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1. 发明授权

US06503537B2 Preparation of powder agglomerates 有权
公开(公告)号：US06503537B2
公开(公告)日：2003-01-07
申请号：US09824377
申请日：2001-04-02
申请人： Tsong-Toh Yang
发明人： Tsong-Toh Yang
IPC分类号： A61K914
CPC分类号： A61K9/1617 , A61K9/1623 , A61K47/183 , A61K47/26
摘要： The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.

2. 发明授权

US5829434A Inhaler for powdered medications 失效
标题翻译：吸入粉末药物
公开(公告)号：US5829434A
公开(公告)日：1998-11-03
申请号：US446804
申请日：1995-06-01
申请人： Thomas J. Ambrosio , Charles R. Ashley , Alan J. Bilanin , Charles M. Huck , Andrew E. Kaufman , David J. Kenyon , Srinivas Manthena , Henry R. Sochon , Ken Wilkinson , Tsong-Toh Yang
发明人： Thomas J. Ambrosio , Charles R. Ashley , Alan J. Bilanin , Charles M. Huck , Andrew E. Kaufman , David J. Kenyon , Srinivas Manthena , Henry R. Sochon , Ken Wilkinson , Tsong-Toh Yang
IPC分类号： A61M13/00 , A61M11/00 , A61M15/00 , B65B7/14 , G06M1/16
CPC分类号： A61M15/0065 , A61M11/002 , A61M15/0025 , A61M15/0068 , A61M15/0073 , B65B7/14 , G06M1/163 , A61M2202/064
摘要： A powder inhaler comprising: a powder housing for holding a supply of powdered material to be dispensed and a metering plate for holding a metered amount of said powdered material, the metering plate being alternately positionable below said supply of powdered material or within an inhalation conduit, by means of a bi-directional, angle-limited relative rotation about a common central axis; a counter for providing a visual count of the number of doses of said powdered material that have been dispensed or remain to be dispensed in response to the relative rotation, the counter including: a continuous counter ring and a coaxially mounted intermittent counter ring, both rings being mounted on a base in surrounding relation to a retaining post, being rotatable about the common central axis and having counting indicia thereon for displaying said visual count; and a display means through which at least one of the counting indicia is displayed to indicate a count corresponding to a number of doses of powdered material that have been dispensed or remain to be dispensed.
摘要翻译： PCT No.PCT / US93 / 12076 Sec。 371日期：1995年6月1日 102（e）1995年6月1日PCT 1993年12月16日PCT公布。出版物WO94 / 14492 日期1994年7月7日一种粉末吸入器，包括：用于保持要分配的粉末材料供应的粉末壳体和用于保持计量的所述粉末材料的计量板，所述计量板可交替地定位在所述粉末材料供应下方或在吸入管道内，通过围绕公共中心轴线的双向角度限制的相对旋转; 计数器，用于响应于相对旋转而提供所分配或保持分配的所述粉末材料的剂量数量的视觉计数器，所述计数器包括：连续计数器环和同轴安装的间歇计数器环，两个环被安装在围绕着保持柱的基座上，可围绕公共中心轴线旋转并且在其上具有用于显示所述视觉计数的计数标记; 以及显示装置，通过该显示装置显示计数标记中的至少一个以指示对应于已经被分配或保留分配的粉末材料的剂量的数量的计数。

3. 发明申请

US20090298802A1 Pharmaceutical Compositions 审中-公开
标题翻译：药物组合物
公开(公告)号：US20090298802A1
公开(公告)日：2009-12-03
申请号：US11887642
申请日：2006-03-30
申请人： Joel A. Sequeira , Tsong-Toh Yang
发明人： Joel A. Sequeira , Tsong-Toh Yang
IPC分类号： A61K31/56 , A61P11/00
CPC分类号： A61K31/58 , A61K9/0073 , A61K31/40 , A61K31/46 , A61K31/47 , A61K45/06 , A61K2300/00
摘要： Disclosed are inhalable medicaments and methods based on an anticholinergic in combination with a corticosteroid, and a long acting beta agonist, for simultaneous or sequential administration in the prevention or treatment of a respiratory, inflammatory or obstructive airway disease. In addition, disclosed are inhalable medicaments and methods based on combinations of an anticholinergic and a corticosteroid; an anticholinergic and a long acting beta agonist; or a corticosteroid and a long acting beta agonist, for simultaneous or sequential administration in the prevention or treatment of a respiratory, inflammatory or obstructive airway disease. Also disclosed are inhalable medicaments and methods comprising a phosphodiesterase IV inhibitor for administration in the prevention or treatment of a respiratory, inflammatory or obstructive airway disease.
摘要翻译：公开了基于抗胆碱能药物与皮质类固醇联合的可吸入药物和方法以及长效β激动剂，用于同时或连续施用以预防或治疗呼吸道，炎性或阻塞性气道疾病。此外，公开了基于抗胆碱能药和皮质类固醇组合的可吸入药物和方法; 抗胆碱能药和长效β激动剂; 或皮质类固醇和长效β激动剂，用于同时或连续施用以预防或治疗呼吸道，炎性或阻塞性气道疾病。还公开了可吸入药物和方法，其包含用于预防或治疗呼吸道，炎性或阻塞性气道疾病的磷酸二酯酶IV抑制剂。

4. 发明授权

US07387794B2 Preparation of powder agglomerate 有权
标题翻译：粉末聚集体的制备
公开(公告)号：US07387794B2
公开(公告)日：2008-06-17
申请号：US11028788
申请日：2005-01-04
申请人： Tsong-Toh Yang
发明人： Tsong-Toh Yang
IPC分类号： A61K9/14 , A61M11/00
CPC分类号： A61K9/1617 , A61K9/1623 , A61K47/183 , A61K47/26
摘要： The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.
摘要翻译：本发明涉及一种生产药物和固体粘合剂附聚物的方法。该方法包括产生单独的附聚颗粒，然后通过施加例如水分，在附聚后转化其可转化的无定形含量。还可考虑能够转化的聚集体以及包含其的成品附聚物和口服和鼻给药系统。该方法产生坚固的附聚物，但在给药期间将产生可接受的细颗粒级分。

5. 发明申请

US20050123608A1 Preparation of powder agglomerate 有权
标题翻译：粉末聚集体的制备
公开(公告)号：US20050123608A1
公开(公告)日：2005-06-09
申请号：US11028788
申请日：2005-01-04
申请人： Tsong-Toh Yang
发明人： Tsong-Toh Yang
IPC分类号： A61K9/16 , A61K47/18 , A61K47/26 , A61K38/00 , A61K31/47 , A61K31/58 , B27N3/00
CPC分类号： A61K9/1617 , A61K9/1623 , A61K47/183 , A61K47/26
摘要： The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.
摘要翻译：本发明涉及一种生产药物和固体粘合剂附聚物的方法。该方法包括产生单独的附聚颗粒，然后通过施加例如水分，在附聚后转化其可转化的无定形含量。还可考虑能够转化的聚集体以及包含其的成品附聚物和口服和鼻给药系统。该方法产生坚固的附聚物，但在给药期间将产生可接受的细颗粒级分。

6. 发明授权

US06623760B1 Method of preparing particles for agglomeration 有权
标题翻译：制备团聚颗粒的方法
公开(公告)号：US06623760B1
公开(公告)日：2003-09-23
申请号：US09490796
申请日：2000-01-26
申请人： Tsong-Toh Yang , Stephen K. C. Yu , Charles G. Eckhart , Michael B. Mitchell
发明人： Tsong-Toh Yang , Stephen K. C. Yu , Charles G. Eckhart , Michael B. Mitchell
IPC分类号： A61K914
CPC分类号： A61K9/145 , A61K31/167 , A61K31/58
摘要： Methods of preparing particulates for agglomeration, having a specified particle size distribution and desired convertible amorphous content, are described. The method involves a plurality of micronizing steps at least two of which are separated by a curing step. In the curing step, a stimulus such as humidity may be used to crystallize at least some, and in many instances preferably all, of the convertible amorphous content.
摘要翻译：描述了制备具有特定粒度分布和所需可转化非晶体含量的附聚颗粒的方法。该方法涉及多个微粉化步骤，其中至少两个通过固化步骤分离。在固化步骤中，可以使用诸如湿度的刺激来使至少一些，并且在许多情况下优选全部可结晶的无定形含量。

7. 发明申请

US20080206346A1 PREPARATION OF POWDER AGGLOMERATES 有权
标题翻译：粉末聚集体的制备
公开(公告)号：US20080206346A1
公开(公告)日：2008-08-28
申请号：US12117434
申请日：2008-05-08
申请人： Tsong-Toh Yang
发明人： Tsong-Toh Yang
IPC分类号： A61K9/16
CPC分类号： A61K9/1617 , A61K9/1623 , A61K47/183 , A61K47/26
摘要： The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.
摘要翻译：本发明涉及一种生产药物和固体粘合剂附聚物的方法。该方法包括产生单独的附聚颗粒，然后通过施加例如水分，在附聚后转化其可转化的无定形含量。还可考虑能够转化的聚集体以及包含其的成品附聚物和口服和鼻给药系统。该方法产生坚固的附聚物，但在给药期间将产生可接受的细颗粒级分。

8. 发明授权

US06495167B2 Preparation of powder agglomerates 有权
标题翻译：粉末团块的制备
公开(公告)号：US06495167B2
公开(公告)日：2002-12-17
申请号：US09901205
申请日：2001-07-09
申请人： Tsong-Toh Yang
发明人： Tsong-Toh Yang
IPC分类号： A61K914
CPC分类号： A61K9/0043 , A61K9/0075 , A61K9/1617 , A61K9/1623 , A61K31/58 , A61K47/183 , A61K47/26
摘要： The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.
摘要翻译：本发明涉及一种生产药物和固体粘合剂附聚物的方法。该方法包括产生单独的附聚颗粒，然后通过施加例如水分，在附聚后转化其可转化的无定形含量。还可考虑能够转化的聚集体以及包含其的成品附聚物和口服和鼻给药系统。该方法产生坚固的附聚物，但在给药期间将产生可接受的细颗粒级分。

9. 发明申请

US20080118566A1 PREPARATION OF POWDER AGGLOMERATES 有权
公开(公告)号：US20080118566A1
公开(公告)日：2008-05-22
申请号：US11947608
申请日：2007-11-29
申请人： Tsong-Toh Yang
发明人： Tsong-Toh Yang
IPC分类号： A61K9/14 , A61P11/06 , A61K31/58
CPC分类号： A61K9/0043 , A61K9/0075 , A61K9/1617 , A61K9/1623 , A61K31/58 , A61K47/183 , A61K47/26
摘要： The invention relates to a method of producing an agglomerate of drug and solid binder. The process involves producing individual agglomerate particles and then converting the convertible amorphous content of same, following agglomeration, by the application of, for example, moisture. Agglomerates capable of conversion as well as the finished agglomerates and oral and nasal dosing systems including same are also contemplated. The process produces agglomerates which are rugged but which will produce an acceptable fine particle fraction during dosing.

10. 发明授权

US5687710A Inhaler for powdered medications having spiral deagglomeration chamber 失效
标题翻译：具有螺旋解聚腔的药物吸入器
公开(公告)号：US5687710A
公开(公告)日：1997-11-18
申请号：US458928
申请日：1995-06-01
申请人： Thomas J. Ambrosio , Alan J. Bilanin , Andrew E. Kaufman , David J. Kenyon , Srinivas Manthena , Tsong-Toh Yang
发明人： Thomas J. Ambrosio , Alan J. Bilanin , Andrew E. Kaufman , David J. Kenyon , Srinivas Manthena , Tsong-Toh Yang
IPC分类号： A61M13/00 , A61M11/00 , A61M15/00 , B65B7/14 , G06M1/16 , A61M16/00 , B05D7/14 , B65D83/06
CPC分类号： A61M15/0065 , A61M11/002 , A61M15/0025 , A61M15/0068 , A61M15/0073 , B65B7/14 , G06M1/163 , A61M2202/064
摘要： A powder dispenser includes a powder housing for holding a supply of powdered material to be dispensed, the powder housing including an inhalation conduit provided displaced relation to the powdered material supply; a metering plate including a metered dose hole for holding a metered amount of the powdered material, and positioned below the powdered material supply, the metering plate and the powder housing being relatively rotatable with respect to each other about a common central axis; a counter providing a visual count of the number of doses of the powdered material that have been dispensed or remain to be dispensed in response to the relative rotation, the counter including counter rings providing the visual count, the counter rings being rotatable about the common central axis and having indicia thereon which display the visual count, and an actuating mechanism rotatable about the central axis for incrementally rotating the counter rings in response to the relative rotation; a nozzle for breaking up agglomerates of powdered material from the inhalation conduit to form micronized powdered material, the nozzle including a cavity for changing the direction of flow of the powder from the direction of the inhalation conduit to a second different direction, and a curved wall for substantially continuously changing the direction of flow of the powder in a spiral manner in the second direction in the cavity; and a closure cap covering the powder housing and priming the powder dispenser for use automatically upon removal thereof.
摘要翻译：粉末分配器包括用于保持要分配的粉末材料供应的粉末壳体，所述粉末壳体包括与所述粉末材料供应相关联地设置的吸入管道; 计量板，包括用于保持计量的粉末材料的计量剂量孔，并定位在粉末材料供应下方，计量板和粉末壳体围绕公共中心轴线可相对于彼此相对旋转; 计数器提供响应于相对旋转而被分配或保持分配的粉末材料的剂量数量的视觉计数，所述计数器包括提供视觉计数的计数器环，所述计数器环可围绕公共中心旋转并且在其上具有显示视觉计数的标记;以及致动机构，其可围绕中心轴线旋转，用于响应于相对旋转逐渐旋转计数器环; 用于从吸入管道分解粉末材料的团块以形成微粉化的粉末材料的喷嘴，所述喷嘴包括用于将粉末从吸入管道的方向改变到第二不同方向的空腔，以及弯曲的壁用于在空腔中沿第二方向以螺旋方式基本上连续地改变粉末的流动方向; 以及封盖，其覆盖所述粉末壳体并且将所述粉末分配器启动，以在移除所述粉末分配器时自动使用。

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