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1. 发明授权

US08221330B2 Measurement for EEG reactivity 有权
标题翻译： EEG反应性测量
公开(公告)号：US08221330B2
公开(公告)日：2012-07-17
申请号：US12940143
申请日：2010-11-05
申请人： Mika Sarkela , Juha Virtanen , Hanna E. Viertio-Oja , Tapani Salmi
发明人： Mika Sarkela , Juha Virtanen , Hanna E. Viertio-Oja , Tapani Salmi
IPC分类号： A61B5/04
CPC分类号： A61B5/0484 , A61B5/7203 , A61B5/7221 , G06F19/00 , G16H10/60
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a valid signal model is constructed for an EEG signal obtained from the subject. A time reference corresponding to a stimulus is applied and further signal data is obtained from the time series, the further signal data being subsequent to the time reference. By employing the further signal data, the method tests whether the signal model remains to be a valid signal model for the EEG signal also after the stimulus, and indicates, based on the test, whether reactivity is present in the physiological signal.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动获得目标和可靠的反应性测量，并且没有经过训练的EEG专家的存在，为从受试者获得的EEG信号构建了有效的信号模型。施加对应于刺激的时间基准，并且从时间序列获得进一步的信号数据，其后的信号数据在时间基准之后。通过采用进一步的信号数据，该方法也在刺激之后测试信号模型是否仍然是用于EEG信号的有效信号模型，并且基于该测试指示生理信号中是否存在反应性。

2. 发明授权

US08064993B2 Measurement of EEG reactivity 有权
标题翻译：测量脑电反应性
公开(公告)号：US08064993B2
公开(公告)日：2011-11-22
申请号：US11273574
申请日：2005-11-14
申请人： Hanna E. Viertiö-Oja , Mika Särkelä , Juha Virtanen , Tapani Salmi
发明人： Hanna E. Viertiö-Oja , Mika Särkelä , Juha Virtanen , Tapani Salmi
IPC分类号： A61B5/04 , A61B5/00
CPC分类号： A61B5/0484
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a time reference corresponding to a stimulus is detected and the physiological signal data obtained from the subject is aligned with the time reference. Two sets of values are determined for a measure indicative of the amount of irregularity in the physiological signal data, both sets including at least one value of the said measure and having defined positions with respect to the time reference in time domain. Based on the two sets, the apparatus determines whether reactivity is present in the physiological signal data.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动地获得反应性的目的和可靠的测量，并且没有训练有素的脑电专家的存在，检测到对应于刺激的时间基准，并且从对象获得的生理信号数据与时间参考对准。对于表示生理信号数据中的不规则量的量度来确定两组值，两组都包括所述测量的至少一个值，并且相对于时域中的时间参考具有定义的位置。基于这两组，该装置确定生理信号数据中是否存在反应性。

3. 发明申请

US20110087127A1 MEASUREMENT FOR EEG REACTIVITY 有权
标题翻译：测量脑电反应
公开(公告)号：US20110087127A1
公开(公告)日：2011-04-14
申请号：US12940143
申请日：2010-11-05
申请人： Mika Särkelä , Juha Virtanen , Hanna E. Viertiö-Oja , Tapani Salmi
发明人： Mika Särkelä , Juha Virtanen , Hanna E. Viertiö-Oja , Tapani Salmi
IPC分类号： A61B5/0476
CPC分类号： A61B5/0484 , A61B5/7203 , A61B5/7221 , G06F19/00 , G16H10/60
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a valid signal model is constructed for an EEG signal obtained from the subject. A time reference corresponding to a stimulus is applied and further signal data is obtained from the time series, the further signal data being subsequent to the time reference. By employing the further signal data, the method tests whether the signal model remains to be a valid signal model for the EEG signal also after the stimulus, and indicates, based on the test, whether reactivity is present in the physiological signal.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动获得目标和可靠的反应性测量，并且没有经过训练的EEG专家的存在，为从受试者获得的EEG信号构建了有效的信号模型。施加对应于刺激的时间基准，并且从时间序列获得进一步的信号数据，其后的信号数据在时间基准之后。通过采用进一步的信号数据，该方法也在刺激之后测试信号模型是否仍然是用于EEG信号的有效信号模型，并且基于该测试指示生理信号中是否存在反应性。

4. 发明申请

US20070179399A1 Measurement of EEG reactivity 有权
标题翻译：测量脑电反应性
公开(公告)号：US20070179399A1
公开(公告)日：2007-08-02
申请号：US11523789
申请日：2006-09-19
申请人： Hanna E. Viertio-Oja , Mika Sarkela , Juha Virtanen , Tapani Salmi
发明人： Hanna E. Viertio-Oja , Mika Sarkela , Juha Virtanen , Tapani Salmi
IPC分类号： A61B5/00 , A61B5/04 , A61B5/05
CPC分类号： A61B5/0484 , A61B5/4064
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a time reference corresponding to a stimulus is detected and the physiological signal data obtained from the subject is aligned with the time reference. Two sets of values are determined for a measure indicative of the amount of irregularity in the physiological signal data, both sets including at least one value of the said measure and having defined positions with respect to the time reference in time domain. Based on the two sets, the apparatus determines whether reactivity is present in the physiological signal data.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动地获得反应性的目的和可靠的测量，并且没有训练有素的脑电专家的存在，检测到对应于刺激的时间基准，并且从对象获得的生理信号数据与时间参考对准。对于表示生理信号数据中的不规则量的量度来确定两组值，两组都包括所述测量的至少一个值，并且相对于时域中的时间参考具有定义的位置。基于这两组，该装置确定生理信号数据中是否存在反应性。

5. 发明授权

US08145297B2 Measurement of EEG reactivity 有权
标题翻译：测量脑电反应性
公开(公告)号：US08145297B2
公开(公告)日：2012-03-27
申请号：US11523789
申请日：2006-09-19
申请人： Hanna E. Viertiö-Oja , Mika Särkelä , Juha Virtanen , Tapani Salmi
发明人： Hanna E. Viertiö-Oja , Mika Särkelä , Juha Virtanen , Tapani Salmi
IPC分类号： A61B5/04
CPC分类号： A61B5/0484 , A61B5/4064
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a time reference corresponding to a stimulus is detected and the physiological signal data obtained from the subject is aligned with the time reference. Two sets of values are determined for a measure indicative of the amount of irregularity in the physiological signal data, both sets including at least one value of the said measure and having defined positions with respect to the time reference in time domain. Based on the two sets, the apparatus determines whether reactivity is present in the physiological signal data.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动地获得反应性的目的和可靠的测量，并且没有训练有素的脑电专家的存在，检测到对应于刺激的时间基准，并且从对象获得的生理信号数据与时间参考对准。对于表示生理信号数据中的不规则量的量度来确定两组值，两组都包括所述测量的至少一个值，并且相对于时域中的时间参考具有定义的位置。基于这两组，该装置确定生理信号数据中是否存在反应性。

6. 发明授权

US07844324B2 Measurement of EEG reactivity 有权
标题翻译：测量脑电反应性
公开(公告)号：US07844324B2
公开(公告)日：2010-11-30
申请号：US11674732
申请日：2007-02-14
申请人： Mika Särkelä , Juha Virtanen , Hanna E. Viertiö-Oja , Tapani Salmi
发明人： Mika Särkelä , Juha Virtanen , Hanna E. Viertiö-Oja , Tapani Salmi
IPC分类号： A61B5/04
CPC分类号： A61B5/0484 , A61B5/7203 , A61B5/7221 , G06F19/00 , G16H10/60
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a valid signal model is constructed for an EEG signal obtained from the subject. A time reference corresponding to a stimulus is applied and further signal data is obtained from the time series, the further signal data being subsequent to the time reference. By employing the further signal data, the method tests whether the signal model remains to be a valid signal model for the EEG signal also after the stimulus, and indicates, based on the test, whether reactivity is present in the physiological signal.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动获得目标和可靠的反应性测量，并且没有经过训练的EEG专家的存在，为从受试者获得的EEG信号构建了有效的信号模型。施加对应于刺激的时间基准，并且从时间序列获得进一步的信号数据，其后的信号数据在时间基准之后。通过采用进一步的信号数据，该方法也在刺激之后测试信号模型是否仍然是用于EEG信号的有效信号模型，并且基于该测试指示生理信号中是否存在反应性。

7. 发明申请

US20080194981A1 Measurement of EEG Reactivity 有权
标题翻译：测量脑电反应
公开(公告)号：US20080194981A1
公开(公告)日：2008-08-14
申请号：US11674732
申请日：2007-02-14
申请人： Mika Sarkela , Juha Virtanen , Hanna E. Viertio-Oja , Tapani Salmi
发明人： Mika Sarkela , Juha Virtanen , Hanna E. Viertio-Oja , Tapani Salmi
IPC分类号： A61B5/0476
CPC分类号： A61B5/0484 , A61B5/7203 , A61B5/7221 , G06F19/00 , G16H10/60
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a valid signal model is constructed for an EEG signal obtained from the subject. A time reference corresponding to a stimulus is applied and further signal data is obtained from the time series, the further signal data being subsequent to the time reference. By employing the further signal data, the method tests whether the signal model remains to be a valid signal model for the EEG signal also after the stimulus, and indicates, based on the test, whether reactivity is present in the physiological signal.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动获得目标和可靠的反应性测量，并且没有经过训练的EEG专家的存在，为从受试者获得的EEG信号构建了有效的信号模型。施加对应于刺激的时间基准，并且从时间序列获得进一步的信号数据，其后的信号数据在时间基准之后。通过采用进一步的信号数据，该方法也在刺激之后测试信号模型是否仍然是用于EEG信号的有效信号模型，并且基于该测试指示生理信号中是否存在反应性。

8. 发明申请

US20070112278A1 Measurement of EEG reactivity 有权
公开(公告)号：US20070112278A1
公开(公告)日：2007-05-17
申请号：US11273574
申请日：2005-11-14
申请人： Hanna Viertio-Oja , Mika Sarkela , Juha Virtanen , Tapani Salmi
发明人： Hanna Viertio-Oja , Mika Sarkela , Juha Virtanen , Tapani Salmi
IPC分类号： A61B5/00 , A61B5/05 , A61B5/04
CPC分类号： A61B5/0484
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a time reference corresponding to a stimulus is detected and the physiological signal data obtained from the subject is aligned with the time reference. Two sets of values are determined for a measure indicative of the amount of irregularity in the physiological signal data, both sets including at least one value of the said measure and having defined positions with respect to the time reference in time domain. Based on the two sets, the apparatus determines whether reactivity is present in the physiological signal data.

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