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1. 发明授权

US06753162B1 Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells 失效
标题翻译：通过嵌合CD4受体细胞对HIV感染细胞的靶向细胞溶解
公开(公告)号：US06753162B1
公开(公告)日：2004-06-22
申请号：US08394388
申请日：1995-02-24
申请人： Brian Seed , Babak Banapour , Charles Romeo , Waldemar Kolanus
发明人： Brian Seed , Babak Banapour , Charles Romeo , Waldemar Kolanus
IPC分类号： C12P2106
CPC分类号： A61K35/17 , A61K35/15 , A61K38/00 , C07K14/705 , C07K14/70503 , C07K14/7051 , C07K14/70514 , C07K14/70535 , C07K19/00 , C07K2319/00 , C12N9/1205 , C12N2799/023
摘要： Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed is a second method of treating HIV in a mammal involving administering to the mammal an effective amount of therapeutic cells expressing a membrane-bound, proteinaceous chimeric receptor comprising an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.
摘要翻译：公开了一种在哺乳动物中引导针对HIV感染细胞的细胞免疫应答的方法，包括向哺乳动物施用有效量的表达膜结合蛋白质嵌合受体的治疗细胞，所述受体细胞包含（a）细胞外部分，其包括能够特异性识别和结合HIV感染细胞但不介导HIV感染的CD4片段，和（b）能够发信号通知治疗细胞破坏受体结合的HIV感染细胞的细胞内部分。还公开了治疗哺乳动物HIV的第二种方法，其涉及向哺乳动物施用有效量的表达膜结合的蛋白质嵌合受体的治疗细胞，其包含细胞外部分，其包括能够特异性识别和结合的CD4片段艾滋病毒感染细胞，但不介导艾滋病毒感染。还公开了表达嵌合受体的细胞和编码嵌合受体的DNA和载体。

2. 发明授权

US06284240B1 Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells 有权
标题翻译：通过嵌合CD4受体细胞对HIV感染细胞的靶向细胞溶解
公开(公告)号：US06284240B1
公开(公告)日：2001-09-04
申请号：US09218950
申请日：1998-12-22
申请人： Brian Seed , Babak Banapour , Charles Romeo , Waldemar Kolanus
发明人： Brian Seed , Babak Banapour , Charles Romeo , Waldemar Kolanus
IPC分类号： A61K4800
CPC分类号： A61K35/15 , A61K35/13 , A61K35/17 , A61K35/545 , A61K38/00 , C07K14/705 , C07K14/70503 , C07K14/7051 , C07K14/70514 , C07K14/70535 , C07K19/00 , C07K2319/00 , C12N9/1205 , C12N2799/023
摘要： Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.
摘要翻译：公开了一种在哺乳动物中引导针对HIV感染细胞的细胞免疫应答的方法，包括向哺乳动物施用有效量的表达膜结合蛋白质嵌合受体的治疗细胞，所述受体细胞包含（a）细胞外部分，其包括能够特异性识别和结合HIV感染细胞但不介导HIV感染的CD4片段，和（b）能够发信号通知治疗细胞破坏受体结合的HIV感染细胞的细胞内部分。还公开了表达嵌合受体的细胞和编码嵌合受体的DNA和载体。

3. 发明授权

US07094599B2 Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells 有权
公开(公告)号：US07094599B2
公开(公告)日：2006-08-22
申请号：US09939537
申请日：2001-08-24
申请人： Brian Seed , Babak Banapour , Charles Romeo , Waldemar Kolanus
发明人： Brian Seed , Babak Banapour , Charles Romeo , Waldemar Kolanus
IPC分类号： C12N5/16
CPC分类号： A61K35/15 , A61K35/13 , A61K35/17 , A61K35/545 , A61K38/00 , C07K14/705 , C07K14/70503 , C07K14/7051 , C07K14/70514 , C07K14/70535 , C07K19/00 , C07K2319/00 , C12N9/1205 , C12N2799/023
摘要： Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.

4. 发明授权

US5851828A Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells 失效
公开(公告)号：US5851828A
公开(公告)日：1998-12-22
申请号：US284391
申请日：1994-08-02
申请人： Brian Seed , Babak Banapour , Charles Romeo , Waldemar Kolanus
发明人： Brian Seed , Babak Banapour , Charles Romeo , Waldemar Kolanus
IPC分类号： C12N15/09 , A61K35/12 , A61K35/13 , A61K35/14 , A61K35/15 , A61K35/17 , A61K35/26 , A61K35/545 , A61K38/00 , A61K39/00 , A61K39/21 , A61K48/00 , A61P31/12 , C07H21/04 , C07K14/705 , C07K14/725 , C07K14/73 , C07K14/735 , C07K19/00 , C12N5/10 , C12N9/12
CPC分类号： A61K35/15 , A61K35/13 , A61K35/17 , A61K35/545 , C07K14/705 , C07K14/70503 , C07K14/7051 , C07K14/70514 , C07K14/70535 , C07K19/00 , C12N9/1205 , A61K38/00 , C07K2319/00 , C12N2799/023
摘要： Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.

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