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1. 发明授权

US06613533B2 Histamine receptor 失效
公开(公告)号：US06613533B2
公开(公告)日：2003-09-02
申请号：US09812216
申请日：2001-03-19
申请人： Jiang X. Behan , Joseph A. Hedrick , Thomas M. Laz , Frederick J. Monsma , Kelley L. Morse , Shelby P. Umland , Suke Wang
发明人： Jiang X. Behan , Joseph A. Hedrick , Thomas M. Laz , Frederick J. Monsma , Kelley L. Morse , Shelby P. Umland , Suke Wang
IPC分类号： G01N33566
CPC分类号： G01N33/566 , C07K14/723 , G01N2333/4719
摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

2. 发明授权

US06204017B1 Polynucleotide encoding a histamine receptor 有权
标题翻译：编码组胺受体的多核苷酸
公开(公告)号：US06204017B1
公开(公告)日：2001-03-20
申请号：US09414010
申请日：1999-10-07
申请人： Jiang X. Behan , Joseph A. Hedrick , Thomas M. Laz , Frederick J. Monsma , Kelley L. Morse , Shelby P. Umland , Suke Wang
发明人： Jiang X. Behan , Joseph A. Hedrick , Thomas M. Laz , Frederick J. Monsma , Kelley L. Morse , Shelby P. Umland , Suke Wang
IPC分类号： C12N1512
CPC分类号： G01N33/566 , C07K14/723 , G01N2333/4719
摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.
摘要翻译：本发明提供分离的哺乳动物组胺受体，分离或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。本发明进一步提供了与受体特异性结合并可用于治疗由组胺引起或介导的医学病症的抗体及其抗原结合片段。还提供了用于鉴定哺乳动物组胺受体的特异性激动剂和拮抗剂的筛选方法。

3. 发明授权

US06221616B1 DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof 失效
公开(公告)号：US06221616B1
公开(公告)日：2001-04-24
申请号：US09478601
申请日：2000-01-06
申请人： John A. Salon , Thomas M. Laz , Raisa Nagorny , Amy E. Wilson
发明人： John A. Salon , Thomas M. Laz , Raisa Nagorny , Amy E. Wilson
IPC分类号： G01N3353
CPC分类号： A61M1/3621 , C07K14/72
摘要： This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

4. 发明授权

US07547523B2 Histamine receptor 失效
公开(公告)号：US07547523B2
公开(公告)日：2009-06-16
申请号：US11620337
申请日：2007-01-05
申请人： Jiang X. Behan , Joseph A. Hedrick , Thomas M. Laz , Frederick James Monsma, Jr. , Kelley L. Morse , Shelby P. Umland , Suke Wang
发明人： Jiang X. Behan , Joseph A. Hedrick , Thomas M. Laz , Frederick James Monsma, Jr. , Kelley L. Morse , Shelby P. Umland , Suke Wang
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： G01N33/566 , C07K14/723 , G01N2333/4719
摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

5. 发明授权

US06291195B1 DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof 失效
公开(公告)号：US06291195B1
公开(公告)日：2001-09-18
申请号：US09478602
申请日：2000-01-06
申请人： John A. Salon , Thomas M. Laz , Raisa Nagorny , Amy E. Wilson
发明人： John A. Salon , Thomas M. Laz , Raisa Nagorny , Amy E. Wilson
IPC分类号： G01N3353
CPC分类号： A61M1/3621 , C07K14/72
摘要： This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

6. 发明授权

US06221613B1 DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof 失效
标题翻译：编码人黑色素浓缩激素受体（MCH1）的DNA及其用途
公开(公告)号：US06221613B1
公开(公告)日：2001-04-24
申请号：US09224426
申请日：1998-12-31
申请人： John A. Salon , Thomas M. Laz , Raisa Nagorny , Amy E. Wilson
发明人： John A. Salon , Thomas M. Laz , Raisa Nagorny , Amy E. Wilson
IPC分类号： G01N3353
CPC分类号： A61M1/3621 , C07K14/72
摘要： This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.
摘要翻译：本发明提供编码人MCH1受体的纯化的人MCH1受体的核酸，纯化的人MCH1受体，包含分离的编码人MCH1受体的核酸的载体，包含该载体的细胞，针对人MCH1受体的抗体，用于检测核酸的核酸探针编码人MCH1受体的酸，与编码人MCH1受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变型人MCH1受体的DNA的转基因非人动物，分离人MCH1受体的方法，治疗异常的方法与人MCH1受体的活性相关，以及确定化合物与哺乳动物MCH1受体结合的方法。

7. 发明授权

US07393655B2 Methods of identifying melanin concentrating hormone receptor antagonists 失效
标题翻译：识别黑色素浓缩激素受体拮抗剂的方法
公开(公告)号：US07393655B2
公开(公告)日：2008-07-01
申请号：US10825581
申请日：2004-04-15
申请人： John A. Salon , Thomas M. Laz , Raisa Nagorny , Amy F. Wilson
发明人： John A. Salon , Thomas M. Laz , Raisa Nagorny , Amy F. Wilson
IPC分类号： G01N33/53 , C12N15/00 , C07K14/00
CPC分类号： A61M1/3621 , C07K14/72
摘要： This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.
摘要翻译：本发明提供编码人MCH1受体的纯化的人MCH1受体的核酸，纯化的人MCH1受体，包含分离的编码人MCH1受体的核酸的载体，包含该载体的细胞，针对人MCH1受体的抗体，用于检测核酸的核酸探针编码人MCH1受体的酸，与编码人MCH1受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变型人MCH1受体的DNA的转基因非人动物，分离人MCH1受体的方法，治疗异常的方法与人MCH1受体的活性相关，以及确定化合物与哺乳动物MCH1受体结合的方法。

8. 发明授权

US07166705B2 Histamine receptor antibody 有权
标题翻译：组胺受体抗体
公开(公告)号：US07166705B2
公开(公告)日：2007-01-23
申请号：US10616088
申请日：2003-07-08
申请人： Jiang X. Behan , Joseph A. Hedrick , Thomas M. Laz , Frederick J. Monsma , Kelley L. Morse , Shelby P. Umland , Suke Wang
发明人： Jiang X. Behan , Joseph A. Hedrick , Thomas M. Laz , Frederick J. Monsma , Kelley L. Morse , Shelby P. Umland , Suke Wang
IPC分类号： C07K16/28
CPC分类号： G01N33/566 , C07K14/723 , G01N2333/4719
摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.
摘要翻译：本发明提供分离的哺乳动物组胺受体，分离或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。本发明进一步提供了与受体特异性结合并可用于治疗由组胺引起或介导的医学病症的抗体及其抗原结合片段。还提供了用于鉴定哺乳动物组胺受体的特异性激动剂和拮抗剂的筛选方法。

9. 发明授权

US06939953B2 Leukotriene receptor 失效
标题翻译：白三烯受体
公开(公告)号：US06939953B2
公开(公告)日：2005-09-06
申请号：US10104340
申请日：2002-03-22
申请人： Suke Wang , Ling Pang , Thomas M. Laz
发明人： Suke Wang , Ling Pang , Thomas M. Laz
IPC分类号： C07K14/705 , C12N15/12 , G01N33/567
CPC分类号： C07K14/705
摘要： The present invention provides an isolated mammalian leukotriene receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by leukotriene. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian leukotriene receptor.
摘要翻译：本发明提供分离的哺乳动物白三烯受体，分离或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。本发明进一步提供与受体特异性结合并可用于治疗由白三烯引起或介导的医学病症的抗体及其抗原结合片段。还提供了用于鉴定哺乳动物白三烯受体的特异性激动剂和拮抗剂的筛选方法。

10. 发明授权

US06723552B2 DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof 失效
公开(公告)号：US06723552B2
公开(公告)日：2004-04-20
申请号：US09885478
申请日：2001-06-20
申请人： John A. Salon , Thomas M. Laz , Raisa Nagorny , Amy E. Wilson
发明人： John A. Salon , Thomas M. Laz , Raisa Nagorny , Amy E. Wilson
IPC分类号： C12N121
CPC分类号： A61M1/3621 , C07K14/72
摘要： This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

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