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1. 发明申请

US20160355514A1 PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES 审中-公开
公开(公告)号：US20160355514A1
公开(公告)日：2016-12-08
申请号：US15243289
申请日：2016-08-22
申请人： Kenneth W. BAIR , Timm R. BAUMEISTER , Peter DRAGOVICH , Francis GOSSELIN , Po-Wai YUEN , Mark ZAK , Xiaozhang ZHENG
发明人： Kenneth W. BAIR , Timm R. BAUMEISTER , Peter DRAGOVICH , Francis GOSSELIN , Po-Wai YUEN , Mark ZAK , Xiaozhang ZHENG
IPC分类号： C07D471/04 , C07D491/048 , C07D495/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/706 , A61K45/06 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00
摘要： Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.

2. 发明授权

US08859198B2 Detection and use of antiviral resistance mutations 有权
标题翻译：检测和使用抗病毒药物的突变
公开(公告)号：US08859198B2
公开(公告)日：2014-10-14
申请号：US12303942
申请日：2007-06-04
申请人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman , Thomas Bock , William Sievert , Sharon Lewin
发明人： Angeline Ingrid Bartholomeusz , Stephen Locarnini , Anna Ayre , Lilly Ka Wai Yuen , Peter William Angus , Joseph John Sasadeusz , Paul Desmond , Hans Tillman , Thomas Bock , William Sievert , Sharon Lewin
IPC分类号： C12Q1/70 , A61K39/00 , A61K39/29 , A61K39/25 , C12N7/00 , C07K14/005
CPC分类号： C12Q1/706 , A61K39/12 , A61K39/29 , C07K14/005 , C12N7/00 , C12N2730/10122 , C12N2730/10134 , C12Q2600/156
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. Vaccines and diagnostic assays are also contemplated herein.
摘要翻译：本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。疫苗和诊断测定也在本文中考虑。

3. 发明申请

US20140024649A1 Substituted Benzamides and Their Uses 有权
标题翻译：取代苯甲酰胺及其用途
公开(公告)号：US20140024649A1
公开(公告)日：2014-01-23
申请号：US13878682
申请日：2011-10-10
申请人： Amato Giaccia , Edwin Lai , Olga Razorenova , Denise Chan , Michael Patrick Hay , Muriel Bonnet , Connie Sun , Ray Tabibiazar , Po-wai Yuen
发明人： Amato Giaccia , Edwin Lai , Olga Razorenova , Denise Chan , Michael Patrick Hay , Muriel Bonnet , Connie Sun , Ray Tabibiazar , Po-wai Yuen
IPC分类号： C07D413/12
CPC分类号： C07D413/12 , C07D213/75 , C07D263/32 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/14 , C07D417/12
摘要： Provided herein are Substituted Benzamides, compositions, and method of their manufacture and use.
摘要翻译：本文提供了取代的苯甲酰胺，组合物及其制造和使用方法。

4. 发明授权

US08590143B2 Apparatus for delivering semiconductor components to a substrate 有权
标题翻译：用于将半导体部件输送到基板的装置
公开(公告)号：US08590143B2
公开(公告)日：2013-11-26
申请号：US13115261
申请日：2011-05-25
申请人： Kui Kam Lam , Yen Hsi Tang , Wai Yuen Cheung , Wing Kin Lam
发明人： Kui Kam Lam , Yen Hsi Tang , Wai Yuen Cheung , Wing Kin Lam
IPC分类号： B23P19/00
CPC分类号： H01L21/67144 , H01L24/75 , Y10T29/515 , Y10T29/53174 , Y10T29/53178 , Y10T29/53183
摘要： An apparatus 200 for delivering semiconductor components 212 to a substrate 206a; 206b; 500a; 500b; 500c during semiconductor package manufacturing. The apparatus 200 comprises a platform 216 and a plurality of delivery modules 202a, 202b affixed to the platform 216. Each of the plurality of delivery modules 202a, 202b has a support device 204a; 204b for supporting the substrate 206a; 206b; 500a; 500b; 500c, as well as a delivery device 208a; 208b for delivering the semiconductor components 212 to the substrate 206a; 206b; 500a; 500b; 500c. In particular, heights of the support devices 204a, 204 are mutually leveled for conveying the substrate 206a; 206b; 500a; 500b; 500c between the plurality of delivery modules 202a, 202b.
摘要翻译：用于将半导体部件212输送到基板206a的装置200; 206b; 500a 500b; 500c在半导体封装制造过程中。装置200包括平台216和固定到平台216的多个传送模块202a，202b。多个传送模块202a，202b中的每一个具有支撑装置204a; 204b，用于支撑基板206a; 206b; 500a; 500b; 500c，以及输送装置208a; 208b，用于将半导体部件212传送到基板206a; 206b; 500a; 500b; 500c。特别地，支撑装置204a，204的高度相互平齐以输送基板206a; 206b; 500a; 500b; 500c在多个传送模块202a，202b之间。

5. 发明授权

US08008000B2 Viral variants detection and application 有权
标题翻译：病毒变体检测和应用
公开(公告)号：US08008000B2
公开(公告)日：2011-08-30
申请号：US12346622
申请日：2008-12-30
申请人： Angeline Ingrid Bartholomeusz , Stephen Alister Locarnini , Anna Ayres , Lilly Ka Wai Yuen , Joseph John Sasadeusz
发明人： Angeline Ingrid Bartholomeusz , Stephen Alister Locarnini , Anna Ayres , Lilly Ka Wai Yuen , Joseph John Sasadeusz
IPC分类号： C12Q1/70 , C12Q1/00 , C12N1/21
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2730/10122 , C12Q1/706
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.
摘要翻译：本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。本发明进一步考虑了用于检测此类病毒变体的测定法，该测定法可用于监测抗病毒治疗方案和开发针对病毒剂，特别是HBV变体的新的或修饰的疫苗。本发明还考虑使用病毒变体来筛选和/或开发或设计能够抑制病毒感染，复制和/或释放的试剂。

6. 发明授权

US07875423B2 HBV variants detection and application 有权
标题翻译： HBV变异检测和应用
公开(公告)号：US07875423B2
公开(公告)日：2011-01-25
申请号：US10576906
申请日：2004-10-20
申请人： Angeline Ingrid Bartholomeusz , Stephen Alister Locarnini , Anna Ayres , Lilly Ka Wai Yuen , Joseph John Sasadeusz
发明人： Angeline Ingrid Bartholomeusz , Stephen Alister Locarnini , Anna Ayres , Lilly Ka Wai Yuen , Joseph John Sasadeusz
IPC分类号： C12Q1/70 , C12Q1/00 , C12N1/21
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2730/10122 , C12Q1/706
摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.
摘要翻译：本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。更具体地，本发明涉及对核苷或核苷酸类似物表现出完全或部分抗性和/或与抗体对抗病毒表面成分的降低的交互性的乙型肝炎病毒（HBV）变体，包括对这些抗体的敏感性降低。本发明进一步考虑了用于检测此类病毒变体的测定法，该测定法可用于监测抗病毒治疗方案和开发针对病毒剂，特别是HBV变体的新的或修饰的疫苗。本发明还考虑使用病毒变体来筛选和/或开发或设计能够抑制病毒感染，复制和/或释放的试剂。

7. 发明授权

US07485636B2 Therapeutic pyrazolo[3,4-b]pyridines and indazoles 失效
标题翻译：治疗性吡唑并[3,4-b]吡啶和吲唑
公开(公告)号：US07485636B2
公开(公告)日：2009-02-03
申请号：US11446277
申请日：2006-06-02
申请人： Po-Wai Yuen
发明人： Po-Wai Yuen
IPC分类号： A61K31/535 , C07D413/12
CPC分类号： C07D231/56 , C07D401/04 , C07D403/12 , C07D413/12 , C07D471/04
摘要： The present invention provides for compounds of Formula I: wherein R2, R3, R4, R5, R6, R7, X, and L have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of central nervous disorders and conditions including attention deficit hyperactivity disorder, neuropathic pain, urinary incontinence, anxiety, depression, and schizophrenia and fibromyalgia. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
摘要翻译：本发明提供式I化合物：其中R2，R3，R4，R5，R6，R7，X和L具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗中枢神经障碍和包括注意力缺陷多动障碍，神经性疼痛，尿失禁，焦虑，抑郁和精神分裂症以及纤维肌痛的病症。还提供了包含一种或多种式I化合物的药物组合物。

8. 发明授权

US07207688B2 Interactive shoe light device 有权
标题翻译：互动鞋灯装置
公开(公告)号：US07207688B2
公开(公告)日：2007-04-24
申请号：US11208274
申请日：2005-08-18
申请人： Wong Wai Yuen , Wong Kui Hang
发明人： Wong Wai Yuen , Wong Kui Hang
IPC分类号： F21W121/06 , F21V21/08
CPC分类号： A43B3/001 , A43B3/0005 , Y10S362/80
摘要： An interactive shoe light device includes at least one power source, at least one motion switch to generate an activation signal in response to an electrical engagement within the motion switch, the activation signal indicating at least duration of electrical engagement within the motion switch, an integrated circuit functioning as a controller, the integrated circuit electrically connected to the motion switch to receive the activation signal, and lighting elements electrically connected to the integrated circuit. The lighting elements are selectively actuated by the integrated circuit to illuminate the lighting elements in one or more predetermined illumination patterns depending on the duration of electrical engagement indicated by the activation signal. For a short duration, all lighting elements flash in a flashing pattern for a pre-determined period. For a long duration, only one lighting element lights up and continues for a few seconds after the switch is opened.
摘要翻译：交互式鞋灯设备包括至少一个电源，至少一个运动开关，以响应于运动开关内的电接合而产生激活信号，所述激活信号指示运动开关内至少电连接的持续时间，集成电路用作控制器，集成电路电连接到运动开关以接收激活信号，以及照明元件电连接到集成电路。照明元件由集成电路选择性地启动，以根据由激活信号指示的电接合的持续时间以一个或多个预定照明图案照亮照明元件。在短时间内，所有照明元件以闪烁的模式闪烁一段预定的时间。长时间，开关打开后，只有一个照明元件亮起并持续几秒钟。

9. 发明申请

US20050151656A1 Weather sensing station and associated methods 审中-公开
标题翻译：天气传感站及相关方法
公开(公告)号：US20050151656A1
公开(公告)日：2005-07-14
申请号：US11002774
申请日：2004-12-02
申请人： Wai Yuen
发明人： Wai Yuen
IPC分类号： G01J1/42 , G01N1/22 , G01N15/06 , G01W1/04 , G01W1/06 , G01W1/00
CPC分类号： G01W1/06 , G01J1/429 , G01N1/2273 , G01N15/06 , G01W1/04
摘要： In one embodiment, a weather sensing station includes one or more remote wireless sense units for sensing environmental conditions. A base station processes wireless signals from the wireless sense units and indicates the environmental conditions. A running display string may be used to display the data on a display string of the base station. Wireless sense units may include an air quality sense unit and, for example, a UV sensor. Air quality information and UV energy information may then be determined and displayed as data or indicated through graphical symbols.
摘要翻译：在一个实施例中，天气感测站包括用于感测环境条件的一个或多个远程无线感测单元。基站处理来自无线感测单元的无线信号并指示环境条件。可以使用正在运行的显示字符串来显示基站的显示串上的数据。无线感测单元可以包括空气质量感测单元和例如UV传感器。然后可以确定空气质量信息和UV能量信息，并将其显示为数据或通过图形符号指示。

10. 发明授权

US06642398B2 Mono-and disubstituted 3-propyl gamma-aminobutyric acids 失效
标题翻译：单取代和二取代的3-丙基γ-氨基丁酸
公开(公告)号：US06642398B2
公开(公告)日：2003-11-04
申请号：US10324929
申请日：2002-12-20
申请人： Thomas Richard Belliotti , Justin Stephen Bryans , Ihoezo Victor Ekhato , Augustine Tobi Osuma , Robert Michael Schelkun , Jacob Bradley Schwarz , Andrew John Thorpe , Lawrence David Wise , David Juergen Wustrow , Po-Wai Yuen
发明人： Thomas Richard Belliotti , Justin Stephen Bryans , Ihoezo Victor Ekhato , Augustine Tobi Osuma , Robert Michael Schelkun , Jacob Bradley Schwarz , Andrew John Thorpe , Lawrence David Wise , David Juergen Wustrow , Po-Wai Yuen
IPC分类号： C07D1000
CPC分类号： C07C229/32 , C07B2200/07 , C07C229/08 , C07C229/20 , C07C229/22 , C07C229/30 , C07C229/34 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.
摘要翻译：本发明是一系列新型的单取代和二取代的3-丙基γ-氨基丁酸，其化合物可用作治疗癫痫，微弱发作，运动功能减退，颅内疾病，神经变性障碍，抑郁症，焦虑症，恐慌症，疼痛，神经病理学障碍，关节炎，睡眠障碍，IBS和胃损伤。制备化合物和有用的中间体的方法也是本发明的一部分。

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