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1. 发明申请

US20070120280A1 Methods and apparatus using electrostatic atomization to form liquid vesicles 有权
标题翻译：使用静电雾化形成液体囊泡的方法和装置
公开(公告)号：US20070120280A1
公开(公告)日：2007-05-31
申请号：US10555432
申请日：2004-05-14
申请人： Thomas Anchordoquy , Corinne Lengsfeld , Kelly Brinkley , Ryan Jones
发明人： Thomas Anchordoquy , Corinne Lengsfeld , Kelly Brinkley , Ryan Jones
IPC分类号： B01J13/04
CPC分类号： B01J13/04 , B01J13/14 , Y10T428/2984 , Y10T428/2985 , Y10T428/2989
摘要： The methods of the invention employ electrostatic atomization to form a compound droplet of at least two miscible fluids. The compound droplet comprises a core of a first fluid and a layer of a second fluid completely surrounding the core. The first fluid contains the agent to be encapsulated and the second fluid contains an encapsulating agent. The first and second liquids are miscible. The encapsulated droplets can contain a variety of materials including, but not limited to, polynucleotides such as DNA and RNA, proteins, bioactive agents or drugs, food, pesticides, herbicides, fragrances, antifoulants, dyes, oils, inks, cosmetics, catalysts, detergents, curing agents, flavors, fuels, metals, paints, photographic agents, biocides, pigments, plasticizers, propellants and the like and components thereof. The droplets can be encapsulated by a variety of materials, including, but not limited to, lipid bilayers and polymer shells. An additional complete or partial layer of a third fluid can be formed on the outside of the second fluid layer. The third fluid can contain a targeting or steric stabilizing agent.
摘要翻译：本发明的方法采用静电雾化形成至少两种可混溶流体的复合液滴。复合液滴包括第一流体的芯和完全围绕芯的第二流体层。第一流体含有待包封的试剂，第二流体含有封装剂。第一和第二液体是可混溶的。包封的液滴可以包含多种材料，包括但不限于多核苷酸如DNA和RNA，蛋白质，生物活性剂或药物，食品，农药，除草剂，香料，防污剂，染料，油，油墨，化妆品，催化剂，洗涤剂，固化剂，香料，燃料，金属，油漆，照相剂，杀生物剂，颜料，增塑剂，推进剂等及其组分。液滴可以被各种材料包封，包括但不限于脂双层和聚合物壳。可以在第二流体层的外侧形成另外的第三流体的完全或部分层。第三种流体可以含有靶向或立体稳定剂。

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