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1. 发明申请

US20070248642A1 Foam and use thereof 审中-公开
标题翻译：泡沫及其用途
公开(公告)号：US20070248642A1
公开(公告)日：2007-10-25
申请号：US11712789
申请日：2007-03-01
申请人： Michael Dornish , Therese Andersen , Jan Egil Melvik
发明人： Michael Dornish , Therese Andersen , Jan Egil Melvik
IPC分类号： A61K9/70 , A61K47/38 , A61K47/46
CPC分类号： A61L31/042 , A61K9/122 , A61L15/28 , A61L15/425 , A61L27/20 , A61L27/56 , A61L31/146 , C08J9/28 , C08J2201/0504 , C08J2205/02 , C08J2305/00 , C08L5/04
摘要： The invention provides a method of producing a gelled foam comprising the steps of:forming a dispersion by mixing i) a solution comprising a soluble polysaccharide and a plasticizer and adding a polysaccharide/gel-forming ion particles or ii) a soluble, preferably immediately soluble, polysaccharide, preferably an alginate, a polysaccharide/gel-forming ion particles, and adding a solvent, said dispersion (ii) further comprising a water soluble plasticizer to make the dispersion and then aerating the dispersion to form the foam. The foam may be inhomogeneous in structure which is useful in providing improved delivery of a component carried in the foam and in degradation.
摘要翻译：本发明提供一种生产凝胶泡沫的方法，包括以下步骤：通过混合形成分散体i）包含可溶性多糖和增塑剂的溶液并加入多糖/凝胶形成离子颗粒或ii）可溶性，优选立即溶解，多糖，优选藻酸盐，多糖/凝胶形成离子颗粒，并加入溶剂，所述分散体（ii）还包含水溶性增塑剂以制备分散体，然后使分散体充气以形成泡沫。泡沫体的结构可能不均匀，其可用于提供在泡沫中携带的组分的改进递送和降解。

2. 发明申请

US20070254016A1 Biodegradable foam 审中-公开
标题翻译：可生物降解泡沫
公开(公告)号：US20070254016A1
公开(公告)日：2007-11-01
申请号：US11712611
申请日：2007-03-01
申请人： Therese Andersen , Are Kristiansen , Sara Joslin
发明人： Therese Andersen , Are Kristiansen , Sara Joslin
IPC分类号： A61K9/70 , C12N11/04
CPC分类号： A61L27/56 , A61K9/122 , A61K47/36 , A61L27/20 , A61L27/38 , A61L27/48
摘要： The invention relates to a method for forming a dried absorbent foam having an open pore network and pores by preparing an aqueous dispersion comprising an enzymatically biodegradable biopolymer and a foaming agent and optionally one or more of gel-forming ions, a plasticizer, a crosslinking agent and a pH modifier, forming, preparing or mixing a foam from the aqueous dispersion and drying the foam to form a dried foam containing open pores. Gelled composites made from the foams are also provided. The invention is particularly useful in providing foams and composites for use in biomedical applications and as an anti-adhesive in tissue regeneration and wound management.
摘要翻译：本发明涉及通过制备包含酶可生物降解的生物聚合物和发泡剂的水性分散体以及任选的一种或多种凝胶形成离子，增塑剂，交联剂，形成具有开孔网络和孔的干燥吸收泡沫体的方法和pH调节剂，从水分散体形成，制备或混合泡沫，并干燥泡沫以形成含有开孔的干燥泡沫。还提供了由泡沫制成的凝胶复合材料。本发明特别可用于提供用于生物医学应用的泡沫和复合材料以及组织再生和伤口管理中的抗粘合剂。

3. 发明申请

US20100178313A1 Implantable Degradable Biopolymer Fiber Devices 审中-公开
标题翻译：可植入降解生物聚合物纤维装置
公开(公告)号：US20100178313A1
公开(公告)日：2010-07-15
申请号：US12663641
申请日：2008-06-13
申请人： Christian Klein Larsen , Therese Andersen
发明人： Christian Klein Larsen , Therese Andersen
IPC分类号： A61K9/00 , A61K38/00 , A61K38/22 , A61K38/08 , A61K38/10 , A61P43/00
CPC分类号： A61L31/042 , A61L31/14 , A61L31/148
摘要： Degradable fibers that include biopolymers, as well as implantable devices including one or more fibers made from degradable biopolymers, e.g., alginate, chitosan, hyaluronans or their derivatives. The devices provide a combination of degradability and biocompatibility with physical properties suitable for use of the devices as implants. Exemplary devices are fastening devices including one or more biopolymer fibers. The use of such degradable biopolymers minimizes or eliminates the need for a second surgery to remove the implant, thereby eliminating the additional cost and potential complications of such a second surgery and should reduce the likelihood of secondary fractures resulting from the stress-shielding effect or the presence of screws holes that serve as stress concentrators. Methods for the fabrication of the degradable biopolymer fibers of the present invention are also provided, as well as methods for the fabrication of implantable degradable devices of the present invention which contain one or more degradable biopolymer fibers.
摘要翻译：包括生物聚合物的可降解纤维，以及包括由可降解生物聚合物制成的一种或多种纤维的可植入装置，例如藻酸盐，壳聚糖，透明质酸或其衍生物。这些装置提供降解性和生物相容性与适合于使用装置作为植入物的物理性质的组合。示例性装置是包括一种或多种生物聚合物纤维的紧固装置。使用这种可降解的生物聚合物可最大限度地减少或消除第二次手术去除植入物的需要，从而消除这种第二次手术的额外成本和潜在的并发症，并且应降低由应力屏蔽效应引起的继发性骨折的可能性或存在用作应力集中器的螺钉孔。还提供了用于制造本发明的可降解生物聚合物纤维的方法，以及用于制造本发明的可植入式可降解装置的方法，其包含一种或多种可降解的生物聚合物纤维。

4. 发明申请

US20100172953A1 Biopolymer Based Implantable Degradable Devices 审中-公开
标题翻译：基于生物聚合物的植入式可降解设备
公开(公告)号：US20100172953A1
公开(公告)日：2010-07-08
申请号：US12663591
申请日：2008-06-13
申请人： Christian Klein Larsen , Therese Andersen
发明人： Christian Klein Larsen , Therese Andersen
IPC分类号： A61K38/18 , A61F2/00 , A61P19/04
CPC分类号： A61L31/042 , A61L31/14 , A61L31/148
摘要： Implantable degradable devices for tissue repair or reconstruction comprising biopolymers, as well as to methods of manufacture and use thereof. The implantable device is formed by the application of pressure and the device may include up to about 65% by weight of water, based on the total weight of the implantable degradable fastening device. Methods for making implantable, degradable devices from biopolymers by application of pressure are also disclosed. The invention provides the ability to customize the device in various ways to influence properties such as mechanical strength, degradation rate and swellability.
摘要翻译：用于组织修复或重建的可植入可降解装置，包括生物聚合物，以及其制造和使用方法。可植入装置通过施加压力而形成，并且基于可植入式可降解紧固装置的总重量，该装置可以包括高达约65重量％的水。还公开了通过施加压力从生物聚合物制造可植入的可降解装置的方法。本发明提供以各种方式定制装置以影响诸如机械强度，降解速率和溶胀性等性能的能力。

5. 发明申请

US20090010983A1 Alginate Coated, Polysaccharide Gel-Containing Foam Composite, Preparative Methods, and Uses Thereof 审中-公开
标题翻译：藻酸盐涂层，含多糖凝胶的泡沫复合材料，制备方法及其用途
公开(公告)号：US20090010983A1
公开(公告)日：2009-01-08
申请号：US12138738
申请日：2008-06-13
申请人： Jan Egil Melvik , Therese Andersen
发明人： Jan Egil Melvik , Therese Andersen
IPC分类号： A61K35/12 , C12N5/06 , A61F2/04 , A61P3/10 , A61K47/36
CPC分类号： C08J9/365 , A61L27/38 , A61L27/48 , A61L27/52 , A61L27/56 , A61L31/005 , A61L31/129 , A61L31/145 , A61L31/146 , C08J9/42 , C08J2207/10 , C08J2305/00 , C08J2305/02 , C08J2305/04 , C08J2305/06 , C08J2305/08 , C08K3/105 , C08K3/26 , C08K3/32 , C08K5/053 , C08L1/284 , C08L3/02 , C08L5/00 , C08L5/02 , C08L5/04 , C08L5/06 , C08L5/08 , C09D105/04 , C12N5/0068 , C12N2533/72 , C12N2533/74 , C12N2533/80
摘要： The invention relates to composites comprising a polysaccharide gelled within pores of a foam and an polysaccharide coating, methods of preparation, and uses thereof, for example, in biomedical applications such as cell culture media and implants, controlled release delivery systems, food applications, industrial applications, and personal care applications such as cosmetic and oral hygiene.
摘要翻译：本发明涉及包含在泡沫孔内多糖凝胶化的多糖和多糖包衣的复合材料，其制备方法及其用途，例如生物医学应用如细胞培养基和植入物，控制释放递送系统，食品应用，工业应用和个人护理应用，如化妆品和口腔卫生。

6. 发明授权

US09028872B2 Gelled composite 有权
标题翻译：凝胶复合材料
公开(公告)号：US09028872B2
公开(公告)日：2015-05-12
申请号：US11712612
申请日：2007-03-01
申请人： Olav Gaserod , Therese Andersen , Jan Egil Melvik , Michael Dornish , Peter J. Riley
发明人： Olav Gaserod , Therese Andersen , Jan Egil Melvik , Michael Dornish , Peter J. Riley
IPC分类号： A61K9/70 , A61L27/56 , A61K9/12 , A61K47/36 , A61L27/20 , A61L27/38 , A61L27/48
CPC分类号： A61L27/56 , A61K9/122 , A61K47/36 , A61L27/20 , A61L27/38 , A61L27/48
摘要： The invention relates to composites comprising a polysaccharide gelled within pores of a foam, methods of preparation, and uses thereof, for example, in biomedical applications such as cell culture media and implants, controlled release delivery systems, food applications, industrial applications, and personal care applications such as cosmetic and oral hygiene. The composites of the present invention are simple to formulate using few steps and are useful for entrapping heat-sensitive components, such as cells, drugs, flavors or fragrances within the polysaccharide gel. In addition, the invention provides for a composite able to gently immobilize fragile components, such as living cells, without exposing such components to shear forces.
摘要翻译：本发明涉及包含在泡沫的孔内凝胶化的多糖的复合材料，制备方法及其用途，例如在生物医学应用中，例如细胞培养基和植入物，控制释放递送系统，食品应用，工业应用和个人护理应用如化妆品和口腔卫生。本发明的复合材料使用几个步骤简单的配制，并且可用于在多糖凝胶内捕获热敏组分如细胞，药物，香料或香料。此外，本发明提供了一种复合材料，其能够轻柔地固定易碎组分如活细胞，而不会使这些组分暴露于剪切力。

7. 发明授权

US08257727B2 Medical devices coated with a fast dissolving biocompatible coating 失效
标题翻译：涂有快速溶解生物相容性涂层的医疗器械
公开(公告)号：US08257727B2
公开(公告)日：2012-09-04
申请号：US11486836
申请日：2006-07-14
申请人： Michael Dornish , Christian Klein Larsen , Therese Andersen
发明人： Michael Dornish , Christian Klein Larsen , Therese Andersen
IPC分类号： A61F2/00
CPC分类号： A61L31/10 , A61L27/34 , A61L29/10 , A61L29/14 , A61L31/14 , C08L5/00 , C08L5/04 , C08L5/08
摘要： The present invention relates to a medical device comprising a biocompatible medical coating adhered thereto, wherein the coating comprises at least one of a non-crosslinked, water soluble salt of: (i) alginic acid, (ii) hyaluronic acid or (iii) chitosan, wherein the coating is readily dissolvable in at least one mammalian body fluid.
摘要翻译：本发明涉及一种包括粘附在其上的生物相容性医用涂层的医疗装置，其中该涂层包括以下中的至少一种：非交联的水溶性盐，其中：（i）藻酸，（ii）透明质酸或（iii）壳聚糖其中所述涂层容易溶于至少一种哺乳动物体液中。

8. 发明申请

US20080033392A1 Gelled composite 有权
标题翻译：凝胶复合材料
公开(公告)号：US20080033392A1
公开(公告)日：2008-02-07
申请号：US11712612
申请日：2007-03-01
申请人： Olav Gaserod , Therese Andersen , Jan Melvik , Michael Dornish , Peter Riley
发明人： Olav Gaserod , Therese Andersen , Jan Melvik , Michael Dornish , Peter Riley
IPC分类号： A61M31/00 , A23L1/00 , A61K35/12 , A61P43/00 , C12N5/00 , B01D21/01 , A61K36/02 , A61K9/00
CPC分类号： A61L27/56 , A61K9/122 , A61K47/36 , A61L27/20 , A61L27/38 , A61L27/48
摘要： The invention relates to composites comprising a polysaccharide gelled within pores of a foam, methods of preparation, and uses thereof, for example, in biomedical applications such as cell culture media and implants, controlled release delivery systems, food applications, industrial applications, and personal care applications such as cosmetic and oral hygiene. The composites of the present invention are simple to formulate using few steps and are useful for entrapping heat-sensitive components, such as cells, drugs, flavors or fragrances within the polysaccharide gel. In addition, the invention provides for a composite able to gently immobilize fragile components, such as living cells, without exposing such components to shear forces.
摘要翻译：本发明涉及包含在泡沫的孔内凝胶化的多糖的复合材料，制备方法及其用途，例如在生物医学应用中，例如细胞培养基和植入物，控制释放递送系统，食品应用，工业应用和个人护理应用如化妆品和口腔卫生。本发明的复合材料使用几个步骤简单的配制，并且可用于在多糖凝胶内捕获热敏组分如细胞，药物，香料或香料。此外，本发明提供了一种复合材料，其能够轻柔地固定易碎组分如活细胞，而不会使这些组分暴露于剪切力。

9. 发明申请

US20070077271A1 Medical devices coated with a fast dissolving biocompatible coating 失效
标题翻译：涂有快速溶解生物相容性涂层的医疗器械
公开(公告)号：US20070077271A1
公开(公告)日：2007-04-05
申请号：US11486836
申请日：2006-07-14
申请人： Michael Dornish , Christian Larsen , Therese Andersen
发明人： Michael Dornish , Christian Larsen , Therese Andersen
IPC分类号： A61F2/02
CPC分类号： A61L31/10 , A61L27/34 , A61L29/10 , A61L29/14 , A61L31/14 , C08L5/00 , C08L5/04 , C08L5/08
摘要： The present invention relates to a medical device comprising a biocompatible medical coating adhered thereto, wherein the coating comprises at least one of a non-crosslinked, water soluble salt of: (i) alginic acid, (ii) hyaluronic acid or (iii) chitosan, wherein the coating is readily dissolvable in at least one mammalian body fluid.
摘要翻译：本发明涉及一种包括粘附在其上的生物相容性医用涂层的医疗装置，其中该涂层包括以下中的至少一种：非交联的水溶性盐，其中：（i）藻酸，（ii）透明质酸或（iii）壳聚糖其中所述涂层容易溶于至少一种哺乳动物体液中。

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