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1. 发明授权

US07083977B2 Monkey-origin embryonic stem cells 失效
公开(公告)号：US07083977B2
公开(公告)日：2006-08-01
申请号：US10311146
申请日：2001-06-15
申请人： Norio Nakatsuji , Takashi Tada , Ryuzo Torii , Yoshihiko Hosoi , Akira Iritani , Teruo Akuta
发明人： Norio Nakatsuji , Takashi Tada , Ryuzo Torii , Yoshihiko Hosoi , Akira Iritani , Teruo Akuta
IPC分类号： C12Q1/68 , C12N5/00 , C12N5/06
CPC分类号： C12N5/0606 , C12N2503/00 , C12N2503/02
摘要： A method for producing a monkey-derived embryonic stem cell comprising the steps of carrying out fertilization by insemination by in vitro fertilization or intracytoplasmic sperm injection using a monkey ovum and monkey sperms, thereby giving a fertilized ovum, allowing the fertilized ovum to differentiate into a blastocyst by in vitro culture, and establishing an ES cell line using the blastocyst; the monkey ES cell obtained by the method, a method for screening a reagent for specific differentiation into cell or tissue by using the ES cell; and a differentiated cell or differentiated tissue each differentiated from the ES cell. According to the present invention, applications of the embryonic stem cells to embryological studies clinical applications, experimental models, and the like on primates, studies of diseases, are expected.

2. 发明申请

US20100021442A1 METHOD FOR PROMOTING IMMUNOTHERAPY USING AN AGENT FOR ELEVATING DENDRITIC CELL PRECURSOR LEVEL IN BLOOD 审中-公开
标题翻译：促进免疫功能的方法，用于增加血液中的细胞前体水平
公开(公告)号：US20100021442A1
公开(公告)日：2010-01-28
申请号：US12554676
申请日：2009-09-04
申请人： Kouji MATSUSHIMA , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
发明人： Kouji MATSUSHIMA , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
IPC分类号： A61K35/12 , A61P37/00
CPC分类号： A61K38/195
摘要： Although the fields of therapeutic applications of dendritic cells are now expanding, dendritic cell precursors exist only in a small amount in the peripheral blood and, therefore, it is still difficult to obtain them in a therapeutically useful amount even though they are proliferated in vitro. Therefore, it is a key point in performing a therapy with the use of dendritic cells in practice to elevate dendritic cell precursor level in the peripheral blood of a patient. The present invention provides an agent for elevating dendritic cell precursor level in the blood which comprises an agonist to a receptor expressed in immature dendritic cells or a functional derivative thereof as the active ingredient.
摘要翻译：尽管树突状细胞的治疗应用领域现在正在扩大，但是树突状细胞前体在外周血中仅存在少量，因此即使体外增殖，仍然难以以治疗有用的量获得它们。因此，在实践中使用树突状细胞进行治疗是关键点，以提高患者外周血中的树突状细胞前体水平。本发明提供了一种用于提高血液中树突状细胞前体水平的试剂，其包含对未成熟树突状细胞中表达的受体的激动剂或其功能性衍生物作为活性成分。

3. 发明授权

US06235521B1 Phage bonded to a nuclear location signal 失效
标题翻译：噬菌体与核定位信号
公开(公告)号：US06235521B1
公开(公告)日：2001-05-22
申请号：US09242131
申请日：1999-09-10
申请人： Mahito Nakanishi , Emi Nagoshi , Teruo Akuta , Katsuo Takeda , Mamoru Hasegawa
发明人： Mahito Nakanishi , Emi Nagoshi , Teruo Akuta , Katsuo Takeda , Mamoru Hasegawa
IPC分类号： C12N700
CPC分类号： C12N15/1037 , C12N15/85 , C12N15/86 , C12N15/87 , C12N2795/10343
摘要： A &lgr; phage with a nuclear localization signal has been obtained by constructing a vector capable of expressing a fused protein between a gpD protein constituting the head of a &lgr; phage and a nuclear localization signal sequence, transforming Escherichia coli with this vector, and propagating a mutant &lgr; phage which cannot express the gpD protein in E. coli in this transformant. It has been confirmed that the resulting &lgr; phage is capable of packaging &lgr; phage DNAs of 80% and 100% genome sizes. After further confirming that the nuclear localization signal exposed on the outside of the head of this phage, this phage has been microinjected into cells to analyze its nuclear localization activity. Thus, it has been clarified that this phage has a nuclear localization activity.
摘要翻译：通过构建能够在构成羔羊噬菌体的头部的gpD蛋白质和核定位信号序列之间表达融合蛋白的载体，通过该载体转化大肠杆菌并扩增突变体，获得具有核定位信号的羔羊噬菌体在该转化体中不能在大肠杆菌中表达gpD蛋白的羔羊噬菌体。已经证实，所得的羔羊噬菌体能够包装80％和100％基因组大小的羔羊噬菌体DNA。在进一步证实核定位信号暴露在该噬菌体头部的外部时，该噬菌体已被微量注入细胞以分析其核定位活性。因此，已经澄清这种噬菌体具有核定位活动。

4. 发明授权

US06759231B2 Phage with nuclear localization signal 失效
标题翻译：噬菌体与核定位信号
公开(公告)号：US06759231B2
公开(公告)日：2004-07-06
申请号：US09844813
申请日：2001-04-27
申请人： Mahito Nakanishi , Emi Nagoshi , Teruo Akuta , Katsuo Takeda , Mamoru Hasegawa
发明人： Mahito Nakanishi , Emi Nagoshi , Teruo Akuta , Katsuo Takeda , Mamoru Hasegawa
IPC分类号： C12N120
CPC分类号： C12N15/1037 , C12N15/85 , C12N15/86 , C12N15/87 , C12N2795/10343
摘要： A &lgr; phage with a nuclear localization signal has been obtained by constructing a vector capable of expressing a fused protein between a gpD protein constituting the head of a &lgr; phage and a nuclear localization signal sequence, transforming Escherichia coli with this vector, and propagating a mutant &lgr; phage which cannot express the gpD protein in E. coli in this transformant. It has been confirmed that the resulting &lgr; phage is capable of packaging &lgr; phage DNAs of 80% and 100% genome sizes. After further confirming that the nuclear localization signal exposed on the outside of the head of this phage, this phage has been microinjected into cells to analyze its nuclear localization activity. Thus, it has been clarified that this phage has a nuclear localization activity.
摘要翻译：已经通过构建能够在构成λ噬菌体的头部的gpD蛋白质和核定位信号序列之间表达融合蛋白质的载体，用该载体转化大肠杆菌并扩增突变体来获得具有核定位信号的λ噬菌体 λ噬菌体在该转化体中不能在大肠杆菌中表达gpD蛋白。已经证实所得的λ噬菌体能够包装80％和100％基因组大小的λ噬菌体DNA。在进一步证实核定位信号暴露在该噬菌体头部的外部时，该噬菌体已被微量注入细胞以分析其核定位活性。因此，已经澄清这种噬菌体具有核定位活动。

5. 发明授权

US07935814B2 Nitroguanosine-3′ 5′-cyclic monophosphate compound and protein kinase G activating agent 有权
标题翻译：硝基鸟苷-3'5'-环状单磷酸化合物和蛋白激酶G活化剂
公开(公告)号：US07935814B2
公开(公告)日：2011-05-03
申请号：US11817168
申请日：2006-02-28
申请人： Takaaki Akaike , Teruo Akuta
发明人： Takaaki Akaike , Teruo Akuta
IPC分类号： C07H19/213
CPC分类号： C07H19/213
摘要： An object of the present invention is to provide a novel compound that is an agonist of guanosine-3′,5′-cyclic monophosphate and has an effect of activating protein kinase G. The present invention provides 8-guanosine-3′,5′-cyclic monophosphate compound which is represented by the following formula, and a pharmaceutical composition, especially a protein kinase G activating agent, which contains the 8-guanosine-3′,5′-cyclic monophosphate compound as an active ingredient.
摘要翻译：本发明的目的是提供作为鸟苷-3'，5'-环状单磷酸酯的激动剂的新化合物，具有激活蛋白激酶G的作用。本发明提供8-鸟苷-3'，5' 由下式表示的单环磷酸酯化合物和含有8-鸟苷-3'，5'-环状单磷酸酯化合物作为活性成分的药物组合物，特别是蛋白激酶G活化剂。

6. 发明申请

US20100316592A1 AQUEOUS PREPARATION COMPRISING eMIP AS ACTIVE INGREDIENT 审中-公开
标题翻译：包含eMIP作为主动成分的水质准备
公开(公告)号：US20100316592A1
公开(公告)日：2010-12-16
申请号：US12502959
申请日：2009-07-14
申请人： Teruo AKUTA , Yoshiko Aoki
发明人： Teruo AKUTA , Yoshiko Aoki
IPC分类号： A61K38/16
CPC分类号： A61K38/195 , A61K9/0019 , A61K9/08 , A61K47/02 , A61K47/183
摘要： An objective of the present invention is to provide aqueous preparations comprising eMIP, a derivative of macrophage inflammatory protein 1α (MIP-1α) which has an immunopotentiation activity, and stabilizer(s). The present inventors conducted dedicated studies to achieve the above-described objective. As a result, the present inventors discovered that eMIP degradation is suppressed by addition of at least one or more additives selected from sodium chloride, L-histidine, L-arginine, L-arginine hydrochloride, L-lysine hydrochloride, citric acid, and sodium edetate (EDTA). Furthermore, the present inventors demonstrated that phosphate buffer of pH 5 to pH 7 is a preferable pH adjuster for the aqueous eMIP preparations of the present invention.
摘要翻译：本发明的目的是提供包含eMIP，具有免疫增强活性的巨噬细胞炎症蛋白1α（MIP-1α）的衍生物和稳定剂的含水制剂。本发明人进行了专门的研究以实现上述目的。结果，本发明人发现通过添加选自氯化钠，L-组氨酸，L-精氨酸，L-精氨酸盐酸盐，L-赖氨酸盐酸盐，柠檬酸和钠中的至少一种或多种添加剂，可以抑制eMIP降解乙二胺四乙酸（EDTA）。此外，本发明人证明，pH5〜pH7的磷酸盐缓冲液是本发明的含水eMIP制剂的优选的pH调节剂。

7. 发明申请

US20090215716A1 NITROGUANOSINE-3' 5'-CYCLIC MONOPHOSPHATE COMPOUND AND PROTEIN KINASE G ACTIVATING AGENT 有权
标题翻译： NITROGUANOSINE-3'5'-环状单磷酸酯化合物和蛋白激酶G激活剂
公开(公告)号：US20090215716A1
公开(公告)日：2009-08-27
申请号：US11817168
申请日：2006-02-28
申请人： Takaaki Akaike , Teruo Akuta
发明人： Takaaki Akaike , Teruo Akuta
IPC分类号： A61K31/708 , C07H19/20 , A61P9/12
CPC分类号： C07H19/213
摘要： An object of the present invention is to provide a novel compound that is an agonist of guanosine-3′,5′-cyclic monophosphate and has an effect of activating protein kinase G. The present invention provides 8-guanosine-3′,5′-cyclic monophosphate compound which is represented by the following formula, and a pharmaceutical composition, especially a protein kinase G activating agent, which contains the 8-guanosine-3′,5′-cyclic monophosphate compound as an active ingredient.
摘要翻译：本发明的目的是提供作为鸟苷-3'，5'-环状单磷酸酯的激动剂的新化合物，具有激活蛋白激酶G的作用。本发明提供8-鸟苷-3'，5' 由下式表示的单环磷酸酯化合物和含有8-鸟苷-3'，5'-环状单磷酸酯化合物作为活性成分的药物组合物，特别是蛋白激酶G活化剂。

8. 发明申请

US20060210531A1 Agent eleveting dendritic cell precursor level in blood 审中-公开
标题翻译：代谢物提取树突状细胞前体血液中的水平
公开(公告)号：US20060210531A1
公开(公告)日：2006-09-21
申请号：US10531580
申请日：2003-10-21
申请人： Kouji Matsushima , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
发明人： Kouji Matsushima , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
IPC分类号： A61K38/19 , C07K14/52
CPC分类号： A61K38/195
摘要： Although the fields of therapeutic applications of dendritic cells are now expanding, dendritic cell precursors exist only in a small amount in the peripheral blood and, therefore, it is still difficult to obtain them in a therapeutically useful amount even though they are proliferated in vitro. Therefore, it is a key point in performing a therapy with the use of dendritic cells in practice to elevate dendritic cell precursor level in the peripheral blood of a patient. The present invention provides an agent for elevating dendritic cell precursor level in the blood which comprises an agonist to a receptor expressed in immature dendritic cells or a functional derivative thereof as the active ingredient.
摘要翻译：尽管树突状细胞的治疗应用领域现在正在扩大，但是树突状细胞前体在外周血中仅存在少量，因此即使体外增殖，仍然难以以治疗有用的量获得它们。因此，在实践中使用树突状细胞进行治疗是关键点，以提高患者外周血中的树突状细胞前体水平。本发明提供了一种用于提高血液中树突状细胞前体水平的试剂，其包含对未成熟树突状细胞中表达的受体的激动剂或其功能性衍生物作为活性成分。

9. 发明授权

US06740524B1 Nucleic acid transfer phage 失效
标题翻译：核酸转运噬菌体
公开(公告)号：US06740524B1
公开(公告)日：2004-05-25
申请号：US09720003
申请日：2001-09-04
申请人： Teruo Akuta , Haruhiko Yokoi , Hajime Okuyama , Katsuo Takeda , Mamoru Hasegawa , Mahito Nakanishi
发明人： Teruo Akuta , Haruhiko Yokoi , Hajime Okuyama , Katsuo Takeda , Mamoru Hasegawa , Mahito Nakanishi
IPC分类号： C12N1586
CPC分类号： C07K14/005 , A61K48/00 , C07K2319/01 , C07K2319/09 , C12N15/86 , C12N2740/16322 , C12N2800/30 , Y10S435/975
摘要： The present invention provides a novel phage expressing in its head a bi-functional protein that has nuclear translocation and cell adhesion activities. The phage is used to package a foreign substance such as a gene. As a bi-functional protein, TAT protein of HIV can be used. The phage is useful in gene therapy.
摘要翻译：本发明提供了一种在其头部表达具有核易位和细胞粘附活性的双功能蛋白质的新型噬菌体。噬菌体用于包装诸如基因的异物。作为双功能蛋白质，可以使用HIV的TAT蛋白。噬菌体可用于基因治疗。

10. 发明申请

US20080124307A1 Method for promoting immunotherapy 审中-公开
标题翻译：促进免疫治疗的方法
公开(公告)号：US20080124307A1
公开(公告)日：2008-05-29
申请号：US11819147
申请日：2007-06-25
申请人： Kouji Matsushima , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
发明人： Kouji Matsushima , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
IPC分类号： A61K35/12 , A61P37/00
CPC分类号： A61K38/195
摘要： Although the fields of therapeutic applications of dendritic cells are now expanding, dendritic cell precursors exist only in a small amount in the peripheral blood and, therefore, it is still difficult to obtain them in a therapeutically useful amount even though they are proliferated in vitro. Therefore, it is a key point in performing a therapy with the use of dendritic cells in practice to elevate dendritic cell precursor level in the peripheral blood of a patient. The present invention provides an agent for elevating dendritic cell precursor level in the blood which comprises an agonist to a receptor expressed in immature dendritic cells or a functional derivative thereof as the active ingredient.
摘要翻译：尽管树突状细胞的治疗应用领域现在正在扩大，但是树突状细胞前体在外周血中仅存在少量，因此即使体外增殖，仍然难以以治疗有用的量获得它们。因此，在实践中使用树突状细胞进行治疗是关键点，以提高患者外周血中的树突状细胞前体水平。本发明提供了一种用于提高血液中树突状细胞前体水平的试剂，其包含对未成熟树突状细胞中表达的受体的激动剂或其功能性衍生物作为活性成分。

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