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1. 发明授权

US10409294B2 Field service device and method for facilitating a processing system replacement in a vibratory flowmeter 有权
公开(公告)号：US10409294B2
公开(公告)日：2019-09-10
申请号：US14366388
申请日：2012-01-10
申请人： Timothy J. Cunningham , David J. Kapolnek
发明人： Timothy J. Cunningham , David J. Kapolnek
IPC分类号： G05D7/06 , G01F25/00 , G01F1/84 , G06F9/06
摘要： A field service device (280) for facilitating a processing system replacement in a vibratory flowmeter is provided. The field service device (280) includes a field service device processor (282) configured to interface with one or more vibratory flowmeter processing systems and a storage system (285) configured to store pre-replacement operationally-derived values (252a), post-replacement operationally-derived values (252b), and one or more scaling factors (266). The field service device processor (282) is configured to obtain pre-replacement operationally-derived values (252a), obtain post-replacement operationally-derived values (252b) after an old processing system has been replaced with a replacement processing system, generate the one or more scaling factors (266) as a ratio of one or more pre-replacement operationally-derived values (252a) to one or more post-replacement operationally-derived values (252b), and download the one or more scaling factors (266).

2. 发明授权

US08785401B2 Methods for treating diseases having an inflammatory component related to phospholipase A2 有权
标题翻译：用于治疗具有与磷脂酶A2相关的炎症成分的疾病的方法
公开(公告)号：US08785401B2
公开(公告)日：2014-07-22
申请号：US11988253
申请日：2006-07-10
申请人： Timothy J. Cunningham , Lihua Yao
发明人： Timothy J. Cunningham , Lihua Yao
IPC分类号： A61K38/08 , A61P29/00 , C07K7/06
CPC分类号： G01N33/573 , G01N33/564 , G01N2333/918 , G01N2333/92 , G01N2800/285
摘要： The present invention relates to methods useful to monitor central and peripheral nervous system neuron/axon destruction resulting from an increase in acute phase inflammatory enzymes. The methods have applicability to monitoring the progress of neurological diseases, including multiple sclerosis and Alzheimer's disease, as well as neuroinflammatory damage that results from sports injuries, vigorous physical activity or any form of physical abuse. The invention further relates to methods of treating multiple sclerosis or other diseases with an inflammatory component related to phospholipase A2.
摘要翻译：本发明涉及用于监测由急性期炎症酶增加引起的中枢和周围神经系统神经元/轴突破坏的方法。该方法适用于监测包括多发性硬化和阿尔茨海默病在内的神经系统疾病进展，以及运动损伤，体力活动或任何形式的身体虐待引起的神经炎症性损伤。本发明还涉及用与磷脂酶A2相关的炎性成分治疗多发性硬化症或其它疾病的方法。

3. 发明授权

US06535826B2 Mass flowmeter methods, apparatus, and computer program products using correlation-measure-based status determination 有权
公开(公告)号：US06535826B2
公开(公告)日：2003-03-18
申请号：US09785869
申请日：2001-02-16
申请人： Timothy J. Cunningham , David Lee Campbell , Thomas Dean Sharp
发明人： Timothy J. Cunningham , David Lee Campbell , Thomas Dean Sharp
IPC分类号： G06F100
CPC分类号： G01F1/8431 , G01F1/8436 , G01F1/8477 , G01F1/849
摘要： Motion signals representing motion of a conduit of a mass flowmeter are mode selective filtered to generate a plurality of mode selective filtered motion signals such that the plurality of mode selective filtered motion signals preferentially represent motion associated with a vibrational mode of the conduit. A plurality of time difference estimates is generated from the plurality of mode selective filtered motion signals. A correlation measure is generated from the plurality of time difference estimates. A status of the mass flowmeter system is determined from the generated correlation measure. In some embodiments, the correlation measure comprises an intercept parameter of a scaling function that relates the plurality of time difference estimates to a plurality of reference time differences representing motion of the conduit at a known mass flow. In other embodiments, the correlation measure comprises a correlation coefficient estimated from the plurality of time difference estimates. In still other embodiments, the correlation measure comprises an error of estimate. The mass flowmeter system status may be determined by determining a change in the correlation measure, and corrective action may then be taken if the determined change satisfies a predetermined criterion. The invention may be embodied as methods, apparatus and computer program products.

4. 发明授权

US06427127B1 Vibrating conduit process parameter sensors, operating methods and computer program products utilizing complex modal estimation 失效
标题翻译：振动管道工艺参数传感器，操作方法和使用复杂模态估计的计算机程序产品
公开(公告)号：US06427127B1
公开(公告)日：2002-07-30
申请号：US09116389
申请日：1998-07-16
申请人： Timothy J. Cunningham
发明人： Timothy J. Cunningham
IPC分类号： G01F100
CPC分类号： G01F1/8413 , G01F1/8436 , G01F1/8477
摘要： A process parameter such as mass flow is determined in a vibrating conduit process parameter sensor using a complex modal transformation estimated from a plurality of motion signals representing motion of the parameter sensor conduit. According to an aspect of the invention, a complex eigenvector is provided representing motion of the conduit at the plurality of locations at a known mass flow. A plurality of motion signals is received from a plurality of motion transducers, the plurality of motion signals indicating motion at a plurality of locations on the conduit as a material flows through the conduit. A complex modal transformation relating the received plurality of motion signals to the complex eigenvector is estimated. Mass flow through the conduit is estimated from the known mass flow and the estimated complex modal transformation. Related apparatus and computer program products are also discussed.
摘要翻译：在振动导管工艺参数传感器中使用由表示参数传感器导管的运动的多个运动信号估计的复模态变换来确定诸如质量流的过程参数。根据本发明的一个方面，提供了一种复合特征向量，其表示在已知质量流下在多个位置处的导管的运动。从多个运动换能器接收多个运动信号，所述多个运动信号指示作为材料的导管上的多个位置处的运动通过导管。估计将接收的多个运动信号与复特征向量相关联的复数模态变换。通过导管的质量流量是从已知质量流量和估计的复合模态变换估计的。还讨论了相关设备和计算机程序产品。

5. 发明授权

US06262024B1 Neuron regulatory factor for promoting neuron survival 失效
标题翻译：神经元调节因子促进神经元存活
公开(公告)号：US06262024B1
公开(公告)日：2001-07-17
申请号：US08936477
申请日：1997-09-18
申请人： Timothy J. Cunningham , Forrest Haun , Kathie L. Eagleson , Pat R. Levitt , Sarah E. Kennedy
发明人： Timothy J. Cunningham , Forrest Haun , Kathie L. Eagleson , Pat R. Levitt , Sarah E. Kennedy
IPC分类号： C07K14475
CPC分类号： C07K14/475 , A61K38/00
摘要： A neuron regulatory factor (NRF), derived from cells of the central nervous system, is provided. A cytoprotective peptide (CPP) component of NRF is also provided, as are methods of using NRF or its CPP component. NRF comprises a large polypeptide or complex of polypeptides that is distinct from several other known neurotrophic or neuron regulatory factors. The CPP component of NRF is an acidic protein or protein complex whose amino acid sequence is unique among known protein sequences. Both NRF and its CPP component are capable of promoting survival and neurite outgrowth of cultured neurons in vitro, and preventing neuron degeneration and promoting neuron survival in vivo. The CPP component of NRF also exhibits a cytoprotective effect on non-neuronal cells.
摘要翻译：提供了从中枢神经系统细胞衍生的神经元调节因子（NRF）。还提供了NRF的细胞保护肽（CPP）组分，以及使用NRF或其CPP组分的方法。 NRF包括与几种其他已知的神经营养因子或神经元调节因子不同的大多肽或多肽复合物。 NRF的CPP组分是酸性蛋白质或蛋白质复合物，其氨基酸序列在已知的蛋白质序列中是独特的。 NRF及其CPP组分能够促进体外培养的神经元的存活和神经突生长，并预防神经元变性并促进体内神经元的存活。 NRF的CPP组分也对非神经元细胞表现出细胞保护作用。

6. 发明授权

US06199022B1 Drive circuit modal filter for a vibrating tube flowmeter 失效
标题翻译：用于振动管流量计的驱动电路模态滤波器
公开(公告)号：US06199022B1
公开(公告)日：2001-03-06
申请号：US08890785
申请日：1997-07-11
申请人： Timothy J. Cunningham
发明人： Timothy J. Cunningham
IPC分类号： G01F158
CPC分类号： G01F1/8413 , G01F1/8431 , G01F1/8436 , G01F1/8477 , G01N2009/006
摘要： A drive system for a vibrating tube-based measurement instrument employing a spatial filter to produce a drive signal having modal content only at a desired vibration mode. Multiple feedback sensors located at different locations along a vibrating tube produce multiple feedback sensors. Each feedback signal has applied to it a weighting or gain factor. All of the weighted feedback signals are then summed to produce a drive signal, or a signal proportional to a drive signal, having improved modal content as compared to any of the feedback signals by themselves. The weighting factors are selected by any of several means. One method is to build the eigenvector matrix for the vibrating flow tube by extracting the eigenvectors from a finite element model of the vibrating structure. The inverse or psuedo-inverse of the eigenvector matrix is calculated to obtain the modal filter vector. The appropriate set of weighting coefficients are selected from the modal filter vector.
摘要翻译：一种用于基于振动管的测量仪器的驱动系统，其采用空间滤波器来产生仅在所需振动模式下具有模态含量的驱动信号。位于振动管不同位置的多个反馈传感器产生多个反馈传感器。每个反馈信号已经将其加权或增益因子。然后将所有加权反馈信号相加以产生与任何反馈信号本身相比具有改进的模态内容的驱动信号或与驱动信号成比例的信号。加权因子是通过几种手段之一来选择的。一种方法是通过从振动结构的有限元模型中提取特征向量来建立振动流管的特征向量矩阵。计算特征向量矩阵的逆或伪反演，以获得模态滤波器向量。从模态滤波器向量中选择适当的加权系数集合。

7. 发明授权

US6092429A Driver for oscillating a vibrating conduit 失效
标题翻译：用于振荡振动导管的驱动器
公开(公告)号：US6092429A
公开(公告)日：2000-07-25
申请号：US984927
申请日：1997-12-04
申请人： Timothy J. Cunningham , Stuart J. Shelley
发明人： Timothy J. Cunningham , Stuart J. Shelley
IPC分类号： G01F1/84 , G01N9/00 , G01F1/78
CPC分类号： G01F1/8413 , G01F1/8431 , G01F1/8436 , G01F1/8477 , G01N9/002 , G01N2009/006
摘要： A process parameter measurement device, and in particular a Coriolis mass flowmeter or vibrating tube densimeter, having a driver or drivers for inducing oscillation of at least one conduit. The drivers are attached at locations along the vibrating conduit selected to influence certain modes of interest. A driver is located near an area of maximum amplitude of a desired vibration mode and near an area of minimum amplitude of an undesired vibration mode. Various known experimental modal analysis or modeling techniques are used to determine the appropriate locations for one or more drivers. Multiple drivers located according to the present invention are used to influence, i.e., excite or suppress, multiple modes. In addition, multiple, separate drive circuits produce multiple, electronically isolated drive signals for delivering greater total power to the vibrating conduit.
摘要翻译：过程参数测量装置，特别是科里奥利质量流量计或振动管密度计，其具有用于引起至少一个导管的振荡的驱动器或驱动器。驱动器连接在被选择以影响某些感兴趣模式的振动导管的位置。驱动器位于期望的振动模式的最大幅度的区域附近并且在不期望的振动模式的最小幅度的区域附近。使用各种已知的实验模态分析或建模技术来确定一个或多个驱动器的适当位置。使用根据本发明的多个驱动器来影响，即激发或抑制多种模式。此外，多个独立的驱动电路产生多个电子隔离的驱动信号，用于向振动管道提供更大的总功率。

8. 再颁专利

USRE36376E Stability coriolis mass flow meter 失效
标题翻译：稳定性科里奥利质量流量计
公开(公告)号：USRE36376E
公开(公告)日：1999-11-09
申请号：US110015
申请日：1998-07-02
申请人： Donald R. Cage , James R. Ruesch , Timothy J. Cunningham
发明人： Donald R. Cage , James R. Ruesch , Timothy J. Cunningham
IPC分类号： G01F1/84
CPC分类号： G01F1/8409 , G01F1/8413 , G01F1/8477
摘要： An optimized Coriolis mass flow meter is disclosed which has improved stability to excitations caused by external influences. A primary source of improvement involves determining by modal analysis of the flow conduit a location for the sensor means that minimizes the influence of external excitation of one or more of the first in phase bending mode, the first out of phase bending mode, the first out of phase twist mode, the second out of phase twist mode, the second out of phase bending mode and the third out of phase bending mode.
摘要翻译： PCT No.PCT / US90 / 03284第 371日期：1992年1月16日 102（e）日期1992年1月16日PCT Filed 1990年6月8日PCT公布。出版物WO90 / 15310C 1990年12月12日公开了一种优化的科里奥利质量流量计，其具有改善由外部影响引起的激发的稳定性。改进的主要来源包括通过流量管道的模态分析来确定传感器装置的位置，该位置使得第一同相弯曲模式，第一异相弯曲模式中的一个或多个的外部激励的影响最小化，的相位扭曲模式，第二异相扭曲模式，第二异相弯曲模式和第三异相弯曲模式。

9. 发明申请

US20130143792A1 Use of CHEC Peptides to Treat Neurological and Cardiovascular Diseases and Disorders 有权
标题翻译：使用CHEC肽治疗神经和心血管疾病和疾病
公开(公告)号：US20130143792A1
公开(公告)日：2013-06-06
申请号：US13640192
申请日：2011-03-28
申请人： Timothy J. Cunningham
发明人： Timothy J. Cunningham
IPC分类号： A61K38/08
CPC分类号： A61K38/08
摘要： The present invention describes compositions and methods for treating and preventing non-degenerative neurological diseases and disorders associated with elevated sPLA2 activity as well as cardiovascular diseases using a CHEC peptide to inhibit sPLA2 activity.
摘要翻译：本发明描述了用于治疗和预防与升高的sPLA2活性相关的非退行性神经疾病和病症以及使用CHEC肽抑制sPLA2活性的心血管疾病的组合物和方法。

10. 发明授权

US08280651B2 Meter electronics and methods for verification diagnostics for a flow meter 有权
标题翻译：用于流量计的仪表电子和验证诊断方法
公开(公告)号：US08280651B2
公开(公告)日：2012-10-02
申请号：US12948141
申请日：2010-11-17
申请人： Matthew Joseph Rensing , Andrew Timothy Patten , Timothy J. Cunningham , Mark James Bell
发明人： Matthew Joseph Rensing , Andrew Timothy Patten , Timothy J. Cunningham , Mark James Bell
IPC分类号： G01N11/00
CPC分类号： G01F1/8477 , G01F1/8413 , G01F1/8431 , G01F1/8436 , G01F15/024 , G01F25/0007 , G01N9/002
摘要： Meter electronics (20) for a flow meter (5) is provided according to an embodiment of the invention. The meter electronics (20) includes an interface (201) for receiving a vibrational response from the flow meter (5) and a processing system (203) in communication with the interface (201). The vibrational response is a response to a vibration of the flow meter (5) at a substantially resonant frequency. The processing system (203) is configured to receive the vibrational response from the interface (201), determine a frequency (ω0) of the vibrational response, determine a response voltage (V) and a drive current (I) of the vibrational response, measure a decay characteristic (ζ) of the flow meter (5), and determine the stiffness parameter (K) from the frequency (ω0), the response voltage (V), the drive current (I), and the decay characteristic (ζ).
摘要翻译：根据本发明的实施例提供了一种用于流量计（5）的仪表电子装置（20）。仪表电子设备（20）包括用于从流量计（5）接收振动响应的接口（201）和与接口（201）通信的处理系统（203）。振动响应是基本上共振频率对流量计（5）的振动的响应。处理系统（203）被配置为从接口（201）接收振动响应，确定振动响应的频率（ω0），确定响应电压（V）和振动响应的驱动电流（I）测量流量计（5）的衰减特性（ζ），并从频率（ω0），响应电压（V），驱动电流（I）和衰减特性（ζ）确定刚度参数（K））。

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