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1. 发明申请

US20110240247A1 METHOD FOR MANUFACTURING CLAD MATERIAL AND EQUIPMENT FOR MANUFACTURING THE SAME 有权
标题翻译：制造粘合材料的方法及其制造方法
公开(公告)号：US20110240247A1
公开(公告)日：2011-10-06
申请号：US13160966
申请日：2011-06-15
申请人： Masayuki Takada , Yasuhiro Nishioka , Tomohiro Nishimura , Kenji Tokuda , Toshiki Ueda , Makoto Morishita , Takashi Inaba , Akihiro Tsuruno , Yoshinori Kato , Fumihiro Koshigoe , Masaki Tanigawa , Naoki Sakashita , Kenji Harada , Jitsuto Shikata , Masanori Ikeda
发明人： Masayuki Takada , Yasuhiro Nishioka , Tomohiro Nishimura , Kenji Tokuda , Toshiki Ueda , Makoto Morishita , Takashi Inaba , Akihiro Tsuruno , Yoshinori Kato , Fumihiro Koshigoe , Masaki Tanigawa , Naoki Sakashita , Kenji Harada , Jitsuto Shikata , Masanori Ikeda
IPC分类号： B22D25/02
CPC分类号： B32B3/00 , B22D11/007 , B23K20/04 , B23K35/22 , B23K35/40 , B23K2101/16 , B32B15/016 , C22C21/00 , C22F1/04 , Y10T428/12736 , Y10T428/12764 , Y10T428/12993
摘要： Skin material of a clad material is composed of one or more layers, each layer of the skin materials is made of a metal different from the core material in their component compositions, and at least one layer of the skin material has a cast microstructure, when the skin material is superposed on either of one or both faces of the core material.
摘要翻译：包层材料的表皮材料由一层或多层组成，每层表层材料由其组分组成中不同于核心材料的金属制成，并且至少一层表层材料具有铸造微结构，当表皮材料叠合在芯材的一个或两个面上。

2. 发明授权

US07351825B2 Cyclopropane compounds and pharmaceutical use thereof 失效
标题翻译：环丙烷化合物及其药物用途
公开(公告)号：US07351825B2
公开(公告)日：2008-04-01
申请号：US11011773
申请日：2004-12-15
申请人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafumi Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
发明人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafumi Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
IPC分类号： C07D265/00 , C07D295/00 , C07D237/00 , C07D409/00 , C07D411/00 , C07D217/00 , C07D211/00 , C07D213/00 , C07D271/00 , C07D413/00 , C07D498/00 , C07D277/00 , C07D257/00 , C07D233/00 , C07D231/00 , C07D207/00 , C07D333/00 , C07D307/00 , C07D303/00 , C07D309/00 , C07D311/00
CPC分类号： C07C311/29 , C07C311/13 , C07C311/20 , C07C311/22 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07C2603/08 , C07C2603/18 , C07C2603/30 , C07D205/04 , C07D207/48 , C07D209/44 , C07D211/58 , C07D211/96 , C07D213/18 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/81 , C07D213/82 , C07D217/08 , C07D231/12 , C07D233/64 , C07D237/12 , C07D239/22 , C07D243/08 , C07D257/04 , C07D261/08 , C07D271/06 , C07D271/107 , C07D277/26 , C07D277/36 , C07D277/82 , C07D295/26 , C07D307/79 , C07D307/91 , C07D333/18 , C07D333/34 , C07D333/36 , C07D333/38 , C07D333/62 , C07D401/04 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30, etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有聚集蛋白聚糖蛋白聚糖酶抑制活性和MMP-13抑制活性的化合物，可用作骨关节炎，类风湿性关节炎等的治疗剂，更具体而言，可以使用式（1）的环丙烷化合物：其中R 1 是 - （CH 2）2 -X-（CH 2）n - SUP> 1等，其中m和n相同或不同，并且各自为0至6，X为单键等，而A 1为取代的C _{3-14个烃环基等; R 2和R 3相同或不同，并且各自为氢原子， - （CH 2）2 N 其中p和q为 - （CH 2）2 - - - - CH 2 - 相同或不同，并且各自为0至6，X 1为单键等，而A 2为任选取代的C 3-14烷基，烃环等; R 4是-CO 2 R 9等，其中R 9是氢原子等。 ; 和R 20和R 21相同或不同，各自为氢原子， - （CH 2 CH 2）m 12 其中m12和m12（其中m12和m12）相同或不同，各自为0至6，X 12为单键等，R 30为氢原子等; 或其前药或其药学上可接受的盐。}

3. 发明授权

US07244727B2 Fused bicyclic nitrogen-containing heterocycles 失效
标题翻译：稠合双环含氮杂环
公开(公告)号：US07244727B2
公开(公告)日：2007-07-17
申请号：US10720844
申请日：2003-11-21
申请人： Brian M. Fox , Noboru Furukawa , Xiaolin Hao , Kiyosei Iio , Takashi Inaba , Simon M. Jackson , Frank Kayser , Marc Labelle , Kexue Li , Takuya Matsui , Dustin L. McMinn , Nobuya Ogawa , Steven M. Rubenstein , Shoichi Sagawa , Kazuyuki Sugimoto , Masahiro Suzuki , Masahiro Tanaka , Guosen Ye , Atsuhito Yoshida , Jian Zhang
发明人： Brian M. Fox , Noboru Furukawa , Xiaolin Hao , Kiyosei Iio , Takashi Inaba , Simon M. Jackson , Frank Kayser , Marc Labelle , Kexue Li , Takuya Matsui , Dustin L. McMinn , Nobuya Ogawa , Steven M. Rubenstein , Shoichi Sagawa , Kazuyuki Sugimoto , Masahiro Suzuki , Masahiro Tanaka , Guosen Ye , Atsuhito Yoshida , Jian Zhang
IPC分类号： C07D498/04 , A61K31/542 , A61P3/04 , A61P3/08 , C07D491/04 , C07D495/04 , A61K31/538 , A61K31/519
CPC分类号： C07D491/04
摘要： Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the activity of proteins involved in lipid metabolism and cell proliferation.
摘要翻译：本文提供了可用于治疗或预防代谢和细胞增殖性疾病或病症的化合物，药物组合物和方法。特别地，本发明提供调节参与脂质代谢和细胞增殖的蛋白质的活性的化合物。

4. 发明授权

US06806276B2 2-oxoquinoline compounds and pharmaceutical uses thereof 失效
标题翻译： 2-氧代喹啉化合物及其药物用途
公开(公告)号：US06806276B2
公开(公告)日：2004-10-19
申请号：US10245861
申请日：2002-09-16
申请人： Takashi Inaba , Tetsudo Kaya , Hiroyuki Iwamura
发明人： Takashi Inaba , Tetsudo Kaya , Hiroyuki Iwamura
IPC分类号： A61K3147
CPC分类号： C07D215/227 , C07D215/54 , C07D401/12 , C07D405/12
摘要： A 2-oxoquinoline compound or its pharmaceutically acceptable salt of general formula [I]: (wherein each symbol in the formula is as determined in the description), and its pharmaceutical use. The compound [I] of the present invention and its pharmaceutically acceptable salts selectively act on cannabinoid receptors, particularly on peripheral type cannabinoid receptors, and have fewer side effects on the central nervous system, having great immunosuppressive action, anti-inflammatory action or antiallergic action. Therefore, these compounds are useful as cannabinoid receptors (particularly peripheral type cannabinoid receptors) modulator, immunosuppressants, anti-inflammatory agents, and antiallergic agents.
摘要翻译： 2-氧代喹啉化合物或其通式[I]的药学上可接受的盐：其中式中的每个符号如说明书中所确定）及其药物用途。本发明的化合物[I]及其药学上可接受的盐选择性地作用于大麻素受体，特别是对外周型大麻素受体，对中枢神经系统具有较少的副作用，具有很大的免疫抑制作用，抗炎作用或抗过敏作用。因此，这些化合物可用作大麻素受体（特别是外周型大麻素受体）调节剂，免疫抑制剂，抗炎剂和抗过敏剂。

5. 发明授权

US06509352B1 2-oxoquinoline compounds and medicinal uses thereof 失效
标题翻译： 2-氧代喹啉化合物及其药物用途
公开(公告)号：US06509352B1
公开(公告)日：2003-01-21
申请号：US09869895
申请日：2001-08-29
申请人： Takashi Inaba , Tetsudo Kaya , Hiroyuki Iwamura
发明人： Takashi Inaba , Tetsudo Kaya , Hiroyuki Iwamura
IPC分类号： A61K3147
CPC分类号： C07D215/227 , C07D215/54 , C07D401/12 , C07D405/12
摘要： A 2-oxoquinoline compound or its pharmaceutically acceptable salt of general formula [I]: (wherein each symbol in the formula is as determined in the description), and its pharmaceutical use. The compound [I] of the present invention and its pharmaceutically acceptable salts selectively act on cannabinoid receptors, particularly on peripheral type cannabinoid receptors, and have fewer side effects on the central nervous system, having great immunosuppressive action, anti-inflammatory action or antiallergic action. Therefore, these compounds are useful as cannabinoid receptors (particularly peripheral type cannabinoid receptors) modulator, immunosuppressants, anti-inflammatory agents, and antiallergic agents.
摘要翻译： 2-氧代喹啉化合物或其通式[I]的药学上可接受的盐：其中式中的每个符号如说明书中所确定）及其药物用途。本发明的化合物[I]及其药学上可接受的盐选择性地作用于大麻素受体，特别是对外周型大麻素受体，对中枢神经系统具有较少的副作用，具有很大的免疫抑制作用，抗炎作用或抗过敏作用。因此，这些化合物可用作大麻素受体（特别是外周型大麻素受体）调节剂，免疫抑制剂，抗炎剂和抗过敏剂。

6. 发明授权

US5245050A Derivatives of physiologically active substance ML-236B and process for production thereof 失效
标题翻译：生理活性物质ML-236B的衍生物及其生产方法
公开(公告)号：US5245050A
公开(公告)日：1993-09-14
申请号：US427085
申请日：1989-10-03
申请人： Akira Endo , Tadashi Toshioka , Isao Umezawa , Masayuki Yuasa , Takashi Inaba , Tsutomu Inoue
发明人： Akira Endo , Tadashi Toshioka , Isao Umezawa , Masayuki Yuasa , Takashi Inaba , Tsutomu Inoue
IPC分类号： A61K31/22 , A61K31/365 , A61K31/366 , A61P3/06 , C07C67/293 , C07C67/313 , C07C69/00 , C07C69/24 , C07D309/30
CPC分类号： C07C69/00 , C07D309/30 , C07C2103/00
摘要： A compound represented by the following general formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different, and represent a hydrogen or halogen, and ring-opened free acid, amides and salts thereof are provided. The present invention also provides a process for the production of the above-mentioned compound starting from the known compound ML-236B.
摘要翻译： PCT No.PCT / JP89 / 00201 Sec。 371日期：1989年10月3日 102（e）日期1989年10月3日PCT 1989年2月28日PCT PCT。出版物WO89 / 08094 日本9月8日，1989年由以下通式表示的化合物：其中R 1和R 2相同或不同，表示氢或卤素，并且提供开环游离酸，酰胺和盐。本发明还提供从已知化合物ML-236B开始制备上述化合物的方法。

7. 发明授权

US5216150A Derivatives of isoquinoline (and naphthalene) sulfonamides 失效
标题翻译：异喹啉（和萘）磺酰胺的衍生物
公开(公告)号：US5216150A
公开(公告)日：1993-06-01
申请号：US758808
申请日：1991-09-12
申请人： Hiroyoshi Hidaka , Tomohiko Ishikawa , Masatoshi Hagiwara , Tsutomu Inoue , Kenji Naitoh , Osamu Sakuma , Masayuki Yuasa , Tadashi Morita , Tadashi Toshioka , Isao Umezawa , Takashi Inaba
发明人： Hiroyoshi Hidaka , Tomohiko Ishikawa , Masatoshi Hagiwara , Tsutomu Inoue , Kenji Naitoh , Osamu Sakuma , Masayuki Yuasa , Tadashi Morita , Tadashi Toshioka , Isao Umezawa , Takashi Inaba
IPC分类号： C07C311/16 , C07D217/02 , C07D217/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10
CPC分类号： C07D401/12 , C07C311/16 , C07D217/02 , C07D217/10 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10
摘要： Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.
摘要翻译：具有血管平滑肌松弛活性的新型喹啉磺氨基衍生物以及血小板凝集抑制活性和对蛋白激酶A，肌球蛋白轻链激酶，蛋白激酶C和钙调蛋白依赖性蛋白激酶II的抑制活性，但几乎没有作用或心脏功能; 制备衍生物的方法和含有该衍生物的药物组合物。

8. 发明授权

US5059692A Novel compounds exhibiting a vasodilating activity and inhibitory activity for platelet aggregation 失效
标题翻译：新型化合物展示血小板聚集的血管活性和抑制活性
公开(公告)号：US5059692A
公开(公告)日：1991-10-22
申请号：US574730
申请日：1990-08-30
申请人： Hiroyoshi Hidaka , Tomohiko Ishikawa , Tsutomu Inoue , Masayuki Yuasa , Takashi Inaba , Kenji Naito , Osamu Sakuma , Tadashi Morita , Shinpei Kidokoro
发明人： Hiroyoshi Hidaka , Tomohiko Ishikawa , Tsutomu Inoue , Masayuki Yuasa , Takashi Inaba , Kenji Naito , Osamu Sakuma , Tadashi Morita , Shinpei Kidokoro
IPC分类号： C07D495/04 , C07D495/14
CPC分类号： C07D495/04 , C07D495/14
摘要： Novel compounds represented by the formula: ##STR1## wherein R.sub.1 represents an alkyl group having 1 to 3 carbon atoms, R.sub.2 represents an amino group or a group of formula ##STR2## in which R.sub.4 represents an alkyl group having 1 to 3 carbon atoms, R.sub.5 represents an alkyl group having 1 to 3 carbon atoms or may combine with R.sub.6 to form a five or six membered ring containing 4 to 5 carbon atoms, R.sub.6 represents a hydrogen atom or may combine with R.sub.5 to form a five or six membered ring containing 4 to 5 carbon atoms, R.sub.3 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms or a halogen atom, X represents a carbonyl group or a methylene group, Y represents a sulfur atom or a vinylene group and pharmaceutically acceptable salts thereof which exhibit a vasodilating activity and inhibitory activity for platelet aggregation. Thus, they are useful as therapeutic agents for treatment of angina pectoris, hypertension, throbosis and the like.

9. 发明授权

US5014552A Flow meter 失效
标题翻译：流量计
公开(公告)号：US5014552A
公开(公告)日：1991-05-14
申请号：US446375
申请日：1989-12-05
申请人： Shoji Kamiunten , Shigeru Aoshima , Takashi Tsumura , Kouichi Ochiai , Takashi Inaba
发明人： Shoji Kamiunten , Shigeru Aoshima , Takashi Tsumura , Kouichi Ochiai , Takashi Inaba
IPC分类号： G01F1/68 , G01F1/684
CPC分类号： G01F1/6842
摘要： A flow sensor comprising a flow passage, a rectifying element such as a plurality of screens or a honeycomb structure or both, arranged in the flow passage, a flow passage reducer for reducing the flow passage behind the rectifying element, and a thermal flow sensor, such as for example a micro bridge sensor, mounted at a location immediately behind the reducer. The above structure can largely reduce disturbance in flow to thereby enable highly accurate measurements of a wide range of flow without a low pass filter.

10. 发明授权

US08420011B2 Aluminum alloy plate and process for producing the same 有权
标题翻译：铝合金板及其制造方法
公开(公告)号：US08420011B2
公开(公告)日：2013-04-16
申请号：US11814124
申请日：2006-01-13
申请人： Makoto Morishita , Katsushi Matsumoto , Shigenobu Yasunaga , Takashi Inaba
发明人： Makoto Morishita , Katsushi Matsumoto , Shigenobu Yasunaga , Takashi Inaba
IPC分类号： C22C21/06 , C22F1/04
CPC分类号： B22D11/003 , B21B2003/001 , B22D11/0622 , B22D11/0682 , C22C21/06 , C22C21/08 , C22F1/047
摘要： The present invention provides an Al—Mg series alloy sheet of high-Mg with improved press formability and homogeneity which can be applied to automobile outer panels and inner panels. This is an Al—Mg series aluminum alloy sheet having 0.5 to 3 mm in thickness cast by twin-roll continuous casting and cold rolled, comprising over 8% but not more than 14% Mg, 1.0% or less Fe, and 0.5% or less Si with the remainder being Al and unavoidable impurities wherein the mean conductivity of the aluminum alloy sheet is in the range of at least 20 IACS % but less than 26 IACS %, the strength-ductility balance (tensile strength×total elongation) as a material property of the aluminum alloy sheet is 11000 (MPa %) or more, and the homogeneity and press formability of the sheet have been improved.
摘要翻译：本发明提供了可以应用于汽车外板和内板的具有改善的冲压成形性和均匀性的高Mg的Al-Mg系合金板。这是通过双辊连续铸造和冷轧铸造的厚度为0.5至3mm的Al-Mg系铝合金板，包含超过8％但不超过14％的Mg，1.0％或更少的Fe和0.5％或较少的Si，其余为Al和不可避免的杂质，其中铝合金板的平均导电率在至少20IACS％但小于26IACS％的范围内，强度 - 延展性平衡（拉伸强度×总伸长率）为铝合金板的材料特性为11000（MPa％）以上，片材的均匀性和冲压成形性提高。

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