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1. 发明授权

US06417349B1 Water-soluble extract of asiaticoside and madecassoside from Centella asiatica and isolating method thereof 失效
标题翻译：积雪草苷和积雪草苷的水溶性提取物及其分离方法
公开(公告)号：US06417349B1
公开(公告)日：2002-07-09
申请号：US08957958
申请日：1997-10-27
申请人： Kweon Kim , Seung-Yong Lee , Sung-Ki Seo , Byeong-Ryong Hwang , Jin-Kyu Park
发明人： Kweon Kim , Seung-Yong Lee , Sung-Ki Seo , Byeong-Ryong Hwang , Jin-Kyu Park
IPC分类号： C07H100
CPC分类号： C07H13/08
摘要： A water-soluble extract of asiaticoside and madecassoside from Centella asiatica and an isolating method thereof. In the isolating method an aqueous alcohol containing Centella asiatica is subjected to cold-precipitation to obtain an extract. The extract in the aqueous alcohol is treated with a halogenide solvent for layer separation, and then the aqueous layer is extracted with a higher alcohol. The extract in the alcohol layer is washed first with sodium hydroxide and then with water. After being concentrated, the extract is crystallized with ethyl acetate to obtain crystals and the crystals are washed. A method for treating liver cells in a mammal includes administering to a mammal an effective amount of the extract from Centella asiatica containing asiaticoside and madecassoside.
摘要翻译：积雪草苷和积雪草积雪草苷的水溶性提取物及其分离方法。在分离方法中，将含有积雪草积分的含水醇进行冷沉淀以获得提取物。含水醇中的提取物用卤化物溶剂处理层分离，然后用高级醇萃取水层。酒精层中的提取物首先用氢氧化钠洗涤，然后用水洗涤。浓缩后，萃取液用乙酸乙酯结晶，得到结晶，洗涤结晶。用于治疗哺乳动物肝细胞的方法包括给予哺乳动物有效量的积雪草积雪草提取物和积雪草苷。

2. 发明申请

US20070246768A1 Nonvolatile memory device and method of fabricating the same 审中-公开
标题翻译：非易失性存储器件及其制造方法
公开(公告)号：US20070246768A1
公开(公告)日：2007-10-25
申请号：US11653592
申请日：2007-01-16
申请人： Kyong-min Kim , Byoung-dong Kim , Sung-ki Seo
发明人： Kyong-min Kim , Byoung-dong Kim , Sung-ki Seo
IPC分类号： H01L21/8247 , H01L29/788
CPC分类号： H01L29/7883 , H01L29/40114 , H01L29/42324 , H01L29/513
摘要： A nonvolatile memory device and a method of fabricating the same are disclosed. The method includes forming a tunnel oxide film and a conductive film for a floating gate on a semiconductor substrate; nitriding the top surface of the conductive film for a floating gate; oxidizing the nitrided top surface of the conductive film for a floating gate that is nitrided, forming an ONO film comprising a lower oxide film, a nitride film and an upper oxide film sequentially laminated on the surface-modified conductive film for a floating gate to complete formation of the dielectric film; and forming the conductive film for a control gate on the dielectric film.
摘要翻译：公开了一种非易失性存储器件及其制造方法。该方法包括在半导体衬底上形成隧道氧化物膜和浮栅的导电膜; 氮化导电膜的顶表面用于浮动栅极; 氧化用于被氮化的浮栅的导电膜的氮化顶表面，形成包含依次层压在用于浮动栅极的表面改性导电膜上的低氧化物膜，氮化物膜和上氧化膜的ONO膜以完成电介质膜的形成; 并在电介质膜上形成用于控制栅极的导电膜。

3. 发明授权

US6127546A Process for the preparation of oxazoline compound 失效
标题翻译：恶唑啉化合物的制备方法
公开(公告)号：US6127546A
公开(公告)日：2000-10-03
申请号：US515591
申请日：2000-02-29
申请人： Jin Kyu Park , Kyung Seok Choi , Han Won Lee , Sung Ki Seo , Won Hun Ham , Chang Young Oh , Kee Young Lee , Yong Hyun Kim , Min Sung Park
发明人： Jin Kyu Park , Kyung Seok Choi , Han Won Lee , Sung Ki Seo , Won Hun Ham , Chang Young Oh , Kee Young Lee , Yong Hyun Kim , Min Sung Park
IPC分类号： C07D263/14 , B01J31/24 , C07B61/00 , C07D233/54 , C07D263/12 , C07D263/16
CPC分类号： C07D233/64
摘要： The present invention relates to a process for the preparation of an oxazoline compound which is easily chemically converted to a beta-amino-alpha-hydroxy acid or a gamma-amino-beta-hydroxy acid. The method comprises producing a compound of the following formula (4) using .alpha.-amino acid. The produced compound (4) is subjected to an intramolecular cyclization to produce an oxazoline compound of the following formula (3). The oxazoline compound (3) is oxidized at a vinyl group with RuCl.sub.3 or NaIO.sub.4 to produce an oxazoline compound of the following formula (1) which is easily chemically converted to a beta-amino-alpha-hydroxy acid. Alternatively, the oxazoline compound (3) may also be treated with 9-borabiclo[3.3.1]nonane such that a hydroxy group is introduced into the end of the vinyl group of the oxazoline compound(3). The introduced end hydroxy group is oxidized with RuCl.sub.3 or NaIO.sub.4 to produce an oxazoline compound of the following formula (2) which is easily chemically converted to a gamma-amino-hydroxy acid.
摘要翻译：本发明涉及一种易于化学转化为β-氨基-α-羟基酸或γ-氨基-β-羟基酸的恶唑啉化合物的制备方法。该方法包括使用α-氨基酸制备下式（4）的化合物。将所制备的化合物（4）进行分子内环化，得到下式（3）的恶唑啉化合物。恶唑啉化合物（3）用乙烯基用RuCl 3或NaIO 4氧化，得到容易化学转化为β-氨基-α-羟基酸的下式（1）的恶唑啉化合物。或者，恶唑啉化合物（3）也可以用9-硼烷[3.3.1]壬烷处理，使得羟基被引入到恶唑啉化合物（3）的乙烯基的末端。引入的末端羟基用RuCl 3或NaIO 4氧化以产生下式（2）的恶唑啉化合物，其易于化学转化为γ-氨基 - 羟基酸。

4. 发明授权

US6071898A Asiatic acid derivatives having modified A-ring 失效
标题翻译：具有改性A环的亚洲酸衍生物
公开(公告)号：US6071898A
公开(公告)日：2000-06-06
申请号：US308875
申请日：1999-05-25
申请人： Sang Sup Jew , Hyeung Geun Park , Hee Doo Kim , Young Hoon Jung , Young Choong Kim , Hong Pyo Kim , Mi Kyeong Lee , Hee Sung Choi , Eung Seok Lee , Chi Hyoung Yoo , Doo Yeon Lim , Jeong Hoon Kim , Hee Man Kim , Sung Ki Seo , Tae Gyu Nam , Ducky Han , Pil Jong Shim , Ju Eun Jung , Hee Young Beom
发明人： Sang Sup Jew , Hyeung Geun Park , Hee Doo Kim , Young Hoon Jung , Young Choong Kim , Hong Pyo Kim , Mi Kyeong Lee , Hee Sung Choi , Eung Seok Lee , Chi Hyoung Yoo , Doo Yeon Lim , Jeong Hoon Kim , Hee Man Kim , Sung Ki Seo , Tae Gyu Nam , Ducky Han , Pil Jong Shim , Ju Eun Jung , Hee Young Beom
IPC分类号： A61K31/56 , A61P1/16 , A61P35/00 , C07C61/29 , C07C61/40 , C07C62/30 , C07C62/32 , C07C69/00 , C07C69/757 , C07F7/18 , C07J69/00 , C07J53/00
CPC分类号： C07C69/757 , C07C61/29 , C07C61/40 , C07C62/30 , C07J69/00 , C07C2103/52 , Y10S514/893
摘要： Asiatic acid derivatives having a modified A-ring, as represented by formula 1 are disclosed. ##STR1## Pharmaceutical compositions and methods of treating cancer and hepatotoxicity utilizing compounds of formula 1 are also disclosed.
摘要翻译： PCT No.PCT / KR97 / 00240 Sec。 371日期1999年5月25日 102（e）日期1999年5月25日PCT 1997年11月27日PCT公布。第WO98 / 23575号公报日期：1998年6月4日公开了具有由式1表示的改性A环的亚氨基酸衍生物。还公开了利用式1化合物治疗癌症和肝毒性的药物组合物和方法。

5. 发明授权

US06169112A Medicines for treating dementia or cognitive disorder, which comprises asiatic acid derivatives 失效
标题翻译：用于治疗痴呆或认知障碍的药物，其包含积雪草酸衍生物
公开(公告)号：US06169112A
公开(公告)日：2001-01-02
申请号：US09308876
申请日：1999-05-25
申请人： Sang Sup Jew , Hyeung Geun Park , Hee Doo Kim , Young Hoon Jung , Young Choong Kim , So Ra Kim , Sung Ki Seo , Tae Gyu Nam , Ducky Han , Chi Hyoung Yoo , Doo Yeon Lim , Jeong Hoon Kim , Hee Man Kim , Jae Ho Park , Pil Jong Shim , Ju Eun Jung , Hee Young Beom
发明人： Sang Sup Jew , Hyeung Geun Park , Hee Doo Kim , Young Hoon Jung , Young Choong Kim , So Ra Kim , Sung Ki Seo , Tae Gyu Nam , Ducky Han , Chi Hyoung Yoo , Doo Yeon Lim , Jeong Hoon Kim , Hee Man Kim , Jae Ho Park , Pil Jong Shim , Ju Eun Jung , Hee Young Beom
IPC分类号： A01N3700
CPC分类号： A61K31/19 , A61K31/215
摘要： Disclosed is the use of 2-oxoasiatic acid in the treatment of dementia or cognitive disorders.
摘要翻译：公开了2-氧基碳酸在治疗痴呆或认知障碍中的用途

6. 发明授权

US6143900A Stereoselective synthesis of oxazoline derivative 失效
标题翻译：恶唑啉衍生物的立体选择性合成
公开(公告)号：US6143900A
公开(公告)日：2000-11-07
申请号：US426778
申请日：1999-10-26
申请人： Won Hun Ham , Kyung Seok Choi , Han Won Lee , Sung Ki Seo , Jin Kyu Park , Ki Young Lee , Yong Hyun Kim
发明人： Won Hun Ham , Kyung Seok Choi , Han Won Lee , Sung Ki Seo , Jin Kyu Park , Ki Young Lee , Yong Hyun Kim
IPC分类号： C07C231/12 , C07C233/71 , C07D263/10 , C07D263/12 , C07D305/14 , C07D263/34
CPC分类号： C07D263/10 , C07C231/12 , C07C233/71 , C07D263/12 , C07D305/14 , C07B2200/07
摘要： The present invention relates to stereoselective synthetic method of oxazoline derivative. More particularly, it relates to a synthetic method of oxazoline derivative having the structure of formula I. ##STR1## wherein R represents phenyl, benzyl, methyl, ethyl, isopropyl, isobutyl, cyclohexyl or cyclohexylmethyl.
摘要翻译：本发明涉及恶唑啉衍生物的立体选择性合成方法。更具体地说，本发明涉及具有式I结构的恶唑啉衍生物的合成方法，其中R表示苯基，苄基，甲基，乙基，异丙基，异丁基，环己基或环己基甲基。

7. 发明授权

US5834437A Asiatic acid derivatives its manufacturing method and dermatological agent containing it 失效
标题翻译：亚洲酸衍生物其制造方法和皮肤病学药剂含有它
公开(公告)号：US5834437A
公开(公告)日：1998-11-10
申请号：US566130
申请日：1995-12-01
申请人： Sang-Sup Jew , Hee-Doo Kim , Young-Hoon Jung , Eun-Hee Park , Sung-Ki Seo , Tae-Gyu Nam , Duc-Ky Hahn , Jae-Ho Park , Pil-Jong Sim , Min-Jung Lim , Kyung-Haw Lim
发明人： Sang-Sup Jew , Hee-Doo Kim , Young-Hoon Jung , Eun-Hee Park , Sung-Ki Seo , Tae-Gyu Nam , Duc-Ky Hahn , Jae-Ho Park , Pil-Jong Sim , Min-Jung Lim , Kyung-Haw Lim
IPC分类号： C07D303/38 , A61K31/045 , A61K31/19 , A61K31/215 , A61K31/335 , A61K31/336 , A61K31/695 , A61K36/23 , A61P17/00 , C07C33/14 , C07C61/29 , C07C62/30 , C07C62/32 , C07C62/38 , C07C69/00 , C07C69/753 , C07C309/66 , C07C323/61 , C07D309/12 , C07J63/00 , C07J71/00 , A61K31/70 , C07H15/24
CPC分类号： C07C69/00 , C07C309/66 , C07C323/61 , C07C33/14 , C07C62/32 , C07C62/38 , C07J63/008 , C07J71/0005 , C07J71/001 , C07C2103/00
摘要： The object of the present invention is to provide asiatic acid derivatives, its pharmaceutically acceptable salts or esters. Asiatic acid, its trisaccharide asiaticoside and mddecassic acid, extracted from Centella asiatica have been used for a long time in the management of skin scars and chronic ulcers. In this invention, asiatic acid derivatives synthesized from asiatic acid show excellent wound-healing properties.
摘要翻译：本发明的目的是提供积雪草酸衍生物，其药学上可接受的盐或酯。从积雪草积雪提取的积雪草，三糖积雪草苷和十六烷酸已经被用于治疗皮肤瘢痕和慢性溃疡的很长时间。在本发明中，由积雪草酸合成的积雪草酸衍生物具有良好的伤口愈合性。

8. 发明授权

US06293830B1 Terminal connecting device having a restraining structure 有权
标题翻译：具有约束结构的端子连接装置
公开(公告)号：US06293830B1
公开(公告)日：2001-09-25
申请号：US09495936
申请日：2000-02-02
申请人： Sang-Joong Park , Sung-Ki Seo , Ki-Dong Park , Sang-Cheul Lee , Hyoung-Bin Lee , Young-Min Kim , Ho-Keun Oh , Ki-Sung Kim
发明人： Sang-Joong Park , Sung-Ki Seo , Ki-Dong Park , Sang-Cheul Lee , Hyoung-Bin Lee , Young-Min Kim , Ho-Keun Oh , Ki-Sung Kim
IPC分类号： H01R438
CPC分类号： H01R9/26
摘要： A terminal connecting device includes a main body of a terminal block having diaphragms and supporting strips, a terminal plate positioned at the top of the supporting strips, movable terminals supported by a spring to attach or detach lead wire positioned on the terminal plate, a restraining structure, proximate to the movable terminals, which limits the movement of the lead wire, and a terminal screw coupled with the movable terminals after being penetrated through the through hole of the lead wire and fastened at a screw hole of the terminal plate. The restraining structure restricts the lead wire from diverting or dropping, thereby preventing safety accidents such as stopping the operation of facility or electric shock. The restraining structure also allows easy penetration of the terminal screw through the through hole of the lead wire in fixing the lead wire, thereby improving productivity due to ease of fastening the terminal screw. The restraining structure may be extending parts extending from the movable parts or hitching jugs protruding at both lateral surfaces of the main body.
摘要翻译：端子连接装置包括具有隔膜和支撑条的端子块的主体，位于支撑条的顶部的端子板，由弹簧支撑的可移动端子，用于附接或分离位于端子板上的引线，限制靠近可动端子的结构，其限制引线的移动，以及在穿过引线的通孔并紧固在端子板的螺钉孔之后与可动端子耦合的端子螺钉。限制结构限制了引线的转向或下落，从而防止了设备停止或触电等安全事故。限制结构还允许端子螺钉在固定导线时容易地穿过引线的通孔，从而通过紧固端子螺丝来提高生产率。约束结构可以是从可移动部分延伸的部分或在主体的两个侧表面处突出的钩子壶。

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