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1. 发明申请

US20120022072A1 PTERIN ANALOGS 审中-公开
标题翻译：蛋白类似物
公开(公告)号：US20120022072A1
公开(公告)日：2012-01-26
申请号：US13235115
申请日：2011-09-16
申请人： Emil D. Kakkis , Erik Foehr , Sianna Castillo , Steven W. Szczepanski , Paul John Kostel
发明人： Emil D. Kakkis , Erik Foehr , Sianna Castillo , Steven W. Szczepanski , Paul John Kostel
IPC分类号： A61K31/519 , A61P7/00 , A61P9/12 , A61P3/10 , A61P25/00 , A61P25/16 , A61P25/24 , C07D475/04 , A61P9/10
CPC分类号： C07D475/04
摘要： Disclosed herein are analogs of tetrahydrobiopterin, compositions containing the same, and methods of treating an individual suffering from a condition responsive to tetrahydrobiopterin by administration of the analog. These analogs are contemplated for use wherever tetrahydrobiopterin is currently used to treat conditions responsive to tetrahydrobiopterin therapies.
摘要翻译：本文公开的是四氢生物喋呤的类似物，含有它们的组合物，以及通过给予类似物治疗患有对四氢生物喋呤的病症的个体的方法。这些类似物被考虑用于四氢生物喋呤目前用于治疗对四氢生物喋呤疗法有反应的病症。

2. 发明申请

US20100016328A1 PTERIN ANALOGS 审中-公开
公开(公告)号：US20100016328A1
公开(公告)日：2010-01-21
申请号：US12500537
申请日：2009-07-09
申请人： Emil D. KAKKIS , Erik FOEHR , Sianna CASTILLO , Steven W. SZCZEPANSKI , Paul John KOSTEL
发明人： Emil D. KAKKIS , Erik FOEHR , Sianna CASTILLO , Steven W. SZCZEPANSKI , Paul John KOSTEL
IPC分类号： A61K31/519 , C07D475/04 , A61P9/00 , A61P3/00 , G01N27/26
CPC分类号： C07D475/04
摘要： Disclosed herein are analogs of tetrahydrobiopterin, compositions containing the same, and methods of treating an individual suffering from a condition responsive to tetrahydrobiopterin by administration of the analog. These analogs are contemplated for use wherever tetrahydrobiopterin is currently used to treat conditions responsive to tetrahydrobiopterin therapies.

3. 发明授权

US06184234B2 Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl or pyridyl)methyl]piperidines 失效
标题翻译：杀虫剂N-（取代的芳基甲基）-4- [双（取代的苯基或吡啶基）甲基]哌啶
公开(公告)号：US06184234B2
公开(公告)日：2001-02-06
申请号：US09414375
申请日：1999-10-07
申请人： Ian R. Silverman , Daniel H. Cohen , John W. Lyga , Steven W. Szczepanski , Syed F. Ali , Thomas G. Cullen , Robert N. Henrie, II , Clinton J. Peake
发明人： Ian R. Silverman , Daniel H. Cohen , John W. Lyga , Steven W. Szczepanski , Syed F. Ali , Thomas G. Cullen , Robert N. Henrie, II , Clinton J. Peake
IPC分类号： A01N4340
CPC分类号： C07D231/12 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/60 , A01N43/653 , A01N43/713 , A01N43/76 , A01N43/82 , A01N47/20 , A01N55/00 , C07D211/14 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/94 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/10 , C07D417/12 , C07F7/1804
摘要： Compounds of the following structure, the corresponding N-oxides and agriculturally acceptable salts thereof, are disclosed as effective insecticides: wherein U is —(CH2)n—; Q is hydroxy; and R is: and wherein V, W, Y, and Z are each hydrogen; X is a five- or six-membered heterocycle; optionally substituted with bromine, chlorine, fluorine, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkoxyalkyl, haloalkoxyalkyl, or aminocarbonyl; and the heterocycle is optionally connected to the phenyl ring through a —O—, —S—, —(CH2)p, —C(O)—, or —O—(CR3R4)q linkage; R1 and R2 are independently selected from phenyl or pyridyl substituted with pentahalothio, haloalkylthio, haloalkylsulfinyl, or haloalkylsulfonyl; phenyl substituted with —OC(M)2O—, where M is bromine, chorine or fluorine, to provide a dihalobenzodioxolyl fused ring; or pyridyl substituted with —OC(M)2O— to provide a dihalodioxolenopyridyl fused ring; R3 and R4 are independently selected from hydrogen and methyl; n and p are independently 1, 2, or 3; and q is 1 or 2; with the proviso that at least one of R1 and R2 is substituted in the para position of the phenyl ring or the 5-position of the 2-pyridyl ring; each alkyl portion of said optional substituent on X wherein the optional substituent is alkyl, haloalkyl, alkoxyl, haloalkoxyl, alkoxyalkyl, or haloalkoxyalkyl contains from 1 to 4 carbon atoms; each heterocycle contains from 1 to 4 nitrogen atoms, 1 or 2 oxygen or sulfur atoms, or 1 or 2 nitrogen atoms and an oxygen or sulfur atom; and the corresponding N-oxides and agriculturally acceptable salts.
摘要翻译：以下结构的化合物，其相应的N-氧化物和农业上可接受的盐被公开为有效的杀虫剂：其中U是 - （CH 2）n - ; Q是羟基; 且R为：且其中V，W，Y和Z各自为氢; X为五元或六元杂环; 任选被溴，氯，氟，氰基，烷基，卤代烷基，烷氧基，卤代烷氧基，烷氧基烷基，卤代烷氧基烷基或氨基羰基取代; 并且杂环任选地通过-O - ， - S - ， - （CH 2）p，-C（O） - 或-O-（CR 3 R 4）q键连接到苯环; R 1和R 2独立地选自苯基或被五卤代硫代，卤代烷硫基，卤代烷基亚磺酰基或卤代烷基磺酰基取代的吡啶基; 用-OC（M）2 O-取代的苯基，其中M是溴，氯或氟，得到二卤代二苯甲基稠合环; 或被-OC（M）2 O-取代的吡啶基，以提供二卤代苯并吡啶基稠环; R 3和R 4独立地选自氢和甲基; n和p独立地为1,2或3; 平均值为1或2; 条件是R 1和R 2中的至少一个在苯环的对位或2-吡啶基环的5-位上被取代; X上任选取代基的每个烷基部分，其中任选的取代基是烷基，卤代烷基，烷氧基，卤代烷氧基，烷氧基烷基或卤代烷氧基烷基含有1至4个碳原子; 每个杂环含有1至4个氮原子，1或2个氧或硫原子，或1或2个氮原子和氧或硫原子; 和相应的N-氧化物和农业上可接受的盐。

4. 发明授权

US6017931A Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines 失效
标题翻译：含有n-（取代的苯基甲基）-4- [双（取代的苯基）甲基]哌啶的杀虫组合物
公开(公告)号：US6017931A
公开(公告)日：2000-01-25
申请号：US706033
申请日：1996-08-30
申请人： Ian R. Silverman , Daniel H. Cohen , John W. Lyga , Steven W. Szczepanski , Syed F. Ali
发明人： Ian R. Silverman , Daniel H. Cohen , John W. Lyga , Steven W. Szczepanski , Syed F. Ali
IPC分类号： C07D211/22 , C07D211/94 , A61K31/445 , C07D211/20
CPC分类号： C07D211/22 , C07D211/94
摘要： Compositions containing compounds of the following structure, some of which are novel, and the corresponding N-oxides and agriculturally acceptable salts, are disclosed as effective insecticides: ##STR1## in which U is --(CH.sub.2).sub.n --;Q is hydroxy;R is ##STR2## in which V, W, and Z are each hydrogen; X is selected from alkoxy, haloalkoxy, alkoxyalkyl, cycloalkylalkoxy, halocycloalkylalkoxy, alkoxycarbonyl, haloalkoxycarbonyl, cycloalkylalkoxycarbonyl, halocycloalkylalkoxycarbonyl, alkoxyalkoxycarbonyl, alkoxycarbonylamino, haloalkoxycarbonylamino, cycloalkylalkoxycarbonylamino, halocycloalkylalkoxycarbonylamino, alkylaminocarbonyl, haloalkylaminocarbonyl, cyanoalkoxycarbonylamino, phenylcarbonylamino, and phenoxycarbonyl, each cycloalkyl moiety or phenyl ring optionally substituted with halogen; Y is selected from hydrogen and halogen; n is 1, 2, or 3; R.sup.1 and R.sup.2 are independently selected from phenyl or pyridyl, each substituted with haloalkyl, haloalkoxy, or alkylthio; with the proviso that each aliphatic moiety contains not more than 6 carbon atoms, and halogen means bromine, chlorine or fluorine.
摘要翻译：公开了含有以下结构的化合物的组合物，其中一些是新的，以及相应的N-氧化物和农业上可接受的盐作为有效的杀虫剂：其中U是 - （CH 2）n - ; Q是羟基; R是其中V，W和Z各自为氢; 卤素烷氧基羰基氨基，烷基氨基羰基，卤代烷基氨基羰基氨基，烷基氨基羰基，卤代烷基氨基羰基，氰基烷氧基羰基氨基，苯基羰基氨基和苯氧羰基，各环烷基部分或苯环任选地用卤素取代; Y选自氢和卤素; n为1,2或3; R 1和R 2独立地选自苯基或吡啶基，各自被卤代烷基，卤代烷氧基或烷硫基取代; 条件是每个脂族部分含有不超过6个碳原子，卤素是指溴，氯或氟。

5. 发明授权

US5795901A Insecticidal N-(substituted arylmethyl)-4-�bis(substituted aryl)hydroxymethyl!piperidinium salts 失效
标题翻译：杀虫剂N-（取代的芳基甲基）-4- [双（取代的芳基）羟甲基]哌啶鎓盐
公开(公告)号：US5795901A
公开(公告)日：1998-08-18
申请号：US852160
申请日：1997-05-06
申请人： Steven W. Szczepanski
发明人： Steven W. Szczepanski
IPC分类号： A01N43/40 , A01N43/54 , A01N43/713 , A01N47/12 , C07D211/14 , C07D211/22
CPC分类号： A01N43/713 , A01N43/40 , A01N43/54 , A01N47/12 , C07D211/14
摘要： Compounds of the following structure are disclosed as effective insecticides: ##STR1## in which Q is hydroxy; U is --(CH.sub.2).sub.n --, where n is 1; R is ##STR2## in which V, W, Y, and Z are each hydrogen; X is alkoxy, cycloalkylalkoxy, alkoxycarbonyl, alkoxycarbonylamino, or a five- or six-membered heteroaryl or heteroaryloxy, each heteroaryl optionally substituted with halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkoxyalkyl, or haloalkoxyalkyl; R.sup.1 and R.sup.2 are independently selected from haloalkyl; phenyl substituted with halogen, halothio, haloalkyl, or haloalkoxy; or a five- or six-membered heteroaryl substituted with halogen or haloalkyl; R.sup.3 is alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, dialkylaminoalkyl, alkylaminocarbonyloxyalkyl, alkylthioalkyl, alkylsulfonylalkyl, alkylcarbonyloxyalkyl, alkoxycarbonylalkyl, carboxyalkyl, carboxyarylalkyl, arylcarbonyl, sulfonato, or sulfonatoalkyl, and may bear a negative charge resulting in an inner salt; and a separate anion is chloride, bromide, iodide, or an phenyl or alkyl sulfate or sulfonate; with the proviso that at least one of R.sup.1 and R.sup.2 is phenyl substituted in the para position or pyrid-2-yl or pyrimidin-2-yl, each substituted in the the 5-position; each aliphatic moiety contains not more than 4 carbon atoms, except that R.sup.3 may contain up to eighteen carbon atoms; halogen means bromine, chlorine, or fluorine; each heteroaryl contains from 1 to 4 nitrogen atoms, or 1 or 2 oxygen or sulfur atoms, or 1 or 2 nitrogen atoms and an oxygen or sulfur atom.
摘要翻译：公开了以下结构的化合物作为有效的杀虫剂：其中Q是羟基的 U是 - （CH 2）n - ，其中n是1; R是其中V，W，Y和Z各自为氢的氰基，烷基，卤代烷基，烷氧基，卤代烷氧基，烷氧基烷基或卤代烷氧基烷基;任选被卤素，氰基，烷氧基，卤代烷氧基， R 1和R 2独立地选自卤代烷基; 被卤素，卤代硫代，卤代烷基或卤代烷氧基取代的苯基; 或被卤素或卤代烷基取代的五或六元杂芳基; R3是烷基，卤代烷基，羟基烷基，烷氧基烷基，二烷基氨基烷基，烷基氨基羰基氧基烷基，烷基硫代烷基，烷基磺酰基烷基，烷基羰基氧基烷基，烷氧基羰基烷基，羧基烷基，羧基芳基烷基，芳基羰基，磺酸根或磺酸基烷基，并且可能带有负电荷，而单独的阴离子是氯化物，溴化物，碘化物或苯基或烷基硫酸盐或磺酸盐; 条件是R1和R2中的至少一个是在对位取代的苯基或吡啶-2-基或嘧啶-2-基，其各自在5-位取代; 每个脂族部分含有不超过4个碳原子，除了R 3可含有至多18个碳原子; 卤素是指溴，氯或氟; 每个杂芳基含有1至4个氮原子，或1或2个氧或硫原子，或1或2个氮原子和氧或硫原子。

6. 发明授权

US5639763A Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines 失效
标题翻译：杀虫剂N-（取代芳基甲基）-4- [双（取代苯基）甲基]哌啶
公开(公告)号：US5639763A
公开(公告)日：1997-06-17
申请号：US389675
申请日：1995-02-16
申请人： Ian R. Silverman , Daniel H. Cohen , John W. Lyga , Steven W. Szczepanski , Syed F. Ali
发明人： Ian R. Silverman , Daniel H. Cohen , John W. Lyga , Steven W. Szczepanski , Syed F. Ali
IPC分类号： C07D211/18 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/60 , A01N43/653 , A01N43/713 , A01N43/76 , A01N43/82 , A01N47/20 , A01N55/00 , C07D211/14 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/94 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/10 , C07D417/12 , C07D521/00 , C07F7/18 , A61K31/445 , C07D605/06
CPC分类号： C07D401/06 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/60 , A01N43/653 , A01N43/713 , A01N43/76 , A01N43/82 , A01N47/20 , A01N55/00 , C07D211/14 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/94 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/10 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/10 , C07D417/12 , C07F7/1856
摘要： Compounds of the following structure, the corresponding N-oxides and agriculturally acceptable salts, are disclosed as effective insecticides: ##STR1## in which U is selected from --(CH.sub.2).sub.n -- and ethylidene; Q is selected from hydrogen, hydroxy, sulfhydryl, and fluorine; R is ##STR2## in which V is selected from hydrogen, halogen, alkyl, haloalkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsilyloxy, dialkylamino, cyano, nitro, hydroxy, and phenyl; Y and Z are independently selected from hydrogen and alkoxy; W and X taken together is --OCH.sub.2 CH.sub.2 O--, --CH.sub.2 C(CH.sub.3).sub.2 O--, --OC(CH.sub.3).sub.2 O--, or --N.dbd.C(C.sub.2 H.sub.5)O--; R.sup.1 and R.sup.2 are independently selected from phenyl substituted with halogen, alkyl, haloalkyl, haloalkoxy, alkoxyalkyl, hydroxy, arylthio, alkoxy, dialkylamino, dialkylaminosulfonyl, hydroxyalkylaminocarbonyl, alkylsulfonyloxy, and haloalkylsulfonyloxy; and n is 1, 2, or 3.
摘要翻译：以下结构的化合物，相应的N-氧化物和农业上可接受的盐被公开为有效的杀虫剂：其中U选自 - （CH 2）n - 和亚乙基; Q选自氢，羟基，巯基和氟; R是其中V选自氢，卤素，烷基，卤代烷基，烷氧基，烷硫基，烷基亚磺酰基，烷基甲硅烷氧基，二烷基氨基，氰基，硝基，羟基和苯基的 Y和Z独立地选自氢和烷氧基; W和X一起取代为-OCH 2 CH 2 O-，-CH 2 C（CH 3）2 O-，-OC（CH 3）2 O-或-N = C（C 2 H 5）O-; R 1和R 2独立地选自被卤素，烷基，卤代烷基，卤代烷氧基，烷氧基烷基，羟基，芳硫基，烷氧基，二烷基氨基，二烷基氨基磺酰基，羟烷基氨基羰基，烷基磺酰氧基和卤代烷基磺酰氧基取代的苯基。且n为1,2或3。

7. 发明授权

US07977332B2 Insecticidal N-(heteroarylalkyl)alkanediamine derivatives 有权
标题翻译：杀虫剂N-（杂芳基烷基）烷二胺衍生物
公开(公告)号：US07977332B2
公开(公告)日：2011-07-12
申请号：US10580481
申请日：2004-12-02
申请人： David M. Roush , John F. Chiarello , Jianming Yu , Benjamin J. Dugan , George Theodoridis , Manorama M. Patel , Walter H. Yeager , Steven W. Szczepanski
发明人： David M. Roush , John F. Chiarello , Jianming Yu , Benjamin J. Dugan , George Theodoridis , Manorama M. Patel , Walter H. Yeager , Steven W. Szczepanski
IPC分类号： C07D213/02 , A01N43/08
CPC分类号： C07D213/26 , A01N43/40 , A01N43/50 , A01N43/78 , A01N43/82 , A01N43/88 , A01N47/40 , A01N51/00 , A01N57/26 , C07D213/38 , C07D213/64 , C07D213/70 , C07D213/73 , C07D233/64 , C07D237/08 , C07D237/12 , C07D239/30 , C07D241/16 , C07D261/08 , C07D263/34 , C07D273/00 , C07D277/32 , C07D285/06 , C07D307/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07F9/58
摘要： Certain noel N-(heteroarylalkyl)alkanediamine derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula I: wherein Ar, a, r, R, Ra, Rb, Rc, Rd, b, c, Re, Rf, Rg, Rh, R5, d, e, U, V, X, WR6 and R7 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.
摘要翻译：某些Noel N-（杂芳基烷基）烷二胺衍生物提供了意想不到的杀虫和杀螨活性。这些化合物由式I表示：其中Ar，a，r，R，Ra，Rb，Rc，Rd，b，c，Re，Rf，Rg，Rh，R5，d，e，U，V，X，和R7完全描述于此。此外，还公开了包含杀虫有效量的至少一种式I化合物和任选的有效量的至少一种第二化合物与至少一种与杀虫相容的载体的组合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

8. 发明授权

US5569664A Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl) methyl]p i 失效
标题翻译：杀虫剂n-（取代的芳基甲基）-4- [双（取代的苯基）甲基]哌啶
公开(公告)号：US5569664A
公开(公告)日：1996-10-29
申请号：US445315
申请日：1995-05-19
申请人： Ian R. Silverman , Daniel H. Cohen , John W. Lyga , Steven W. Szczepanski , Syed F. Ali
发明人： Ian R. Silverman , Daniel H. Cohen , John W. Lyga , Steven W. Szczepanski , Syed F. Ali
IPC分类号： C07D211/22 , C07D211/24 , C07D211/94 , C07D401/06 , C07D401/10 , C07D409/06 , C07D413/06 , A61K31/445 , C07D211/20
CPC分类号： C07D401/06 , C07D211/22 , C07D211/24 , C07D211/94 , C07D401/10 , C07D409/06 , C07D413/06
摘要： Compounds of the following structure, the corresponding N-oxides and agriculturally acceptable salts, are disclosed as effective insecticides: ##STR1## in which U is selected from ##STR2## Q is selected from hydrogen, hydroxy, sulfhydryl, and fluorine; R is selected from a heterocycle having 5 or 6 ring atoms, optionally fused to a benzene ring, and ##STR3## wherein V, W, X, Y, Z are as defined in the specification.
摘要翻译：公开了以下结构的化合物，相应的N-氧化物和农业上可接受的盐作为有效杀虫剂：其中U选自（CH 2）n，其中n为1,2或3; A Q选自氢，羟基，巯基和氟; R选自具有5或6个环原子的杂环，任选地与苯环稠合，并且其中V，W，X，Y，Z如说明书中所定义。

9. 发明申请

US20110065710A1 Insecticidal N-(Heteroarylalkyl)Alkanediamine Derivatives 有权
标题翻译：杀虫剂N-（杂芳基烷基）烷基胺衍生物
公开(公告)号：US20110065710A1
公开(公告)日：2011-03-17
申请号：US10580481
申请日：2004-12-02
申请人： David M. Roush , John F. Chiarello , Jianming Yu , Benjamin J. Dugan , George Theodoridis , Manorama M. Patel , Walter H. Yeager , Steven W. Szczepanski
发明人： David M. Roush , John F. Chiarello , Jianming Yu , Benjamin J. Dugan , George Theodoridis , Manorama M. Patel , Walter H. Yeager , Steven W. Szczepanski
IPC分类号： A61K31/4965 , A61K31/50 , A61K31/426 , A61K31/44
CPC分类号： C07D213/26 , A01N43/40 , A01N43/50 , A01N43/78 , A01N43/82 , A01N43/88 , A01N47/40 , A01N51/00 , A01N57/26 , C07D213/38 , C07D213/64 , C07D213/70 , C07D213/73 , C07D233/64 , C07D237/08 , C07D237/12 , C07D239/30 , C07D241/16 , C07D261/08 , C07D263/34 , C07D273/00 , C07D277/32 , C07D285/06 , C07D307/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07F9/58
摘要： Certain noel N-(heteroarylalkyl)alkanediamine derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula I: wherein Ar, a, r, R, Ra, Rb, Rc, Rd, b, c, Re, Rf, Rg, Rh, R5, d, e, U, V, X, WR6 and R7 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.
摘要翻译：某些Noel N-（杂芳基烷基）烷二胺衍生物提供了意想不到的杀虫和杀螨活性。这些化合物由式I表示：其中Ar，a，r，R，Ra，Rb，Rc，Rd，b，c，Re，Rf，Rg，Rh，R5，d，e，U，V，X，和R7完全描述于此。此外，还公开了包含杀虫有效量的至少一种式I化合物和任选的有效量的至少一种第二化合物与至少一种与杀虫相容的载体的组合物; 以及控制昆虫的方法，包括将所述组合物施用于存在昆虫或预期存在的场所。

10. 发明授权

US6030987A Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl or pyridyl)methyl]piperidines 失效
标题翻译：杀虫剂N-（取代的芳基甲基）-4- [双（取代的苯基或吡啶基）甲基]哌啶
公开(公告)号：US6030987A
公开(公告)日：2000-02-29
申请号：US981456
申请日：1998-08-11
申请人： Ian R. Silverman , Daniel H. Cohen , John W. Lyga , Steven W. Szczepanski , Syed F. Ali , Thomas G. Cullen , Robert N. Henrie, II , Clinton J. Peake
发明人： Ian R. Silverman , Daniel H. Cohen , John W. Lyga , Steven W. Szczepanski , Syed F. Ali , Thomas G. Cullen , Robert N. Henrie, II , Clinton J. Peake
IPC分类号： A01N43/40 , A01N43/54 , A01N43/56 , A01N43/653 , A01N43/713 , A01N43/76 , A01N43/82 , C07D401/10 , C07D417/10
CPC分类号： A01N43/713 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/653 , A01N43/76 , A01N43/82
摘要： Compounds of structure (I) ##STR1## the corresponding N-oxides and agriculturally acceptable salts are disclosed as effective insecticides. In said formula, U is --(CH.sub.2)n--; Q is hydroxy, R is formula (II) ##STR2## in which V, W, Y and Z are hydrogen; X is a five- or six-membered heterocycle optionally substituted; and the heterocycle is optionally connected to the phenyl ring through a --O--, --S-- --CH.sub.2)p--, or --O(CR.sup.3 R.sup.4)q linkage; R.sup.1 and R.sup.2 are independently selected from phenyl or pyridyl substituted with haloalkyl or haloalkoxy; R.sup.3, R.sup.4, n, p, and 1 are as defined in the specification.
摘要翻译： PCT No.PCT / US96 / 07206 Sec。 371日期：1998年8月11日 102（e）1998年8月11日PCT PCT 1996年5月17日PCT公布。公开号WO96 / 36228 PCT 日期：1996年11月21日公开了结构（Ⅰ）化合物对应的N-氧化物和农业上可接受的盐作为有效杀虫剂。在所述式中，U是 - （CH 2）n - ; Q是羟基，R是式（II），其中V，W，Y和Z是氢; X是任选取代的五或六元杂环; 并且杂环任选地通过-O - ， - S--CH 2）对 - 或-O（CR 3 R 4）q键连接到苯环上; R 1和R 2独立地选自苯基或被卤代烷基或卤代烷氧基取代的吡啶基; R3，R4，n，p和1如说明书中所定义。

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