/70514 , C07K14/70535 , C07K19/00 , C07K2319/00
摘要： Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. The chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent, and (b) an intracellular portion of a protein-tyrosine kinase which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.
摘要翻译：公开了一种通过在哺乳动物细胞中表达嵌合受体来引导细胞反应的方法，所述嵌合受体导致细胞特异性识别和破坏感染剂，感染了感染剂，肿瘤或癌细胞的细胞，或自身免疫产生的细胞。嵌合受体包括能够特异性识别和结合靶细胞或靶感染剂的细胞外部分，和（b）蛋白质 - 酪氨酸激酶的细胞内部分，其能够表达治疗细胞以破坏受体结合靶细胞或受体结合的靶感染剂。还公开了表达嵌合受体的细胞和编码嵌合受体的DNA。

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