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1. 发明授权

US07599735B2 Electrode configuration for central nervous system monitoring 失效
标题翻译：电极配置用于中枢神经系统监测
公开(公告)号：US07599735B2
公开(公告)日：2009-10-06
申请号：US11316374
申请日：2005-12-22
申请人： Hanna E. Viertiö-Oja , Timothy Sampson
发明人： Hanna E. Viertiö-Oja , Timothy Sampson
IPC分类号： A61B5/04
CPC分类号： A61B5/0478 , A61B5/0496 , A61B5/6814
摘要： The invention relates to a method for positioning electrodes in an electrode array comprising a plurality of electrodes for central nervous system (CNS) monitoring from the forehead of a subject. In order to enable efficient detection of eye movement artifacts with a minimum number of electrodes, first and second electrodes are positioned so that eye movement in one of the horizontal or vertical directions causes a negligible overall voltage change between the first and second electrodes and at least a third electrode is positioned so that eye movement in the other of said horizontal and vertical directions causes a high potential difference between the third electrode and an auxiliary electrode, wherein the auxiliary electrode is one of the electrodes in a set comprising one of the first and second electrodes and a fourth electrode. The first and second electrodes are arranged to record an EEG signal and the third electrode and the auxiliary electrode are arranged to record an EOG signal indicative of eye movements of the subject.
摘要翻译：本发明涉及一种用于将电极定位在电极阵列中的方法，所述电极阵列包括从对象的前额监测的用于中枢神经系统（CNS）的多个电极。为了能够以最小数量的电极有效地检测眼睛运动假象，第一和第二电极被定位成使得在水平或垂直方向之一上的眼睛运动导致第一和第二电极之间的总体电压变化可忽略，并且至少第三电极被定位成使得在所述水平和垂直方向中的另一个中的眼睛运动导致第三电极和辅助电极之间的高电位差，其中辅助电极是包括第一和第二电极之一中的电极之一，第二电极和第四电极。第一和第二电极被设置为记录EEG信号，并且第三电极和辅助电极被布置成记录指示对象的眼睛运动的EOG信号。

2. 发明授权

US07844324B2 Measurement of EEG reactivity 有权
标题翻译：测量脑电反应性
公开(公告)号：US07844324B2
公开(公告)日：2010-11-30
申请号：US11674732
申请日：2007-02-14
申请人： Mika Särkelä , Juha Virtanen , Hanna E. Viertiö-Oja , Tapani Salmi
发明人： Mika Särkelä , Juha Virtanen , Hanna E. Viertiö-Oja , Tapani Salmi
IPC分类号： A61B5/04
CPC分类号： A61B5/0484 , A61B5/7203 , A61B5/7221 , G06F19/00 , G16H10/60
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a valid signal model is constructed for an EEG signal obtained from the subject. A time reference corresponding to a stimulus is applied and further signal data is obtained from the time series, the further signal data being subsequent to the time reference. By employing the further signal data, the method tests whether the signal model remains to be a valid signal model for the EEG signal also after the stimulus, and indicates, based on the test, whether reactivity is present in the physiological signal.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动获得目标和可靠的反应性测量，并且没有经过训练的EEG专家的存在，为从受试者获得的EEG信号构建了有效的信号模型。施加对应于刺激的时间基准，并且从时间序列获得进一步的信号数据，其后的信号数据在时间基准之后。通过采用进一步的信号数据，该方法也在刺激之后测试信号模型是否仍然是用于EEG信号的有效信号模型，并且基于该测试指示生理信号中是否存在反应性。

3. 发明授权

US07783343B2 Monitoring of the cerebral state of a subject 有权
标题翻译：监测受试者的大脑状态
公开(公告)号：US07783343B2
公开(公告)日：2010-08-24
申请号：US11176944
申请日：2005-07-07
申请人： Mika Särkelä , Hanna E. Viertiö-Oja , Satu Jääskeläinen , Jaakko Långsjö , Anu Maksimow , Elina Salmi , Harry Scheinin
发明人： Mika Särkelä , Hanna E. Viertiö-Oja , Satu Jääskeläinen , Jaakko Långsjö , Anu Maksimow , Elina Salmi , Harry Scheinin
IPC分类号： A61B5/04
CPC分类号： A61B5/048
摘要： The invention relates to a method and apparatus for monitoring the cerebral state of a subject. At least one of a first and second parameters is derived from the physiological signal data obtained from the subject, wherein the first parameter is indicative of the sum of spectral values of the physiological signal data in a first frequency band lying above high frequency EEG activity and the second parameter is indicative of the relative magnitudes of a first sum of k-th order spectral values and a second sum of n-th order spectral values. The second sum is calculated over a frequency band lying above high frequency EEG activity (k>2 and n>1). A state index is then formed, which is dependent on the at least one parameter and indicative of the cerebral state of the subject. The first and second parameters may be used in the Bispectral Index (BIS™) algorithm.
摘要翻译：本发明涉及一种用于监测受试者的脑状态的方法和装置。第一参数和第二参数中的至少一个来源于从对象获得的生理信号数据，其中第一参数表示在高频EEG活动之上的第一频带中的生理信号数据的频谱值之和，以及第二参数表示第k个频谱值的第一个和的第n个和第n个频谱值之和的相对幅度。在高频EEG活动（k> 2和n> 1）以上的频带上计算第二和。然后形成状态指数，其依赖于至少一个参数并指示受试者的大脑状态。第一和第二参数可用于双谱指数（BIS TM）算法。

4. 发明授权

US08145297B2 Measurement of EEG reactivity 有权
标题翻译：测量脑电反应性
公开(公告)号：US08145297B2
公开(公告)日：2012-03-27
申请号：US11523789
申请日：2006-09-19
申请人： Hanna E. Viertiö-Oja , Mika Särkelä , Juha Virtanen , Tapani Salmi
发明人： Hanna E. Viertiö-Oja , Mika Särkelä , Juha Virtanen , Tapani Salmi
IPC分类号： A61B5/04
CPC分类号： A61B5/0484 , A61B5/4064
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a time reference corresponding to a stimulus is detected and the physiological signal data obtained from the subject is aligned with the time reference. Two sets of values are determined for a measure indicative of the amount of irregularity in the physiological signal data, both sets including at least one value of the said measure and having defined positions with respect to the time reference in time domain. Based on the two sets, the apparatus determines whether reactivity is present in the physiological signal data.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动地获得反应性的目的和可靠的测量，并且没有训练有素的脑电专家的存在，检测到对应于刺激的时间基准，并且从对象获得的生理信号数据与时间参考对准。对于表示生理信号数据中的不规则量的量度来确定两组值，两组都包括所述测量的至少一个值，并且相对于时域中的时间参考具有定义的位置。基于这两组，该装置确定生理信号数据中是否存在反应性。

5. 发明授权

US07725173B2 Measurement of responsiveness of a subject with lowered level of consciousness 有权
标题翻译：测量具有较低意识水平的受试者的反应性
公开(公告)号：US07725173B2
公开(公告)日：2010-05-25
申请号：US11211137
申请日：2005-08-24
申请人： Hanna E. Viertiö-Oja , Kimmo Uutela , Petteri Lapinlampi
发明人： Hanna E. Viertiö-Oja , Kimmo Uutela , Petteri Lapinlampi
IPC分类号： A61B5/04
CPC分类号： A61B5/4821 , A61B5/0484 , A61B5/0488 , A61B5/4839 , A61B5/7203
摘要： The invention relates to a method and apparatus for measuring the responsiveness of a subject with lowered level of consciousness. Physiological signal data is obtained from the subject and a first measure indicative of the level of consciousness of the subject is derived from the physiological signal data. In order to obtain an objective measure of the responsiveness of the subject and to improve the specificity of patient monitoring, a sequence of the first measure is recorded without inducing arousals in the subject and a second measure indicative of a responsiveness of the subject is determined based on the recorded sequence. The determination of the second measure may be independent of the unintentional stimuli that cause arousals in the patient or the stimuli causing such arousals in the clinical environment may be detected to find out their effect on the first measure.
摘要翻译：本发明涉及一种用于测量具有较低意识水平的受试者的反应性的方法和装置。从受检者获得生理信号数据，并且从生理信号数据导出指示受试者的意识水平的第一度量。为了获得对受试者的反应性的客观测量并提高患者监测的特异性，记录第一测量的顺序而不诱导受试者的觉醒，并且基于主体的响应性确定第二个度量记录序列。第二措施的确定可以独立于在患者中引起觉醒的无意刺激，或者可以检测到引起临床环境中的这种觉醒的刺激，以发现它们对第一测量的影响。

6. 发明授权

US07509161B2 Method and apparatus for determining the cerebral state of a patient using generalized spectral entropy of the EEG signal 有权
标题翻译：使用EEG信号的广泛频谱熵来确定患者的脑状态的方法和装置
公开(公告)号：US07509161B2
公开(公告)日：2009-03-24
申请号：US10967030
申请日：2004-10-15
申请人： Hanna E. Viertiö-Oja
发明人： Hanna E. Viertiö-Oja
IPC分类号： A61B5/04
CPC分类号： A61B5/048 , A61B5/7203 , A61B5/7257
摘要： A method and apparatus for ascertaining the cerebral state of a patient using generalized spectral entropy of the EEG signal.
摘要翻译：一种用于使用EEG信号的广泛频谱熵来确定患者的脑状态的方法和装置。

7. 发明授权

US06731975B1 Method and apparatus for determining the cerebral state of a patient with fast response 有权
标题翻译：用于确定具有快速反应的患者的大脑状态的方法和装置
公开(公告)号：US06731975B1
公开(公告)日：2004-05-04
申请号：US09688891
申请日：2000-10-16
申请人： Hanna E. Viertiö-Oja , Borje T. Rantala
发明人： Hanna E. Viertiö-Oja , Borje T. Rantala
IPC分类号： A61B504
CPC分类号： G06K9/00523 , A61B5/04014 , A61B5/0476 , A61B5/0488 , A61B5/16 , A61B5/4821 , A61B5/7203 , A61B5/7257 , A61B5/726
摘要： A method and apparatus for ascertaining the cerebral state of a patient. The method/apparatus may find use in ascertaining the depth of anesthesia of the patient. In one embodiment, the entropy of the patient's EEG signal data is determined as an indication of the cerebral state. A frequency domain power spectrum quantity is obtained from the patient's EMG signal data. The latter quantity can be updated more frequently than the EEG entropy due to its higher frequency. The EEG entropy indication and the EMG power spectrum indication can be combined into a composite indicator that provides an immediate indication of changes in the cerebral state of the patient. In another embodiment, the frequency range over which the entropy of the biopotential signal from the patient is determined is broadened to encompass both EEG signal data and EMG signal data and the entropy so determined used as an indication of the patient's cerebral state.
摘要翻译：一种用于确定患者的大脑状态的方法和装置。方法/装置可用于确定患者的麻醉深度。在一个实施例中，将患者的EEG信号数据的熵确定为脑状态的指示。从患者的EMG信号数据获得频域功率谱量。由于其较高的频率，后者的数量可以比EEG熵更频繁地更新。 EEG熵指示和EMG功率谱指示可以组合成复合指示器，其提供患者脑部状态变化的即时指示。在另一个实施例中，确定来自患者的生物电位信号的熵的频率范围被扩大以包括EEG信号数据和EMG信号数据以及被确定的用作患者脑状态的指示的熵。

8. 发明授权

US09398863B2 Detection of anomalies in measurement of level of hypnosis 有权
标题翻译：检测催眠水平测量异常
公开(公告)号：US09398863B2
公开(公告)日：2016-07-26
申请号：US11765627
申请日：2007-06-20
申请人： Hanna E. Viertiö-Oja
发明人： Hanna E. Viertiö-Oja
IPC分类号： A61B5/04 , A61B5/0476 , A61B5/00 , A61M5/172 , A61M16/00 , A61M16/18 , G06F19/00 , G09B23/28
CPC分类号： A61B5/0476 , A61B5/4035 , A61B5/4821 , A61M5/1723 , A61M16/0051 , A61M16/026 , A61M16/18 , A61M2205/3561 , A61M2205/3584 , A61M2205/502 , A61M2205/52 , A61M2230/04 , A61M2230/10 , A61M2230/30 , G06F19/00 , G06F19/3456 , G09B23/28 , G16H50/50
摘要： The invention relates to detection of anomalies related to a measurement of the hypnotic level of a subject. In order to detect when a measure indicative of the hypnotic level of a subject is anomalous either due to a medical reason or due to an interference, the measure is monitored and state information indicative of the activity of the autonomous nervous system of the subject and drug effect information indicative of the hypnotic drug effect in the subject are employed to check whether the measure fulfills a predetermined consistency condition requiring that the measure changes consistently with at least one of the drug effect information and the state information. An anomaly, indicative of an abnormal change in the measure, is detected when the measure fails to fulfill the predetermined consistency condition.
摘要翻译：本发明涉及检测与受试者的催眠水平的测量有关的异常。为了检测指示受试者的催眠水平的测量是否由于医疗原因或由于干扰而是异常的，则监测该测量并且指示受试者和药物的自主神经系统的活动的状态信息使用表示该受试者的催眠药效果的效果信息来检查该测量是否满足预定的一致性条件，要求该测量与药物效果信息和状态信息中的至少一个一致地变化。当测量不能满足预定的一致性条件时，检测到指示测量的异常变化的异常。

9. 发明授权

US08064993B2 Measurement of EEG reactivity 有权
标题翻译：测量脑电反应性
公开(公告)号：US08064993B2
公开(公告)日：2011-11-22
申请号：US11273574
申请日：2005-11-14
申请人： Hanna E. Viertiö-Oja , Mika Särkelä , Juha Virtanen , Tapani Salmi
发明人： Hanna E. Viertiö-Oja , Mika Särkelä , Juha Virtanen , Tapani Salmi
IPC分类号： A61B5/04 , A61B5/00
CPC分类号： A61B5/0484
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a time reference corresponding to a stimulus is detected and the physiological signal data obtained from the subject is aligned with the time reference. Two sets of values are determined for a measure indicative of the amount of irregularity in the physiological signal data, both sets including at least one value of the said measure and having defined positions with respect to the time reference in time domain. Based on the two sets, the apparatus determines whether reactivity is present in the physiological signal data.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动地获得反应性的目的和可靠的测量，并且没有训练有素的脑电专家的存在，检测到对应于刺激的时间基准，并且从对象获得的生理信号数据与时间参考对准。对于表示生理信号数据中的不规则量的量度来确定两组值，两组都包括所述测量的至少一个值，并且相对于时域中的时间参考具有定义的位置。基于这两组，该装置确定生理信号数据中是否存在反应性。

10. 发明申请

US20110087127A1 MEASUREMENT FOR EEG REACTIVITY 有权
标题翻译：测量脑电反应
公开(公告)号：US20110087127A1
公开(公告)日：2011-04-14
申请号：US12940143
申请日：2010-11-05
申请人： Mika Särkelä , Juha Virtanen , Hanna E. Viertiö-Oja , Tapani Salmi
发明人： Mika Särkelä , Juha Virtanen , Hanna E. Viertiö-Oja , Tapani Salmi
IPC分类号： A61B5/0476
CPC分类号： A61B5/0484 , A61B5/7203 , A61B5/7221 , G06F19/00 , G16H10/60
摘要： The invention relates to a method and apparatus for assessing the reactivity observable in a certain physiological signal, especially the EEG signal, of a comatose subject. In order to obtain an objective and a reliable measure of the reactivity automatically and without the presence of a trained EEG specialist, a valid signal model is constructed for an EEG signal obtained from the subject. A time reference corresponding to a stimulus is applied and further signal data is obtained from the time series, the further signal data being subsequent to the time reference. By employing the further signal data, the method tests whether the signal model remains to be a valid signal model for the EEG signal also after the stimulus, and indicates, based on the test, whether reactivity is present in the physiological signal.
摘要翻译：本发明涉及一种用于评估昏迷患者的特定生理信号，特别是EEG信号中可观察到的反应性的方法和装置。为了自动获得目标和可靠的反应性测量，并且没有经过训练的EEG专家的存在，为从受试者获得的EEG信号构建了有效的信号模型。施加对应于刺激的时间基准，并且从时间序列获得进一步的信号数据，其后的信号数据在时间基准之后。通过采用进一步的信号数据，该方法也在刺激之后测试信号模型是否仍然是用于EEG信号的有效信号模型，并且基于该测试指示生理信号中是否存在反应性。

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