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    • 5. 发明授权
    • Substituted purine derivatives as inhibitors of cell adhesion
    • 取代嘌呤衍生物作为细胞粘附的抑制剂
    • US06747016B1
    • 2004-06-08
    • US10030290
    • 2002-03-06
    • Anuschirwan PeymanJochen KnolleThomas R GadekJean-Francois GourvestJean-Marie Ruxer
    • Anuschirwan PeymanJochen KnolleThomas R GadekJean-Francois GourvestJean-Marie Ruxer
    • C07D47334
    • C07D473/34
    • The present invention relates to compounds of formula (I), in which B, D, E, G, X, Y, Z, R1, R2 and s have the meanings indicated in the claims, their physiologically tolerable salts and their prodrugs. The compounds of formula (I) are valuable pharmacologically active compounds. They are vitronectin receptor antagonist and inhibitors of cell adhesion and are suitable for the therapy and prophylaxis of illnesses which are based on the interaction between vitronectin receptors and their ligands in cell-cell or cell-matrix interaction processes or which can be prevented, alleviated or cured by influencing such interactions. For example, they can be applied for inhibiting bone resorption by osteoclasts and thus for treating and preventing osteoporosis, or for inhibiting undesired angiogenesis or prolifertion of cells of the vascular smooth musculature. The invention furthermore relates to processes for the preparation of compounds of formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
    • 本发明涉及式(I)化合物,其中B,D,E,G,X,Y,Z,R 1,R 2和s具有权利要求书中所示的含义, 盐及其前药。 式(I)化合物是有价值的药理活性化合物。 它们是玻连蛋白受体拮抗剂和细胞粘附抑制剂,并且适用于治疗和预防基于玻连蛋白受体及其配体在细胞 - 细胞或细胞 - 基质相互作用过程中的相互作用的疾病,或可被预防,缓解或 通过影响这种相互作用来治愈。 例如,它们可以用于抑制破骨细胞的骨吸收,从而用于治疗和预防骨质疏松症,或用于抑制血管平滑肌肉细胞的不期望的血管生成或增殖。 本发明还涉及制备式(I)化合物,其用途,特别是作为药物中的活性成分的方法,以及包含它们的药物组合物。