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1. 发明公开

US20230324664A1 Spinning disk microscope device with potentially enhanced image resolution 审中-公开
公开(公告)号：US20230324664A1
公开(公告)日：2023-10-12
申请号：US18132307
申请日：2023-04-07
申请人： Till I.D. GmbH
发明人： Christian Seebacher , Rainer Uhl
IPC分类号： G02B21/08 , G01N21/64 , G02B21/16 , G02B27/14
CPC分类号： G02B21/08 , G01N21/6458 , G02B21/16 , G02B27/141 , G01N2021/6463
摘要： Disclosed herein is a device for enabling observation of a fluorescent sample with a microscope, the device including a disk-shaped body rotatable around a central axis of the disk-shaped body, including microoptical elements or microlenses for spot-generation, and, optionally, microoptical elements or microlenses for condensing emission-spots and enabling super resolution imaging of the sample. The device may further include additional pinholes for spatial filtering of the emission light, but not affecting the excitation light.

2. 发明公开

US20230168479A1 METHOD FOR ACCELERATED MICROSCOPY OF LARGE SAMPLES 审中-公开
公开(公告)号：US20230168479A1
公开(公告)日：2023-06-01
申请号：US17922375
申请日：2021-04-27
申请人： Till I.D. GmbH
发明人： Christian SEEBACHER , Andreas DEEG , Rainer UHL
IPC分类号： G02B21/00
CPC分类号： G02B21/0036 , G02B21/0032 , G02B21/008
摘要： A method for acquiring microscope-images of sample being larger than a field of view of a microscope, the method comprising creating a continuous relative movement between a sample and the microscope, wherein the optical axis of a microscope objective is substantially perpendicular to the vector of the relative movement, illuminating a part of the sample through the microscope objective, wherein the illuminated part of the sample is smaller than the field of view and forms an illumination slit, moving the illumination slit in a scanning direction across the field of view, and detecting light from the sample collected by the microscope objective, wherein the sample is moved in the same direction as the scanning direction or in a direction perpendicular to the scanning direction while the illumination slit is moved across the field of view.

3. 发明授权

US10520713B2 System for confocal illumination of a sample 有权
公开(公告)号：US10520713B2
公开(公告)日：2019-12-31
申请号：US15227069
申请日：2016-08-03
申请人： Till I.D. GmbH
发明人： Rainer Uhl
IPC分类号： G02B21/00 , G02B21/16 , G01N21/64
摘要： A system for confocal observation of a sample, having a mask, which is arranged in both an illumination beam path and in an image beam path and which is rotatable around a central axis, openings arranged in a pinhole plane, an arrangement of focusing micro-optics aligned with the geometric arrangement of the openings of the mask to generate a focal pattern, and an optical assembly with an objective, and which is configured to image the focal pattern onto the sample for generating an illumination pattern moving across the sample and to collect light from the sample by the objective and to image it onto the openings of the mask for confocal filtering. The focal plane and pinhole plane are separated by a distance and the optical assembly has a path length difference compensation arrangement which is selective with regard to the illumination light and the light collected from the sample.

4. 发明授权

US09606345B2 Microscope device 有权
公开(公告)号：US09606345B2
公开(公告)日：2017-03-28
申请号：US14346906
申请日：2012-09-28
申请人： FEI Company , TILL I.D. GMBH
发明人： Rainer Uhl , Martin Schropp
IPC分类号： G02B21/00 , G02B21/06 , G02B21/14 , G02B21/36 , G02B27/58 , G01N21/64
CPC分类号： G02B21/06 , G01N21/6458 , G02B21/0032 , G02B21/14 , G02B21/367 , G02B27/58
摘要： A microscope has an objective, a light source illuminating a sample over an illumination beam path, an arrangement producing a flat illumination pattern which is structured in both spatial directions on the sample, a surface detector detecting light coming over one picture beam path, an arrangement shifting the illumination pattern on the sample in one displacement direction, and a control unit taking one picture at a time of the light which was detected by the detector as phase picture in different positions of the pattern along the displacement direction and to computationally reconstruct from these phase pictures an overall picture of the illuminated sample region. The displacement direction is oblique to the main axes of symmetry of the illumination pattern and depending on the illumination pattern is chosen such that the number of phase pictures which is necessary for the picture reconstruction corresponds to the theoretically minimally required value.

5. 发明公开

US20240264421A1 METHOD AND DEVICE FOR GENERATING MICROSCOPIC LAYER IMAGES OF 3-DIMENSIONAL FLUORESCENT OBJECTS 审中-公开
公开(公告)号：US20240264421A1
公开(公告)日：2024-08-08
申请号：US18435028
申请日：2024-02-07
申请人： TILL I.D. GmbH
发明人： Rainer UHL , Martin SCHROPP
IPC分类号： G01N21/64 , G06T11/60
CPC分类号： G02B21/0076 , G02B21/367 , G06T5/50 , G01N21/6458 , G01N21/6486 , G06T2207/10056 , G06T2207/10064 , G06T2207/20221 , G06T2207/20224
摘要： The invention relates to a method and a device for generating microscopic layer images of 3-dimensional fluorescent objects, the layer images being largely freed from interference signals from other planes. A first region of a sample is subject to a regular illumination pattern formed by a plurality of light islands, with spacing such that the excitation intensity outside the island regions approaches zero. The emission signal emitted by the sample is detected to generate a raw image of the region. The raw image being subject to interpolation of first interference signals from regions outside the illumination islands. Generating a 2-dimensional interference signal map from the interpolated interference signals; and, generating an emission image, freed from interference signals, of the object by subtracting the 2-dimensional interference signal map from the detected emission signal.

6. 发明授权

US12055701B1 Method and device for generating microscopic layer images of 3-dimensional fluorescent objects 有权
公开(公告)号：US12055701B1
公开(公告)日：2024-08-06
申请号：US18435028
申请日：2024-02-07
申请人： TILL I.D. GmbH
发明人： Rainer Uhl , Martin Schropp
IPC分类号： G02B21/36 , G02B21/00 , G06T5/50 , G01N21/64
CPC分类号： G02B21/0076 , G02B21/367 , G06T5/50 , G01N21/6458 , G01N21/6486 , G06T2207/10056 , G06T2207/10064 , G06T2207/20221 , G06T2207/20224
摘要： The invention relates to a method and a device for generating microscopic layer images of 3-dimensional fluorescent objects, the layer images being largely freed from interference signals from other planes. A first region of a sample is subject to a regular illumination pattern formed by a plurality of light islands, with spacing such that the excitation intensity outside the island regions approaches zero. The emission signal emitted by the sample is detected to generate a raw image of the region. The raw image being subject to interpolation of first interference signals from regions outside the illumination islands. Generating a 2-dimensional interference signal map from the interpolated interference signals; and, generating an emission image, freed from interference signals, of the object by subtracting the 2-dimensional interference signal map from the detected emission signal.

7. 发明申请

US20170038573A1 SYSTEM FOR CONFOCAL ILLUMINATION OF A SAMPLE 审中-公开
标题翻译：一个样品的共焦照明系统
公开(公告)号：US20170038573A1
公开(公告)日：2017-02-09
申请号：US15227069
申请日：2016-08-03
申请人： Till I.D. GmbH
发明人： Rainer Uhl
IPC分类号： G02B21/00 , G02B21/16
摘要： A system for confocal observation of a sample, having a mask, which is arranged in both an illumination beam path and in an image beam path and which is rotatable around a central axis, openings arranged in a pinhole plane, an arrangement of focusing micro-optics aligned with the geometric arrangement of the openings of the mask to generate a focal pattern, and an optical assembly with an objective, and which is configured to image the focal pattern onto the sample for generating an illumination pattern moving across the sample and to collect light from the sample by the objective and to image it onto the openings of the mask for confocal filtering. The focal plane and pinhole plane are separated by a distance and the optical assembly has a path length difference compensation arrangement which is selective with regard to the illumination light and the light collected from the sample.
摘要翻译：一种用于共焦观察样品的系统，具有掩模，其布置在照明光束路径和图像光束路径中并且可围绕中心轴线旋转，布置在针孔平面中的开口，光学元件与掩模的开口的几何布置对准以产生焦点图案，以及具有物镜的光学组件，其被配置为将焦点图案成像到样品上，以产生移动穿过样品的照射图案并收集通过目标从样品的光，并将其成像到掩模的开口上以进行共聚焦滤光。焦平面和针孔平面被分开一段距离，并且光学组件具有路径长度差补偿装置，其对照明光和从样品收集的光是选择性的。

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