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1. 发明授权

US06233482B1 Method of electroporation mediated delivery of drugs and genes 有权
标题翻译：电穿孔介导的药物和基因递送方法
公开(公告)号：US06233482B1
公开(公告)日：2001-05-15
申请号：US09189062
申请日：1998-11-09
申请人： Gunter A. Hofmann , Sukhendu B. Dev , Steven C. Dimmer , Jeffrey I. Levatter , Gurvinder S. Nanda
发明人： Gunter A. Hofmann , Sukhendu B. Dev , Steven C. Dimmer , Jeffrey I. Levatter , Gurvinder S. Nanda
IPC分类号： A61N130
CPC分类号： A61N1/327 , A61N1/0502 , A61N1/325
摘要： A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, the invention provides a method of EPT utilizing low voltage and long pulse length for inducing cell death. One embodiment of the invention includes a system for clinical electroporation that includes a needle array electrode having a “keying” element that determines the set point of the therapy voltage pulse and/or selectable array switching patterns. A number of electrode applicator designs permit access to and treatment of a variety of tissue sites. Another embodiment provides a laparoscopic needle applicator that is preferably combined with an endoscope for minimally invasive EPT.
摘要翻译：一种用于体内电穿孔治疗的方法和装置。使用本发明所述的电穿孔治疗（EPT），通过使用本发明的装置的电穿孔和化学治疗剂的组合治疗的肿瘤引起体内肿瘤消退。在一个实施方案中，本发明提供了一种利用低电压和长脉冲长度诱导细胞死亡的EPT的方法。本发明的一个实施例包括用于临床电穿孔的系统，其包括具有确定治疗电压脉冲和/或可选阵列切换模式的设定点的“键控”元件的针阵列电极。许多电极施加器设计允许访问和处理各种组织部位。另一实施例提供一种腹腔镜针施加器，其优选地与用于微创EPT的内窥镜组合。

2. 发明授权

US6055453A Apparatus for addressing needle array electrodes for electroporation therapy 失效
标题翻译：用于电针治疗针阵列电极的装置
公开(公告)号：US6055453A
公开(公告)日：2000-04-25
申请号：US905240
申请日：1997-08-01
申请人： Gunter A. Hofmann , Sukhendu B. Dev , Steven C. Dimmer , Jeffrey I. Levatter , Gurvinder S. Nanda
发明人： Gunter A. Hofmann , Sukhendu B. Dev , Steven C. Dimmer , Jeffrey I. Levatter , Gurvinder S. Nanda
IPC分类号： A61B17/34 , A61B18/14 , A61N1/00 , A61N1/04 , A61N1/05 , A61N1/30 , A61N1/32
CPC分类号： A61N1/327 , A61N1/0502 , A61N1/325
摘要： A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, the invention provides a method of EPT utilizing low voltage and long pulse length for inducing cell death. One embodiment of the invention includes a system for clinical electroporation that includes a needle array electrode having a "keying" element that determines the set point of the therapy voltage pulse and/or selectable array switching patterns. A number of electrode applicator designs permit access to and treatment of a variety of tissue sites. Another embodiment provides a laparoscopic needle applicator that is preferably combined with an endoscope for minimally invasive EPT.
摘要翻译：一种用于体内电穿孔治疗的方法和装置。使用本发明所述的电穿孔治疗（EPT），通过使用本发明的装置的电穿孔和化学治疗剂的组合治疗的肿瘤引起体内肿瘤消退。在一个实施方案中，本发明提供了一种利用低电压和长脉冲长度诱导细胞死亡的EPT的方法。本发明的一个实施例包括用于临床电穿孔的系统，其包括具有确定治疗电压脉冲和/或可选阵列切换模式的设定点的“键控”元件的针阵列电极。许多电极施加器设计允许访问和处理各种组织部位。另一实施例提供一种腹腔镜针施加器，其优选地与用于微创EPT的内窥镜组合。

3. 发明授权

US5993434A Method of treatment using electroporation mediated delivery of drugs and genes 失效
公开(公告)号：US5993434A
公开(公告)日：1999-11-30
申请号：US537265
申请日：1995-09-29
申请人： Sukhendu B. Dev , Gunter A. Hofmann
发明人： Sukhendu B. Dev , Gunter A. Hofmann
IPC分类号： A61N1/32 , A61M31/00
CPC分类号： A61N1/327 , A61N1/325 , C12M35/02
摘要： A method for in vivo electrotherapy, or electroporation-mediated therapy, using a needle array apparatus is provided. Treatment of tumors with a combination of electroporation using the apparatus of the invention, and a chemotherapeutic agent, caused regression of tumors in vivo.

4. 发明授权

US5944710A Electroporation-mediated intravascular delivery 失效
公开(公告)号：US5944710A
公开(公告)日：1999-08-31
申请号：US668725
申请日：1996-06-24
申请人： Sukhendu B. Dev , Nagendu B. Dev , Gunter A. Hofmann
发明人： Sukhendu B. Dev , Nagendu B. Dev , Gunter A. Hofmann
IPC分类号： B82B1/00 , A61F2/958 , A61N1/30 , A61N1/32 , A61M31/00
CPC分类号： A61N1/327 , A61N1/325 , A61N1/306 , Y10S977/906
摘要： A method for sustained intravascular delivery via electroporation is provided. The method is useful for delivery of therapeutic compositions such as antithrombotic and anticoagulant agents. The invention also provides a catheter apparatus for introducing a composition into at least one cell in a vessel in a subject.

5. 发明授权

US6068650A Method of Selectively applying needle array configurations 有权
标题翻译：选择性应用针阵列配置的方法
公开(公告)号：US6068650A
公开(公告)日：2000-05-30
申请号：US189070
申请日：1998-11-09
申请人： Gunter A. Hofmann , Sukhendu B. Dev , Steven C. Dimmer , Jeffrey I. Levatter , Gurvinder S. Nanda
发明人： Gunter A. Hofmann , Sukhendu B. Dev , Steven C. Dimmer , Jeffrey I. Levatter , Gurvinder S. Nanda
IPC分类号： A61B17/34 , A61B18/14 , A61N1/00 , A61N1/04 , A61N1/05 , A61N1/30 , A61N1/32
CPC分类号： A61N1/327 , A61N1/0502 , A61N1/325
摘要： A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described, tumors treated by a combination of electroporation using the apparatus and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, a method of EPT utilizes low voltage and long pulse length for inducing cell death. One embodiment includes a system for clinical electroporation that includes a needle array electrode having a "keying" element that determines the set point of the therapy voltage pulse and/or selectable array switching patterns. A number of electrode applicator designs permit access to and treatment of a variety of tissue sites. Another embodiment provides a laparoscopic needle applicator that is preferably combined with an endoscope for minimally invasive EPT.
摘要翻译：一种用于体内电穿孔治疗的方法和装置。使用如上所述的电穿孔治疗（EPT），通过使用该装置的电穿孔组合治疗的肿瘤和化学治疗剂引起体内肿瘤消退。在一个实施方案中，EPT的方法利用低电压和长脉冲长度来诱导细胞死亡。一个实施例包括用于临床电穿孔的系统，其包括具有确定治疗电压脉冲和/或可选阵列切换模式的设定点的“键控”元件的针阵列电极。许多电极施加器设计允许访问和处理各种组织部位。另一实施例提供一种腹腔镜针施加器，其优选地与用于微创EPT的内窥镜组合。

6. 发明授权

US06216034B1 Method of programming an array of needle electrodes for electroporation therapy of tissue 有权
标题翻译：编织电极阵列的方法，用于组织的电穿孔治疗
公开(公告)号：US06216034B1
公开(公告)日：2001-04-10
申请号：US09227417
申请日：1999-01-08
申请人： Gunter A. Hofmann , Sukhendu B. Dev , Steven C. Dimmer , Jeffrey I. Levatter , Gurvinder S. Nanda
发明人： Gunter A. Hofmann , Sukhendu B. Dev , Steven C. Dimmer , Jeffrey I. Levatter , Gurvinder S. Nanda
IPC分类号： A61N130
CPC分类号： A61N1/327 , A61B2018/143 , A61N1/325
摘要： A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, the invention provides a method of EPT utilizing low voltage and long pulse length for inducing cell death. One embodiment of the invention includes a system for clinical electroporation that includes a needle array electrode having a “keying” element that determines the set point of the therapy voltage pulse and/or selectable array switching patterns. A number of electrode applicator designs permit access to and treatment of a variety of tissue sites. Another embodiment provides a laparoscopic needle applicator that is preferably combined with an endoscope for minimally invasive EPT.
摘要翻译：一种用于体内电穿孔治疗的方法和装置。使用本发明所述的电穿孔治疗（EPT），通过使用本发明的装置的电穿孔和化学治疗剂的组合治疗的肿瘤引起体内肿瘤消退。在一个实施方案中，本发明提供了一种利用低电压和长脉冲长度诱导细胞死亡的EPT的方法。本发明的一个实施例包括用于临床电穿孔的系统，其包括具有确定治疗电压脉冲和/或可选阵列切换模式的设定点的“键控”元件的针阵列电极。许多电极施加器设计允许访问和处理各种组织部位。另一实施例提供一种腹腔镜针施加器，其优选地与用于微创EPT的内窥镜组合。

7. 发明授权

US06865416B2 Electrically induced vessel vasodilation 有权
标题翻译：电导血管血管扩张
公开(公告)号：US06865416B2
公开(公告)日：2005-03-08
申请号：US09969367
申请日：2001-10-01
申请人： Nagendu B. Dev , Sukhendu B. Dev , Gunter A. Hofmann
发明人： Nagendu B. Dev , Sukhendu B. Dev , Gunter A. Hofmann
IPC分类号： A61N1/30 , A61N1/32 , A61N1/36
CPC分类号： A61N1/327 , A61N1/325 , Y10S977/883 , Y10S977/904 , Y10S977/905
摘要： The invention provides methods for inducing or increasing the vasodilation of a vessel. The invention further provides methods for inducing or increasing the flow of fluid through a vessel. An electrical impulse is applied to the vessel in order to induce or increase vessel vasodilation or to induce or increase the flow of fluid through the vessel. In a particular embodiment, a novel double-balloon catheter system incorporating electroporation technology has been designed and is used to apply the electrical impulse endoluminally.
摘要翻译：本发明提供诱导或增加血管的血管舒张的方法。本发明还提供了用于诱导或增加通过容器的流体流动的方法。为了诱导或增加血管血管舒张或诱导或增加通过血管的流体流动，向血管施加电脉冲。在一个具体的实施方案中，已经设计了一种包含电穿孔技术的新型双气囊导管系统，并且被用于内腔内施加电脉冲。

8. 发明授权

US06347247B1 Electrically induced vessel vasodilation 有权
公开(公告)号：US06347247B1
公开(公告)日：2002-02-12
申请号：US09307216
申请日：1999-05-07
申请人： Nagendu B. Dev , Sukhendu B. Dev , Gunter A. Hofmann
发明人： Nagendu B. Dev , Sukhendu B. Dev , Gunter A. Hofmann
IPC分类号： A61N100
CPC分类号： A61N1/327 , A61N1/325 , Y10S977/883 , Y10S977/904 , Y10S977/905
摘要： The invention provides methods for inducing or increasing the vasodilation of a vessel. The invention further provides methods for inducing or increasing the flow of fluid through a vessel. An electrical impulse is applied to the vessel in order to induce or increase vessel vasodilation or to induce or increase the flow of fluid through the vessel. In a particular embodiment, a novel double-balloon catheter system incorporating electroporation technology has been designed and is used to apply the electrical impulse endoluminally.

9. 发明授权

US06181964B2 Minimally invasive apparatus and method to electroporate drugs and genes into tissue 有权
标题翻译：将药物和基因电穿孔进入组织的微创装置和方法
公开(公告)号：US06181964B2
公开(公告)日：2001-01-30
申请号：US09189360
申请日：1998-11-09
申请人： Gunter A. Hofmann , Sukhendu B. Dev , Steven C. Dimmer , Jeffrey I. Levatter , Gurvinder S. Nanda
发明人： Gunter A. Hofmann , Sukhendu B. Dev , Steven C. Dimmer , Jeffrey I. Levatter , Gurvinder S. Nanda
IPC分类号： A61N130
CPC分类号： A61N1/327 , A61N1/0502 , A61N1/325
摘要： A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, the invention provides a method of EPT utilizing low voltage and long pulse length for inducing cell death. One embodiment of the invention includes a system for clinical electroporation that includes a needle array electrode having a “keying” element that determines the set point of the therapy voltage pulse and/or selectable array switching patterns. A number of electrode applicator designs permit access to and treatment of a variety of tissue sites. Another embodiment provides a laparoscopic needle applicator that is preferably combined with an endoscope for minimally invasive EPT.
摘要翻译：一种用于体内电穿孔治疗的方法和装置。使用本发明所述的电穿孔治疗（EPT），通过使用本发明的装置的电穿孔和化学治疗剂的组合治疗的肿瘤引起体内肿瘤消退。在一个实施方案中，本发明提供了一种利用低电压和长脉冲长度诱导细胞死亡的EPT的方法。本发明的一个实施例包括用于临床电穿孔的系统，其包括具有确定治疗电压脉冲和/或可选阵列切换模式的设定点的“键控”元件的针阵列电极。许多电极施加器设计允许访问和处理各种组织部位。另一实施例提供一种腹腔镜针施加器，其优选地与用于微创EPT的内窥镜组合。

10. 发明授权

US6014584A Electroporation therapy apparatus 失效
标题翻译：电穿孔治疗仪
公开(公告)号：US6014584A
公开(公告)日：2000-01-11
申请号：US227416
申请日：1999-01-08
申请人： Gunter A. Hofmann , Sukhendu B. Dev , Steven C. Dimmer , Jeffrey I. Levatter , Gurvinder S. Nanda
发明人： Gunter A. Hofmann , Sukhendu B. Dev , Steven C. Dimmer , Jeffrey I. Levatter , Gurvinder S. Nanda
IPC分类号： A61B17/34 , A61B18/14 , A61N1/00 , A61N1/04 , A61N1/05 , A61N1/30 , A61N1/32
CPC分类号： A61N1/327 , A61N1/0502 , A61N1/325
摘要： A method and apparatus for in vivo electroporation therapy. Using electroporation therapy (EPT) as described in the invention, tumors treated by a combination of electroporation using the apparatus of the invention and a chemotherapeutic agent caused regression of tumors in vivo. In one embodiment, the invention provides a method of EPT utilizing low voltage and long pulse length for inducing cell death. One embodiment of the invention includes a system for clinical electroporation that includes a needle array electrode having a "keying" element that determines the set point of the therapy voltage pulse and/or selectable array switching patterns. A number of electrode applicator designs permit access to and treatment of a variety of tissue sites. Another embodiment provides a laparoscopic needle applicator that is preferably combined with an endoscope for minimally invasive EPT.
摘要翻译：一种用于体内电穿孔治疗的方法和装置。使用本发明所述的电穿孔治疗（EPT），通过使用本发明的装置的电穿孔和化学治疗剂的组合治疗的肿瘤引起体内肿瘤消退。在一个实施方案中，本发明提供了一种利用低电压和长脉冲长度诱导细胞死亡的EPT的方法。本发明的一个实施例包括用于临床电穿孔的系统，其包括具有确定治疗电压脉冲和/或可选阵列切换模式的设定点的“键控”元件的针阵列电极。许多电极施加器设计允许访问和处理各种组织部位。另一实施例提供一种腹腔镜针施加器，其优选地与用于微创EPT的内窥镜组合。

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