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1. 发明授权

US07390293B2 Modification of properties and geometry of heart tissue to influence function 失效
标题翻译：改变心脏组织的性质和几何形状来影响功能
公开(公告)号：US07390293B2
公开(公告)日：2008-06-24
申请号：US10770266
申请日：2004-02-02
申请人： Swaminathan Jayaraman
发明人： Swaminathan Jayaraman
IPC分类号： A61F2/00
CPC分类号： A61F2/2481 , A61B17/00234 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B17/12186 , A61B17/1219 , A61B2017/00044 , A61B2017/00243 , A61F2/02 , A61L27/222 , A61L27/227 , A61L27/24 , A61L27/50 , A61L27/52 , A61L27/56 , A61L31/14 , A61L31/16 , A61L2300/258 , A61L2300/412 , A61M2210/125
摘要： Materials, devices and methods for the treatment of congestive heart failure are disclosed. In these methods, the volume of the left ventricle is reduced, thereby increasing the efficiency of the pumping action of the heart. Volume reduction is accomplished by introduction of biocompatible materials into the wall of the left ventricle, or into the ventricle itself. Also disclosed is a method for ventricular geometry reduction wherein flexible, elastic bands are attached to the external surface of the heart to affect a decrease in the volume of the left ventricle. Other disclosed devices include catheters and elastic bands that are usable in these treatments. Finally, disclosed is a device having an anchor disposed proximate the heart's apex, a plurality of petals, and a tensioning band secured to at least one of the petals.
摘要翻译：公开了用于治疗充血性心力衰竭的材料，装置和方法。在这些方法中，左心室的体积减小，从而提高心脏的泵送作用的效率。通过将生物相容性材料引入左心室壁或者进入心室来实现体积减少。还公开了一种心室几何减少的方法，其中柔性弹性带附接到心脏的外表面以影响左心室体积的减小。其他公开的装置包括可用于这些处理的导管和弹性带。最后，公开了一种装置，其具有靠近心脏的顶点布置的锚固件，多个瓣膜和固定到至少一个瓣瓣的张紧带。

2. 发明申请

US20070239199A1 Inferior vena cava filter 审中-公开
标题翻译：下腔静脉滤器
公开(公告)号：US20070239199A1
公开(公告)日：2007-10-11
申请号：US11394661
申请日：2006-03-31
申请人： Swaminathan Jayaraman
发明人： Swaminathan Jayaraman
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2002/016 , A61F2230/0006 , A61F2230/005 , A61F2230/0076 , A61F2230/0078 , A61F2230/0091 , A61F2230/0093 , A61F2250/0039 , A61M25/04
摘要： The present invention relates to a vascular filter including a coiled wire formed of a shape memory material for implantation into a vessel. The vascular filter captures particulates within the blood flow in the vessel, without substantially interfering with the normal blood flow. Prior to implantation, the coiled wire is generally elongated and thereafter it reverts to a predetermined shape that is suitable for filtering the blood flow. The predetermined shape of the vascular filter includes a plurality of loops coaxially disposed about a longitudinal axis and has a conical portion and a cylindrical portion.
摘要翻译：本发明涉及一种血管过滤器，其包括由用于注入血管的形状记忆材料形成的盘绕线。血管过滤器捕获血管内血液中的微粒，而不会基本上干扰正常的血流。在植入之前，螺旋线通常是细长的，之后它回复到适合于过滤血流的预定形状。血管过滤器的预定形状包括围绕纵向轴线同轴设置的多个环，并且具有圆锥形部分和圆柱形部分。

3. 发明申请

US20050187564A1 Occlusive coil manufacturing and delivery 审中-公开
标题翻译：闭塞线圈制造和交付
公开(公告)号：US20050187564A1
公开(公告)日：2005-08-25
申请号：US11084946
申请日：2005-03-21
申请人： Swaminathan Jayaraman
发明人： Swaminathan Jayaraman
IPC分类号： A61B17/00 , A61B17/12 , A61B17/10
CPC分类号： A61B17/12145 , A61B17/12022 , A61B17/12109 , A61B17/12172 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/12054 , A61B2017/12095
摘要： The present invention includes a coiled wire formed of a shape memory material for implantation into an anatomical defect. After implantation of one or more of the coiled wires according to the present invention, the defect is occluded and thereby corrected or treated. Prior to implantation, the coiled wire is generally elongated and thereafter it reverts to a predetermined shape that is suitable for occluding the defect. At least one clip having at least two prongs may be provided on the wire for attachment to body tissue. Preferably the wire is made of nickel-titanium. In an alternative embodiment, the coil includes a plurality of layers. At least one of these layers is formed of a shape memory material.
摘要翻译：本发明包括由用于植入解剖缺陷的形状记忆材料形成的盘绕线。在植入根据本发明的一个或多个线圈之后，缺陷被封闭，从而被校正或处理。在植入之前，螺旋线通常是细长的，之后其回复到适合于阻塞缺陷的预定形状。具有至少两个尖头的至少一个夹子可以设置在线上以附着到身体组织。优选地，导线由镍钛制成。在替代实施例中，线圈包括多个层。这些层中的至少一个由形状记忆材料形成。

4. 发明授权

US06790218B2 Occlusive coil manufacture and delivery 失效
标题翻译：闭塞线圈制造和交付
公开(公告)号：US06790218B2
公开(公告)日：2004-09-14
申请号：US09739830
申请日：2000-12-20
申请人： Swaminathan Jayaraman
发明人： Swaminathan Jayaraman
IPC分类号： A61M2900
CPC分类号： A61B17/12022 , A61B17/0057 , A61B17/12109 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B17/12177 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61B2017/00867 , A61B2017/12095
摘要： The present invention includes a coiled wire formed of a shape memory material for implantation into an anatomical defect. After implantation of one or more of the coiled wires according to the present invention, the defect is occluded and thereby corrected or treated. Prior to implantation, the coiled wire is generally elongated and thereafter it reverts to a predetermined shape that is suitable for occluding the defect. At least one clip having at least two prongs may be provided on the wire for attachment to body tissue. Preferably the wire is made of nickel-titanium. In an alternative embodiment, the coil includes a plurality of layers. At least one of these layers is formed of a shape memory material.
摘要翻译：本发明包括由用于植入解剖缺陷的形状记忆材料形成的盘绕线。在植入根据本发明的一个或多个线圈之后，缺陷被封闭，从而被校正或处理。在植入之前，螺旋线通常是细长的，之后其回复到适合于阻塞缺陷的预定形状。具有至少两个尖头的至少一个夹子可以设置在线上以附着到身体组织。优选地，导线由镍钛制成。在替代实施例中，线圈包括多个层。这些层中的至少一个由形状记忆材料形成。

5. 发明授权

US06685627B2 Modification of properties and geometry of heart tissue to influence heart function 有权
标题翻译：改变心脏组织的性质和几何形状来影响心脏功能
公开(公告)号：US06685627B2
公开(公告)日：2004-02-03
申请号：US09988293
申请日：2001-11-19
申请人： Swaminathan Jayaraman
发明人： Swaminathan Jayaraman
IPC分类号： A61F200
CPC分类号： A61F2/2481 , A61B17/00234 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B17/12186 , A61B17/1219 , A61B2017/00044 , A61B2017/00243 , A61F2/02 , A61L27/222 , A61L27/227 , A61L27/24 , A61L27/50 , A61L27/52 , A61L27/56 , A61L31/14 , A61L31/16 , A61L2300/258 , A61L2300/412 , A61M2210/125
摘要： Materials, devices and methods for the treatment of congestive heart failure are disclosed. In these methods, the volume of the left ventricle is reduced, thereby increasing the efficiency of the pumping action of the heart. Volume reduction is accomplished by introduction of biocompatible materials into the wall of the left ventricle, or into the ventricle itself. Suitable biocompatible materials include those that undergo a phase transition within the ventricle or within the wall of the ventricle, and are thereby converted from a substantially liquid state to a substantially solid state. Such materials also include those which increase in volume during the transition from the liquid state to the solid state. Also disclosed is a method for ventricular geometry reduction wherein flexible, elastic bands are attached to the external surface of the heart to effect a decrease in the volume of the left ventricle. Finally, disclosed are devices including catheters and elastic bands that are usable in these treatments.
摘要翻译：公开了用于治疗充血性心力衰竭的材料，装置和方法。在这些方法中，左心室的体积减小，从而提高心脏的泵送作用的效率。通过将生物相容性材料引入左心室壁或者进入心室来实现体积减少。合适的生物相容性材料包括在心室内或心室壁内经历相变的那些，从而从基本上液态转变为基本上固态。这种材料还包括在从液体状态转变为固态过程中体积增加的材料。还公开了一种心室几何减少的方法，其中柔性弹性带附接到心脏的外表面以实现左心室体积的减小。最后，公开了可用于这些处理的装置，包括导管和弹性带。

6. 发明授权

US06360749B1 Modification of properties and geometry of heart tissue to influence heart function 有权
公开(公告)号：US06360749B1
公开(公告)日：2002-03-26
申请号：US09414708
申请日：1999-10-08
申请人： Swaminathan Jayaraman
发明人： Swaminathan Jayaraman
IPC分类号： A61B1900
CPC分类号： A61L27/222 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B17/12186 , A61B17/1219 , A61B2017/00044 , A61B2017/00243 , A61F2/2481 , A61L27/227 , A61L27/24 , A61L27/50 , A61L27/52 , A61L27/56 , A61L31/14 , A61L31/16 , A61L2300/258 , A61L2300/412 , A61L2430/20 , A61M2210/125
摘要： Materials, devices and methods for the treatment of congestive heart failure are disclosed. In these methods, the volume of the left ventricle is reduced, thereby increasing the efficiency of the pumping action of the heart. Volume reduction is accomplished by introduction of biocompatible materials into the wall of the left ventricle, or into the ventricle itself. Suitable biocompatible materials include those that undergo a phase transition within the ventricle or within the wall of the ventricle, and are thereby converted from a substantially liquid state to a substantially solid state. Such materials also include those which increase in volume during the transition from the liquid state to the solid state. Also disclosed is a method for ventricular geometry reduction wherein flexible, elastic bands are attached to the external surface of the heart to effect a decrease in the volume of the left ventricle. Finally, disclosed are devices including catheters and elastic bands that are usable in these treatments.

7. 发明授权

US06312406B1 Delivery mechanism for balloons, drugs, stents and other physical/mechanical agents and method of use 失效
标题翻译：气球，药物，支架等物理/机械剂的运送机制及使用方法
公开(公告)号：US06312406B1
公开(公告)日：2001-11-06
申请号：US09305138
申请日：1999-05-04
申请人： Swaminathan Jayaraman
发明人： Swaminathan Jayaraman
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M2025/0177 , A61M2025/0183 , A61M2029/025
摘要： A balloon catheter for use with a guidewire is disclosed. The catheter has a body with a balloon located thereon, preferably at the distal end. A lumen within the catheter body communicates with the interior of the balloon which can be inflated by known methods with saline solution. A series of sleeve members of predetermined lengths and sizes are coupled to and positioned along the length of the catheter body. One or more of the sleeve members can span the length of the balloon. Each sleeve member has a passageway and both an exit and entry port so that the guidewire can pass therethrough. Instead of a balloon, the catheter can include a device member that forms a chamber which can store medicine until discharged at the desired site within the blood vessel. Apertures or pores on the catheter body allow for the perfusion of blood or the delivery of medicine to the site of the blood vessel. A method of operation is also disclosed.
摘要翻译：公开了一种与导丝一起使用的球囊导管。导管具有位于其上的球囊，优选在远端。导管体内的内腔与球囊的内部连通，可以通过已知方法用盐水溶液充气。具有预定长度和尺寸的一系列套筒构件联接到导管主体的长度并沿其布置。一个或多个套筒构件可以跨越气球的长度。每个套筒构件具有通道和出口和入口两者，使得导丝可以穿过其中。代替气球，导管可以包括形成室的装置构件，其可以存储药物，直到在血管内的期望位置排出。导管体上的孔或孔允许血液灌注或将药物输送到血管部位。还公开了一种操作方法。

8. 发明授权

US5893887A Stent for positioning at junction of bifurcated blood vessel and method of making 失效
标题翻译：用于在分叉血管交界处定位的支架和制造方法
公开(公告)号：US5893887A
公开(公告)日：1999-04-13
申请号：US949549
申请日：1997-10-14
申请人： Swaminathan Jayaraman
发明人： Swaminathan Jayaraman
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2/954 , A61F2002/065 , A61F2002/828 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2230/0008
摘要： A stent has a generally cylindrical shape having a series of slots or other surface discontinuities facilitating adherence to the inner walls of a blood vessel. In one embodiment, one end of the stent has a terminus that is tapered at a non-orthogonal angle with respect to the axis of elongation of the stent. In other embodiments, both ends are angled non-orthogonally with respect to the longitudinal axis of the stent. The particular angle that each end surface of the stent makes with the longitudinal axis of the stent may be varied, in each case, to accommodate to bifurcated blood vessels of varying sizes, shapes and configurations. Use of stents in accordance with the teachings of the present invention precludes wall portions of a stent from protruding into a passage of a blood vessel in a manner that would cause restricted flow through the blood vessel. The method of making the stent in accordance with the teachings of the present invention is also disclosed.
摘要翻译：支架具有大致圆柱形形状，其具有一系列狭槽或其它表面不连续性，有助于粘附于血管的内壁。在一个实施例中，支架的一端具有相对于支架的伸长轴线以非正交角度渐缩的终点。在其他实施例中，两端相对于支架的纵向轴线非正交成角度。支架的每个端表面与支架的纵向轴线形成的特定角度可以在每种情况下变化，以适应不同尺寸，形状和构造的分叉血管。根据本发明的教导使用支架排除支架的壁部分以会导致限制流经血管的方式突出到血管的通道中。还公开了根据本发明的教导制造支架的方法。

9. 发明申请

US20220175392A1 OCCLUDING ANATOMICAL STRUCTURES 有权
公开(公告)号：US20220175392A1
公开(公告)日：2022-06-09
申请号：US17677316
申请日：2022-02-22
申请人： Swaminathan JAYARAMAN
发明人： Swaminathan JAYARAMAN
IPC分类号： A61B17/12
摘要： An elongate resilient tube of a mesh of shape memory alloy is used to therapeutically occlude an opening in body tissue. The tube is compressible so that it can be delivered to the opening in the body within a catheter. The tube self-expands as it is released from the catheter to contiguously form, sequentially an outer perimeter structure and an inner perimeter structure disposed within the outer perimeter structure to conformingly engage an inner side of the outer perimeter structure, a plate shaped structure, and a flexible connector between them. J-shaped hooks extend from the perimeter structure to flexibly engage tissue of the body opening without piercing the tissue.

10. 发明授权

US11179545B2 System and method for delivery of therapeutic agent through a catheter 有权
公开(公告)号：US11179545B2
公开(公告)日：2021-11-23
申请号：US15767188
申请日：2016-10-12
申请人： Swaminathan Jayaraman
发明人： Swaminathan Jayaraman
IPC分类号： A61M25/00 , A61M5/20 , A61M5/00 , A61M5/158 , A61M5/145 , A61M5/315 , A61B17/34 , A61B17/00
摘要： A system and method for delivering a therapeutic agent such as filler materials, biocompatible gels, and other substances through a catheter. The therapeutic agent can be a single component or multiple components that are delivered separately or mixed just prior to delivery or at the delivery site. The system and method use an automated delivery mechanism to maximize delivery of the therapeutic agent to the target tissue and minimize loss of the therapeutic agent within the catheter. The system and method are particularly useful for interventional approaches that deliver therapeutic agents to the wall of the heart.

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