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1. 发明授权

US08767264B2 Printing device and printing method 有权
标题翻译：印刷装置和印刷方式
公开(公告)号：US08767264B2
公开(公告)日：2014-07-01
申请号：US13428528
申请日：2012-03-23
申请人： Toshiaki Kakutani , Takuma Hayashi
发明人： Toshiaki Kakutani , Takuma Hayashi
IPC分类号： H04N1/40 , H04N1/405 , B41J2/205
CPC分类号： B41J2/07 , H04N1/4051
摘要： When dot data indicating whether or not a dot is formed on the basis of the gradation value for each pixel, dots belonging to a plurality of pixel groups having different printing conditions are printed in a common region in an overlapping manner, and the distribution of dots in the common region has a noise characteristic possessing a peak in the spatial frequency region on the high-frequency side. In a case where first and second pixels belonging to two pixel groups are proximal pixels in the common region in a predetermined gradation range in which probabilities k1 and k2 at which a dot is formed in the first and second pixels are such that k1
摘要翻译：当表示是否基于每个像素的灰度值形成点的点数据时，属于具有不同打印条件的多个像素组的点以重叠的方式打印在公共区域中，并且点的分布在公共区域具有在高频侧的空间频率区域具有峰值的噪声特性。在属于两个像素组的第一和第二像素是在预定灰度范围内的公共区域中的近像素的情况下，其中在第一和第二像素中形成点的概率k1和k2使得k1 <0.5和 k2 <0.5，两个近像素中的点的概率K被设定为接近k1·k2。

2. 发明授权

US06414218B1 Mouse model for rheumatoid arthritis 失效
标题翻译：类风湿关节炎的小鼠模型
公开(公告)号：US06414218B1
公开(公告)日：2002-07-02
申请号：US09483897
申请日：2000-01-18
申请人： Denise L. Faustman , Takuma Hayashi
发明人： Denise L. Faustman , Takuma Hayashi
IPC分类号： A01K6700
CPC分类号： G01N33/5082 , A01K67/027
摘要： Nonobese Diabetic Mice (NOD mice) that do not develop diabetes may be bred to produce F1 offspring that develop a condition that closely mimics rheumatoid arthritis (RA) in humans. The RA-like disease in the F1 mice, designated NOD-RA mice, is similar to human RA in clinical, radiological, histological and serological characteristics. The parents (F0) and their progeny (F1) are not diabetic and never develop hyperglycemia, and the parental mice (F0) do not themselves exhibit any symptoms of the RA-like condition that afflicts some of their progeny. The incidence, penetrance, gender domination, progression, and lifelong exacerbation of symptoms after pregnancy shown in the RA-like condition afflicting NOD-RA mice are all comparable to phenomena observed in the human disease. The NOD-RA mice provide a new spontaneous model of human RA that will be useful for studying rheumatoid arthritis and testing new drugs and reagents for treating or diagnosing the disease.
摘要翻译：不会发展为糖尿病的非肥胖糖尿病小鼠（NOD小鼠）可能繁殖，以产生F1后代，其发展出类似于人类类风湿性关节炎（RA）的病症。称为NOD-RA小鼠的F1小鼠中的RA样疾病在临床，放射学，组织学和血清学特征中类似于人RA。父母（F0）及其子代（F1）不是糖尿病，不会发生高血糖症，而父母小鼠（F0）本身并不表现出任何影响其某些后代的RA样症状。患有RAD样状况的妊娠后症状的发生率，外显率，性别统治，进展和终身恶化均与人类疾病中观察到的现象相当。 NOD-RA小鼠提供了人类RA的新型自发模型，其可用于研究类风湿性关节炎并测试用于治疗或诊断疾病的新药物和试剂。

3. 发明申请

US20110020792A1 DETECTION OF UTERINE LEIOMYOSARCOMA USING LMP2 失效
标题翻译：使用LMP2检测子宫内膜异位症
公开(公告)号：US20110020792A1
公开(公告)日：2011-01-27
申请号：US12095585
申请日：2006-11-30
申请人： Takuma Hayashi , Yukihiro Kobayashi , Kenji Sano , Akiko Horiuchi , Ikuo Konishi
发明人： Takuma Hayashi , Yukihiro Kobayashi , Kenji Sano , Akiko Horiuchi , Ikuo Konishi
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/53 , G01N33/574 , C07H21/00
CPC分类号： C12Q1/6886 , C12Q2600/112 , G01N33/57442 , G01N2333/4739
摘要： This invention provides a method for detecting the presence of uterine leiomyosarcoma using the transcription or expression level of LMP2 and/or cyclin E in uterine smooth muscle tissue as an indicator and a method for detecting uterine leiomyosarcoma using LMP2 and/or cyclin E as a marker.
摘要翻译：本发明提供了使用LMP2和/或细胞周期蛋白E在子宫平滑肌组织中的转录或表达水平作为指标检测子宫平滑肌肉瘤的存在的方法，以及使用LMP2和/或细胞周期蛋白E作为标记检测子宫平滑肌肉瘤的方法。

4. 发明授权

US06617171B2 Methods for diagnosing and treating autoimmune disease 失效
标题翻译：诊断和治疗自身免疫性疾病的方法
公开(公告)号：US06617171B2
公开(公告)日：2003-09-09
申请号：US09031629
申请日：1998-02-27
申请人： Denise L. Faustman , Takuma Hayashi
发明人： Denise L. Faustman , Takuma Hayashi
IPC分类号： G01N33566
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/4703 , C12N9/1205 , C12N9/6421 , C12Q1/37 , G01N33/564 , G01N2333/9121 , G01N2333/96425 , G01N2500/04 , G01N2800/042
摘要： The invention provides a method of detecting autoimmune disease in a mammal, comprising providing a biological sample from a mammal and detecting proteasome activity, wherein a reduction in proteasome activity from a basal state is indicative of autoimmune disease. In addition, the invention encompasses a method of treating an autoimmune disease in a mammal, comprising administering to a mammal suspected of suffering from an autoimmune disease an agent which restores NF&kgr;B activity in an amount and for a time sufficient to result in normal NF&kgr;B activity in the mammal.
摘要翻译：本发明提供一种检测哺乳动物自身免疫性疾病的方法，其包括从哺乳动物提供生物样品和检测蛋白酶体活性，其中来自基础状态的蛋白酶体活性的降低指示自身免疫性疾病。此外，本发明包括治疗哺乳动物自身免疫性疾病的方法，包括对怀疑患有自身免疫性疾病的哺乳动物施用足以导致NFκB活性正常的量的NFκB活性的药物哺乳动物。

5. 发明授权

US08367887B2 Normal-tension glaucoma model and method for evaluation of test substances by using same 失效
标题翻译：正常眼压青光眼模型及其使用方法
公开(公告)号：US08367887B2
公开(公告)日：2013-02-05
申请号：US12668838
申请日：2008-07-11
申请人： Takuma Hayashi , Yasuko Takahashi , Tomoko Yanagidaira , Shunichiro Taniguchi , Toshinori Murata
发明人： Takuma Hayashi , Yasuko Takahashi , Tomoko Yanagidaira , Shunichiro Taniguchi , Toshinori Murata
IPC分类号： G01N33/00 , A01K67/027 , A01K67/033
CPC分类号： G01N33/5088 , A01K67/0276 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/168
摘要： It is intended to provide a simple normal-tension glaucoma model capable of spontaneously, age-dependently and surly developing conditions similar to symptoms of normal-tension glaucoma which occurs more frequently in elder people, and a method of evaluating therapeutic effect on normal-tension glaucoma whereby a drug useful in treating and diagnosing can be conveniently screened by using the normal-tension glaucoma model. A normal-tension glaucoma model comprising a nonhuman mammal, which is deficient in a transcriptional regulator NF-κBp50 and thus spontaneously develops the normal-tension glaucoma symptom age-relatedly, an organ or a tissue thereof or cells collected from any of the same. A method of evaluating therapeutic effect on normal-tension glaucoma of a test substance which comprises administering or adding the test substance to the above-described nonhuman mammal, an organ or a tissue thereof or cells collected from any of the same, and measuring a morphological defect, cell count, pressure, the expression amount or activity strength of a protein, the expression amount of a nucleic acid and/or the activity strength of an antibody in the organ, tissue and/or cells as indication(s) for the evaluation.
摘要翻译：旨在提供一种能够自发地，年龄依赖性地和显着地发展类似于老年人更频繁发生的正常张力性青光眼症状的正常张力青光眼模型，以及评估对正常张力的治疗效果的方法通过使用正常张力性青光眼模型，可以容易地筛选可用于治疗和诊断的药物的青光眼。包含非转基因哺乳动物的正常张力性青光眼模型，其在转录调节因子NF-κBp50中是不足的，因此自发地发生与其相关的正常张力性青光眼症状年龄的器官或其组织或从任何相同。评价对被检物质的正常张力性青光眼的治疗效果的方法，其包括向所述非人类哺乳动物，器官或组织施用或添加测试物质或从其中任一种收集的细胞，并测量形态学缺陷，细胞计数，压力，蛋白质的表达量或活性强度，核酸的表达量和/或器官，组织和/或细胞中抗体的活性强度作为评价指标。

6. 发明申请

US20120242734A1 PRINTING DEVICE AND PRINTING METHOD 有权
标题翻译：打印设备和打印方法
公开(公告)号：US20120242734A1
公开(公告)日：2012-09-27
申请号：US13428528
申请日：2012-03-23
申请人： Toshiaki KAKUTANI , Takuma HAYASHI
发明人： Toshiaki KAKUTANI , Takuma HAYASHI
IPC分类号： B41J2/205
CPC分类号： B41J2/07 , H04N1/4051
摘要： When dot data indicating whether or not a dot is to be formed is formed on the basis of the gradation value for each pixel, dots belonging to a plurality of pixel groups having different printing conditions are printed in a common region in an overlapping manner, and the distribution of dots in the common region has a noise characteristic possessing a peak in the spatial frequency region on the high-frequency side. In a case where first and second pixels belonging to two pixel groups are proximal pixels in the common region in a predetermined gradation range in which probabilities k1 and k2 at which a dot is formed in the first and second pixels are such that k1
摘要翻译：当基于每个像素的灰度值形成指示是否形成点的点数据时，属于具有不同打印条件的多个像素组的点以重叠的方式打印在公共区域中，并且公共区域中的点的分布具有在高频侧的空间频率区域中具有峰值的噪声特性。在属于两个像素组的第一和第二像素是在预定灰度范围内的公共区域中的近像素的情况下，其中在第一和第二像素中形成点的概率k1和k2使得k1 <0.5和 k2 <0.5，两个近像素中的点的概率K被设定为接近k1·k2。

7. 发明授权

US08206896B2 Detection of uterine leiomyosarcoma using LMP2 失效
标题翻译：使用LMP2检测子宫平滑肌肉瘤
公开(公告)号：US08206896B2
公开(公告)日：2012-06-26
申请号：US12095585
申请日：2006-11-30
申请人： Takuma Hayashi , Yukihiro Kobayashi , Kenji Sano , Akiko Horiuchi , Ikuo Konishi
发明人： Takuma Hayashi , Yukihiro Kobayashi , Kenji Sano , Akiko Horiuchi , Ikuo Konishi
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , G01N33/57442 , G01N2333/4739
摘要： This invention provides a method for detecting the presence of uterine leiomyosarcoma using the transcription or expression level of LMP2 and/or cyclin E in uterine smooth muscle tissue as an indicator and a method for detecting uterine leiomyosarcoma using LMP2 and/or cyclin E as a marker.
摘要翻译：本发明提供了使用LMP2和/或细胞周期蛋白E在子宫平滑肌组织中的转录或表达水平作为指标检测子宫平滑肌肉瘤的存在的方法，以及使用LMP2和/或细胞周期蛋白E作为标记检测子宫平滑肌肉瘤的方法。

8. 发明申请

US20100259791A1 INK JET PRINTING APPARATUS AND PRINTING METHOD 审中-公开
标题翻译：喷墨打印设备和打印方法
公开(公告)号：US20100259791A1
公开(公告)日：2010-10-14
申请号：US12758378
申请日：2010-04-12
申请人： Takuma HAYASHI , Toshiaki KAKUTANI
发明人： Takuma HAYASHI , Toshiaki KAKUTANI
IPC分类号： H04N1/405
CPC分类号： H04N1/58 , H04N1/6052
摘要： Provided is an ink jet printing apparatus capable of printing halftone image data representing a halftone image including at least color components of cyan, magenta, and yellow, the ink jet printing apparatus including: an input unit which is used to input the halftone image data; a smoothing unit which creates smoothing image data by performing a smoothing process only on the yellow component in the halftone image data or performing a smoothing process having a smoothing degree relatively stronger than those of other color components on the yellow component; and a printing control unit which controls execution of a printing process on the basis of the smoothing image data.
摘要翻译：本发明提供一种喷墨打印设备，其能够打印表示至少包括青色，品红色和黄色的颜色分量的半色调图像的半色调图像数据，该喷墨打印设备包括：输入单元，用于输入半色调图像数据; 平滑单元，其通过仅对所述半色调图像数据中的黄色分量执行平滑处理，或者执行平滑处理，所述平滑处理具有与所述黄色分量上的其它颜色分量相比更强的平滑度; 以及打印控制单元，其基于平滑图像数据控制打印处理的执行。

9. 发明申请

US20050158302A1 Methods for diagnosing and treating autoimmune disease 审中-公开
标题翻译：诊断和治疗自身免疫性疾病的方法
公开(公告)号：US20050158302A1
公开(公告)日：2005-07-21
申请号：US10775487
申请日：2004-02-10
申请人： Denise Faustman , Takuma Hayashi
发明人： Denise Faustman , Takuma Hayashi
IPC分类号： A61K38/00 , A61K38/17 , A61K38/19 , A61K48/00 , A61P37/06 , C07K14/47 , C12N9/12 , C12N9/64 , C12Q1/37 , G01N33/564 , A61K39/395 , G01N33/53 , G01N33/567
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/4703 , C12N9/1205 , C12N9/6421 , C12Q1/37 , G01N33/564 , G01N2333/9121 , G01N2333/96425 , G01N2500/04 , G01N2800/042
摘要： The invention provides a method of activating NFκB activity in a mammal afflicted with an autoimmune disease in which a reduction in NFκB activity is observed, comprising administering to a mammal suffering from the autoimmune disease a therapeutically effective amount of a polypeptide which activates NFκB, so as to treat the autoimmune disease in the mammal.
摘要翻译：本发明提供了一种在患有自身免疫性疾病的哺乳动物中激活NFκB活性的方法，其中观察到NFκB活性降低，包括向患有自身免疫疾病的哺乳动物施用治疗有效量的激活NFkappaB的多肽，以便治疗哺乳动物的自身免疫性疾病。

10. 发明授权

US06773705B1 Methods for diagnosing and treating autoimmune disease 有权
标题翻译：诊断和治疗自身免疫性疾病的方法
公开(公告)号：US06773705B1
公开(公告)日：2004-08-10
申请号：US09258682
申请日：1999-02-26
申请人： Denise L. Faustman , Takuma Hayashi
发明人： Denise L. Faustman , Takuma Hayashi
IPC分类号： A61K3900
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/4703 , C12N9/1205 , C12N9/6421 , C12Q1/37 , G01N33/564 , G01N2333/9121 , G01N2333/96425 , G01N2500/04 , G01N2800/042
摘要： The invention provides a method of detecting autoimmune disease in a mammal, comprising providing a biological sample from a mammal and detecting proteasome activity, wherein a reduction in proteasome activity from a basal state is indicative of autoimmune disease. In addition, the invention encompasses a method of treating an autoimmune disease in a mammal, comprising administering to a mammal suspected of suffering from an autoimmune disease an agent which restores NF&kgr;B activity in an amount and for a time sufficient to result in normal NF&kgr;B activity in the mammal.
摘要翻译：本发明提供一种检测哺乳动物自身免疫性疾病的方法，其包括从哺乳动物提供生物样品和检测蛋白酶体活性，其中来自基础状态的蛋白酶体活性的降低指示自身免疫性疾病。此外，本发明包括治疗哺乳动物自身免疫性疾病的方法，包括对怀疑患有自身免疫性疾病的哺乳动物施用足以导致NFκB活性正常的量的NFκB活性的药物哺乳动物。

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