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    • 3. 发明授权
    • Method for making a stopper
    • 制造塞子的方法
    • US6165402A
    • 2000-12-26
    • US16566
    • 1998-01-30
    • Mark E. GabbardTimothy J. GabbardJoseph M. Voytilla
    • Mark E. GabbardTimothy J. GabbardJoseph M. Voytilla
    • B29C43/20B29C43/02B29C43/14B29C43/34B29C45/02B29C45/14B65D51/00B29C39/10
    • B29C43/021B29C43/146B29C43/203B29C45/02B29C45/14B29C2043/3615B29C2045/14237B29K2105/256B29L2031/565B65D51/005
    • A method for making a stopper. The method includes the step of providing a first tool defining a first tool cavity and a second tool defining a second molding cavity. A first plug member having an upper surface and a lower surface also is provided, the upper surface of the first plug member having a concave portion. The first plug member is faced in the first cavity such that at least a portion of the lower surface of the first plug member is in contact with the first cavity. The second tool defines a hole therethrough such that the hold provides fluid contact between the second tool cavity and a point exterior to the second tool. A polymeric material is transferred through the hole defined by the second tool into the second cavity defined by the second tool and into the concave portion of the upper surface of the first plug member such that the polymeric material forms a second plug member having an upper surface and a lower surface, the upper surface of the second plug member being defined by the molding surface defined by the second tool. The first plug member and the second plug member define a stopper. The stopper is then removed form the first and second tools.
    • 制造塞子的方法。 该方法包括提供限定第一工具空腔的第一工具和限定第二模腔的第二工具的步骤。 还设置有具有上表面和下表面的第一插塞构件,第一插塞构件的上表面具有凹部。 第一插塞构件面对第一空腔,使得第一插塞构件的下表面的至少一部分与第一空腔接触。 第二工具限定穿过其中的孔,使得保持件提供第二工具空腔与第二工具外部的点之间的流体接触。 聚合材料通过由第二工具限定的孔转移到由第二工具限定的第二空腔中并进入第一插塞构件的上表面的凹部,使得聚合材料形成具有上表面的第二插塞构件 和下表面,第二插塞构件的上表面由第二工具限定的模制表面限定。 第一塞子构件和第二塞子构件限定塞子。 然后从第一和第二工具移除塞子。
    • 5. 发明授权
    • Rotary seal stopper
    • 旋转密封塞
    • US06499617B1
    • 2002-12-31
    • US09617609
    • 2000-07-17
    • John J. Niedospial, Jr.Mark E. GabbardTimothy J. Gabbard
    • John J. Niedospial, Jr.Mark E. GabbardTimothy J. Gabbard
    • B65D4116
    • B65D47/265A61J1/1412A61J1/1468A61J1/1481A61J1/1487A61J1/18B65D51/002Y10S604/905
    • Rotary seal valve/container assembly allowing withdrawal of a medical fluid contained in the container by the use of a device such as a syringe or IV set having a luer connector. The rotary seal valve includes: an elastomeric stopper having a cavity; a rotary seal bottom insert positioned in the bottom portion of the cavity; a rotary seal top insert, equipped with threads and serving as a male luer connector, rotatably engaging the bottom insert. One or more holes are provided in the bottom inset and top insert which holes are alignable with each other, by rotating the top insert, forming one or more channels through which the medical fluid is accessed. Upon rotating the top insert in opposite direction the rotary valve can be closed. A removable cap positioned over the rotary seal valve maintains the rotary seal valve in aseptic condition.
    • 旋转密封阀/容器组件允许通过使用诸如具有鲁尔连接器的注射器或IV装置的装置来取出容纳在容器中的医用流体。 旋转密封阀包括:具有空腔的弹性塞子; 定位在空腔底部的旋转密封底部插入件; 旋转密封顶部插入件,配备有螺纹并用作阳性鲁尔连接器,可旋转地接合底部插入件。 通过旋转顶部插入物,形成一个或多个通道,通过该通道可以使药物流体进入其中,一个或多个孔设置在底部插入件和顶部插入件中,这些孔可以彼此对准。 在相反方向旋转顶部插入件时,旋转阀可以关闭。 位于旋转密封阀上方的可拆卸盖将旋转密封阀保持在无菌状态。
    • 10. 发明授权
    • Vial access adapter
    • 样品瓶接口适配器
    • US06139534A
    • 2000-10-31
    • US489619
    • 2000-01-24
    • John J. Niedospial, Jr.Mark E. GabbardTimothy J. Gabbard
    • John J. Niedospial, Jr.Mark E. GabbardTimothy J. Gabbard
    • A61J1/00A61J1/14A61J1/20A61B19/00
    • A61J1/2096A61J1/1406A61J1/201A61J1/2044A61J1/2075A61J1/2082A61J1/2089
    • A vial access adapter for withdrawal of a medical fluid contained in a vial which includes a vial access adapter body having a circular top wall with a plurality of vent holes, a circular second wall spaced from the top wall, and a cylindrical side wall which walls define a chamber for holding an anti-bacterial filter. A first spike centrally located in the vial access adapter body extends through the top wall, chamber, and bottom wall, with one end extending above the top wall terminating in a threaded luer connector, while the other end terminates in a sharp point. A flow channel extends through the first spike designed for withdrawal of the medical fluid from the vial. A second spike positioned parallel to the first spike extends from the second wall, one end of which extends into the chamber, and the other end terminates in a sharp point. A flow channel extends through the second spike designed for air flow from the chamber into the vial. An elastomeric membrane positioned within the threaded luer connector seals the opening in the vial access adapter. Preferably the elastomeric membrane is of M-shaped configuration capable of flexing under pressure and of re-sealing itself after being pierced by a luer connector or a syringe equipped with a luer connector.
    • 用于取出容纳在小瓶中的医用流体的小瓶接入适配器,其包括具有多个通气孔的圆形顶壁的小瓶接入适配器主体,与顶壁间隔开的圆形第二壁,以及圆柱形侧壁, 定义一个用于容纳抗菌过滤器的室。 中心位于小瓶接入适配器主体中的第一个尖峰延伸穿过顶壁,室和底壁,一端延伸到顶壁上方终止于螺纹鲁尔连接器,而另一端终止于尖锐点。 流动通道延伸穿过设计用于从小瓶中取出医用流体的第一尖峰。 平行于第一尖钉定位的第二尖峰从第二壁延伸,其一端延伸到腔室中,另一端终止于尖锐点。 流动通道延伸穿过设计用于从腔室进入小瓶的气流的第二尖峰。 定位在螺纹鲁尔连接器内的弹性体膜密封小瓶接入适配器中的开口。 优选地,弹性体膜是M形构造,其能够在被鲁尔连接器或装有鲁尔连接器的注射器刺穿之后能够在压力下弯曲并且自身重新密封。