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    • 2. 发明授权
    • Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering
    • 生物可吸收袋,含有组织工程不同生物吸收率的生物可吸收材料
    • US06656488B2
    • 2003-12-02
    • US09832700
    • 2001-04-11
    • Chin-Feng YiAnna GosiewskaSusan Roweton
    • Chin-Feng YiAnna GosiewskaSusan Roweton
    • A61F200
    • A61L27/52A61L27/58
    • A device for tissue engineering is formed of a porous bioabsorbable bag containing at least two bioabsorbable materials having different rates of bioabsorption such as beads of different degrading rates and a bioabsorbable binding gel such as fibrin that binds the bioabsorbable materials in relation to each other. Slow degrading beads and the bag may be made of a copolymer of poly(L-lactide) and poly(glycolide), and fast degrading beads may be made of gelatin. The bag may contain cells and/or wound healing stimulants such as growth factors. Hydrolyzing enzymes may be used to enhance biodegradation of polymers. The device can be used to promote in-growth of host tissue into a void by inserting the bag with its contents into the void and conforming the bag to a desired shape. The binding gel may be injected into the bag after being placed in the void .
    • 用于组织工程的装置由含有至少两种具有不同生物吸收速率的生物可吸收材料(例如不同降解率的珠子)和生物可吸收结合凝胶(例如纤维蛋白)的多孔生物可吸收袋形成,其结合生物可吸收材料相互之间。 缓慢降解的珠和袋可以由聚(L-丙交酯)和聚(乙交酯)的共聚物制成,并且快速降解的珠可以由明胶制成。 袋子可以含有细胞和/或伤口愈合兴奋剂如生长因子。 水解酶可用于增强聚合物的生物降解。 该装置可用于通过将其内含物插入到空隙中并将袋符合到期望的形状来促进宿主组织的生长成为空隙。 结合凝胶在放入空隙后可以注入袋中。