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1. 发明申请

US20140378675A1 Methods for Detecting and Measuring Specific Nucleic Acid Sequences 审中-公开
标题翻译：检测和测量特定核酸序列的方法
公开(公告)号：US20140378675A1
公开(公告)日：2014-12-25
申请号：US14479198
申请日：2014-09-05
申请人： Suk-Wah Tam-Chang , Kenneth W. Hunter , Nelson G. Publicover
发明人： Suk-Wah Tam-Chang , Kenneth W. Hunter , Nelson G. Publicover
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q1/6818 , C12Q1/6837 , C12Q2525/185 , C12Q2525/301 , C12Q2565/107 , C12Q2565/101 , C12Q2525/101
摘要： The invention provides novel oligonucleotides and methods of using the same for detection or measurement of specific nucleic acid molecules. The invention also features nucleic acid arrays comprising the oligonucleotides of the invention. An oligonucleotide of the invention comprises (1) a reporter-binding sequence capable of hybridizing to a fluorophore-labeled reporter sequence and (2) a hairpin-forming sequence capable of forming a stem-loop. Formation of the stem-loop modifies (e.g., quenching) the fluorescence signals of the reporter sequence when the reporter sequence is hybridized to the oligonucleotide. This can be achieved, for example, by bringing one or more guanine based in the oligonucleotide into close proximity to the fluorophore(s) of the reporter sequence by virtue of the formation of the stem-loop. Disruption of the stem-loop, such as by hybridization of a target sequence to at least part of the hairpin-forming sequence, produces a detectable change in the fluorescence signals.
摘要翻译：本发明提供新的寡核苷酸及其用于检测或测量特异性核酸分子的方法。本发明还具有包含本发明寡核苷酸的核酸阵列。本发明的寡核苷酸包含（1）能够与荧光团标记的报告基因序列杂交的报告基因结合序列和（2）能够形成茎环的发夹形成序列。当报告物序列与寡核苷酸杂交时，茎环的形成修饰（例如，淬灭）报告基因序列的荧光信号。这可以通过例如通过使一个或多个基于寡核苷酸的鸟嘌呤通过茎 - 环的形成使报告物序列的荧光团靠近来实现。茎环的破坏，例如通过目标序列与形成发夹的序列的至少部分的杂交产生荧光信号的可检测的变化。

2. 发明授权

US08722888B2 Materials and methods for the preparation of anisotropically-ordered solids 失效
标题翻译：用于制备各向异性有序固体的材料和方法
公开(公告)号：US08722888B2
公开(公告)日：2014-05-13
申请号：US13677149
申请日：2012-11-14
申请人： Travis D. Carson , Suk-Wah Tam-Chang
发明人： Travis D. Carson , Suk-Wah Tam-Chang
IPC分类号： C07D221/18
CPC分类号： C07D221/18 , B82Y20/00 , C07D471/06 , C09K19/02 , C09K19/3488 , G02F1/0054 , G02F1/0063 , G02F2001/133726 , G02F2202/36 , Y10T428/10 , Y10T428/1041 , Y10T428/2982
摘要： The invention provides materials and methods for making anisotropic solids which may be in the form of films, layers, shaped elements, and other shaped articles. The methods provide anisotropic solids without the need for rolling, rubbing, or stretching to impart orientational alignment of the molecules of the solid. The methods employ organic or organometallic compounds which are soluble orienting molecules. The solvent or solvent system must be sufficiently volatile to be removed without disruption of the molecular orientation. The soluble orienting molecules include those containing one or more hydrophilic and/or ionic groups and the solvent or solvent system can be a polar organic solvent or solvent system or an aqueous solvent or solvent system. The invention also provides novel compounds having quaterrylene, perylene and naphthalene ring systems carrying one or more hydrophilic and/or ionic groups. These novel compounds can exhibit useful absorption and fluorescence properties in solution and in the solid phase and can exhibit useful liquid crystalline properties.
摘要翻译：本发明提供用于制备各向异性固体的材料和方法，其可以是膜，层，成形元件和其它成形制品的形式。该方法提供各向异性固体，而不需要滚动，摩擦或拉伸以赋予固体分子的取向取向。该方法采用有机或有机金属化合物，它们是可溶取向分子。溶剂或溶剂体系必须具有足够的挥发性以便在不破坏分子取向的情况下除去。可溶取向分子包括含有一个或多个亲水基团和/或离子基团的分子，溶剂或溶剂系统可以是极性有机溶剂或溶剂体系或水溶剂或溶剂体系。本发明还提供具有季铵基，二萘嵌苯和萘环体系携带一个或多个亲水和/或离子基团的新型化合物。这些新型化合物可以在溶液和固相中表现出有用的吸收和荧光特性，并且可以显示出有用的液晶性质。

3. 发明申请

US20130085280A1 MATERIALS AND METHODS FOR THE PREPARATION OF ANISOTROPICALLY-ORDERED SOLIDS 失效
标题翻译：用于制备各向异性固体的材料和方法
公开(公告)号：US20130085280A1
公开(公告)日：2013-04-04
申请号：US13677149
申请日：2012-11-14
申请人： Travis D. Carson , Sean M. Casey , Isaac K. Iverson , Wonewoo Seo , Suk-Wah Tam-Chang
发明人： Travis D. Carson , Sean M. Casey , Isaac K. Iverson , Wonewoo Seo , Suk-Wah Tam-Chang
IPC分类号： C07D221/18
CPC分类号： C07D221/18 , B82Y20/00 , C07D471/06 , C09K19/02 , C09K19/3488 , G02F1/0054 , G02F1/0063 , G02F2001/133726 , G02F2202/36 , Y10T428/10 , Y10T428/1041 , Y10T428/2982
摘要： The invention provides materials and methods for making anisotropic solids which may be in the form of films, layers, shaped elements, and other shaped articles. The methods provide anisotropic solids without the need for rolling, rubbing, or stretching to impart orientational alignment of the molecules of the solid. The methods employ organic or organometallic compounds which are soluble orienting molecules. The solvent or solvent system must be sufficiently volatile to be removed without disruption of the molecular orientation. The soluble orienting molecules include those containing one or more hydrophilic and/or ionic groups and the solvent or solvent system can be a polar organic solvent or solvent system or an aqueous solvent or solvent system. The invention also provides novel compounds having quaterrylene, perylene and naphthalene ring systems carrying one or more hydrophilic and/or ionic groups. These novel compounds can exhibit useful absorption and fluorescence properties in solution and in the solid phase and can exhibit useful liquid crystalline properties.
摘要翻译：本发明提供用于制备各向异性固体的材料和方法，其可以是膜，层，成形元件和其它成形制品的形式。该方法提供各向异性固体，而不需要滚动，摩擦或拉伸以赋予固体分子的取向取向。该方法采用有机或有机金属化合物，它们是可溶取向分子。溶剂或溶剂体系必须具有足够的挥发性以便在不破坏分子取向的情况下除去。可溶取向分子包括含有一个或多个亲水基团和/或离子基团的分子，溶剂或溶剂系统可以是极性有机溶剂或溶剂体系或水溶剂或溶剂体系。本发明还提供具有季铵基，二萘嵌苯和萘环体系携带一个或多个亲水和/或离子基团的新型化合物。这些新型化合物可以在溶液和固相中表现出有用的吸收和荧光特性，并且可以显示出有用的液晶性质。

4. 发明申请

US20110257400A1 MATERIALS AND METHODS FOR THE PREPARATION OF ANISOTROPICALLY-ORDERED SOLIDS 有权
标题翻译：用于制备各向异性固体的材料和方法
公开(公告)号：US20110257400A1
公开(公告)日：2011-10-20
申请号：US13079731
申请日：2011-04-04
申请人： Travis D. Carson , Sean M. Casey , Isaac K. Iverson , Wonewoo Seo , Suk-Wah Tam-Chang
发明人： Travis D. Carson , Sean M. Casey , Isaac K. Iverson , Wonewoo Seo , Suk-Wah Tam-Chang
IPC分类号： C07D471/06
CPC分类号： C07D221/18 , B82Y20/00 , C07D471/06 , C09K19/02 , C09K19/3488 , G02F1/0054 , G02F1/0063 , G02F2001/133726 , G02F2202/36 , Y10T428/10 , Y10T428/1041 , Y10T428/2982
摘要： The invention provides materials and methods for making anisotropic solids which may be in the form of films, layers, shaped elements, and other shaped articles. The methods provide anisotropic solids without the need for rolling, rubbing, or stretching to impart orientational alignment of the molecules of the solid. The methods employ organic or organometallic compounds which are soluble orienting molecules. The solvent or solvent system must be sufficiently volatile to be removed without disruption of the molecular orientation. The soluble orienting molecules include those containing one or more hydrophilic and/or ionic groups and the solvent or solvent system can be a polar organic solvent or solvent system or an aqueous solvent or solvent system. The invention also provides novel compounds having quaterrylene, perylene and naphthalene ring systems carrying one or more hydrophilic and/or ionic groups. These novel compounds can exhibit useful absorption and fluorescence properties in solution and in the solid phase and can exhibit useful liquid crystalline properties.
摘要翻译：本发明提供用于制备各向异性固体的材料和方法，其可以是膜，层，成形元件和其它成形制品的形式。该方法提供各向异性固体，而不需要滚动，摩擦或拉伸以赋予固体分子的取向取向。该方法采用有机或有机金属化合物，它们是可溶取向分子。溶剂或溶剂体系必须具有足够的挥发性以便在不破坏分子取向的情况下除去。可溶取向分子包括含有一个或多个亲水基团和/或离子基团的分子，溶剂或溶剂系统可以是极性有机溶剂或溶剂体系或水溶剂或溶剂体系。本发明还提供具有季铵基，二萘嵌苯和萘环体系携带一个或多个亲水和/或离子基团的新型化合物。这些新型化合物可以在溶液和固相中表现出有用的吸收和荧光特性，并且可以显示出有用的液晶性质。

5. 发明授权

US08334029B2 Materials and methods for the preparation of anisotropically-ordered solids 有权
标题翻译：用于制备各向异性有序固体的材料和方法
公开(公告)号：US08334029B2
公开(公告)日：2012-12-18
申请号：US13079731
申请日：2011-04-04
申请人： Suk-Wah Tam-Chang , Sean M. Casey , Isaac K. Iverson , Wonewoo Seo
发明人： Suk-Wah Tam-Chang , Sean M. Casey , Isaac K. Iverson , Wonewoo Seo
IPC分类号： G02B5/30 , C07D221/18
CPC分类号： C07D221/18 , B82Y20/00 , C07D471/06 , C09K19/02 , C09K19/3488 , G02F1/0054 , G02F1/0063 , G02F2001/133726 , G02F2202/36 , Y10T428/10 , Y10T428/1041 , Y10T428/2982
摘要： The invention provides materials and methods for making anisotropic solids which may be in the form of films, layers, shaped elements, and other shaped articles. The methods provide anisotropic solids without the need for rolling, rubbing, or stretching to impart orientational alignment of the molecules of the solid. The methods employ organic or organometallic compounds which are soluble orienting molecules. The solvent or solvent system must be sufficiently volatile to be removed without disruption of the molecular orientation. The soluble orienting molecules include those containing one or more hydrophilic and/or ionic groups and the solvent or solvent system can be a polar organic solvent or solvent system or an aqueous solvent or solvent system. The invention also provides novel compounds having quaterrylene, perylene and naphthalene ring systems carrying one or more hydrophilic and/or ionic groups. These novel compounds can exhibit useful absorption and fluorescence properties in solution and in the solid phase and can exhibit useful liquid crystalline properties.
摘要翻译：本发明提供用于制备各向异性固体的材料和方法，其可以是膜，层，成形元件和其它成形制品的形式。该方法提供各向异性固体，而不需要滚动，摩擦或拉伸以赋予固体分子的取向取向。该方法采用有机或有机金属化合物，它们是可溶取向分子。溶剂或溶剂体系必须具有足够的挥发性以便在不破坏分子取向的情况下除去。可溶取向分子包括含有一个或多个亲水基团和/或离子基团的分子，溶剂或溶剂系统可以是极性有机溶剂或溶剂体系或水溶剂或溶剂体系。本发明还提供具有季铵基，二萘嵌苯和萘环体系携带一个或多个亲水和/或离子基团的新型化合物。这些新型化合物可以在溶液和固相中表现出有用的吸收和荧光特性，并且可以显示出有用的液晶性质。

6. 发明授权

US07943208B2 Materials and methods for the preparation of anisotropically-ordered solids 有权
标题翻译：用于制备各向异性有序固体的材料和方法
公开(公告)号：US07943208B2
公开(公告)日：2011-05-17
申请号：US12567673
申请日：2009-09-25
申请人： Travis D. Carson , Sean M. Casey , Isaac K. Iverson , Wonewoo Seo , Suk-Wah Tam-Chang
发明人： Travis D. Carson , Sean M. Casey , Isaac K. Iverson , Wonewoo Seo , Suk-Wah Tam-Chang
IPC分类号： G02B5/30 , C07D239/70 , C07D471/02 , C07D235/02
CPC分类号： C07D221/18 , B82Y20/00 , C07D471/06 , C09K19/02 , C09K19/3488 , G02F1/0054 , G02F1/0063 , G02F2001/133726 , G02F2202/36 , Y10T428/10 , Y10T428/1041 , Y10T428/2982
摘要： The invention provides materials and methods for making anisotropic solids which may be in the form of films, layers, shaped elements, and other shaped articles. The methods provide anisotropic solids without the need for rolling, rubbing, or stretching to impart orientational alignment of the molecules of the solid. The methods employ organic or organometallic compounds which are soluble orienting molecules. The solvent or solvent system must be sufficiently volatile to be removed without disruption of the molecular orientation. The soluble orienting molecules include those containing one or more hydrophilic and/or ionic groups and the solvent or solvent system can be a polar organic solvent or solvent system or an aqueous solvent or solvent system. The invention also provides novel compounds having quaterrylene, perylene and naphthalene ring systems carrying one or more hydrophilic and/or ionic groups. These novel compounds can exhibit useful absorption and fluorescence properties in solution and in the solid phase and can exhibit useful liquid crystalline properties.
摘要翻译：本发明提供用于制备各向异性固体的材料和方法，其可以是膜，层，成形元件和其它成形制品的形式。该方法提供各向异性固体，而不需要滚动，摩擦或拉伸以赋予固体分子的取向取向。该方法采用有机或有机金属化合物，它们是可溶取向分子。溶剂或溶剂体系必须具有足够的挥发性以便在不破坏分子取向的情况下除去。可溶取向分子包括含有一个或多个亲水基团和/或离子基团的分子，溶剂或溶剂系统可以是极性有机溶剂或溶剂体系或水溶剂或溶剂体系。本发明还提供具有季铵基，二萘嵌苯和萘环体系携带一个或多个亲水和/或离子基团的新型化合物。这些新型化合物可以在溶液和固相中表现出有用的吸收和荧光特性，并且可以显示出有用的液晶性质。

7. 发明授权

US07625497B2 Materials and methods for the preparation of anisotropically-ordered solids 失效
标题翻译：用于制备各向异性有序固体的材料和方法
公开(公告)号：US07625497B2
公开(公告)日：2009-12-01
申请号：US10996133
申请日：2004-11-22
申请人： Isaac K. Iverson , Suk-Wah Tam-Chang
发明人： Isaac K. Iverson , Suk-Wah Tam-Chang
IPC分类号： C09K19/02 , B32B5/16
CPC分类号： C07D221/18 , B82Y20/00 , C07D471/06 , C09K19/02 , C09K19/3488 , G02F1/0054 , G02F1/0063 , G02F2001/133726 , G02F2202/36 , Y10T428/10 , Y10T428/1041 , Y10T428/2982
摘要： The invention provides materials and methods for making anisotropic solids which may be in the form of films, layers, shaped elements, and other shaped articles. The methods provide anisotropic solids without the need for rolling, rubbing, or stretching to impart orientational alignment of the molecules of the solid. The methods employ organic or organometallic compounds which are soluble orienting molecules. The solvent or solvent system must be sufficiently volatile to be removed without disruption of the molecular orientation. The soluble orienting molecules include those containing one or more hydrophilic and/or ionic groups and the solvent or solvent system can be a polar organic solvent or solvent system or an aqueous solvent or solvent system. The invention also provides novel compounds having quaterrylene, perylene and naphthalene ring systems carrying one or more hydrophilic and/or ionic groups. These novel compounds can exhibit useful absorption and fluorescence properties in solution and in the solid phase and can exhibit useful liquid crystalline properties.
摘要翻译：本发明提供用于制备各向异性固体的材料和方法，其可以是膜，层，成形元件和其它成形制品的形式。该方法提供各向异性固体，而不需要滚动，摩擦或拉伸以赋予固体分子的取向取向。该方法采用有机或有机金属化合物，它们是可溶取向分子。溶剂或溶剂体系必须具有足够的挥发性以便在不破坏分子取向的情况下除去。可溶取向分子包括含有一个或多个亲水基团和/或离子基团的分子，溶剂或溶剂系统可以是极性有机溶剂或溶剂体系或水溶剂或溶剂体系。本发明还提供具有季铵基，二萘嵌苯和萘环体系携带一个或多个亲水和/或离子基团的新型化合物。这些新型化合物可以在溶液和固相中表现出有用的吸收和荧光特性，并且可以显示出有用的液晶性质。

8. 发明申请

US20080293580A1 Methods for Detecting and Measuring Specific Nucleic Acid Sequences 审中-公开
标题翻译：检测和测量特定核酸序列的方法
公开(公告)号：US20080293580A1
公开(公告)日：2008-11-27
申请号：US10578248
申请日：2004-11-08
申请人： Suk-Wah Tam-Chang , Kenneth W. Hunter , Nelson G. Publicover
发明人： Suk-Wah Tam-Chang , Kenneth W. Hunter , Nelson G. Publicover
IPC分类号： C40B30/04 , C40B40/08 , C07H21/00
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q1/6818 , C12Q1/6837 , C12Q2525/185 , C12Q2525/301 , C12Q2565/107 , C12Q2565/101 , C12Q2525/101
摘要： The invention provides novel oligonucleotides and methods of using the same for detection or measurement of specific nucleic acid molecules. The invention also features nucleic acid arrays comprising the oligonucleotides of the invention. An oligonucleotide of the invention comprises (1) a reporter-binding sequence capable of hybridizing to a fluorrophore-labeled reporter sequence and (2) a hairpin-forming sequence capable of forming a stem-loop. Formation of the stem-loop modifies (e.g., quenching) the fluorescence signals of the reporter sequence when the reporter sequence is hybridized to the oligonucleotide. This can be achieved, for example, by bringing one or more guanine based in the oligonucleotide into close proximity to the fluorophore(s) of the reporter sequence by virtue of the formation of the stem-loop. Disruption of the stem-loop, such as by hybridization of a target sequence to at least part of the hairpin-forming sequence, produces a detectable change in the fluorescence signals.
摘要翻译：本发明提供新的寡核苷酸及其用于检测或测量特异性核酸分子的方法。本发明还具有包含本发明寡核苷酸的核酸阵列。本发明的寡核苷酸包含（1）能够与荧光标记的报道基因序列杂交的报告基因结合序列和（2）能够形成茎环的发夹形成序列。当报告物序列与寡核苷酸杂交时，茎环的形成修饰（例如，淬灭）报告基因序列的荧光信号。这可以通过例如通过使一个或多个基于寡核苷酸的鸟嘌呤通过茎 - 环的形成使报告物序列的荧光团靠近来实现。茎环的破坏，例如通过目标序列与形成发夹的序列的至少部分的杂交产生荧光信号的可检测的变化。

9. 发明申请

US20050253983A1 Materials and methods for the preparation of anisotropically-ordered solids 失效
标题翻译：用于制备各向异性有序固体的材料和方法
公开(公告)号：US20050253983A1
公开(公告)日：2005-11-17
申请号：US10996133
申请日：2004-11-22
申请人： Travis Carson , Sean Casey , Isaac Iverson , Wonewoo Seo , Suk-Wah Tam-Chang
发明人： Travis Carson , Sean Casey , Isaac Iverson , Wonewoo Seo , Suk-Wah Tam-Chang
IPC分类号： C07D221/18 , C07D471/02 , C07D471/06 , C09K19/00 , C09K19/02 , C09K19/34 , G02F1/00 , G02F1/1335 , G02F1/1337
CPC分类号： C07D221/18 , B82Y20/00 , C07D471/06 , C09K19/02 , C09K19/3488 , G02F1/0054 , G02F1/0063 , G02F2001/133726 , G02F2202/36 , Y10T428/10 , Y10T428/1041 , Y10T428/2982
摘要： The invention provides materials and methods for making anisotropic solids which may be in the form of films, layers, shaped elements, and other shaped articles. The methods provide anisotropic solids without the need for rolling, rubbing, or stretching to impart orientational alignment of the molecules of the solid. The methods employ organic or organometallic compounds which are soluble orienting molecules. The solvent or solvent system must be sufficiently volatile to be removed without disruption of the molecular orientation. The soluble orienting molecules include those containing one or more hydrophilic and/or ionic groups and the solvent or solvent system can be a polar organic solvent or solvent system or an aqueous solvent or solvent system. The invention also provides novel compounds having quaterrylene, perylene and naphthalene ring systems carrying one or more hydrophilic and/or ionic groups. These novel compounds can exhibit useful absorption and fluorescence properties in solution and in the solid phase and can exhibit useful liquid crystalline properties.
摘要翻译：本发明提供用于制备各向异性固体的材料和方法，其可以是膜，层，成形元件和其它成形制品的形式。该方法提供各向异性固体，而不需要滚动，摩擦或拉伸以赋予固体分子的取向取向。该方法采用有机或有机金属化合物，它们是可溶取向分子。溶剂或溶剂体系必须具有足够的挥发性以便在不破坏分子取向的情况下除去。可溶取向分子包括含有一个或多个亲水基团和/或离子基团的分子，溶剂或溶剂系统可以是极性有机溶剂或溶剂体系或水溶剂或溶剂体系。本发明还提供具有季铵基，二萘嵌苯和萘环体系携带一个或多个亲水和/或离子基团的新型化合物。这些新型化合物可以在溶液和固相中表现出有用的吸收和荧光特性，并且可以显示出有用的液晶性质。

10. 发明申请

US20140106983A1 Methods for Detecting and Measuring Specific Nucleic Acid Sequences 审中-公开
标题翻译：检测和测量特定核酸序列的方法
公开(公告)号：US20140106983A1
公开(公告)日：2014-04-17
申请号：US14105944
申请日：2013-12-13
申请人： Suk-Wah Tam-Chang , Kenneth W Hunter , Nelson G Publicover
发明人： Suk-Wah Tam-Chang , Kenneth W Hunter , Nelson G Publicover
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q1/6818 , C12Q1/6837 , C12Q2525/185 , C12Q2525/301 , C12Q2565/107 , C12Q2565/101 , C12Q2525/101
摘要： The invention provides novel oligonucleotides and methods of using the same for detection or measurement of specific nucleic acid molecules. The invention also features nucleic acid arrays comprising the oligonucleotides of the invention. An oligonucleotide of the invention comprises (1) a reporter-binding sequence capable of hybridizing to a fluorrophore-labeled reporter sequence and (2) a hairpin-forming sequence capable of forming a stem-loop. Formation of the stem-loop modifies (e.g., quenching) the fluorescence signals of the reporter sequence when the reporter sequence is hybridized to the oligonucleotide. This can be achieved, for example, by bringing one or more guanine based in the oligonucleotide into close proximity to the fluorophore(s) of the reporter sequence by virtue of the formation of the stem-loop. Disruption of the stem-loop, such as by hybridization of a target sequence to at least part of the hairpin-forming sequence, produces a detectable change in the fluorescence signals.
摘要翻译：本发明提供新的寡核苷酸及其用于检测或测量特异性核酸分子的方法。本发明还具有包含本发明寡核苷酸的核酸阵列。本发明的寡核苷酸包含（1）能够与荧光标记的报道基因序列杂交的报告基因结合序列和（2）能够形成茎环的发夹形成序列。当报告物序列与寡核苷酸杂交时，茎环的形成修饰（例如，淬灭）报告基因序列的荧光信号。这可以通过例如通过使一个或多个基于寡核苷酸的鸟嘌呤通过茎 - 环的形成使报告物序列的荧光团靠近来实现。茎环的破坏，例如通过目标序列与形成发夹的序列的至少部分的杂交产生荧光信号的可检测的变化。

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