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1. 发明授权

US4542099A Method for manufacturing restriction enzymes from Bifidobacteria 失效
标题翻译：双歧杆菌限制酶的制备方法
公开(公告)号：US4542099A
公开(公告)日：1985-09-17
申请号：US240363
申请日：1981-03-04
申请人： Toshizo Sakurai , Toshiyuki Kosaka
发明人： Toshizo Sakurai , Toshiyuki Kosaka
IPC分类号： C12N9/16 , C12N9/22 , C12R1/01
CPC分类号： C12N9/22 , Y10S435/822
摘要： This invention relates to a method for manufacturing restriction enzymes, which comprises cultivating a restriction enzyme-producing strain belonging to Bifidobacterium and recovering the restriction enzyme from the bacteria thus cultivated.
摘要翻译：本发明涉及限制性内切酶的制造方法，其特征在于，包括培养属于双歧杆菌的限制性内切酶产生菌，并从所培养的细菌中回收限制酶。

2. 发明授权

US4532211A Coliform bacillus having a gene for the production of staphylokinase and a process for production of staphylokinase therewith 失效
标题翻译：具有葡萄球菌激酶生产基因的大肠菌杆菌及其生产葡萄球菌激酶的方法
公开(公告)号：US4532211A
公开(公告)日：1985-07-30
申请号：US434503
申请日：1982-10-15
申请人： Tomoyuki Sako , Saeko Sawaki , Toshizo Sakurai , Masahiko Mutai , Isamu Kondo
发明人： Tomoyuki Sako , Saeko Sawaki , Toshizo Sakurai , Masahiko Mutai , Isamu Kondo
IPC分类号： C12N1/21 , C07K14/31 , C12N1/20 , C12N9/52 , C12N15/09 , C12R1/19 , C12R1/92 , C12P21/00 , C07H21/04 , C12N1/00 , C12N9/48 , C12N9/50 , C12N15/00 , C12P21/02 , C12P21/04
CPC分类号： C07K14/31
摘要： Novel coliform bacillus useful for industrial production of staphylokinase, a fibrinolytic enzyme, and process for the production of staphylokinase using said microbe are provided. The novel microbe comprises a recombinant DNA, carrying genetic information for the production of staphylokinase, said genetic information being DNA derived from a temperate phage DNA of Staphylococcus aureus.
摘要翻译：提供了可用于工业生产葡萄球菌激酶，纤维蛋白溶解酶的新型大肠杆菌，以及使用所述微生物生产葡萄球菌激酶的方法。该新型微生物包含重组DNA，携带用于产生葡萄球菌激酶的遗传信息，所述遗传信息是衍生自金黄色葡萄球菌的温带噬菌体DNA的DNA。

3. 发明授权

US4771039A Botulinus toxin neutralizer 失效
标题翻译：肉毒毒素中和剂
公开(公告)号：US4771039A
公开(公告)日：1988-09-13
申请号：US844026
申请日：1986-03-25
申请人： Ryuichiro Tanaka , Koutaro Takamizawa , Hiroo Takayama , Toshizo Sakurai , Mitsuo Mada , Masahiko Mutai
发明人： Ryuichiro Tanaka , Koutaro Takamizawa , Hiroo Takayama , Toshizo Sakurai , Mitsuo Mada , Masahiko Mutai
IPC分类号： A61K35/20 , A61K31/00 , A61P39/02 , C07H15/10 , A61K31/70 , A61K31/685 , A61K35/48
CPC分类号： C07H15/10 , A61K31/00 , A61K35/20 , Y10S514/823
摘要： A botulinus toxin neutralizer comprising heat-treated fat globule membranes of animal milk or gangliosides isolated from fat globule membranes of animal milk. The neutralizer of the former nature is prepared from a material containing fat globules of animal milk by fractionating the material for separating the membranes of the fat globules from the rest of the material, and subjecting the separated fat globule membranes to heat treatment. The neutralizer of the former nature is prepared from a material containing fat globules by fractionating the material for separating the membranes of the fat globules from the rest of the material, and isolating gangliosides from the globule membranes.
摘要翻译：一种肉毒杆菌毒素中和剂，其包含动物乳的热处理脂肪球膜或从动物乳的脂肪球膜分离的神经节苷脂。前者性质的中和剂是由含有动物乳的脂肪球的材料制成的，分离用于将脂肪球的膜与其余材料分离的材料，并对分离的脂肪球膜进行热处理。前者性质的中和剂由含有脂肪球的材料制备，通过分离用于将脂肪球的膜与其余材料分离的材料，并从球状膜中分离神经节苷脂。

4. 发明授权

US5306730A Botulinum toxin neutralizer 失效
标题翻译：肉毒毒素中和剂
公开(公告)号：US5306730A
公开(公告)日：1994-04-26
申请号：US887652
申请日：1992-05-26
申请人： Yoshitaka Nagai , Koutaro Takamizawa , Ryuichiro Tanaka , Hiroo Takayama , Toshizo Sakurai , Masahiko Mutai
发明人： Yoshitaka Nagai , Koutaro Takamizawa , Ryuichiro Tanaka , Hiroo Takayama , Toshizo Sakurai , Masahiko Mutai
IPC分类号： A61K31/20
CPC分类号： A61K31/20
摘要： A botulinum toxin neutralizer comprising at least one fatty acid having the number of carbon atoms of at least 12. Such a fatty acid may be any of saturated fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, nonadecanoic acid, arachidic acid, and behenic acid or any of unsaturated fatty acids such as oleic acid. The toxin neutralizer acts as if it were an antagonistic receptor for botulinum toxin and, when encountering botulinum toxin in human body, directly combines with the toxin and disables the toxin from combining with the neuromuscular tissues of human body to prevent the outbreak of botulism. The toxin thus neutralized and affixed to the botulinum toxin neutralizer is excreted from the human body. The botulinum toxin neutralizer can be manufactured easily and economically from a naturally occurring glyceride and is thus far less costly then the known antitoxin of ganglioside GT1b produced from bovine brain.
摘要翻译：包含至少一种碳原子数至少为12的脂肪酸的肉毒毒素中和剂。这种脂肪酸可以是饱和脂肪酸，如月桂酸，肉豆蔻酸，棕榈酸，硬脂酸，十九烷酸，花生四烯酸酸和山萮酸或任何不饱和脂肪酸如油酸。毒素中和剂的作用就好像是肉毒杆菌毒素的拮抗受体一样，当遇到肉毒杆菌毒素时，与毒素直接结合，使毒素与人体神经肌肉组织结合，防止肉毒杆菌爆发。因此中和并附着于肉毒毒素中和剂的毒素从人体排出。肉毒杆菌毒素中和剂可以从天然存在的甘油酯容易地和经济地制造，因此从已知的由牛脑产生的神经节苷脂GT1b的抗毒素成本远远低于成本。

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