专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09074228B2 Process for the preparation of optically active chiral amines 有权
标题翻译：光学活性手性胺的制备方法
公开(公告)号：US09074228B2
公开(公告)日：2015-07-07
申请号：US12223730
申请日：2007-02-13
申请人： Karen Robins , Uwe Bornscheuer , Matthias Höhne
发明人： Karen Robins , Uwe Bornscheuer , Matthias Höhne
IPC分类号： C12P13/00 , C12N9/10 , C12P13/02 , C12P13/06 , C12P13/22
CPC分类号： C12P17/10 , C12N9/1096 , C12P13/001 , C12P13/02 , C12P13/06 , C12P13/22 , C12Y206/01018
摘要： The present invention relates to the production of optically pure secondary amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.
摘要翻译：本发明涉及光合纯仲胺的制备，其可以用作例如药物产品的合成中的中间产物。

2. 发明申请

US20110207186A1 Isoforms of Pig Liver Esterase 有权
标题翻译：猪肝酯酶的同种型
公开(公告)号：US20110207186A1
公开(公告)日：2011-08-25
申请号：US12532347
申请日：2008-03-11
申请人： Uwe Bornscheuer , Anke Hummel , Dominique Böttcher , Elke Brüsehaber , Kai Doderer , Harald Trauthwein
发明人： Uwe Bornscheuer , Anke Hummel , Dominique Böttcher , Elke Brüsehaber , Kai Doderer , Harald Trauthwein
IPC分类号： C12N9/16 , C07H21/04 , C12N1/21 , C12P7/02 , C12N15/63 , C12N5/10 , C12P7/62 , C12P7/40
CPC分类号： C12N9/18 , C12P7/02 , C12P7/42 , C12P7/62 , C12P41/004
摘要： The invention relates to novel mutants of γPLE, to vehicles containing the same and to their use in the production of enantiomer-enriched alcohols, carboxylic acids and esters.
摘要翻译：本发明涉及γPLE的新颖突变体，其涉及含有该突变体的载体及其在制备富含对映异构体的醇，羧酸和酯的用途。

3. 发明授权

US06706500B2 Process for the preparation of L-menthol 有权
标题翻译：制备L-薄荷醇的方法
公开(公告)号：US06706500B2
公开(公告)日：2004-03-16
申请号：US10041892
申请日：2002-01-07
申请人： Ian-Lucas Gatfield , Jens-Michael Hilmer , Uwe Bornscheuer , Rolf Schmidt , Sandra Vorlová
发明人： Ian-Lucas Gatfield , Jens-Michael Hilmer , Uwe Bornscheuer , Rolf Schmidt , Sandra Vorlová
IPC分类号： C12P700
CPC分类号： C12P41/004 , C12P7/02 , Y10S435/921
摘要： L-Menthol is prepared from D,L-menthyl derivatives by enantioselective enzymatic cleavage.
摘要翻译： L-薄荷醇由D，L-薄荷醇衍生物通过对映选择性酶裂解制备。

4. 发明授权

US06365398B1 Process for preparation to stereoisomeric carboxylic acid esters 失效
标题翻译：立体异构羧酸酯的制备方法
公开(公告)号：US06365398B1
公开(公告)日：2002-04-02
申请号：US09505709
申请日：2000-02-17
申请人： Uwe Bornscheuer , Erik Henke , Hong Yang
发明人： Uwe Bornscheuer , Erik Henke , Hong Yang
IPC分类号： C12P4100
CPC分类号： C12P7/62 , C12P41/005
摘要： The present invention relates to a process for the preparation of stereoisomeric carboxylic acid esters consisting of an acid and of an alcohol component each having at least one chiral center, at least one stereoisomer of the carboxylic acid ester being present in an excess, by reacting a racemic carboxylic acid ester with a racemic alcohol in the presence of a carboxyl ester hydrolase (EC 3.1.1).
摘要翻译：本发明涉及制备由酸和醇组分组成的立体异构羧酸酯的方法，每一种具有至少一个手性中心，至少一种羧酸酯的立体异构体以过量存在，通过使外消旋羧酸酯与外消旋醇在羧基酯水解酶（EC 3.1.1）存在下反应。

5. 发明授权

US08728750B2 Process for preparation of optically active N-protected 3-aminopyrrolidine or optically active N-protected 3-aminopiperidine and the corresponding ketones by optical resolution of the racemic amine mixtures employing a bacterial omega-transaminase 有权
标题翻译：通过旋光拆分外消旋胺混合物制备光学活性N-保护的3-氨基吡咯烷或光学活性N-保护的3-氨基哌啶和相应的酮的方法，其使用细菌ω-转氨酶
公开(公告)号：US08728750B2
公开(公告)日：2014-05-20
申请号：US12438674
申请日：2007-09-06
申请人： Karen Robins , Uwe Bornscheuer , Matthias Höhne
发明人： Karen Robins , Uwe Bornscheuer , Matthias Höhne
IPC分类号： C12Q1/52 , C12P1/00
CPC分类号： C12P17/10 , C12P13/001 , C12P13/06 , C12P13/22 , C12P17/12 , C12P35/06 , C12P41/007
摘要： The present invention relates to the production of optically active amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.
摘要翻译：本发明涉及光合活性胺的制备，其可用作例如药物产品的合成中的中间产物。

6. 发明申请

US20120276247A1 Lipase Variants 审中-公开
标题翻译：脂肪酶变体
公开(公告)号：US20120276247A1
公开(公告)日：2012-11-01
申请号：US13098124
申请日：2011-04-29
申请人： Uwe Bornscheuer , Henrike Brundiek , Andrew Evitt , Stefan Sass , Friedericke Bönisch , Robert Kourist
发明人： Uwe Bornscheuer , Henrike Brundiek , Andrew Evitt , Stefan Sass , Friedericke Bönisch , Robert Kourist
IPC分类号： C12N9/20 , C12N9/02 , C12N15/57 , C12N15/63 , A23D9/00 , C12N15/81 , C12N1/21 , C12N1/19 , A23D9/04 , C12N11/02 , C12N15/70
CPC分类号： C12N9/20 , A23D9/04 , C12P7/6454
摘要： The present invention relates to a newly identified lipase belonging to the Ustilaginaceae family of Basidomycetes and variants thereof. The invention also relates to polynucleotides encoding the lipase and the variants thereof. The invention further relates to procedures for producing the lipase, and variants thereof, polypeptides and polynucleotides. The invention further relates to lipase variants with an increased trans-selectivity. The invention further relates to lipase variants with a preference for long chain fatty acid esters or carboxylic acid moieties with a chain length greater than C12. The invention further relates to a method of reducing, or eliminating, trans-fatty acids from liquid oil stable enough for frying systems.
摘要翻译：本发明涉及属于Basidomycetes的Ustilaginaceae科的新鉴定的脂肪酶及其变体。本发明还涉及编码脂肪酶的多核苷酸及其变体。本发明还涉及产生脂肪酶的方法及其变体，多肽和多核苷酸。本发明还涉及具有增加的反式选择性的脂肪酶变体。本发明还涉及优选长链脂肪酸酯或链长大于C12的羧酸部分的脂肪酶变体。本发明还涉及一种减少或消除来自液体油的反式脂肪酸足以用于煎炸系统的方法。

7. 发明申请

US20090311745A1 GROUP OF ESTERASES FOR THE ENANTIOSELECTIVE PRODUCTION OF FINE AND SPECIALITY CHEMICALS 有权
公开(公告)号：US20090311745A1
公开(公告)日：2009-12-17
申请号：US12300275
申请日：2007-05-03
申请人： Klaus Liebeton , Jürgen Eck , Uwe Bornscheuer , Dominique Böttcher , Peter Langer , Esen Bellur
发明人： Klaus Liebeton , Jürgen Eck , Uwe Bornscheuer , Dominique Böttcher , Peter Langer , Esen Bellur
IPC分类号： C12P21/00 , C12P7/62 , C12P7/40 , C12P7/02 , C12N15/00 , C12N15/74 , C12N9/18 , C12N1/21 , C12N15/63 , C07K16/40 , C07H21/00
CPC分类号： C12N9/18
摘要： The present invention relates to a polynucleotide encoding an enzyme having carboxylesterase [E.C. 3.1.1.1] activity, wherein the coding sequence is selected from the group consisting of (a) a polynucleotide encoding an amino acid sequence as depicted in any one of SEQ ID NOs: 2, 4, 6, 8, 10 and 12; (b) a polynucleotide having or comprising a nucleotide sequence encoding an enzyme, wherein the nucleic acid sequence is as shown in any one of SEQ ID NOs: 1, 3, 5, 7, 9 and 11; (c) a polynucleotide having or comprising a nucleotide sequence encoding a fragment or derivative of an enzyme encoded by a polynucleotide of (a) or (b), wherein in said derivative one or more amino acid residues are conservatively substituted compared to the amino acid sequence of (a); (d) a polynucleotide encoding an enzyme having carboxylesterase activity which polynucleotide is at least 66% identical to a polynucleotide encoding an enzyme as shown in one of SEQ ID NOs: 2, 4, 6, 8, 10 and 12; (e) a polynucleotide having or comprising a nucleotide sequence the complementary strand of which hybridizes to a polynucleotide as defined in any one of (a) to (d); and (f) a polynucleotide having or comprising a nucleotide sequence being degenerate to the nucleotide sequence of the polynucleotide of (d) or (e); or the complementary strand of such a polynucleotide of (a) to (f) or fragments thereof useful as specific probes or primers. The present invention also relates to a host genetically engineered with the polynucleotide of the present invention or the vector of the present invention. The present invention also relates to a process for producing a polypeptide having carboxylesterase [E.C. 3.1.1.1] activity, comprising culturing the host of the present invention and recovering the polypeptide produced by said host. Moreover, The present invention also relates to a process for producing bacteria or eukaryotic cells capable of expressing a polypeptide having carboxylesterase [E.C. 3.1.1.1] activity, the process comprising genetically engineering bacteria or eukaryotic cells with the vector of the present invention. Finally, the present invention relates to (poly)peptides, antibodies, compositions and various methods for the production of optically active compounds.

8. 发明授权

US08304223B2 Isoforms of pig liver esterase 有权
标题翻译：猪肝酯酶的异构体
公开(公告)号：US08304223B2
公开(公告)日：2012-11-06
申请号：US12532347
申请日：2008-03-11
申请人： Uwe Bornscheuer , Anke Hummel , Dominique Böttcher , Elke Brüsehaber , Kai Doderer , Harald Trauthwein
发明人： Uwe Bornscheuer , Anke Hummel , Dominique Böttcher , Elke Brüsehaber , Kai Doderer , Harald Trauthwein
IPC分类号： C12N9/18
CPC分类号： C12N9/18 , C12P7/02 , C12P7/42 , C12P7/62 , C12P41/004
摘要： The invention relates to novel mutants of γPLE, to vehicles containing the same and to their use in the production of enantiomer-enriched alcohols, carboxylic acids and esters.
摘要翻译：本发明涉及γPLE的新颖突变体，其涉及含有该突变体的载体及其在制备富含对映异构体的醇，羧酸和酯的用途。

9. 发明申请

US20120156706A1 PROCESS FOR THE IDENTIFICATION AND PREPARATION OF A (R)-SPECIFIC OMEGA-TRANSAMINASE 有权
标题翻译：鉴定和制备（R） - 优质欧米茄 - 转移酶的方法
公开(公告)号：US20120156706A1
公开(公告)日：2012-06-21
申请号：US13393201
申请日：2010-08-13
申请人： Matthias Hoehne , Uwe Bornscheuer , Karen Robins , Sebastian Schaetzle
发明人： Matthias Hoehne , Uwe Bornscheuer , Karen Robins , Sebastian Schaetzle
IPC分类号： G06F17/30 , C12Q1/52 , C12P13/00 , C12N9/10
CPC分类号： G06F19/22 , C12N9/1096 , C12P13/001
摘要： The present invention relates to processes for the screening, preparation and characterization of (R)-selective ω-transaminases, to transaminases obtained thereby and their uses in various transamination processes.
摘要翻译：本发明涉及用于（R）选择性ω-转氨酶的筛选，制备和表征的方法，由此获得的转氨酶及其在各种氨基转移过程中的用途。

10. 发明申请

US20090325224A1 PROCESS FOR PREPARATION OF OPTICALLY ACTIVE N-PROTECTED 3-AMINOPYRROLIDINE OR OPTICALLY ACTIVE N-PROTECTED 3-AMINOPIPERIDINE AND THE CORRESPONDING KETONES BY OPTICAL RESOLUTION OF THE RACEMIC AMINE MIXTURES EMPLOYING A BACTERIAL OMEGA-TRANSAMINASE 有权
标题翻译：制备光活性N-保护的3-氨基吡咯烷酮或光活性N-保护的3-氨基嘌呤和通过光聚合反应的游离胺类混合物的方法通过使用细菌的欧米茄 - 转移酶
公开(公告)号：US20090325224A1
公开(公告)日：2009-12-31
申请号：US12438674
申请日：2007-09-06
申请人： Karen Robins , Uwe Bornscheuer , Matthias Höhne
发明人： Karen Robins , Uwe Bornscheuer , Matthias Höhne
IPC分类号： C12P13/00 , C12P35/00 , C12P13/04 , C12P17/10 , C12P17/12
CPC分类号： C12P17/10 , C12P13/001 , C12P13/06 , C12P13/22 , C12P17/12 , C12P35/06 , C12P41/007
摘要： The present invention relates to the production of optically active amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.
摘要翻译：本发明涉及光合活性胺的制备，其可用作例如药物产品的合成中的中间产物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式