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1. 发明授权

US5480971A Peralkylated oligopeptide mixtures 失效
标题翻译：过烷基化寡肽混合物
公开(公告)号：US5480971A
公开(公告)日：1996-01-02
申请号：US257782
申请日：1994-06-09
申请人： Richard A. Houghten , John M. Ostresh , Sylvie Blondelle
发明人： Richard A. Houghten , John M. Ostresh , Sylvie Blondelle
IPC分类号： C07K1/04 , C07K1/12 , C12Q1/18 , C07K7/06 , A61K38/00
CPC分类号： C07K1/04 , C07K1/12 , C12Q1/18
摘要： Linear C.sub.1 -C.sub.7 -alkyl peralkylated oligopeptide sets of molecules are specific peralkylated oligopeptides, disclosed, as are their methods of synthesis and use in acceptor binding assays. Each molecule or chain of a set contains the same number of two to about ten substituted C.sub.1 -C.sub.7 -alkyl peralkylated amino acid residues, and the member chains of a set are present in equimolar amounts. The chains of a set contain one or more predetermined peralkylated amino acid residues at one or more predetermined positions of the peralkylated oligopeptide chain. The set contains equimolar amounts of at least six different peralkylated amino acid residues at one or more of the same predetermined positions of the peralkylated oligopeptide chain. Libraries of such sets, processes for their use and solid support-linked peralkylated sets are also contemplated, as are specific permethylated oligopeptides such as those having 5-8 phenylalanine residues that have antimicrobial properties.
摘要翻译：线性C 1 -C 7烷基全烷基化寡肽组分子是特异性全烷基化寡肽，其公开在合成和在受体结合测定中使用的方法。一组的每个分子或链含有相同数量的两个至约十个取代的C 1 -C 7烷基全烷基化氨基酸残基，并且一组的成员链以等摩尔量存在。一组的链在全烷基化寡肽链的一个或多个预定位置含有一个或多个预定的全烷基化氨基酸残基。该组在全烷基化寡肽链的一个或多个相同的预定位置含有等摩尔量的至少六个不同的烷基化氨基酸残基。还考虑了这些组的文库，其使用方法和固体支持物连接的全烷基化组，特定的二甲基化寡肽如具有5-8个具有抗微生物性质的苯丙氨酸残基的寡肽。

2. 发明授权

US06251854B1 N-methyl-d-aspartate receptor channel blockers and method for identifying such 失效
标题翻译： N-甲基-D-天冬氨酸受体通道阻断剂及其鉴定方法
公开(公告)号：US06251854B1
公开(公告)日：2001-06-26
申请号：US09381434
申请日：1999-12-06
申请人： Mauricio Montal , Antonio Ferrer-Montiel , Jaime Merino , Sylvie Blondelle , Richard Houghten
发明人： Mauricio Montal , Antonio Ferrer-Montiel , Jaime Merino , Sylvie Blondelle , Richard Houghten
IPC分类号： A61K3800
CPC分类号： C07D487/04 , A61K31/4188 , A61K38/08 , C07K5/06095 , C07K5/0817 , C07K7/06
摘要： Compounds that provide protection against excitotoxic neuronal damage are selected from the group consisting of Arg-rich oligopeptides and compounds of formula 1: where R1 is alkyl, alkenyl, or hydroxyalkyl, aminoalkyl, or alkoxy-alkyl; and R2 and R3 are each natural or artificial amino acid side chains.
摘要翻译：提供针对兴奋性毒性神经元损伤的保护的化合物选自富含Arg的寡肽和式1的化合物：其中R 1是烷基，烯基或羟烷基，氨基烷基或烷氧基 - 烷基; R2和R3各自为天然或人造氨基酸侧链。

3. 发明授权

US5645996A Melittin-related polypeptides, mixture sets and libraries thereof 失效
标题翻译：蜂毒肽相关多肽，混合物组及其文库
公开(公告)号：US5645996A
公开(公告)日：1997-07-08
申请号：US295086
申请日：1994-08-24
申请人： Sylvie Blondelle , Richard A. Houghten , Enrique Perez-Paya
发明人： Sylvie Blondelle , Richard A. Houghten , Enrique Perez-Paya
IPC分类号： C07K14/435 , G01N33/53
CPC分类号： C07K14/43572 , Y10S436/807 , Y10S436/815
摘要： Sets and libraries of sets of polypeptides that are related in sequence to melittin are disclosed that have antimicrobial, hemolytic and hydrolyrically catalytic activities, as are processes for making and using the same. A contemplated set is a mixture of equimolar amounts of a polypeptide of SEQ ID NO:2, and more preferably SEQ ID NO:3.
摘要翻译：公开了与蜂毒肽序列相关的多肽组和文库，其具有抗微生物，溶血和水解催化活性，以及制备和使用它们的方法。预期的组是等摩尔量的SEQ ID NO：2的多肽，更优选SEQ ID NO：3的混合物。

4. 发明授权

US5582997A Lysine/leucine polypeptides, mixture sets and libraries thereof 失效
标题翻译：赖氨酸/亮氨酸多肽，混合物组及其文库
公开(公告)号：US5582997A
公开(公告)日：1996-12-10
申请号：US295085
申请日：1994-08-24
申请人： Sylvie Blondelle , Richard A. Houghten , Enrique Perez-Paya
发明人： Sylvie Blondelle , Richard A. Houghten , Enrique Perez-Paya
IPC分类号： C07K7/08 , G01N33/68 , G01N33/53 , G01N33/531
CPC分类号： G01N33/68 , C07K7/08
摘要： Polypeptides, sets and libraries of sets of polypeptides that are related in sequence to the polypeptide of SEQ ID NO:1 are disclosed that have antimicrobial, hemolytic and hydrolytically catalytic activities, as are processes for making and using the same. A contemplated set is a mixture of equimolar amounts of a polypeptide of SEQ ID NO:2. Particularly preferred polypeptides include those of SEQ ID NOs:3-9.
摘要翻译：公开了具有抗菌，溶血和水解催化活性的与SEQ ID NO：1的多肽序列相关的多肽多肽，组和多组文库，以及制备和使用它们的方法。预期的组是等摩尔量的SEQ ID NO：2的多肽的混合物。特别优选的多肽包括SEQ ID NO：3-9的多肽。

5. 发明授权

US5294605A Amphiphilic peptide compositions and analogues thereof 失效
标题翻译：两亲肽组合物及其类似物
公开(公告)号：US5294605A
公开(公告)日：1994-03-15
申请号：US725331
申请日：1991-07-08
申请人： Richard A. Houghten , Sylvie Blondelle
发明人： Richard A. Houghten , Sylvie Blondelle
IPC分类号： A61K38/00 , C07K7/08 , C07K14/46 , A61K37/02 , C07K7/10
CPC分类号： C07K14/46 , C07K7/08 , A61K38/00
摘要： A process for inhibiting growth of a target cell comprising administering to a host or to a target cell or virus a biologically active peptide which includes one of the following basic structures; R.sub.1 -R.sub.1 -R.sub.2 -R.sub.1 -R.sub.1 -R.sub.2 -R.sub.2 -R.sub.1 -R.sub.1 -R.sub.2 -R.sub.2 -R.sub.1 -R.sub.2 -R.sub.2 ; R.sub.2 -R.sub.1 -R.sub.1 -R.sub.2 -R.sub.2 -R.sub.1 -R.sub.2 -R.sub.2 -R.sub.1 -R.sub.1 -R.sub.2 -R.sub.2 -R.sub.1 -R.sub.1 ; or R.sub.1 -R.sub.2 -R.sub.1 -R.sub.1 -R.sub.2 -R.sub.2 -R.sub.1 -R.sub.1 -R.sub.2 -R.sub.2 -R.sub.1 -R.sub.2 -R.sub.2 -R.sub.1 -R.sub.1 -R.sub.2 -R.sub.2 -R.sub.1, wherein R.sub.1 is a hydrophobic amino acid, and R.sub.2 is a basic hydrophilic or neutral hydrophilic amino acid. A preferred peptide is of the structural formula:(SEQ ID NO:3).Substitution and deletion analogues of this peptide can be prepared that have increased biological activity. Such peptides can be employed as pharmaceuticals.
摘要翻译：一种抑制靶细胞生长的方法，包括向宿主或靶细胞或病毒施用包括以下基本结构之一的生物活性肽; R1-R1-R2-R1-R1-R2-R2-R1-R1-R2-R2-R1-R2-R2; R2-R1-R1-R2-R2-R1-R2-R2-R1-R1-R2-R2-R1-R1; 或R1-R2-R1-R1-R2-R2-R1-R1-R2-R2-R1-R2-R2-R1-R1-R2-R2-R1，其中R1是疏水性氨基酸，R2是碱性亲水或中性亲水氨基酸。优选的肽具有以下结构式：（SEQ ID NO：3）。可以制备具有增加的生物活性的该肽的取代和缺失类似物。这样的肽可以用作药物。

6. 发明授权

US5814470A Melittin-related polypeptides, mixture sets and libraries thereof 失效
标题翻译：蜂毒肽相关多肽，混合物组及其文库
公开(公告)号：US5814470A
公开(公告)日：1998-09-29
申请号：US888562
申请日：1997-07-07
申请人： Sylvie Blondelle , Richard A. Houghten , Enrique Perez-Paya
发明人： Sylvie Blondelle , Richard A. Houghten , Enrique Perez-Paya
IPC分类号： C07K14/435 , G01N33/53
CPC分类号： C07K14/43572 , Y10S436/807 , Y10S436/815
摘要： Sets and libraries of sets of polypeptides that are related in sequence to melittin are disclosed that have antimicrobial, hemolytic and hydrolytically catalytic activities, as are processes for making and using the same. A contemplated set is a mixture of equimolar amounts of a polypeptide of SEQ ID NO:2, and more preferably SEQ ID NO:3.
摘要翻译：公开了与蜂毒肽序列相关的多肽组和文库，其具有抗微生物，溶血和水解催化活性，以及制备和使用它们的方法。预期的组是等摩尔量的SEQ ID NO：2的多肽，更优选SEQ ID NO：3的混合物。

7. 发明授权

US5763193A Peralkylated oligopeptide mixtures 失效
标题翻译：过烷基化寡肽混合物
公开(公告)号：US5763193A
公开(公告)日：1998-06-09
申请号：US577846
申请日：1995-12-22
申请人： Richard A. Houghten , John M. Ostresh , Sylvie Blondelle
发明人： Richard A. Houghten , John M. Ostresh , Sylvie Blondelle
IPC分类号： C07K1/04 , C07K1/12 , C12Q1/18 , G01N33/53
CPC分类号： C07K1/04 , C07K1/12 , C12Q1/18
摘要： Linear C.sub.1 -C.sub.7 -alkyl peralkylated oligopeptide sets of molecules are disclosed, as are their methods of synthesis and use in acceptor binding assays. Each molecule or chain of a set contains the same number of two to about ten substituted C.sub.1 -C.sub.7 -alkyl peralkylated amino acid residues, and the member chains of a set are present in equimolar amounts. The chains of a set contain one or more predetermined peralkylated amino acid residues at one or more predetermined positions of the peralkylated oligopeptide chain. The set contains equimolar amounts of at least six different peralkylated amino acid residues at one or more of the same predetermined positions of the peralkylated oligopeptide chain. Libraries of such sets, processes for their use and solid support-linked peralkylated sets are also contemplated, as are specific permethylated oligopeptides.
摘要翻译：公开了线性C 1 -C 7烷基全烷基化寡肽组分子，以及其在受体结合测定中的合成和使用方法。一组的每个分子或链含有相同数量的两个至约十个取代的C 1 -C 7烷基全烷基化氨基酸残基，并且一组的成员链以等摩尔量存在。一组的链在全烷基化寡肽链的一个或多个预定位置含有一个或多个预定的全烷基化氨基酸残基。该组在全烷基化寡肽链的一个或多个相同的预定位置含有等摩尔量的至少六个不同的烷基化氨基酸残基。这些组的文库，它们的使用方法和固体支持物连接的烷基化组也被考虑，特定的甲基化寡肽也是如此。

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