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1. 发明申请

US20060183236A1 Spectroscopic analysis system and method 有权
标题翻译：光谱分析系统及方法
公开(公告)号：US20060183236A1
公开(公告)日：2006-08-17
申请号：US11404680
申请日：2006-04-14
申请人： Andrew Berlin , Christopher Gerth , Tac-Woong Koo
发明人： Andrew Berlin , Christopher Gerth , Tac-Woong Koo
IPC分类号： G01N33/00
CPC分类号： G01N21/65 , G01N21/658 , G01N2021/052 , G01N2021/653 , G01N2021/655 , Y10T436/143333
摘要： Spectroscopic analysis systems and methods for analyzing samples are disclosed. An analysis system may contain an electromagnetic radiation source to provide radiation, a spectroscopic analysis chamber to perform a coherent Raman spectroscopy (e.g., stimulated Raman or coherent anti-Stokes Raman spectroscopy), and a radiation detector to detect radiation based on the spectroscopy. The chamber may have a resonant cavity to contain a sample for analysis, at least one window to the cavity to transmit the first radiation into the cavity and to transmit a second radiation out, a plurality of reflectors affixed to a housing of the cavity to reflect radiation of a predetermined frequency, the plurality of reflectors separated by a distance that is sufficient to resonate the radiation. The spectroscopic analysis system may be coupled with a nucleic acid sequencing system to receive a single nucleic acid derivative in solution and identify the derivative to sequence the nucleic acid.
摘要翻译：公开了用于分析样品的光谱分析系统和方法。分析系统可以包含用于提供辐射的电磁辐射源，用于执行相干拉曼光谱（例如，受激拉曼或相干反斯托克斯拉曼光谱）的光谱分析室，以及基于光谱检测辐射的辐射检测器。腔室可以具有一个谐振腔，以容纳用于分析的样本，至少一个窗口，用于将腔室中的第一辐射传输到腔体中并将第二辐射透射出来，多个反射器固定到空腔的壳体以反射预定频率的辐射，多个反射器分开足以使辐射共振的距离。光谱分析系统可以与核酸测序系统结合以在溶液中接受单个核酸衍生物，并鉴定衍生物以对核酸进行排序。

2. 发明申请

US20060166243A1 Methods to increase nucleotide signals by raman scattering 审中-公开
标题翻译：通过拉曼散射增加核苷酸信号的方法
公开(公告)号：US20060166243A1
公开(公告)日：2006-07-27
申请号：US11329693
申请日：2006-01-10
申请人： Xing Su , Andrew Berlin , Selena Chan , Steven Kirch , Tac-Woong Koo , Gabi Neubauer , Valluri Rao , Narayanan Sundararajan , Mineo Yamakawa
发明人： Xing Su , Andrew Berlin , Selena Chan , Steven Kirch , Tac-Woong Koo , Gabi Neubauer , Valluri Rao , Narayanan Sundararajan , Mineo Yamakawa
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6869 , C12Q2565/632 , C12Q2563/155 , C12Q2521/319
摘要： The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman labels before incorporation into a nucleic acid. In other embodiments, unlabeled nucleic acids are used. Exonuclease treatment of the nucleic acid results in the release of labeled or unlabeled nucleotides that are detected by Raman spectroscopy. In alternative embodiments of the invention, nucleotides released from a nucleic acid by exonuclease treatment are covalently cross-linked to nanoparticles and detected by surface enhanced Raman spectroscopy (SERS), surface enhanced resonance Raman spectroscopy (SERRS) and/or coherent anti-Stokes Raman spectroscopy (CARS). Other embodiments of the invention concern apparatus for nucleic acid sequencing.
摘要翻译：本文公开的方法和装置涉及通过增强拉曼光谱进行的核酸测序。在本发明的某些实施方案中，在掺入核酸之前，核苷酸与拉曼标记物共价连接。在其它实施方案中，使用未标记的核酸。核酸外切核酸处理导致通过拉曼光谱法检测的标记或未标记的核苷酸的释放。在本发明的替代实施方案中，通过外切核酸酶处理从核酸释放的核苷酸与纳米颗粒共价交联，并通过表面增强拉曼光谱（SERS），表面增强共振拉曼光谱（SERRS）和/或相干反斯托克斯拉曼光谱学（CARS）。本发明的其它实施方案涉及用于核酸测序的装置。

3. 发明授权

US07238477B2 Methods to increase nucleotide signals by Raman scattering 有权
标题翻译：通过拉曼散射增加核苷酸信号的方法
公开(公告)号：US07238477B2
公开(公告)日：2007-07-03
申请号：US10660902
申请日：2003-09-12
申请人： Xing Su , Andrew A. Berlin , Selena Chan , Steven J. Kirch , Tac-Woong Koo , Gabi Neubauer , Valluri Rao , Narayanan Sundararajan , Mineo Yamakawa
发明人： Xing Su , Andrew A. Berlin , Selena Chan , Steven J. Kirch , Tac-Woong Koo , Gabi Neubauer , Valluri Rao , Narayanan Sundararajan , Mineo Yamakawa
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , G01N21/63
CPC分类号： C12Q1/6869 , C12Q2565/632 , C12Q2563/155 , C12Q2521/319
摘要： The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman labels before incorporation into a nucleic acid. In other embodiments, unlabeled nucleic acids are used. Exonuclease treatment of the nucleic acid results in the release of labeled or unlabeled nucleotides that are detected by Raman spectroscopy. In alternative embodiments of the invention, nucleotides released from a nucleic acid by exonuclease treatment are covalently cross-linked to nanoparticles and detected by surface enhanced Raman spectroscopy (SERS), surface enhanced resonance Raman spectroscopy (SERRS) and/or coherent anti-Stokes Raman spectroscopy (CARS). Other embodiments of the invention concern apparatus for nucleic acid sequencing.
摘要翻译：本文公开的方法和装置涉及通过增强拉曼光谱进行的核酸测序。在本发明的某些实施方案中，在掺入核酸之前，核苷酸与拉曼标记物共价连接。在其它实施方案中，使用未标记的核酸。核酸外切核酸处理导致通过拉曼光谱法检测的标记或未标记的核苷酸的释放。在本发明的替代实施方案中，通过外切核酸酶处理从核酸释放的核苷酸与纳米颗粒共价交联，并通过表面增强拉曼光谱（SERS），表面增强共振拉曼光谱（SERRS）和/或相干反斯托克斯拉曼光谱学（CARS）。本发明的其它实施方案涉及用于核酸测序的装置。

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