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1. 发明申请

US20130344119A1 METHOD FOR INDUCING IN VIVO MIGRATION OF STEM CELL 有权
标题翻译：诱导干细胞移植的方法
公开(公告)号：US20130344119A1
公开(公告)日：2013-12-26
申请号：US14003364
申请日：2012-01-26
申请人： Jin Woo Lee , Min Sung Park , Yun Hee Kim
发明人： Jin Woo Lee , Min Sung Park , Yun Hee Kim
IPC分类号： A61K38/20 , A61K38/19
CPC分类号： A61K38/2053 , A61K38/195 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/412 , A61L2430/24 , C07K14/523 , C07K14/5421 , C07K17/02
摘要： The present invention relates to an implantable composition for treating a damaged tissue and a method for inducing an in vivo migration of a cell for treatment to a damaged tissue region. The present invention treats the damaged tissue by inducing/promoting homing of a cell for tissue generation by implanting a biodegradable scaffold reacted with chemotactic factors (for example, IL-8 or MIP-3α) to a damaged location (for example, joint cartilage or skin). Thus, the composition of the present invention can not only be applied to the treatment of a damaged bone tissue, a joint cartilage, or a skin tissue more conveniently and efficiently compared to the conventional technology, but can also be used as a useful treatment supplement agent in cell treatment using allogeneic cell by enabling efficient utilization of cell resources for treatment, the cell resources which are high in scarcity.
摘要翻译：本发明涉及一种用于治疗受损组织的可植入组合物和一种用于诱导细胞进行体内迁移至受损组织区域的方法。本发明通过将与趋化因子（例如IL-8或MIP-3α）反应的可生物降解的支架植入损伤的位置（例如，关节软骨或关节软骨）中，通过诱导/促进用于组织生成的细胞的归巢来治疗受损组织皮肤）。因此，与常规技术相比，本发明的组合物不仅可以用于治疗损伤的骨组织，关节软骨或皮肤组织，而且还可以用作有用的治疗补充剂通过有效利用细胞资源进行治疗，使用同种异体细胞的细胞治疗药物，稀缺性高的细胞资源。

2. 发明申请

US20100255467A1 ASSAYS FOR DETERMINING EXPOSURE TO MULTIWALLED CARBON NANOTUBES 审中-公开
标题翻译：用于确定暴露于多层碳纳米管的测定
公开(公告)号：US20100255467A1
公开(公告)日：2010-10-07
申请号：US12507657
申请日：2009-07-22
申请人： Kevin D. Houston , Min Sung Park
发明人： Kevin D. Houston , Min Sung Park
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/6863 , G01N33/6869 , G01N2333/52 , G01N2333/525 , G01N2333/535 , G01N2333/54 , G01N2333/5412 , G01N2800/40
摘要： Assays useful in determining exposure to multi-walled carbon nanotubes (MWCNTs) are provided. In one aspect, the MWCNT exposure assays operate by detecting a significant increase in the expression levels and/or status of certain cytokines shown to be responsive to MWCNT exposure.
摘要翻译：提供了用于确定暴露于多壁碳纳米管（MWCNT）的测定。在一个方面，MWCNT暴露测定通过检测显示对MWCNT暴露有反应的某些细胞因子的表达水平和/或状态的显着增加而起作用。

3. 发明授权

US09220757B2 Method for inducing in vivo migration of stem cell 有权
标题翻译：诱导干细胞体内迁移的方法
公开(公告)号：US09220757B2
公开(公告)日：2015-12-29
申请号：US14003364
申请日：2012-01-26
申请人： Jin Woo Lee , Min Sung Park , Yun Hee Kim
发明人： Jin Woo Lee , Min Sung Park , Yun Hee Kim
IPC分类号： A61L27/54 , A61L27/18 , A61K38/19 , A61K38/20 , A61L27/56 , A61L27/58 , C07K14/52 , C07K14/54 , C07K17/02
CPC分类号： A61K38/2053 , A61K38/195 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/412 , A61L2430/24 , C07K14/523 , C07K14/5421 , C07K17/02
摘要： The present invention relates to an implantable composition for treating a damaged tissue and a method for inducing an in vivo migration of a cell for treatment to a damaged tissue region. The present invention treats the damaged tissue by inducing/promoting homing of a cell for tissue generation by implanting a biodegradable scaffold reacted with chemotactic factors (for example, IL-8 or MIP-3α) to a damaged location (for example, joint cartilage or skin). Thus, the composition of the present invention can not only be applied to the treatment of a damaged bone tissue, a joint cartilage, or a skin tissue more conveniently and efficiently compared to the conventional technology, but can also be used as a useful treatment supplement agent in cell treatment using allogeneic cell by enabling efficient utilization of cell resources for treatment, the cell resources which are high in scarcity.
摘要翻译：本发明涉及一种用于治疗受损组织的可植入组合物和一种用于诱导细胞进行体内迁移至受损组织区域的方法。本发明通过将与趋化因子（例如IL-8或MIP-3α）反应的可生物降解的支架植入损伤部位（例如，关节软骨或关节软骨），来治疗受损组织，通过诱导/促进用于组织生成的细胞的归巢皮肤）。因此，与常规技术相比，本发明的组合物不仅可以用于治疗损伤的骨组织，关节软骨或皮肤组织，而且还可以用作有用的治疗补充剂通过有效利用细胞资源进行治疗，使用同种异体细胞的细胞治疗药物，稀缺性高的细胞资源。

4. 发明授权

US6127546A Process for the preparation of oxazoline compound 失效
标题翻译：恶唑啉化合物的制备方法
公开(公告)号：US6127546A
公开(公告)日：2000-10-03
申请号：US515591
申请日：2000-02-29
申请人： Jin Kyu Park , Kyung Seok Choi , Han Won Lee , Sung Ki Seo , Won Hun Ham , Chang Young Oh , Kee Young Lee , Yong Hyun Kim , Min Sung Park
发明人： Jin Kyu Park , Kyung Seok Choi , Han Won Lee , Sung Ki Seo , Won Hun Ham , Chang Young Oh , Kee Young Lee , Yong Hyun Kim , Min Sung Park
IPC分类号： C07D263/14 , B01J31/24 , C07B61/00 , C07D233/54 , C07D263/12 , C07D263/16
CPC分类号： C07D233/64
摘要： The present invention relates to a process for the preparation of an oxazoline compound which is easily chemically converted to a beta-amino-alpha-hydroxy acid or a gamma-amino-beta-hydroxy acid. The method comprises producing a compound of the following formula (4) using .alpha.-amino acid. The produced compound (4) is subjected to an intramolecular cyclization to produce an oxazoline compound of the following formula (3). The oxazoline compound (3) is oxidized at a vinyl group with RuCl.sub.3 or NaIO.sub.4 to produce an oxazoline compound of the following formula (1) which is easily chemically converted to a beta-amino-alpha-hydroxy acid. Alternatively, the oxazoline compound (3) may also be treated with 9-borabiclo[3.3.1]nonane such that a hydroxy group is introduced into the end of the vinyl group of the oxazoline compound(3). The introduced end hydroxy group is oxidized with RuCl.sub.3 or NaIO.sub.4 to produce an oxazoline compound of the following formula (2) which is easily chemically converted to a gamma-amino-hydroxy acid.
摘要翻译：本发明涉及一种易于化学转化为β-氨基-α-羟基酸或γ-氨基-β-羟基酸的恶唑啉化合物的制备方法。该方法包括使用α-氨基酸制备下式（4）的化合物。将所制备的化合物（4）进行分子内环化，得到下式（3）的恶唑啉化合物。恶唑啉化合物（3）用乙烯基用RuCl 3或NaIO 4氧化，得到容易化学转化为β-氨基-α-羟基酸的下式（1）的恶唑啉化合物。或者，恶唑啉化合物（3）也可以用9-硼烷[3.3.1]壬烷处理，使得羟基被引入到恶唑啉化合物（3）的乙烯基的末端。引入的末端羟基用RuCl 3或NaIO 4氧化以产生下式（2）的恶唑啉化合物，其易于化学转化为γ-氨基 - 羟基酸。

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