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    • 9. 发明申请
    • PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING DEGENERATIVE BRAIN DISEASE COMPRISING MULTI-TARGETING COMPOUNDS
    • 用于治疗或预防包含多重化合物的变应性脑病的药物组合物
    • US20160243059A1
    • 2016-08-25
    • US14967376
    • 2015-12-14
    • UNIST Academy-Industry Research Corporation
    • Mi Hee LIM
    • A61K31/136A23L1/30
    • A61K31/136A23L33/10A23V2002/00A61K31/13A23V2200/302A23V2200/31A23V2200/322
    • A pharmaceutical composition for treating or preventing a degenerative brain disease, the pharmaceutical composition including, as an active component, a multi-targeting compound for further improving treatment efficiency of a degenerative brain disease such as Alzheimer's disease is disclosed. The pharmaceutical composition includes a compound represented by Formula 1 or 2, wherein the compound of Formula 1 or 2 induces a gathering of amyloid-peptides in a manner of toxicity-free aggregation under conditions both in the presence and absence of metals such as copper and zinc, and also reacts with multiple targets of Alzheimer's diseases at once to inhibit toxicity thereof, the multiple targets including amyloid-peptide, metal-amyloid-peptide, a metal, and an activated oxidizing species. The pharmaceutical composition including the compound of Formula 1 or 2 may be utilized as a therapeutic agent or a health food in regard to a brain disease, including Alzheimer's disease.
    • 公开了一种用于治疗或预防退行性脑病的药物组合物,该药物组合物包括作为活性成分的多靶标化合物,用于进一步提高退行性脑疾病如阿尔茨海默氏病的治疗效率。 该药物组合物包括由式1或2表示的化合物,其中式1或2的化合物以无毒性聚集的方式在存在和不存在金属如铜和铜的条件下诱导淀粉样蛋白聚集 锌,并且同时与阿尔茨海默病的多个靶点一起反应以抑制其毒性,多个靶标包括淀粉样蛋白肽,金属淀粉样肽,金属和活化的氧化物质。 包括式1或2化合物的药物组合物可用作关于脑疾病(包括阿尔茨海默病)的治疗剂或保健食品。