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1. 发明申请

US20130196312A1 GENOMIC LANDSCAPES OF HUMAN BREAST AND COLORECTAL CANCERS 审中-公开
标题翻译：人类乳腺癌和色素沉着病的基因组学观察
公开(公告)号：US20130196312A1
公开(公告)日：2013-08-01
申请号：US13247552
申请日：2011-09-28
申请人： Laura D. WOOD , Williams D. PARSONS , Sian JONES , Jimmy LIN , Tobias SJÖBLOM , Thomas BARBER , Giovanni PARMIGIANI , Victor VELCULESCU , Kenneth W. KINZLER , Bert VOGELSTEIN
发明人： Laura D. WOOD , Williams D. PARSONS , Sian JONES , Jimmy LIN , Tobias SJÖBLOM , Thomas BARBER , Giovanni PARMIGIANI , Victor VELCULESCU , Kenneth W. KINZLER , Bert VOGELSTEIN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要： Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.
摘要翻译：人类癌症是由致癌基因和肿瘤抑制基因突变的积累引起的。为了列出肿瘤发生过程中发生的遗传变化，我们从11个乳腺和11个结肠直肠肿瘤中分离出DNA，并在这些样品中确定了参考序列数据库中的基因序列。根据对18,191个基因的20,857个转录本的外显子的分析，我们得出结论，乳腺癌和结肠直肠癌的基因组景观由少数常见的突变基因“山”组成，更多的基因“山”在低位突变频率。我们描述了统计和生物信息学工具，可以帮助识别在肿瘤发生中发挥作用的突变。这些结果有助于了解人类癌症的性质和异质性以及使用个人基因组学进行肿瘤诊断和治疗。

2. 发明申请

US20090123928A1 Genomic Landscapes of Human Breast and Colorectal Cancers 审中-公开
标题翻译：人类乳腺癌和结肠直肠癌的基因组学风景
公开(公告)号：US20090123928A1
公开(公告)日：2009-05-14
申请号：US12247464
申请日：2008-10-08
申请人： Laura D. Wood , Williams D. Parsons , Sian Jones , Jimmy Lin , Tobias Sjoblom , Thomas Barber , Giovanni Parmigiani , Victor Velculescu , Kenneth W. Kinzler , Bert Vogelstein
发明人： Laura D. Wood , Williams D. Parsons , Sian Jones , Jimmy Lin , Tobias Sjoblom , Thomas Barber , Giovanni Parmigiani , Victor Velculescu , Kenneth W. Kinzler , Bert Vogelstein
IPC分类号： C12Q1/68 , C12Q1/02
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要： Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy.
摘要翻译：人类癌症是由致癌基因和肿瘤抑制基因突变的积累引起的。为了列出肿瘤发生过程中发生的遗传变化，我们从11个乳腺和11个结肠直肠肿瘤中分离出DNA，并在这些样品中确定了参考序列数据库中的基因序列。根据对18,191个基因的20,857个转录本的外显子的分析，我们得出结论，乳腺癌和结肠直肠癌的基因组景观由少数常见的突变基因“山”组成，更多的基因“山”在低位突变频率。我们描述了统计和生物信息学工具，可以帮助识别在肿瘤发生中发挥作用的突变。这些结果有助于了解人类癌症的性质和异质性以及使用个人基因组学进行肿瘤诊断和治疗。

3. 发明授权

US3807672A Kite-flying control reel 失效
标题翻译：飞镖控制卷
公开(公告)号：US3807672A
公开(公告)日：1974-04-30
申请号：US30265172
申请日：1972-11-01
申请人： WILLIAMS D
发明人： WILLIAMS D
IPC分类号： A63H27/00 , B64C31/06
CPC分类号： A63H27/002
摘要： In the representative embodiments of the present invention disclosed herein, a hand-held control reel is provided with a drum for carrying a plurality of parallel control lines adapted to be connected to selected points on a kite. By releasably coupling a crank to the drum, the control lines can be quickly wound onto the drum when the kite is to be pulled in; but the crank will be disengaged to prevent the crank from striking the user when the lines are being unspooled to let the kite out. To regulate the speed at which the control lines can be unreeled, the assembly is provided with a trigger-actuated brake. Alternative line-control mechanisms are shown which are cooperatively arranged to selectively vary the length of one control line in relation to the others for directing the kite into various maneuvers. Of particular significance, the new and improved reel assembly is provided with an arm rest adapted to engage the underside of the user''s forearm and a pistol grip for positioning the user''s index finger adjacent to the brake control trigger.
摘要翻译：在本文公开的本发明的代表性实施例中，手持控制卷轴设置有用于承载适于连接到风筝上的选定点的多个平行控制线的滚筒。通过将曲柄可释放地联接到滚筒，当要将风筝拉入时，可以将控制线快速地卷绕到滚筒上; 但是曲柄将被分离，以防止当线路未被挤压以使风筝出口时曲柄撞击使用者。为了调节控制线可以释放的速度，组件设有触发器驱动的制动器。示出了替代的线路控制机制，其协作地布置成选择性地改变一个控制线相对于其他控制线的长度，以将风筝指向各种操纵。特别重要的是，新的和改进的卷轴组件设置有适于接合使用者前臂的下侧的扶手和用于将使用者的食指定位在制动控制触发器附近的手枪把手。

4. 发明授权

US3778021A Power systems for valve systems 失效
标题翻译：阀系统动力系统
公开(公告)号：US3778021A
公开(公告)日：1973-12-11
申请号：US3778021D
申请日：1971-02-19
申请人： ALEXANDER J , WILLIAMS D
发明人： ALEXANDER J , WILLIAMS D
IPC分类号： G05D23/19 , G05D7/06 , F03G7/06 , F16K31/02
CPC分类号： G05D23/1921
摘要： A closed, self-sustaining power system for the operation of valves includes a first means for storing and containing an expandable system which means communicates with a responsive means of a valve system to enable the valve system to be opened, closed or controlled. A controlled energy means transmits energy to the expandable medium to thereby cause an increase in pressure in the responsive means of the valve system which enables the valve system to respond as desired. After actuation of the responsive means of the valve system, the means for storing is enabled to communicate with a reservoir means which thereby increases the area of the closed system to reduce the pressure in the closed system sufficiently to terminate actuation of the responsive means of the valve system.
摘要翻译：用于操作阀的封闭的自维持动力系统包括用于存储和容纳可膨胀系统的第一装置，该可膨胀系统与阀系统的响应装置连通，以使阀系统能够打开，关闭或控制。受控能量意味着将能量传递到可膨胀介质，从而导致阀系统的响应装置中的压力增加，这使阀系统能够根据需要作出响应。在阀系统的响应装置致动之后，用于存储的装置能够与储存装置连通，从而增加封闭系统的面积，以减小封闭系统中的压力，从而终止致动装置的响应装置阀门系统。

5. 发明授权

US3764976A Pedal mounted signal light 失效
标题翻译：踏板安装信号灯
公开(公告)号：US3764976A
公开(公告)日：1973-10-09
申请号：US3764976D
申请日：1971-06-14
申请人： KIMBALL A , SHEPHARD D , WILLIAMS D , CURRY K
发明人： MAC MAHON P
IPC分类号： B62J6/00 , B62M3/12 , B62J5/00
CPC分类号： B62M3/12 , B62J6/00
摘要： A translucent casing adapted to replace the outer end plate of a conventional bicycle pedal and having batteries, lights and a gravity actuated switch therein. The casing is preferably red in color, to glow when the lights are on. The switch is actuated by merely inverting the pedal on its customary spindle and a cam on that spindle causes the lights to blink. Exterior connections on the casing permit recharging the batteries while they remain in the casing.
摘要翻译：一种半透明外壳，适用于替代传统自行车踏板的外端板，并具有电池，灯和重力驱动开关。外壳优选为红色，当灯亮时，发光。该开关仅通过其常规主轴上的踏板反转来驱动，该主轴上的凸轮使灯闪烁。外壳上的外部连接允许在电池留在外壳中时对电池进行充电。

6. 发明授权

US3727374A Bag filling device 失效
标题翻译：袋装填装置
公开(公告)号：US3727374A
公开(公告)日：1973-04-17
申请号：US3727374D
申请日：1971-11-10
申请人： WILLIAMS D
发明人： WILLIAMS D
IPC分类号： B65B43/36 , B65B67/04
CPC分类号： B65B67/04 , B65B43/36
摘要： The flaps of a stack of plastic bags are clamped by a releasable clamp below the exhaust nozzle of the blower of a packing device, in such position that the airflow blows the top of the outermost bag open away from the stack; above the bag is a feed chute or guide adjustably mounted on the top of the blower, having a pivoted half on a transverse pivot so that it may swing outwardly away from the blower; skirt flanges extending from the lower edge of this pivoted half project into the opened bag so as to keep it open when the pivoted half is swung outwardly by the package or item to be packed; on each side of the pivoted half is a hinged flap swingable outwardly to hold the sides of the bag open when a wider package or article is dropped through the feeding guide; the pivoted half is sufficiently wide to extend substantially beyond the sides of the stationary half of the guide.
摘要翻译：一堆塑料袋的折片由包装装置的鼓风机的排气喷嘴下方的可释放夹具夹紧，使得气流将最外层袋的顶部吹离堆叠; 袋子上方是可调节地安装在鼓风机顶部的进料槽或导向件，在横向枢轴上具有枢转的一半，使得其可以从鼓风机向外摆动; 裙部法兰从该枢转的半突出部的下边缘延伸到打开的袋中，以便当枢转的半部被包装或待包装的物品向外摆动时保持打开; 在枢转的一半的每一侧上，当更宽的包装或物品通过进给引导件下落时，可向外摆动的铰链翼可保持袋的侧面打开; 枢转的一半足够宽以便基本上延伸超过引导件的固定半部的侧面。

7. 发明授权

US08012041B2 Golf club head with variable face thickness 有权
标题翻译：具有可变面厚度的高尔夫球杆头
公开(公告)号：US08012041B2
公开(公告)日：2011-09-06
申请号：US12711435
申请日：2010-02-24
申请人： Evan D. Gibbs , Neil Hall , Williams D. Richardson , Larry G. Tang
发明人： Evan D. Gibbs , Neil Hall , Williams D. Richardson , Larry G. Tang
IPC分类号： A63B53/04
CPC分类号： A63B53/0466 , A63B53/02 , A63B60/00 , A63B2053/0408 , A63B2053/0412 , A63B2053/0416 , A63B2053/042 , A63B2053/045 , A63B2053/0458 , A63B2053/0491
摘要： A face or face insert (40) for a golf club head (20) is disclosed herein. The face (40) has an interior surface (40b) with a first thickness section (200) and a second thickness region (205). The first thickness section (200) preferably has a thickness that is at least 0.025 inch greater than the thickness of the second thickness region (205). In a most preferred embodiment, the first thickness section (200) has an X shape that is rotated around the Y axis (500) by at least 10 degrees. In another preferred embodiment, the face has a first thickness section (200), a second thickness region (205), and a central region (400) having a third thickness. The face or face insert (40) with variable thickness allows for a face or face insert (40) with less mass in a golf club head (20) that conforms to the United States Golf Association regulations.
摘要翻译：本文公开了一种用于高尔夫球杆头（20）的面部或面部插入件（40）。面（40）具有内表面（40b），其具有第一厚度部分（200）和第二厚度区域（205）。第一厚度部分（200）优选地具有比第二厚度区域（205）的厚度大至少0.025英寸的厚度。在最优选的实施例中，第一厚度部分（200）具有绕Y轴（500）旋转至少10度的X形状。在另一优选实施例中，所述面具有第一厚度部分（200），第二厚度区域（205）和具有第三厚度的中心区域（400）。具有可变厚度的面部或面部插入物（40）允许在符合美国高尔夫球会规定的高尔夫球杆头（20）中具有较少质量的面部或面部插入物（40）。

8. 发明授权

US3816263A Biological test 失效
标题翻译：生物测试
公开(公告)号：US3816263A
公开(公告)日：1974-06-11
申请号：US23201372
申请日：1972-03-06
申请人： RABIN B , WILLIAMS D
发明人： WILLIAMS D , RABIN B
IPC分类号： G01N33/50 , G01N31/14
CPC分类号： G01N33/5014 , Y10S435/81
摘要： A method of testing a substance for carcinogenic activity which comprises contacting the substance with isolated cell membranes having masked rearrangase activity and after a predetermined interval of time testing the cell membranes for rearrangase activity. This method enables substances to be screened for possible carcinogenic activity. A test kit is also described.

9. 发明授权

US3741034A Inertial energy storage apparatus 失效
标题翻译：惯性能量储存装置
公开(公告)号：US3741034A
公开(公告)日：1973-06-26
申请号：US6895970
申请日：1970-09-02
申请人： WILLIAMS D , FOWLER K
发明人： POST S
IPC分类号： F16F15/30 , F16C15/00
CPC分类号： F16F15/30 , Y02E60/16 , Y10T74/212
摘要： Inertial energy storage apparatus having two contrarotating rotors the fellies of which include a number of thin rings of high tensile strength material, such as glasses or embedded fiber composites, arranged in concentric shells, the ratio of the Young''s Modulus to the density of the material of each ring being proportional to the nth power of its mean radius, where n is not equal to zero, so that the radial separations between successive shells of rings produced by centrifugal force are reduced as compared with those produced when n is zero (e.g., all rings of the same material). The rotors have alternator-motors in their hubs, by means of which they can be brought to speed, and by means of which the inertial energy stored in them can be extracted in the form of variable-frequency alternating output voltage. This output voltage may be converted by a solid-state cycloconverter to alternating current of selectively variable frequency by means of which to power, for instance, the threephase, squirrel-cage wheel motors of a non-pollution-producing vehicle.

10. 发明授权

US3710466A Machine tools and more particularly to data-controlled machine tools 失效
标题翻译：机床工具，特别是数据控制机床
公开(公告)号：US3710466A
公开(公告)日：1973-01-16
申请号：US3710466D
申请日：1970-09-30
申请人： MOLINS MACHINE CO LTD , HUTCHISON D , WILLIAMS D , WILSON K
发明人： WILLIAMSON D , HUTCHISON J , WILSON K , KAHN C , FAYOLLE L
IPC分类号： B23B3/00 , B23B11/00 , B23Q39/02
CPC分类号： B23Q39/027 , B23B3/00 , B23B11/00 , B23Q2039/004 , B23Q2039/008 , G05B2219/45141 , G05B2219/49376 , G05B2219/50047 , G05B2219/50249 , G05B2219/50293 , Y10T29/5109 , Y10T82/25 , Y10T82/2552 , Y10T82/2587 , Y10T408/37 , Y10T409/305656
摘要： Eleven embodiments of machine tool particularly intended for data-control are disclosed. A rotating workpiece is moved in relation to a lathe tool which is stationary during cutting. Tools such as drills are also provided for working on the end face of the workpiece. In some embodiments the workpiece is movable in two directions mutually perpendicular to its rotational axis as well as along that axis. In some embodiments the machine may act as a milling, drilling or boring machine as well as a lathe. In some embodiments the rotatable workpiece holder may be replaced by a tool holder.
摘要翻译：公开了特别用于数据控制的机床的11个实施例。旋转工件相对于在切割期间静止的车床工具移动。还提供诸如钻头的工具用于在工件的端面上进行加工。在一些实施例中，工件可以在与其旋转轴线以及沿该轴线相互垂直的两个方向上移动。在一些实施例中，机器可以用作铣削，钻孔或钻孔机器以及车床。在一些实施例中，可旋转工件保持器可以由工具保持器代替。

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