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1. 发明申请

US20100209934A1 METHOD OF IDENTIFYING AGENTS WHICH MODULATE THE ACTIVITY OF CALCIUM-ACTIVATED CHLORIDE CHANNEL 审中-公开
标题翻译：识别激活氯化物通道活性的试剂的方法
公开(公告)号：US20100209934A1
公开(公告)日：2010-08-19
申请号：US12738666
申请日：2008-10-17
申请人： Uhtaek Oh , Hawon Cho , Young Duk Yang , Min Ho Tak , Yongwoo Jang , Jae Yeon Koo , Si Young Cho , Yeon Su Jeong
发明人： Uhtaek Oh , Hawon Cho , Young Duk Yang , Min Ho Tak , Yongwoo Jang , Jae Yeon Koo , Si Young Cho , Yeon Su Jeong
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/53
CPC分类号： G01N33/6872 , G01N2333/726 , G01N2500/10
摘要： The present invention provides a method of identifying an agent which modulates an activity of a protein, wherein the protein is represented by the amino acid sequence of SEQ ID NO: 1 or has at least 90% amino acid sequence identity to SEQ ID NO: 1 and transports chloride ions across a cell membrane, comprising: (a) exposing cells which express the protein to the agent; and (b) measuring degree of chloride ion transport in the exposed cells, wherein a change in the degree of chloride ion transport compared to control cells, which express the protein but not exposed to the agent, is indicative of an agent capable of modulating an activity of the protein. The agents identified by this method can be used for the prevention or treatment of various diseases caused by the dysfunction of calcium activated chloride channel.
摘要翻译：本发明提供鉴定调节蛋白质活性的试剂的方法，其中所述蛋白质由SEQ ID NO：1的氨基酸序列表示或与SEQ ID NO：1具有至少90％的氨基酸序列同一性并将氯离子转移穿过细胞膜，包括：（a）将表达蛋白质的细胞暴露于所述试剂; 和（b）测量暴露的细胞中氯离子转运的程度，其中与表达蛋白质但不暴露于试剂的对照细胞相比，氯离子转移程度的变化指示能够调节蛋白质的活性。通过该方法鉴定的药剂可用于预防或治疗由钙活化氯化物通道功能障碍引起的各种疾病。

2. 发明授权

US06476076B1 Vanilloid analogues containing resinferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof 失效
标题翻译：含有作为强效香草素受体激动剂的树脂铁氧化酶药效团的香草酸类似物和镇痛药，其组合物和用途
公开(公告)号：US06476076B1
公开(公告)日：2002-11-05
申请号：US09914000
申请日：2001-08-20
申请人： Jeewoo Lee , Uhtaek Oh , Young-Ho Park , Young-Ger Suh , Hyeung-Geun Park , Hee-Doo Kim
发明人： Jeewoo Lee , Uhtaek Oh , Young-Ho Park , Young-Ger Suh , Hyeung-Geun Park , Hee-Doo Kim
IPC分类号： A01N4728
CPC分类号： C07C335/12 , C07C235/34
摘要： The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The present invention provides a pharmaceutical composition for treating acute, chronic, inflammatory or neuropathic pains or for treating bladder hypersensitivity.
摘要翻译：本发明涉及含有树脂毒素药效学的新型香草酸类似物，包含这些类似物的药物组合物，以及它们作为香草素受体激动剂和强力镇痛药的用途。本发明提供用于治疗急性，慢性，炎性或神经性疼痛或用于治疗膀胱过敏症的药物组合物。

3. 发明申请

US20120015886A1 METHOD FOR PREPARING RECOMBINANT PEPTIDE FROM SPIDER VENOM AND METHOD FOR RELIEVING PAIN 审中-公开
标题翻译：从天花板制备重组蛋白的方法及缓解疼痛的方法
公开(公告)号：US20120015886A1
公开(公告)日：2012-01-19
申请号：US12907475
申请日：2010-10-19
申请人： UhTaek OH , Byung Moon Kim , Seung Pyo Park , Heung Sik Na
发明人： UhTaek OH , Byung Moon Kim , Seung Pyo Park , Heung Sik Na
IPC分类号： A61K38/17 , A61P29/00
CPC分类号： C07K14/43518 , C12N15/815
摘要： The present invention relates to a method for producing a recombinant, spider toxin peptide and analgesic compositions containing said peptide. More specifically, the present invention relates to a method in which the gene for GsMTx4 is subcloned into a vector, so that it is linked to a secretion signal sequence of the alpha factor and under the control of methanol-inducible alcohol oxidase (AOX) promoter to construct a recombinant yeast expression plasmid. Yeast cells are transformed with this plasmid to produce the GsMTx4 peptide and analgesic compositions containing said peptide. The recombinant yeast expression system of the present invention affords a more stable method for producing GsMTx4 than its natural route. Thus the GsMTx4 peptide and its derivatives produced by the method of this invention can be used in the cure of related diseases such as heart failure as the peptide specifically inhibits mechanosensitive ion channels.
摘要翻译：本发明涉及一种生产含有所述肽的重组蜘蛛毒素肽和镇痛组合物的方法。更具体地，本发明涉及将GsMTx4的基因亚克隆到载体中的方法，使其与α因子的分泌信号序列连接并在甲醇诱导型醇氧化酶（AOX）启动子的控制下构建重组酵母表达质粒。用该质粒转化酵母细胞以产生含有所述肽的GsMTx4肽和镇痛组合物。本发明的重组酵母表达系统提供比其自然途径更稳定的产生GsMTx4的方法。因此，通过本发明方法产生的GsMTx4肽及其衍生物可用于治疗诸如心力衰竭等相关疾病，因为该肽特异性抑制机械敏感离子通道。

4. 发明申请

US20090023183A1 Method For Preparing Recombinant Peptide From Spider Venom and Analgesic Composition Containing The Peptide 审中-公开
标题翻译：从蜘蛛毒液制备重组肽的方法和含有肽的止痛组合物
公开(公告)号：US20090023183A1
公开(公告)日：2009-01-22
申请号：US12090664
申请日：2006-10-18
申请人： UhTaek Oh , Byung Moon Kim , Seung Pyo Park , Heung Sik Na
发明人： UhTaek Oh , Byung Moon Kim , Seung Pyo Park , Heung Sik Na
IPC分类号： C12P21/02 , C07H21/04 , C07K14/435
CPC分类号： C07K14/43518 , C12N15/815
摘要： The present invention relates to a method for producing a recombinant, spider toxin peptide and analgesic compositions containing said peptide. More specifically, the present invention relates to a method in which the gene for GsMTx4 is subcloned into a vector, so that it is linked to a secretion signal sequence of the alpha factor and under the control of methanol-inducible alcohol oxidase (AOX) promoter to construct a recombinant yeast expression plasmid. Yeast cells are transformed with this plasmid to produce the GsMTx4 peptide and analgesic compositions containing said peptide. The recombinant yeast expression system of the present invention affords a more stable method for producing GsMTx4 than its natural route. Thus the GsMTx4 peptide and its derivatives produced by the method of this invention can be used in the cure of related diseases such as heart failure as the peptide specifically inhibits mechanosensitive ion channels.
摘要翻译：本发明涉及一种生产含有所述肽的重组蜘蛛毒素肽和镇痛组合物的方法。更具体地，本发明涉及将GsMTx4的基因亚克隆到载体中的方法，使其与α因子的分泌信号序列连接并在甲醇诱导型醇氧化酶（AOX）启动子的控制下构建重组酵母表达质粒。用该质粒转化酵母细胞以产生含有所述肽的GsMTx4肽和镇痛组合物。本发明的重组酵母表达系统提供比其自然途径更稳定的产生GsMTx4的方法。因此，通过本发明方法产生的GsMTx4肽及其衍生物可用于治疗诸如心力衰竭等相关疾病，因为该肽特异性抑制机械敏感离子通道。

5. 发明授权

US06673840B1 Use of lipoxygenase metabolite of arachidonic acid and its derivatives in capsaicin-channel agonist 有权
标题翻译：花生四烯酸及其衍生物脂氧合酶代谢物在辣椒素通道激动剂中的应用
公开(公告)号：US06673840B1
公开(公告)日：2004-01-06
申请号：US09762449
申请日：2001-02-06
申请人： Uhtaek Oh , Sun Wook Hwang
发明人： Uhtaek Oh , Sun Wook Hwang
IPC分类号： A61K3120
CPC分类号： A61K31/202 , A61K31/191 , A61K31/201
摘要： Disclosed is the use of metabolites produced from arachiconic acid by the catalytic action of lipoxygenase as capsaicin-channel or- receptor agonists. The lipoxygenase metavolites of arachidonic acid and their derivatives can activate the capsaicin channel to excite pain nerves, causing serious pain. In contrast, the capsaicin channel activation of the pain nerves, so that an analgesic effects are brought about. The lipoxygenase metabolites of arachidonic acid can be used as an analgesic and in searching for and developing analgesics.
摘要翻译：公开了通过脂氧合酶作为辣椒素通道或受体激动剂的催化作用从花生四烯酸产生的代谢物的用途。花生四烯酸及其衍生物的脂氧合酶代谢物可以激活辣椒素通道，激发疼痛神经，引起严重的疼痛。相比之下，辣椒素通道激活疼痛神经，从而引起镇痛作用。花生四烯酸的脂氧合酶代谢物可用作镇痛药，并可用于寻找和开发镇痛药。

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