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1. 发明申请

US20140106983A1 Methods for Detecting and Measuring Specific Nucleic Acid Sequences 审中-公开
标题翻译：检测和测量特定核酸序列的方法
公开(公告)号：US20140106983A1
公开(公告)日：2014-04-17
申请号：US14105944
申请日：2013-12-13
申请人： Suk-Wah Tam-Chang , Kenneth W Hunter , Nelson G Publicover
发明人： Suk-Wah Tam-Chang , Kenneth W Hunter , Nelson G Publicover
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q1/6818 , C12Q1/6837 , C12Q2525/185 , C12Q2525/301 , C12Q2565/107 , C12Q2565/101 , C12Q2525/101
摘要： The invention provides novel oligonucleotides and methods of using the same for detection or measurement of specific nucleic acid molecules. The invention also features nucleic acid arrays comprising the oligonucleotides of the invention. An oligonucleotide of the invention comprises (1) a reporter-binding sequence capable of hybridizing to a fluorrophore-labeled reporter sequence and (2) a hairpin-forming sequence capable of forming a stem-loop. Formation of the stem-loop modifies (e.g., quenching) the fluorescence signals of the reporter sequence when the reporter sequence is hybridized to the oligonucleotide. This can be achieved, for example, by bringing one or more guanine based in the oligonucleotide into close proximity to the fluorophore(s) of the reporter sequence by virtue of the formation of the stem-loop. Disruption of the stem-loop, such as by hybridization of a target sequence to at least part of the hairpin-forming sequence, produces a detectable change in the fluorescence signals.
摘要翻译：本发明提供新的寡核苷酸及其用于检测或测量特异性核酸分子的方法。本发明还具有包含本发明寡核苷酸的核酸阵列。本发明的寡核苷酸包含（1）能够与荧光标记的报道基因序列杂交的报告基因结合序列和（2）能够形成茎环的发夹形成序列。当报告物序列与寡核苷酸杂交时，茎环的形成修饰（例如，淬灭）报告基因序列的荧光信号。这可以通过例如通过使一个或多个基于寡核苷酸的鸟嘌呤通过茎 - 环的形成使报告物序列的荧光团靠近来实现。茎环的破坏，例如通过目标序列与形成发夹的序列的至少部分的杂交产生荧光信号的可检测的变化。

2. 发明申请

US20130114850A1 SYSTEMS AND METHODS FOR HIGH-RESOLUTION GAZE TRACKING 有权
标题翻译：高分辨率高程跟踪系统与方法
公开(公告)号：US20130114850A1
公开(公告)日：2013-05-09
申请号：US13290948
申请日：2011-11-07
申请人： Nelson G. Publicover , William C. Torch , Christopher N. Spitler
发明人： Nelson G. Publicover , William C. Torch , Christopher N. Spitler
IPC分类号： G06K9/00
CPC分类号： G06K9/00604 , A61B3/0025 , A61B3/024 , A61B3/113 , G02B27/0093 , G06F3/013 , G06K9/0061 , G06T7/74 , G06T2207/30201 , H04N5/2256 , H04N5/247
摘要： A system is mounted within eyewear or headwear to unobtrusively produce and track reference locations on the surface of one or both eyes of an observer. The system utilizes multiple illumination sources and/or multiple cameras to generate and observe glints from multiple directions. The use of multiple illumination sources and cameras can compensate for the complex, three-dimensional geometry of the head and anatomical variations of the head and eye region that occurs among individuals. The system continuously tracks the initial placement and any slippage of eyewear or headwear. In addition, the use of multiple illumination sources and cameras can maintain high-precision, dynamic eye tracking as an eye moves through its full physiological range. Furthermore, illumination sources placed in the normal line-of-sight of the device wearer increase the accuracy of gaze tracking by producing reference vectors that are close to the visual axis of the device wearer.
摘要翻译：将系统安装在眼镜或头饰内以便不引人注目地产生和跟踪观察者的一只眼睛或两只眼睛的表面上的参考位置。该系统利用多个照明源和/或多个照相机来产生和观察来自多个方向的闪光。使用多个照明源和照相机可以补偿头部的复杂的三维几何形状和在个体之间出现的头部和眼睛区域的解剖变化。系统会持续跟踪初始位置和眼镜或头饰的任何滑动。此外，随着眼睛在其完整的生理范围内移动，使用多个照明源和照相机可以保持高精度，动态的眼睛跟踪。此外，放置在设备佩戴者的正常视线中的照明源通过产生靠近设备佩戴者的视轴的参考矢量增加了注视跟踪的精度。

3. 发明授权

US11317518B1 Method for producing electrical connections 有权
公开(公告)号：US11317518B1
公开(公告)日：2022-04-26
申请号：US16558255
申请日：2019-09-02
申请人： Lewis James Marggraff , Nelson G. Publicover , Blake Marggraff , Edward D. Krent , Marc M. Thomas
发明人： Lewis James Marggraff , Nelson G. Publicover , Blake Marggraff , Edward D. Krent , Marc M. Thomas
IPC分类号： H05K3/40 , H05K1/11 , H01L21/768 , H05K1/03 , H05K3/00
摘要： Systems and methods are provided to produce electromechanical interconnections within integrated circuits (ICs), printed circuit boards (PCBs) and between PCBs and other electronic components such as resistors, capacitors and integrated circuits. Elements include so-called “smart pins” or “neuro-pins” that facilitate electrical pathways in the dimension normal to the plane of a PCB. Smart pins or neuro-pins may be inserted using automated processes that do not require the high temperatures normally associated with soldering. Resultant circuits generally contain a large number of layers that are more compact and more readily constructed compared with conventional PCB-based circuitry.

4. 发明授权

US08929589B2 Systems and methods for high-resolution gaze tracking 有权
标题翻译：高分辨率注视跟踪的系统和方法
公开(公告)号：US08929589B2
公开(公告)日：2015-01-06
申请号：US13290948
申请日：2011-11-07
申请人： Nelson G. Publicover , William C. Torch , Christopher N. Spitler
发明人： Nelson G. Publicover , William C. Torch , Christopher N. Spitler
IPC分类号： G06K9/00 , A61B3/113
CPC分类号： G06K9/00604 , A61B3/0025 , A61B3/024 , A61B3/113 , G02B27/0093 , G06F3/013 , G06K9/0061 , G06T7/74 , G06T2207/30201 , H04N5/2256 , H04N5/247
摘要： A system is mounted within eyewear or headwear to unobtrusively produce and track reference locations on the surface of one or both eyes of an observer. The system utilizes multiple illumination sources and/or multiple cameras to generate and observe glints from multiple directions. The use of multiple illumination sources and cameras can compensate for the complex, three-dimensional geometry of the head and anatomical variations of the head and eye region that occurs among individuals. The system continuously tracks the initial placement and any slippage of eyewear or headwear. In addition, the use of multiple illumination sources and cameras can maintain high-precision, dynamic eye tracking as an eye moves through its full physiological range. Furthermore, illumination sources placed in the normal line-of-sight of the device wearer increase the accuracy of gaze tracking by producing reference vectors that are close to the visual axis of the device wearer.
摘要翻译：将系统安装在眼镜或头饰内以便不引人注目地产生和跟踪观察者的一只眼睛或两只眼睛的表面上的参考位置。该系统利用多个照明源和/或多个照相机来产生和观察来自多个方向的闪光。使用多个照明源和照相机可以补偿头部的复杂的三维几何形状和在个体之间出现的头部和眼睛区域的解剖变化。系统会持续跟踪初始位置和眼镜或头饰的任何滑动。此外，随着眼睛在其完整的生理范围内移动，使用多个照明源和照相机可以保持高精度，动态的眼睛跟踪。此外，放置在设备佩戴者的正常视线中的照明源通过产生靠近设备佩戴者的视轴的参考矢量增加了注视跟踪的精度。

5. 发明申请

US20110210239A1 PHOTON EVENT DISTRIBUTION SAMPLING APPARATUS AND METHOD 有权
标题翻译：光电事件分配采样设备和方法
公开(公告)号：US20110210239A1
公开(公告)日：2011-09-01
申请号：US13103749
申请日：2011-05-09
申请人： John L. Sutko , Nelson G. Publicover
发明人： John L. Sutko , Nelson G. Publicover
IPC分类号： G01J1/02 , G01J1/58
CPC分类号： G02B21/16 , G01N21/6456 , G01N21/6458
摘要： Locations of the origins of the photons are acquired from a scanned sample with reference to a scan frame. The location on the sample from which a photon was emitted is inferred from the location of the scan as commanded by a scan drive signal, a feedback signal related to the position of the scan device, or alternatively by the point in time during a scan at which the photon is detected. A position function, e.g., photon probability density, is associated with a photon position. Summing or other processing of photon probability density functions can require fewer photons to converge to an ideal density distribution associated with an image feature than are required using conventional pixel binning. Stored data can be mapped into pixels or voxels of a display or otherwise processed. Original data remains available in the digital storage for post-hoc analysis. Imprecision introduced by the display process need not adversely affect the precision of the collected data.
摘要翻译：参考扫描帧从扫描的样本获取光子的起源的位置。根据扫描驱动信号所指示的扫描位置，与扫描装置的位置相关的反馈信号，或者在扫描期间的时间点，从扫描位置扫描发射光子的位置。检测到光子。位置函数，例如光子概率密度，与光子位置相关联。光子概率密度函数的求和或其他处理可能需要更少的光子收敛到与图像特征相关联的理想密度分布，而不需要使用常规像素分档。存储的数据可以映射到显示器的像素或体素或以其他方式处理。原始数据在数字存储中仍然可用于事后分析。由显示过程引入的不精确度不必对收集的数据的精度产生不利影响。

6. 发明申请

US20140378675A1 Methods for Detecting and Measuring Specific Nucleic Acid Sequences 审中-公开
标题翻译：检测和测量特定核酸序列的方法
公开(公告)号：US20140378675A1
公开(公告)日：2014-12-25
申请号：US14479198
申请日：2014-09-05
申请人： Suk-Wah Tam-Chang , Kenneth W. Hunter , Nelson G. Publicover
发明人： Suk-Wah Tam-Chang , Kenneth W. Hunter , Nelson G. Publicover
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q1/6818 , C12Q1/6837 , C12Q2525/185 , C12Q2525/301 , C12Q2565/107 , C12Q2565/101 , C12Q2525/101
摘要： The invention provides novel oligonucleotides and methods of using the same for detection or measurement of specific nucleic acid molecules. The invention also features nucleic acid arrays comprising the oligonucleotides of the invention. An oligonucleotide of the invention comprises (1) a reporter-binding sequence capable of hybridizing to a fluorophore-labeled reporter sequence and (2) a hairpin-forming sequence capable of forming a stem-loop. Formation of the stem-loop modifies (e.g., quenching) the fluorescence signals of the reporter sequence when the reporter sequence is hybridized to the oligonucleotide. This can be achieved, for example, by bringing one or more guanine based in the oligonucleotide into close proximity to the fluorophore(s) of the reporter sequence by virtue of the formation of the stem-loop. Disruption of the stem-loop, such as by hybridization of a target sequence to at least part of the hairpin-forming sequence, produces a detectable change in the fluorescence signals.
摘要翻译：本发明提供新的寡核苷酸及其用于检测或测量特异性核酸分子的方法。本发明还具有包含本发明寡核苷酸的核酸阵列。本发明的寡核苷酸包含（1）能够与荧光团标记的报告基因序列杂交的报告基因结合序列和（2）能够形成茎环的发夹形成序列。当报告物序列与寡核苷酸杂交时，茎环的形成修饰（例如，淬灭）报告基因序列的荧光信号。这可以通过例如通过使一个或多个基于寡核苷酸的鸟嘌呤通过茎 - 环的形成使报告物序列的荧光团靠近来实现。茎环的破坏，例如通过目标序列与形成发夹的序列的至少部分的杂交产生荧光信号的可检测的变化。

7. 发明授权

US08885877B2 Systems and methods for identifying gaze tracking scene reference locations 有权
标题翻译：用于识别注视跟踪场景参考位置的系统和方法
公开(公告)号：US08885877B2
公开(公告)日：2014-11-11
申请号：US13113003
申请日：2011-05-20
申请人： Nelson G. Publicover , William C. Torch , Gholamreza Amayeh , David Leblanc
发明人： Nelson G. Publicover , William C. Torch , Gholamreza Amayeh , David Leblanc
IPC分类号： G06K9/00
CPC分类号： G06F3/013 , A61B3/113 , G02B27/0093 , G02B27/017 , G02B2027/0138 , G02B2027/014 , G02B2027/0178 , G02B2027/0187 , G06K9/00604 , G06T7/74 , G06T2207/10016 , G06T2207/10024 , G06T2207/30204
摘要： A system is provided for identifying reference locations within the environment of a device wearer. The system includes a scene camera mounted on eyewear or headwear coupled to a processing unit. The system may recognize objects with known geometries that occur naturally within the wearer's environment or objects that have been intentionally placed at known locations within the wearer's environment. One or more light sources may be mounted on the headwear that illuminate reflective surfaces at selected times and wavelengths to help identify scene reference locations and glints projected from known locations onto the surface of the eye. The processing unit may control light sources to adjust illumination levels in order to help identify reference locations within the environment and corresponding glints on the surface of the eye. Objects may be identified substantially continuously within video images from scene cameras to provide a continuous data stream of reference locations.
摘要翻译：提供了一种用于识别设备佩戴者环境内的参考位置的系统。该系统包括安装在耦合到处理单元的眼镜或头饰上的场景相机。该系统可以识别已知几何形状的物体，这些物体在佩戴者的环境中自然发生，或者被有意地放置在佩戴者环境中的已知位置处。一个或多个光源可以安装在头盔上，其在选定的时间和波长处照亮反射表面，以帮助识别从已知位置投射到眼睛表面上的场景参考位置和闪光。处理单元可以控制光源来调节照明水平，以帮助识别环境内的参考位置和眼睛表面上的相应闪光。可以在来自场景摄像机的视频图像内基本上连续地识别对象，以提供参考位置的连续数据流。

8. 发明申请

US20120293773A1 SYSTEMS AND METHODS FOR MEASURING REACTIONS OF HEAD, EYES, EYELIDS AND PUPILS 有权
标题翻译：用于测量头部，眼睛，眼睛和皮肤的反应的系统和方法
公开(公告)号：US20120293773A1
公开(公告)日：2012-11-22
申请号：US13113006
申请日：2011-05-20
申请人： Nelson G. Publicover , William C. Torch
发明人： Nelson G. Publicover , William C. Torch
IPC分类号： A61B3/113
CPC分类号： A61B5/162 , A61B3/0008 , A61B3/0025 , A61B3/112 , A61B3/113 , A61B3/14 , A61B5/1103 , A61B5/1114 , A61B5/6803 , A61B2560/0242 , A61B2562/0204
摘要： Systems and methods are provided to measure reaction times and/or responses for head, eye, eyelid movements, and/or changes in pupil geometry. The system includes eyewear or headwear including one or more eye-tracking cameras for monitoring the position and geometry of at least one eye and its components of the user, one or more scene cameras for monitoring the user's surroundings, and one or more processors to determine reaction times. Optionally, the system may include one or more of a multi-axis accelerometer to monitor head movements, light sources to trigger visual evoked responses, and/or electronic inputs that may be used to indicate the time of occurrence of external reference events. Measured reaction times and other measurements may be monitored for use in a range of applications. Responses and reaction times may be measured continuously over extended periods, even over a lifetime to measure consequences of the aging process.
摘要翻译：提供系统和方法以测量头部，眼睛，眼睑运动和/或瞳孔几何形状变化的反应时间和/或响应。该系统包括眼镜或头饰，包括一个或多个眼睛跟踪摄像机，用于监视至少一只眼睛及其用户部件的位置和几何形状，一个或多个用于监测用户环境的场景摄像机，以及一个或多个处理器以确定反应时间。可选地，系统可以包括用于监测头部运动的多轴加速度计中的一个或多个，用于触发视觉诱发反应的光源和/或可用于指示外部参考事件发生的时间的电子输入。可以监测测量的反应时间和其他测量值以用于一系列应用。响应和反应时间可以在一段时间内连续测量，甚至在一生中测量老化过程的后果。

9. 发明授权

US08168955B2 Photon event distribution sampling apparatus and method 有权
标题翻译：光子事件分布采样设备及方法
公开(公告)号：US08168955B2
公开(公告)日：2012-05-01
申请号：US13103749
申请日：2011-05-09
申请人： John L. Sutko , Nelson G. Publicover
发明人： John L. Sutko , Nelson G. Publicover
IPC分类号： G01J1/00 , G01B11/00
CPC分类号： G02B21/16 , G01N21/6456 , G01N21/6458
摘要： Locations of the origins of the photons are acquired from a scanned sample with reference to a scan frame. The location on the sample from which a photon was emitted is inferred from the location of the scan as commanded by a scan drive signal, a feedback signal related to the position of the scan device, or alternatively by the point in time during a scan at which the photon is detected. A position function, e.g., photon probability density, is associated with a photon position. Summing or other processing of photon probability density functions can require fewer photons to converge to an ideal density distribution associated with an image feature than are required using conventional pixel binning. Stored data can be mapped into pixels or voxels of a display or otherwise processed. Original data remains available in the digital storage for post-hoc analysis. Imprecision introduced by the display process need not adversely affect the precision of the collected data.
摘要翻译：参考扫描帧从扫描的样本获取光子的起源的位置。根据扫描驱动信号所指示的扫描位置，与扫描装置的位置相关的反馈信号，或者在扫描期间的时间点，从扫描位置扫描发射光子的位置。检测到光子。位置函数，例如光子概率密度，与光子位置相关联。光子概率密度函数的求和或其他处理可能需要更少的光子收敛到与图像特征相关联的理想密度分布，而不需要使用常规像素分档。存储的数据可以映射到显示器的像素或体素或以其他方式处理。原始数据在数字存储中仍然可用于事后分析。由显示过程引入的不精确度不必对收集的数据的精度产生不利影响。

10. 发明授权

US07960702B2 Photon event distribution sampling apparatus and method 有权
标题翻译：光子事件分布采样设备及方法
公开(公告)号：US07960702B2
公开(公告)日：2011-06-14
申请号：US11597028
申请日：2005-05-20
申请人： John L. Sutko , Nelson G. Publicover
发明人： John L. Sutko , Nelson G. Publicover
IPC分类号： G01J1/00 , G01B11/00
CPC分类号： G02B21/16 , G01N21/6456 , G01N21/6458
摘要： Locations of the origins of the photons are acquired from a scanned sample with reference to a scan frame. The location on the sample from which a photon was emitted is inferred from the location of the scan as commanded by a scan drive signal, a feedback signal related to the position of the scan device, or alternatively by the point in time during a scan at which the photon is detected. A position function, e.g., photon probability density, is associated with a photon position. Summing or other processing of photon probability density functions can require fewer photons to converge to an ideal density distribution associated with an image feature than are required using conventional pixel binning. Stored data can be mapped into pixels or voxels of a display or otherwise processed. Original data remains available in the digital storage for post-hoc analysis. Imprecision introduced by the display process need not adversely affect the precision of the collected data.
摘要翻译：参考扫描帧从扫描的样本获取光子的起源的位置。根据扫描驱动信号所指示的扫描位置，与扫描装置的位置相关的反馈信号，或者在扫描期间的时间点，从扫描位置扫描发射光子的位置。检测到光子。位置函数，例如光子概率密度，与光子位置相关联。光子概率密度函数的求和或其他处理可能需要更少的光子收敛到与图像特征相关联的理想密度分布，而不需要使用常规像素分档。存储的数据可以映射到显示器的像素或体素或以其他方式处理。原始数据在数字存储中仍然可用于事后分析。由显示过程引入的不精确度不必对收集的数据的精度产生不利影响。

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