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1. 发明授权

US5910506A Imidazole derivatives as anti-HIV agents 失效
标题翻译：咪唑衍生物作为抗HIV剂
公开(公告)号：US5910506A
公开(公告)日：1999-06-08
申请号：US809624
申请日：1997-05-30
申请人： Hirohiko Sugimoto , Tamio Fujiwara
发明人： Hirohiko Sugimoto , Tamio Fujiwara
IPC分类号： A61K31/4164 , A61K31/4178 , A61P31/18 , C07D233/54 , C07D233/58 , C07D233/60 , C07D233/64 , C07D233/84 , C07D401/04 , C07D401/06 , C07D409/04 , A01N43/50 , C07D233/28 , C07D233/40
CPC分类号： C07D233/56 , C07D233/64 , C07D233/84 , C07D401/04 , C07D401/06 , C07D409/04
摘要： An imidazole derivative represented by general formula (I) or a salt thereof, having the effect of specifically inhibiting the growth of HIV as a pathogenic virus and being reduced in toxicity. In said formula R.sup.1 represents hydrogen, C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.7 alkenyl, C.sub.4 -C.sub.12 cycloalkylalkyl, etc.; R.sup.2 represents C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 acyl, hydroxyiminomethyl, hydrazonomethyl or --(CH.sub.2)n--R.sup.4 (R.sup.4 being halogeno, alkoxy, hydroxy, etc.; and n being an integer of 1 to 3); R.sup.3 represents substituted or unsubstituted C.sub.1 -C.sub.6 alkyl; X and Y represent each independently hydrogen, C.sub.1 -C.sub.3 alkyl, halogeno, or nitro; and Z represents S, SO, SO.sub.2 or CH.sub.2. ##STR1##
摘要翻译： PCT No.PCT / JP95 / 01936 Sec。 371日期1997年5月30日 102（e）日期1997年5月30日PCT提交1995年9月25日PCT公布。 WO96 / 10019 PCT出版物日期：1996年5月4日由通式（I）表示的咪唑衍生物或其盐，具有特异性抑制作为致病病毒的HIV生长且毒性降低的作用。在所述式中，R 1表示氢，C 1 -C 20烷基，C 2 -C 7烯基，C 4 -C 12环烷基烷基等; R 2表示C 1 -C 6烷基，C 1 -C 6酰基，羟基亚氨基甲基，亚肼基甲基或 - （CH 2）n -R 4（R 4为卤代，烷氧基，羟基等; n为1至3的整数）。 R 3表示取代或未取代的C 1 -C 6烷基; X和Y各自独立地表示氢，C1-C3烷基，卤代或硝基; Z表示S，SO，SO 2或CH 2。

2. 发明授权

US4734303A Deep-draw-formed vessel and process for preparation thereof 失效
标题翻译：深拉制容器及其制备方法
公开(公告)号：US4734303A
公开(公告)日：1988-03-29
申请号：US886741
申请日：1986-07-18
申请人： Tamio Fujiwara , Kazumi Hirota , Hiroshi Matsubayashi , Tadahiko Katsura
发明人： Tamio Fujiwara , Kazumi Hirota , Hiroshi Matsubayashi , Tadahiko Katsura
IPC分类号： B32B15/08 , B65D1/28 , B65D6/14 , B27N5/02 , B21B45/00 , B21C37/00
CPC分类号： B65D1/28 , B32B15/08 , Y10S220/917 , Y10T428/12431 , Y10T428/12438 , Y10T428/1359
摘要： A deep-draw-formed vessel which is prepared by deep-draw-forming a laminate comprising a steel or iron foil and a plastic film formed on each surface of the steel or iron foil through a layer of an adhesive having an adhesive force of at least 600 g/15 mm of width and an elastic modulus of 50 to 10,000.A Kg/cm.sup.2 inorganic filler such as titanium dioxide is preferably incorporated in the plastic film so as to improve the deep-drawability.
摘要翻译：通过深层拉伸形成包含钢或铁箔的层压板和通过具有粘合力的粘合剂层在钢或铁箔的每个表面上形成的塑料膜制备的深拉成形容器宽度最小为600g / 15mm，弹性模量为50〜10,000。优选在塑料膜中加入Kg / cm2的无机填料如二氧化钛，以提高深冲性。

3. 发明授权

US4340672A Enzymatic synthesis of .beta.-lactam antibacterials 失效
标题翻译： β-内酰胺抗菌药物合成
公开(公告)号：US4340672A
公开(公告)日：1982-07-20
申请号：US188869
申请日：1980-09-19
申请人： Eiji Kondo , Takashi Mitsugi , Tamio Fujiwara , Ryonosuke Muneyuki
发明人： Eiji Kondo , Takashi Mitsugi , Tamio Fujiwara , Ryonosuke Muneyuki
IPC分类号： C12N1/20 , C07D333/24 , C07D499/12 , C07D501/06 , C12N9/80 , C12P35/04 , C12P37/04
CPC分类号： C12N9/80 , C07D333/24 , C12P35/04 , C12P37/04
摘要： Penicillins and cephalosporins can be synthesized by the action of an acylase on a penicillin or cephalosporin nucleus amine as substrate and an ester (I) of the following formula as the acyl source: ##STR1## (wherein RCO is an acyl group in penicillin or cephalosporin side chains;X is a hydrogen atom, lower alkyl group or hydroxy-lower alkyl group;Y is a hydrogen atom or a lower alkyl group; and n is a positive integer).The novel acyl source (I) is also disclosed.
摘要翻译：青霉素和头孢菌素可以通过酰基转移酶对青霉素或头孢菌素核胺作为底物和下式的酯（I）作为酰基来合成：其中RCO是酰基，青霉素或头孢菌素侧链; X为氢原子，低级烷基或羟基 - 低级烷基; Y为氢原子或低级烷基，n为正整数）。还公开了新的酰基源（I）。

4. 发明授权

US5652232A Benzolactam derivatives 失效
标题翻译：苯内酰胺衍生物
公开(公告)号：US5652232A
公开(公告)日：1997-07-29
申请号：US615286
申请日：1996-05-24
申请人： Koichi Shudo , Yasuyuki Endo , Tamio Fujiwara , Akihiko Sato
发明人： Koichi Shudo , Yasuyuki Endo , Tamio Fujiwara , Akihiko Sato
IPC分类号： C07D245/06 , A61K31/395
CPC分类号： C07D245/06
摘要： A benzolactam derivative represented by the following formula (I): ##STR1## wherein n represents an integer of from 1 to 3; R.sup.1 represents a straight- or branched-chain alkyl group or an aralkyl group; R.sup.2 represents a straight- or branched-chain alkyl group; R.sup.3 and R.sup.4 independently represent a hydrogen atom or a straight- or branched-chain alkyl group, and when R.sup.3 and R.sup.4 are adjacent each other on the phenyl group, they may be combined to form a cycloalkyl ring together with two carbon atoms of the phenyl group to which R.sup.3 and R.sup.4 bind, and said cycloalkyl ring may optionally have one or more substituents; and a anti-retroviral agent comprising the same as an active ingredient.
摘要翻译： PCT No.PCT / JP94 / 01561 Sec。 371日期：1996年5月24日 102（e）日期1996年5月24日PCT 1994年9月22日PCT公布。公开号WO95 / 09160 日期：1995年4月6日由下式（I）表示的苯并内酰胺衍生物：其中n表示1〜3的整数， R1表示直链或支链烷基或芳烷基; R2表示直链或支链烷基; R3和R4独立地表示氢原子或直链或支链烷基，当R3和R4在苯基上彼此相邻时，它们可以与苯基的两个碳原子一起形成环烷基环 R 3和R 4结合的基团，并且所述环烷基环可任选地具有一个或多个取代基; 和包含其作为活性成分的抗逆转录病毒剂。

5. 发明授权

US4686152A Packaging material comprising iron foil, and container and container lid composed thereof 失效
标题翻译：包含铁箔的包装材料，以及由其组成的容器和容器盖
公开(公告)号：US4686152A
公开(公告)日：1987-08-11
申请号：US799388
申请日：1985-11-18
申请人： Hiroshi Matsubayashi , Kazumi Hirota , Hisao Iwamoto , Tamio Fujiwara , Nobuyuki Sato , Tadahiko Katsura
发明人： Hiroshi Matsubayashi , Kazumi Hirota , Hisao Iwamoto , Tamio Fujiwara , Nobuyuki Sato , Tadahiko Katsura
IPC分类号： B32B15/08 , B65D1/28
CPC分类号： B32B15/08 , B65D1/28 , Y10S220/917 , Y10S428/925 , Y10T428/12438 , Y10T428/12569 , Y10T428/12722 , Y10T428/12854 , Y10T428/12937
摘要： Disclosed is a packaging material which comprises a laminate having an iron foil having a tensile strength (.sigma..sub.B) in the range represented by the following formula:100 kg/mm.sup.2 .gtoreq..sigma..sub.B .gtoreq.30 kg/mm.sup.2and a thickness (T) in the range represented by the following formula:120 .mu.m.gtoreq.T.gtoreq.15 .mu.mand being provided with a surface treatment layer containing metallic tin, metallic chromium or metallic nickel, and an organic resin covering having a total thickness (t) in the range represented by the following formula:T.sup.1/n C/.sigma..sub.B .gtoreq.t.gtoreq.3 .mu.mwherein n is 5.6 and C is 4630.A metal or pigment having an action of improving the processability, an anti-corrosive action and a hiding action is incorporated or contained in the organic resin coating layer. This packaging material is excellent in processability, corrosion resistance, storability, appearance characteristics and safety.
摘要翻译：公开了一种包装材料，其包括具有在下式表示的范围内的拉伸强度（σB）的铁箔的层压体：100kg / mm 2> / =σB> / = 30kg / mm 2，厚度（ T）在由下式表示的范围内：120μm/ = T> / =15μm，并且设置有包含金属锡，金属铬或金属镍的表面处理层和具有总共的金属铬的有机树脂覆盖物由下式表示的范围内的厚度（t）：T1 / nC / sigma B> / = t> / =3μm其中n为5.6，C为4630.具有改善加工性能的作用的金属或颜料，在有机树脂涂层中掺入或包含防腐蚀作用和隐藏作用。该包装材料的加工性，耐腐蚀性，保存性，外观特性和安全性优异。

6. 发明授权

US6083958A Anti-HIV composition containing imidazole derivative 失效
标题翻译：含有咪唑衍生物的抗HIV组合物
公开(公告)号：US6083958A
公开(公告)日：2000-07-04
申请号：US155655
申请日：1998-10-02
申请人： Tamio Fujiwara
发明人： Tamio Fujiwara
IPC分类号： A61K31/425 , A61K31/44 , A61K31/4439 , A61K31/47 , A61K31/505 , A61K31/66 , C07D401/06 , A61K31/415 , A61K31/445
CPC分类号： A61K31/47 , A61K31/4439 , A61K31/66 , A61K31/70 , C07D401/06
摘要： An anti-HIV composition comprising 2-carbamoyloxymethyl-5-(3,5-dichlorophenylthio)-4-isopropyl-1-(pyridin-4-yl)methyl-1H-imidazole or the pharmaceutical acceptable salt thereof and other one or more anti-HIV compounds is provided.
摘要翻译： PCT No.PCT / JP97 / 00812 Sec。 371日期：1998年10月2日 102（e）1998年10月2日PCT PCT 1997年3月14日PCT公布。公开号WO97 / 37657 日期1997年10月16日包含2-氨基甲酰氧基甲基-5-（3,5-二氯苯硫基）-4-异丙基-1-（吡啶-4-基）甲基-1H-咪唑或其药学上可接受的盐和提供了其它一种或多种抗HIV化合物。

7. 发明授权

US5876984A Sequiterpene derivatives having antiviral activity 失效
标题翻译：具有抗病毒活性的顺反萜衍生物
公开(公告)号：US5876984A
公开(公告)日：1999-03-02
申请号：US43449
申请日：1998-03-20
申请人： Toshiyuki Kamigauchi , Tamio Fujiwara , Hiroyoshi Tani , Yoshimi Kawamura , Isao Horibe
发明人： Toshiyuki Kamigauchi , Tamio Fujiwara , Hiroyoshi Tani , Yoshimi Kawamura , Isao Horibe
IPC分类号： C07D491/052 , C12P17/18 , A61K00/00 , C07D209/56 , C12P1/02 , C07D311/79
CPC分类号： C12P17/18 , C12P17/181
摘要： A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt, or a hydrate thereof, a process for preparing said compound, and a pharmaceutical composition having antiviral activity which comprise said compound.
摘要翻译： PCT No.PCT / JP96 / 02749第 371日期：1998年3月20日 102（e）1998年3月20日PCT PCT 1996年9月25日PCT公布。第WO97 / 11947号公报日期：1997年4月3日制备所述化合物的方法和含有所述化合物的抗病毒活性的药物组合物，式（I）化合物：其中R 1，R 2，

8. 发明授权

US5326780A Imidazole derivatives having anti-HIV activity 失效
标题翻译：具有抗HIV活性的咪唑衍生物
公开(公告)号：US5326780A
公开(公告)日：1994-07-05
申请号：US3126
申请日：1993-01-12
申请人： Hirohiko Sugimoto , Masaru Ogata , Hiroshi Matsumoto , Ken-ichi Sugita , Akihiko Sato , Tamio Fujiwara
发明人： Hirohiko Sugimoto , Masaru Ogata , Hiroshi Matsumoto , Ken-ichi Sugita , Akihiko Sato , Tamio Fujiwara
IPC分类号： A61K31/415 , A61K31/44 , A61K31/4427 , A61P31/12 , C07D233/54 , C07D233/60 , C07D233/64 , C07D233/70 , C07D233/80 , C07D233/84 , C07D233/86 , C07D233/90 , C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D233/66
CPC分类号： C07D233/56 , C07D233/64 , C07D233/80 , C07D233/84 , C07D233/86 , C07D233/90 , C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06
摘要： A novel imidazole derivatives of formula I: ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, or optionally substituted aryl; R.sup.2 is alkyl, optionally substituted aryl optionally substituted aralkyl, or optionally substituted hetero ring group; R.sup.3 is hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, or optionally substituted hydroxyalkyl; R.sup.4 is hydrogen, alkyl, halogen, acyl, optionally substituted hydroxyalkyl, optionally esterified or amidated carboxyl group, hydroxy group, aryl or arylthio; X is S, SO, SO.sub.2, CH.sub.2, or Se; n is an integer of 1 to 3, or a pharmaceutically acceptable salt thereof, said derivative having anti-HIV activity and being useful for the treatment of HIV infections.
摘要翻译：式I的新型咪唑衍生物：其中R 1是氢，烷基，卤素或任选取代的芳基; R 2是烷基，任选取代的芳基任选取代的芳烷基或任选取代的杂环基团; R 3是氢，烷基，任选取代的芳基，任选取代的芳烷基或任选取代的羟烷基; R 4为氢，烷基，卤素，酰基，任选取代的羟基烷基，任选酯化或酰胺化的羧基，羟基，芳基或芳硫基; X是S，SO，SO 2，CH 2或Se; n为1〜3的整数，或其药学上可接受的盐，所述衍生物具有抗HIV活性，可用于治疗HIV感染。

9. 发明授权

US4992636A Sealed container for microwave oven cooking 失效
标题翻译：用于微波炉烹饪的密封容器
公开(公告)号：US4992636A
公开(公告)日：1991-02-12
申请号：US368383
申请日：1989-06-05
申请人： Tsunehisa Namiki , Ikuo Sugiyama , Tamio Fujiwara , Kazuhisa Ishibashi , Isao Tanikawa , Muneki Yamada , Kyuichi Shibasaki
发明人： Tsunehisa Namiki , Ikuo Sugiyama , Tamio Fujiwara , Kazuhisa Ishibashi , Isao Tanikawa , Muneki Yamada , Kyuichi Shibasaki
IPC分类号： B29C65/74 , B65D77/20 , B65D81/34
CPC分类号： B65D81/3453 , B65D2581/344 , B65D2581/3445 , B65D2581/3477 , B65D2581/3479 , B65D2581/3483 , B65D2581/3494 , Y10S99/14
摘要： A container body is sealed by means of a lid made of a flexible sheet having an insulative property and an antenna made of an electrically conductive material which is laminated upon the lid. According to this construction, when the container body is exposed to microwaves within a microwave oven, microwave energy is concentrated at a position near the front end of the antenna and the microwave energy is converted into heat energy, whereby the lid is opened by means of the thus converted heat. The lid can thus be precisely partially melted so as to form an opening of a predeterminedly suitable size.

10. 发明授权

US4915289A Easily openable sealed container 失效
标题翻译：易开封密封容器
公开(公告)号：US4915289A
公开(公告)日：1990-04-10
申请号：US354315
申请日：1989-03-08
申请人： Yasushi Hatano , Tamio Fujiwara , Michio Watanabe , Hideo Kurashima , Kazuo Taira , Kazuma Kuse
发明人： Yasushi Hatano , Tamio Fujiwara , Michio Watanabe , Hideo Kurashima , Kazuo Taira , Kazuma Kuse
IPC分类号： B65D33/00 , B65D77/20 , B65D77/38
CPC分类号： B65D77/2032 , B65D2577/205 , B65D2577/2066
摘要： A container composed of a plurality of container materials the opposing parts of which are sealed by heat sealing, wherein at least an opening start part of the sealed portion is of a laminated structure consisting of the plurality of container materials and an intermediate material inserted therebetween. The intermediate material and one of the container materials are tightly sealed, and the intermediate material and another of the container materials are sealed easily peelably. The inside end edge of the easily peelable seal portion is positioned more toward the center of the container than the inside end edge of the tight seal portion. At an opening start position, the outside end edge of the easily peelable seal portion is positioned more toward the center of the container than the outside end edge of the tight seal portion, and the intermediate material is provided so as to jut outwwardly of a heat sealing flat portion of a container flange. The strength of peeling of this sealed container from its central side is high enough to withstand retorting or the like, and opening of the container from outside can be effected by hand accurately and stably.

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