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1. 发明申请

US20130071355A1 Recombinant Herpes Virus and Pharmaceutical Composition Containing The Same 有权
标题翻译：重组疱疹病毒和含有其的药物组合物
公开(公告)号：US20130071355A1
公开(公告)日：2013-03-21
申请号：US13579628
申请日：2010-02-19
申请人： Tomoki Todo , Hiroshi Fukuhara
发明人： Tomoki Todo , Hiroshi Fukuhara
IPC分类号： C12N7/00 , A61K35/76
CPC分类号： A61K35/763 , A61K35/76 , C12N7/00 , C12N15/86 , C12N15/869 , C12N2710/16621 , C12N2710/16632 , C12N2710/16643 , C12N2710/16671 , C12N2830/008
摘要： An object of the present invention is to provide a highly-safe recombinant herpes virus showing high antitumor activity regardless of the kind, grade of malignancy, or growth rate of tumor cells.The present invention provides a recombinant herpes simplex virus and the like constructed to express an ICP6 gene under control of a tumor-specific promoter or tissue-specific promoter on the genome of the virus.
摘要翻译：本发明的目的是提供一种高度安全的重组疱疹病毒，无论肿瘤细胞的种类，恶性程度或生长速度如何，都显示出高的抗肿瘤活性。本发明提供重组单纯疱疹病毒等，其构建为在病毒基因组上的肿瘤特异性启动子或组织特异性启动子的控制下表达ICP6基因。

2. 发明申请

US20070196336A1 Method For Constructing Recombinant Herpes Simplex Virus 审中-公开
标题翻译：构建重组单纯疱疹病毒的方法
公开(公告)号：US20070196336A1
公开(公告)日：2007-08-23
申请号：US10594962
申请日：2005-03-31
申请人： Tomoki Todo , Hiroshi Fukuhara
发明人： Tomoki Todo , Hiroshi Fukuhara
IPC分类号： A61K48/00 , C12N15/86 , C12N7/00
CPC分类号： C12N15/86 , A61K38/1774 , A61K38/20 , A61K38/208 , C12N7/00 , C12N2710/16632 , C12N2710/16643 , C12N2800/202 , C12N2800/30
摘要： A method is provided for rapidly and reliably constructing recombinant herpes simplex virus (HSV) capable of expressing a target protein in cancer cells. The method for constructing recombinant HSV as claimed in the present invention comprises a first step of inserting into a herpes simplex virus (HSV) genome, a BAC plasmid, which has a loxP site and an FRT site and into which has been inserted at least one type of marker gene expression cassette between the loxP site and the FRP site, a second step of constructing a shuttle vector into which has been respectively inserted at least one type of expression cassette of a gene encoding a target protein, at least one type of marker gene, a loxP site and an FRP site, and inserting the shuttle vector into the loxP site of the HSV genome using Cre recombinase, and a third step of co-infecting a host with the HSV genome and a vector capable of expressing Flp recombinase, and excising the region between the FRT sites in the genome to produce a target recombinant HSV.
摘要翻译：提供了一种快速可靠地构建能够在癌细胞中表达靶蛋白的重组单纯疱疹病毒（HSV）的方法。用于构建本发明所要求的重组HSV的方法包括将第一步骤插入到单纯疱疹病毒（HSV）基因组中，BAC质粒具有loxP位点和FRT位点，其中插入有至少一个类型的loxP位点和FRP位点之间的标记基因表达盒，构建穿梭载体的第二步，其中分别插入至少一种编码靶蛋白的基因的表达盒，至少一种类型的标记基因，loxP位点和FRP位点，并使用Cre重组酶将穿梭载体插入HSV基因组的loxP位点，以及第三步，共同感染宿主与HSV基因组和能够表达Flp重组酶的载体，并切除基因组中的FRT位点之间的区域以产生靶重组HSV。

3. 发明授权

US08945531B2 Recombinant herpes virus and pharmaceutical composition containing the same 有权
标题翻译：重组疱疹病毒和含有其的药物组合物
公开(公告)号：US08945531B2
公开(公告)日：2015-02-03
申请号：US13579628
申请日：2010-02-19
申请人： Tomoki Todo , Hiroshi Fukuhara
发明人： Tomoki Todo , Hiroshi Fukuhara
IPC分类号： A01N63/00 , A61K39/245 , C12N7/00 , C07H21/04 , C12N15/86 , A61K35/76 , C12N15/869
CPC分类号： A61K35/763 , A61K35/76 , C12N7/00 , C12N15/86 , C12N15/869 , C12N2710/16621 , C12N2710/16632 , C12N2710/16643 , C12N2710/16671 , C12N2830/008
摘要： A recombinant herpes virus showing high antitumor activity is provided. In particular, a recombinant herpes simplex virus that expresses an ICP6 gene under control of a tumor-specific promoter or tissue-specific promoter on the genome of the virus is provided.
摘要翻译：提供了显示高抗肿瘤活性的重组疱疹病毒。特别地，提供了在病毒基因组上的肿瘤特异性启动子或组织特异性启动子控制下表达ICP6基因的重组单纯疱疹病毒。

4. 发明授权

US4996372A Process for oxidizing 2,6-diisopropylnaphthalene 失效
标题翻译：氧化2,6-二异丙基萘的方法
公开(公告)号：US4996372A
公开(公告)日：1991-02-26
申请号：US473105
申请日：1990-02-02
申请人： Kenji Saeki , Hiroshi Fukuhara , Tokinori Agoo , Toru Taguchi , Hisaya Miki , Yutaka Haneda , Sadao Yoshimoto
发明人： Kenji Saeki , Hiroshi Fukuhara , Tokinori Agoo , Toru Taguchi , Hisaya Miki , Yutaka Haneda , Sadao Yoshimoto
IPC分类号： C07C27/12 , C07C37/08 , C07C39/14 , C07C67/08 , C07C69/16 , C07C407/00 , C07C409/08
CPC分类号： C07C409/08 , C07C37/08 , C07C407/00 , C07C67/08
摘要： In a process for producing 2,6-dihydroxynaphthalene from 2,6-diisopropylnaphthalene, 2,6-diisopropylnaphthalene is oxidized in the presence of a specific proportion of a basic compound to hydroxylate or hydroperoxylate 2,6-diisopropylnaphthalene in a high conversion, and the resulting intermediate is then subjected to acid cleavage in the presence of hydrogen peroxide to produce 2,6-dihydroxynaphthalene in a high yield. The yield of 2,6-dihydroxynaphthalene increases by subjecting the reaction mixture containing the above intermediate to a purifying operation or dehydrating operation or adding acetone to it before it is submitted to the acid cleavage. 2,6-Dihydroxynaphthalene may be reacted with acetic anhydride to obtain 2,6-diacetoxynaphthalene.

5. 发明授权

US5337779A Automatic drain device 失效
标题翻译：自动排水装置
公开(公告)号：US5337779A
公开(公告)日：1994-08-16
申请号：US615571
申请日：1990-11-19
申请人： Hiroshi Fukuhara
发明人： Hiroshi Fukuhara
IPC分类号： F04B49/06 , F04B39/16 , F04B41/02 , F16T1/00 , F16T1/34 , F16K31/02
CPC分类号： F16T1/00 , Y10T137/3052 , Y10T137/3105 , Y10T137/7306
摘要： An automatic drain device in an air compressor system includes an electrode sensor in a liquid collection cell. An electronic control detects an electrical change in the electrode sensor resulting from contact with liquid in the liquid collection cell and energizes a drain valve for a predetermined time effective to drain the liquid collection cell. A cycle timer triggers the energization of the drain valve when the electrode sensor fails to provide the required electrical change for a predetermined cycle time. Test inputs permit driving the electronic control to simulate sensing of liquid, and also permit energization of the drain valve without involving the remainder of the electronic control.
摘要翻译：空气压缩机系统中的自动排水装置包括液体收集池中的电极传感器。电子控制器检测由于与液体收集单元中的液体接触而导致的电极传感器中的电变化，并且将排水阀通电一预定时间以有效地排出液体收集单元。当电极传感器不能在预定的周期时间内提供所需的电气变化时，周期定时器触发排水阀的通电。测试输入允许驱动电子控制来模拟液体的感测，并且还允许排水阀通电而不涉及电子控制的其余部分。

6. 发明授权

US5180871A Process for producing phenols 失效
标题翻译：酚类生产方法
公开(公告)号：US5180871A
公开(公告)日：1993-01-19
申请号：US839683
申请日：1992-02-24
申请人： Fujihisa Matsunaga , Hiroshi Fukuhara , Mitsuki Yasuhara
发明人： Fujihisa Matsunaga , Hiroshi Fukuhara , Mitsuki Yasuhara
IPC分类号： C07C5/10 , C07C5/367 , C07C37/06 , C07C37/07 , C07C39/06 , C07C45/34
CPC分类号： C07C5/367 , C07C37/06 , C07C37/07 , C07C45/34 , C07C5/10 , C07C2101/14
摘要： A process for producing a phenol from the steps of:(a) partially hydrogenating a benzene, followed by separating the reaction mixture into respective components of a cyclohexene, a cyclohexane and a benzene;(b) oxidizing or hydrating the separated a cyclohexene into oxygen-containing compounds of a cyclohexane;(c) dehydrogenating the oxygen-containing compounds of a cyclohexane into a phenol;(d) dehydrogenating the cyclohexane separated in step (a) to convert the cyclohexane into a benzene; and(e) returning a part or all of hydrogen formed in steps (c) and (d) back to step (a).
摘要翻译：一种从以下步骤生产苯酚的方法：（a）部分氢化苯，然后将反应混合物分离成环己烯，环己烷和苯的各组分; （b）将分离的环己烯氧化或水合成环己烷的含氧化合物; （c）将环己烷的含氧化合物脱氢成苯酚; （d）使在步骤（a）中分离的环己烷脱氢以将环己烷转化为苯; 和（e）将步骤（c）和（d）中形成的氢气的一部分或全部返回到步骤（a）。

7. 发明授权

US5015786A Preparation of cumene through alkylation of an aromatic compound and preparation of phenol through cumene 失效
标题翻译：通过芳族化合物的烷基化制备枯烯并通过异丙苯制备苯酚
公开(公告)号：US5015786A
公开(公告)日：1991-05-14
申请号：US441477
申请日：1989-11-27
申请人： Shintaro Araki , Fujihisa Matsunaga , Hiroshi Fukuhara
发明人： Shintaro Araki , Fujihisa Matsunaga , Hiroshi Fukuhara
IPC分类号： B01J29/08 , C07C20060101 , C07C2/66 , C07C2/86 , C07C29/145 , C07C37/08 , C07C37/14 , C07C37/16 , C07C37/58 , C07C39/04 , C07C45/53 , C07C409/10
CPC分类号： C07C409/10 , C07C2/66 , C07C2/864 , C07C39/04 , C07C407/00 , C07C45/53 , C07C2529/08 , Y02P20/52
摘要： In a first form, a process is provided for preparing phenol by converting acetone by-produced by the cumene process into isopropanol, and alkylating benzene with the isopropanol and optional propylene, thereby forming phenol without acetone by-product. And cumene is prepared by alkylating benzene in the presence of a zeolite catalyst using isopropanol or a mixture of isopropanol and propylene as an alkylating agent. Further provided is the continuous alkylation of benzene with isopropanol wherein a reaction mixture is divided into first and second portions, with the first portion being recycled to the reactor and the second portion being taken out as a reaction product.

8. 发明授权

US06924279B2 Crystalline 1-methylcarbapenem derivatives 失效
标题翻译：结晶1-甲基碳青霉烯衍生物
公开(公告)号：US06924279B2
公开(公告)日：2005-08-02
申请号：US10351944
申请日：2003-01-27
申请人： Isao Kawamoto , Yasuo Shimoji , Hiroshi Fukuhara
发明人： Isao Kawamoto , Yasuo Shimoji , Hiroshi Fukuhara
IPC分类号： A61K31/407 , A61P31/04 , C07D477/20
CPC分类号： C07D477/20 , A61K31/407
摘要： This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I) or of pharmaceutically acceptable salts thereof. The crystalline forms of the 1-methylcarbapenem derivative exhibit excellent antibiotic activity against various bacterial strains and sufficient stability for practical use.
摘要翻译：本发明提供式（I）的1-甲基碳青霉烯衍生物或其药学上可接受的盐的结晶形式。 1-甲基碳青霉烯衍生物的结晶形式对各种细菌菌株表现出优异的抗生素活性，并且在实际应用中具有足够的稳定性。

9. 发明授权

US5763649A Process for producing aromatic carboxylic acids 失效
标题翻译：芳香族羧酸的制造方法
公开(公告)号：US5763649A
公开(公告)日：1998-06-09
申请号：US890001
申请日：1997-07-08
申请人： Hiroshi Fukuhara
发明人： Hiroshi Fukuhara
IPC分类号： C07C51/265
CPC分类号： C07C51/265
摘要： A process for producing aromatic carboxylic acids by subjecting an aromatic compound having one or more substituent alkyl groups and/or partially oxidized substituent alkyl groups to a liquid phase oxidation with a molecular oxygen-containing gas in a reaction solvent containing a lower aliphatic carboxylic acid in the presence of a catalyst composed of a heavy metal compound and a bromine compound, under a condition of a weight proportion of said reaction solvent to said aromatic compound within the range from 6.5 to 70 parts by weight per one part by weight of said aromatic compound, a reaction time within the range from 45 to 4.5 minutes and a product of the numerical value of said weight proportion of the reaction solvent to the aromatic compound multiplied by the numerical value of said reaction time expressed in munute within the range from 270 to 330. The process can facilitate the diffusion of oxygen into the reaction medium and improve the volumetric efficency of the reactor to thereby attain an efficient production of aromatic carboxylic acids with a high productivity.
摘要翻译：一种通过在含有低级脂肪族羧酸的反应溶剂中将含有一个或多个取代烷基和/或部分氧化的取代烷基的芳族化合物与含分子氧的气体进行液相氧化来制备芳族羧酸的方法在所述反应溶剂与所述芳族化合物的重量比例的条件下，由重金属化合物和溴化合物组成的催化剂的存在范围为6.5至70重量份，相对于所述芳族化合物，反应时间在45〜4.5分钟的范围内，反应溶剂与芳族化合物的重量比例的数值乘以所述反应时间的数值乘以munute表示，在270〜330的范围内该方法可以促进氧扩散到反应介质中并提高反应器t的体积效率从而以高生产率实现芳族羧酸的有效生产。

10. 发明授权

US5227563A Preparation of propylene by dehydration of isopropanol in the presence of a pseudo-boehmite derived gamma alumina catalyst 失效
标题翻译：在假勃姆石衍生的γ氧化铝催化剂存在下，通过异丙醇脱水制备丙烯
公开(公告)号：US5227563A
公开(公告)日：1993-07-13
申请号：US700319
申请日：1991-05-09
申请人： Hiroshi Fukuhara , Fujihisa Matsunaga , Mitsuki Yasuhara , Shintaro Araki , Toshiyuki Isaka
发明人： Hiroshi Fukuhara , Fujihisa Matsunaga , Mitsuki Yasuhara , Shintaro Araki , Toshiyuki Isaka
IPC分类号： B01J21/04 , C07C1/24
CPC分类号： B01J21/04 , C07C1/24 , C07C2521/04 , Y02P20/52
摘要： Propylene can be prepared in high yield and selectivity by dehydrating isopropanol in the presence of a .gamma.-alumina catalyst having a mean pore diameter of from 30 to 150 .ANG. with a standard deviation (.sigma..sub.n) of from 10 to 40 .ANG. based on statistic calculation from pore diameter and pore volume.
摘要翻译：丙烯可以通过在平均孔径为30至150的γ-氧化铝催化剂的存在下脱水异丙醇而制备，基于统计学计算，标准偏差（σ）为10至40安培从孔径和孔体积。

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