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1. 发明授权

US5698402A Methods for diagnosing benign prostatic hyperplasia 失效
标题翻译：诊断良性前列腺增生的方法
公开(公告)号：US5698402A
公开(公告)日：1997-12-16
申请号：US393214
申请日：1995-02-23
申请人： Albert A. Luderer , Grant D. Carlson , Robert P. Thiel , Thomas F. Soriano , William J. Kramp
发明人： Albert A. Luderer , Grant D. Carlson , Robert P. Thiel , Thomas F. Soriano , William J. Kramp
IPC分类号： G01N33/573 , G01N33/574 , G01N33/68
CPC分类号： G01N33/68 , G01N33/57434
摘要： The present invention relates to a method for diagnosing benign prostatic hyperplasia (BPH) in a male human patient without requiring a biopsy. The total prostate specific antigen (PSA) level in the blood or serum of the patient is measured. If the patient has a total PSA level of between 2.5 ng/ml, (4.0 ng/ml for those 60 years or over), and 10.0 ng/ml, then the free PSA level in the blood or serum of the patient is measured. The proportion of free PSA to total PSA is calculated. If this proportion is equal to or greater than about 25%, then the patient is diagnosed as having BPH.
摘要翻译：本发明涉及一种用于诊断男性人类患者的良性前列腺增生（BPH）的方法，而不需要活组织检查。测量患者血液或血清中的总前列腺特异性抗原（PSA）水平。如果患者的总PSA水平在2.5ng / ml之间（4.0ng / ml，60岁或以上）和10.0ng / ml，则测量患者血液或血清中的游离PSA水平。计算游离PSA与总PSA的比例。如果该比例等于或大于约25％，则患者被诊断为具有BPH。

2. 发明授权

US6100049A Methods for diagnosing benign prostatic diseases 失效
标题翻译：诊断良性前列腺疾病的方法
公开(公告)号：US6100049A
公开(公告)日：2000-08-08
申请号：US257407
申请日：1999-02-25
申请人： Albert A. Luderer , Grant D. Carlson , Robert P. Thiel , Thomas F. Soriano , William J. Kramp
发明人： Albert A. Luderer , Grant D. Carlson , Robert P. Thiel , Thomas F. Soriano , William J. Kramp
IPC分类号： G01N33/573 , G01N33/574 , G01N33/68
CPC分类号： G01N33/68 , G01N33/57434
摘要： The present invention relates to novel methods for diagnosing benign prostatic diseases (BPD), such as benign prostatic hyperplasia, prostatitis, or glandular atrophy, in a male human patient without requiring a biopsy. The total prostate specific antigen (PSA) level in the blood or serum of the patient is measured. If the patient has a total PSA level of between about 2.5 ng/ml and 10.0 ng/ml, then the free PSA level in the blood or serum of the patient is measured. The proportion of free PSA to total PSA is calculated. If this proportion is equal to or greater than about 25%, then the patient is diagnosed as having BPD. Optionally, if the patient has a total PSA level of between 10.1 ng/ml and 20.0 ng/ml, then the free PSA level in the blood or serum of the patient can also be measured. The proportion of free PSA to total PSA is calculated. If this proportion is equal to or greater than about 25%, then the patient is diagnosed as having BPD.
摘要翻译：本发明涉及在男性人类患者中诊断良性前列腺疾病（BPD），例如良性前列腺增生，前列腺炎或腺体萎缩的新方法，而不需要活组织检查。测量患者血液或血清中的总前列腺特异性抗原（PSA）水平。如果患者的总PSA水平在约2.5ng / ml至10.0ng / ml之间，则测量患者的血液或血清中的游离PSA水平。计算游离PSA与总PSA的比例。如果该比例等于或大于25％，那么患者被诊断为具有BPD。任选地，如果患者的总PSA水平在10.1ng / ml和20.0ng / ml之间，则也可以测量患者的血液或血清中的游离PSA水平。计算游离PSA与总PSA的比例。如果该比例等于或大于25％，那么患者被诊断为具有BPD。

3. 发明授权

US5912135A Methods for diagnosing benign prostatic diseases 失效
公开(公告)号：US5912135A
公开(公告)日：1999-06-15
申请号：US604685
申请日：1996-02-21
申请人： Albert A. Luderer , Grant D. Carlson , Robert P. Thiel , Thomas F. Soriano , William J. Kramp
发明人： Albert A. Luderer , Grant D. Carlson , Robert P. Thiel , Thomas F. Soriano , William J. Kramp
IPC分类号： G01N33/573 , G01N33/574 , G01N33/68
CPC分类号： G01N33/68 , G01N33/57434
摘要： The present invention relates to novel methods for diagnosing benign prostatic diseases (BPD), such as benign prostatic hyperplasia, prostatitis, or glandular atrophy, in a male human patient without requiring a biopsy. The total prostate specific antigen (PSA) level in the blood or serum of the patient is measured. If the patient has a total PSA level of between about 2.5 ng/ml and 10.0 ng/ml, then the free PSA level in the blood or serum of the patient is measured. The proportion of free PSA to total PSA is calculated. If this proportion is equal to or greater than about 25%, then the patient is diagnosed as having BPD. Optionally, if the patient has a total PSA level of between 10.1 ng/ml and 20.0 ng/ml, then the free PSA level in the blood or serum of the patient can also be measured. The proportion of free PSA to total PSA is calculated. If this proportion is equal to or greater than about 25%, then the patient is diagnosed as having BPD.

4. 发明授权

US5710007A Methods for diagnosing prostatic adenocarcinoma 失效
标题翻译：诊断前列腺腺癌的方法
公开(公告)号：US5710007A
公开(公告)日：1998-01-20
申请号：US536215
申请日：1995-09-29
申请人： Albert A. Luderer , Grant D. Carlson , Ya-Ting Chen , Thomas F. Soriano , Robert P. Thiel
发明人： Albert A. Luderer , Grant D. Carlson , Ya-Ting Chen , Thomas F. Soriano , Robert P. Thiel
IPC分类号： G01N33/53 , G01N33/573 , G01N33/574 , G01N33/537 , G01N33/542
CPC分类号： G01N33/57488 , G01N33/57434
摘要： The present invention relates to a method for diagnosing prostatic adenocarcinoma (CAP) in a male human patient without requiring a biopsy. The total prostate specific antigen (PSA) level in the blood or serum of the patient is measured. If the patient has a total PSA level of between 2.5 ng/ml and 20.0 ng/ml, then the free PSA level in the blood or serum of the patient is measured. The proportion of free PSA to total PSA is calculated. If this proportion is less than about 7%, then the patient is diagnosed as having CAP. The present method can also be used on patients that have a total PSA of at least 10.1 ng/ml, but have also had a negative prostate biopsy.
摘要翻译：本发明涉及一种男性人类患者前列腺腺癌（CAP）诊断方法，无需进行活组织检查。测量患者血液或血清中的总前列腺特异性抗原（PSA）水平。如果患者的总PSA水平在2.5ng / ml和20.0ng / ml之间，则测量患者的血液或血清中的游离PSA水平。计算游离PSA与总PSA的比例。如果该比例小于约7％，那么患者被诊断为具有CAP。本方法也可用于总PSA至少为10.1ng / ml，但也具有阴性前列腺活检的患者。

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