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1. 发明授权

US08470577B2 Viral vectors and their use in therapeutic methods 有权
公开(公告)号：US08470577B2
公开(公告)日：2013-06-25
申请号：US12721599
申请日：2010-03-11
申请人： Paul Johnson , Robert L. Martuza , Samuel D. Rabkin , Tomoki Todo
发明人： Paul Johnson , Robert L. Martuza , Samuel D. Rabkin , Tomoki Todo
IPC分类号： C12N7/00 , C12N7/01 , A61K39/245
CPC分类号： A61K39/245 , A61K35/763 , A61K35/768 , A61K38/162 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/585 , C12N7/00 , C12N15/86 , C12N2710/16632 , C12N2710/16634 , C12N2710/16643 , C12N2710/16662 , C12N2710/16671
摘要： The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.

2. 发明申请

US20110070262A1 Viral Vectors and Their Use in Therapeutic Methods 有权
标题翻译：病毒载体及其在治疗方法中的应用
公开(公告)号：US20110070262A1
公开(公告)日：2011-03-24
申请号：US12721599
申请日：2010-03-11
申请人： Paul Johnson , Robert L. Martuza , Samuel D. Rabkin , Tomoki Todo
发明人： Paul Johnson , Robert L. Martuza , Samuel D. Rabkin , Tomoki Todo
IPC分类号： A61K39/245 , C12N7/04 , A61K35/76 , A61P35/00 , A61P37/04 , A61P31/00
CPC分类号： A61K39/245 , A61K35/763 , A61K35/768 , A61K38/162 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/585 , C12N7/00 , C12N15/86 , C12N2710/16632 , C12N2710/16634 , C12N2710/16643 , C12N2710/16662 , C12N2710/16671
摘要： The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
摘要翻译：本发明提供病毒载体（例如，疱疹病毒载体）以及使用这些载体治疗疾病的方法。

3. 发明授权

US07655459B2 Enhancer of anticancer activity in viral therapy and method of preventing or treating cancer 有权
标题翻译：增强病毒治疗中的抗癌活性及预防或治疗癌症的方法
公开(公告)号：US07655459B2
公开(公告)日：2010-02-02
申请号：US10594964
申请日：2005-03-31
申请人： Tomoki Todo
发明人： Tomoki Todo
IPC分类号： C12N15/00
CPC分类号： A61K38/20 , A61K35/763 , A61K38/208 , C12N2710/16632 , A61K2300/00
摘要： The present invention provides a pharmaceutical that safely and effectively enhances the anticancer activity of viral therapy and particularly the antitumor immunity of viral therapy. The present invention also provides a method of preventing or treating cancer that uses this drug. The anticancer activity enhancer according to the present invention contains interleukin as an effective component and is co-administered with a recombinant herpes simplex virus that selectively replicates in cancer cells.
摘要翻译：本发明提供一种安全有效地提高病毒治疗的抗癌活性的药物，特别是病毒治疗的抗肿瘤免疫性。本发明还提供了预防或治疗使用该药物的癌症的方法。根据本发明的抗癌活性增强剂含有白细胞介素作为有效成分，并与在癌细胞中选择性复制的重组单纯疱疹病毒共同施用。

4. 发明申请

US20070196336A1 Method For Constructing Recombinant Herpes Simplex Virus 审中-公开
标题翻译：构建重组单纯疱疹病毒的方法
公开(公告)号：US20070196336A1
公开(公告)日：2007-08-23
申请号：US10594962
申请日：2005-03-31
申请人： Tomoki Todo , Hiroshi Fukuhara
发明人： Tomoki Todo , Hiroshi Fukuhara
IPC分类号： A61K48/00 , C12N15/86 , C12N7/00
CPC分类号： C12N15/86 , A61K38/1774 , A61K38/20 , A61K38/208 , C12N7/00 , C12N2710/16632 , C12N2710/16643 , C12N2800/202 , C12N2800/30
摘要： A method is provided for rapidly and reliably constructing recombinant herpes simplex virus (HSV) capable of expressing a target protein in cancer cells. The method for constructing recombinant HSV as claimed in the present invention comprises a first step of inserting into a herpes simplex virus (HSV) genome, a BAC plasmid, which has a loxP site and an FRT site and into which has been inserted at least one type of marker gene expression cassette between the loxP site and the FRP site, a second step of constructing a shuttle vector into which has been respectively inserted at least one type of expression cassette of a gene encoding a target protein, at least one type of marker gene, a loxP site and an FRP site, and inserting the shuttle vector into the loxP site of the HSV genome using Cre recombinase, and a third step of co-infecting a host with the HSV genome and a vector capable of expressing Flp recombinase, and excising the region between the FRT sites in the genome to produce a target recombinant HSV.
摘要翻译：提供了一种快速可靠地构建能够在癌细胞中表达靶蛋白的重组单纯疱疹病毒（HSV）的方法。用于构建本发明所要求的重组HSV的方法包括将第一步骤插入到单纯疱疹病毒（HSV）基因组中，BAC质粒具有loxP位点和FRT位点，其中插入有至少一个类型的loxP位点和FRP位点之间的标记基因表达盒，构建穿梭载体的第二步，其中分别插入至少一种编码靶蛋白的基因的表达盒，至少一种类型的标记基因，loxP位点和FRP位点，并使用Cre重组酶将穿梭载体插入HSV基因组的loxP位点，以及第三步，共同感染宿主与HSV基因组和能够表达Flp重组酶的载体，并切除基因组中的FRT位点之间的区域以产生靶重组HSV。

5. 发明授权

US08945531B2 Recombinant herpes virus and pharmaceutical composition containing the same 有权
标题翻译：重组疱疹病毒和含有其的药物组合物
公开(公告)号：US08945531B2
公开(公告)日：2015-02-03
申请号：US13579628
申请日：2010-02-19
申请人： Tomoki Todo , Hiroshi Fukuhara
发明人： Tomoki Todo , Hiroshi Fukuhara
IPC分类号： A01N63/00 , A61K39/245 , C12N7/00 , C07H21/04 , C12N15/86 , A61K35/76 , C12N15/869
CPC分类号： A61K35/763 , A61K35/76 , C12N7/00 , C12N15/86 , C12N15/869 , C12N2710/16621 , C12N2710/16632 , C12N2710/16643 , C12N2710/16671 , C12N2830/008
摘要： A recombinant herpes virus showing high antitumor activity is provided. In particular, a recombinant herpes simplex virus that expresses an ICP6 gene under control of a tumor-specific promoter or tissue-specific promoter on the genome of the virus is provided.
摘要翻译：提供了显示高抗肿瘤活性的重组疱疹病毒。特别地，提供了在病毒基因组上的肿瘤特异性启动子或组织特异性启动子控制下表达ICP6基因的重组单纯疱疹病毒。

6. 发明授权

US07749745B2 Viral vectors and their use in therapeutic methods 有权
标题翻译：病毒载体及其在治疗方法中的应用
公开(公告)号：US07749745B2
公开(公告)日：2010-07-06
申请号：US10107036
申请日：2002-03-27
申请人： Paul Johnson , Robert L. Martuza , Samuel D. Rabkin , Tomoki Todo
发明人： Paul Johnson , Robert L. Martuza , Samuel D. Rabkin , Tomoki Todo
IPC分类号： C12N7/00 , C12N7/01 , A61K39/245
CPC分类号： A61K39/245 , A61K35/763 , A61K35/768 , A61K38/162 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/585 , C12N7/00 , C12N15/86 , C12N2710/16632 , C12N2710/16634 , C12N2710/16643 , C12N2710/16662 , C12N2710/16671
摘要： The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
摘要翻译：本发明提供病毒载体（例如，疱疹病毒载体）以及使用这些载体治疗疾病的方法。

7. 发明申请

US20070154451A1 Enhancer of anticancer activity in viral therapy and method of preventing or treating cancer 有权
标题翻译：增强病毒治疗中的抗癌活性及预防或治疗癌症的方法
公开(公告)号：US20070154451A1
公开(公告)日：2007-07-05
申请号：US10594964
申请日：2005-03-31
申请人： Tomoki Todo
发明人： Tomoki Todo
IPC分类号： A61K48/00 , A61K38/20
CPC分类号： A61K38/20 , A61K35/763 , A61K38/208 , C12N2710/16632 , A61K2300/00
摘要： The present invention provides a pharmaceutical that safely and effectively enhances the anticancer activity of viral therapy and particularly the antitumor immunity of viral therapy. The present invention also provides a method of preventing or treating cancer that uses this drug. The anticancer activity enhancer according to the present invention contains interleukin as an effective component and is co-administered with a recombinant herpes simplex virus that selectively replicates in cancer cells.
摘要翻译：本发明提供一种安全有效地提高病毒治疗的抗癌活性的药物，特别是病毒治疗的抗肿瘤免疫性。本发明还提供了预防或治疗使用该药物的癌症的方法。根据本发明的抗癌活性增强剂含有白细胞介素作为有效成分，并与在癌细胞中选择性复制的重组单纯疱疹病毒共同施用。

8. 发明申请

US20120039808A1 Brain Tumor Stem Cell Differentiation Promoter, and Therapeutic Agent for Brain Tumor 审中-公开
标题翻译：脑肿瘤干细胞分化启动子和脑肿瘤治疗剂
公开(公告)号：US20120039808A1
公开(公告)日：2012-02-16
申请号：US13207846
申请日：2011-08-11
申请人： Kohei Miyazono , Hiroaki Ikushima , Keiji Miyazawa , Tomoki Todo , Yasushi Ino
发明人： Kohei Miyazono , Hiroaki Ikushima , Keiji Miyazawa , Tomoki Todo , Yasushi Ino
IPC分类号： A61K49/00 , A61K31/7088 , A61K31/711 , A61K31/713 , A61P35/00 , C12Q1/02 , C12Q1/68 , C40B30/02 , C07H21/00 , C07H21/02 , G01N33/53
CPC分类号： A61K31/713 , A61K31/4439 , A61K45/06 , C12N15/113 , C12N2310/11 , C12N2310/14
摘要： A promoter for differentiation of brain tumor initiating cells is provided.
摘要翻译：提供了用于脑肿瘤起始细胞分化的启动子。

9. 发明申请

US20210023152A1 Swelling-Suppressive Oncolytic Virus 有权
公开(公告)号：US20210023152A1
公开(公告)日：2021-01-28
申请号：US17042161
申请日：2019-03-28
申请人： Tomoki Todo
发明人： Tomoki Todo
IPC分类号： A61K35/768 , C07K16/22 , A61P35/00
摘要： An object of the present invention is to provide a swelling-suppressive virus for treating a tumor. The present invention provides an oncolytic virus containing a gene encoding a vascular endothelial cell growth factor (VEGF) antagonist; and a pharmaceutical composition for treating a tumor, containing the oncolytic virus.

10. 发明申请

US20130071355A1 Recombinant Herpes Virus and Pharmaceutical Composition Containing The Same 有权
标题翻译：重组疱疹病毒和含有其的药物组合物
公开(公告)号：US20130071355A1
公开(公告)日：2013-03-21
申请号：US13579628
申请日：2010-02-19
申请人： Tomoki Todo , Hiroshi Fukuhara
发明人： Tomoki Todo , Hiroshi Fukuhara
IPC分类号： C12N7/00 , A61K35/76
CPC分类号： A61K35/763 , A61K35/76 , C12N7/00 , C12N15/86 , C12N15/869 , C12N2710/16621 , C12N2710/16632 , C12N2710/16643 , C12N2710/16671 , C12N2830/008
摘要： An object of the present invention is to provide a highly-safe recombinant herpes virus showing high antitumor activity regardless of the kind, grade of malignancy, or growth rate of tumor cells.The present invention provides a recombinant herpes simplex virus and the like constructed to express an ICP6 gene under control of a tumor-specific promoter or tissue-specific promoter on the genome of the virus.
摘要翻译：本发明的目的是提供一种高度安全的重组疱疹病毒，无论肿瘤细胞的种类，恶性程度或生长速度如何，都显示出高的抗肿瘤活性。本发明提供重组单纯疱疹病毒等，其构建为在病毒基因组上的肿瘤特异性启动子或组织特异性启动子的控制下表达ICP6基因。

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