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1. 发明申请

US20080076836A1 METHOD AND APPARATUS FOR USING LIGHT TO ENHANCE CELL GROWTH AND SURVIVAL 审中-公开
标题翻译：使用光提高细胞生长和存活的方法和装置
公开(公告)号：US20080076836A1
公开(公告)日：2008-03-27
申请号：US11843573
申请日：2007-08-22
申请人： Darrell Wagner , Haris Sih , Steven Girouard
发明人： Darrell Wagner , Haris Sih , Steven Girouard
IPC分类号： A61K31/00 , A61P43/00 , C12P1/00 , C12Q1/02
CPC分类号： G01N33/5017 , G01N2500/10
摘要： A biologic agent preparation system is provided for producing one or more biologic agents in vitro including pro-growth factors and/or pro-survival factors from cells. The one or more biologic agents are produced in response to exposure of mammalian cells to light. A biologic agent delivery system is also provided that delivers the pro-growth factors and/or pro-survival factors to an injured tissue region, or delivers cells treated with the pro-growth factors and/or pro-survival factors to the injured tissue region.
摘要翻译：提供生物制剂制备系统用于在体外制备一种或多种生物制剂，包括来自细胞的促生长因子和/或促生存因子。响应于哺乳动物细胞暴露于光而产生一种或多种生物制剂。还提供生物剂递送系统，其将促生长因子和/或促生存因子递送至损伤的组织区域，或将用促生长因子和/或促生存因子处理的细胞递送至受损组织区域。

2. 发明申请

US20070036770A1 Biologic device for regulation of gene expression and method therefor 审中-公开
标题翻译：用于调节基因表达的生物装置及其方法
公开(公告)号：US20070036770A1
公开(公告)日：2007-02-15
申请号：US11272432
申请日：2005-11-10
申请人： Darrell Wagner , Haris Sih , Jihong Ou , Jeffrey Ross , Steven Girouard , Ronald Heil
发明人： Darrell Wagner , Haris Sih , Jihong Ou , Jeffrey Ross , Steven Girouard , Ronald Heil
IPC分类号： A61K48/00 , G06F19/00 , C12N15/86
CPC分类号： A61K48/0008 , A61K48/0083 , A61N1/05
摘要： A system and device are provided which include a gene regulatory system controlling expression of one or more expression cassettes present in or released by the device, by emitting one or more stimulations. An expression cassette includes a regulatable transcription control element that is responsive to the emitted stimulations linked to an open reading frame of interest. The system optionally includes a sensor to sense a parameter indicative of a need, a telemetry module to receive an external command, or a programmable device, for regulating gene expression of the open reading frame.
摘要翻译：提供了一种系统和装置，其包括通过发射一种或多种刺激来控制存在于或释放的装置中的一种或多种表达盒的表达的基因调控系统。表达盒包括可调节的转录控制元件，其响应于与感兴趣的开放阅读框架相关联的发射刺激。该系统可选地包括用于感测指示需要的参数的传感器，用于接收外部命令的遥测模块或用于调节开放阅读框的基因表达的可编程设备。

3. 发明申请

US20060190044A1 Cell therapy and neural stimulation for cardiac repair 失效
公开(公告)号：US20060190044A1
公开(公告)日：2006-08-24
申请号：US11063170
申请日：2005-02-22
申请人： Imad Libbus , Jeffrey Ross , Steven Girouard
发明人： Imad Libbus , Jeffrey Ross , Steven Girouard
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61K41/00 , A61N1/362
摘要： A method and system to enhance cell, gene and/or cytokine therapy for cardiac repair in a mammal.

4. 发明申请

US20060136026A1 Inter-atrial septum or superior vena cava electrodes for atrial defibrillation 失效
公开(公告)号：US20060136026A1
公开(公告)日：2006-06-22
申请号：US11333503
申请日：2006-01-17
申请人： Xiangsheng Zheng , Michael Benser , Raymond Ideker , Gregory Walcott , Steven Girouard
发明人： Xiangsheng Zheng , Michael Benser , Raymond Ideker , Gregory Walcott , Steven Girouard
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N1/395 , A61N1/3956 , A61N2001/0585
摘要： An implantable system for the defibrillation of the atria of a patient's heart comprises (a) a first catheter configured for insertion into the right atrium of the heart, preferably without extending into the right ventricle of the heart; a first atrial defibrillation electrode carried by the first catheter and positioned at the atrial septum of the heart (i.e., an atrial septum electrode); (b) a second atrial defibrillation electrode which together with the first atrial defibrillation electrode provides a pair of atrial defibrillation electrodes that are configured for orientation in or about the patient's heart to effect atrial defibrillation, and (c) a pulse generator operatively associated with the pair of atrial defibrillation electrodes for delivering a first atrial defibrillation pulse to the heart of the patient. The second electrode may be configured for positioning through the coronary sinus ostium and in the coronary sinus or a vein on the surface of the left ventricle, such as the great vein. An additional electrode configured for positioning in the superior vena cava, right atrium (including the right atrial appendage, or the right ventricle may also be included, and the pulse generator may be configured or programmed for concurrently delivering a first defibrillation pulse through the additional electrode and the atrial septum electrode, and a second defibrillation pulse through the atrial septum electrode and the second electrode. Electrode assemblies and methods useful for carrying out the invention are also disclosed.

5. 发明申请

US20050288721A1 Method and apparatus to modulate cellular regeneration post myocardial infarct 失效
标题翻译：调节心肌梗塞后细胞再生的方法和装置
公开(公告)号：US20050288721A1
公开(公告)日：2005-12-29
申请号：US10862716
申请日：2004-06-07
申请人： Steven Girouard , Jeffrey Ross , Rodney Salo
发明人： Steven Girouard , Jeffrey Ross , Rodney Salo
IPC分类号： A61M5/142 , A61M5/172 , A61N1/362 , A61N1/365
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2205/3523 , A61M2205/3561 , A61M2210/125 , A61M2230/00 , A61N1/36585
摘要： A system delivers cardiac pacing therapy and chemical and/or biological therapy to modulate myocardial tissue growth in a heart after myocardial infarction (MI). The system includes an agent delivery device to release one or more agents to an MI region to modulate myocardial tissue growth in that region, and a cardiac rhythm management (CRM) device to deliver pacing pulses to enhance the effects of the one or more agents by altering myocardial wall stress and cardiac workload. In one embodiment, the system is an implantable system including an implantable agent delivery device and an implantable CRM device.
摘要翻译：系统提供心脏起搏治疗和化学和/或生物治疗以调节心肌梗塞（MI）后心脏中的心肌组织生长。该系统包括用于将一个或多个药剂释放到MI区域以调节该区域中的心肌组织生长的药剂递送装置，以及心律管理（CRM）装置，以递送起搏脉冲以增强一种或多种药剂的作用改变心肌壁压力和心脏工作量。在一个实施例中，该系统是包括可植入剂递送装置和可植入CRM装置的可植入系统。

6. 发明申请

US20050283195A1 Methods and apparatuses for localizing myocardial infarction during catheterization 失效
标题翻译：导管期局部心肌梗塞的方法和装置
公开(公告)号：US20050283195A1
公开(公告)日：2005-12-22
申请号：US10871865
申请日：2004-06-18
申请人： Joseph Pastore , Steven Girouard
发明人： Joseph Pastore , Steven Girouard
IPC分类号： A61B5/00 , A61B5/0265 , A61B5/11 , A61B8/12 , A61N1/362 , A61N1/37
CPC分类号： A61B5/4839 , A61B5/0071 , A61B5/0084 , A61B5/0265 , A61B5/1107 , A61B5/6869 , A61B8/12 , A61B2562/0219 , A61N1/3702
摘要： A catheter with a tissue property sensor provides for localization of myocardial infarction (MI) by utilizing one or more differences between properties of infarcted myocardial tissue and properties of normal myocardial tissue. The tissue property sensor is to be placed on endocardial wall or epicardial wall during catheterization to sense at least one tissue property allowing for detection of MI. Examples of the tissue property sensor include, but are not limited to, an optical sensor, an acoustic sensor, a contractility sensor, a temperature sensor, and a drug response sensor. In one embodiment, the tissue property sensor senses a tissue property in various locations on endocardial wall or epicardial wall and detects substantial changes in the tissue property that indicate a boundary between infarcted tissue and normal tissue.
摘要翻译：具有组织属性传感器的导管通过利用梗死心肌组织的性质与正常心肌组织的性质之间的一个或多个差异来提供心肌梗死（MI）的定位。在导管插入期间，将组织性质传感器放置在心内膜壁或心外膜上以感测至少一个允许检测MI的组织特性。组织性质传感器的实例包括但不限于光学传感器，声学传感器，收缩性传感器，温度传感器和药物响应传感器。在一个实施例中，组织性质传感器检测心内膜壁或心外壁上各种位置的组织特性，并且检测指示梗塞组织与正常组织之间的边界的组织性质的实质性变化。

7. 发明申请

US20050149133A1 Sensing with compensation for neural stimulator 审中-公开
标题翻译：感应神经刺激器补偿
公开(公告)号：US20050149133A1
公开(公告)日：2005-07-07
申请号：US10746847
申请日：2003-12-24
申请人： Imad Libbus , Qingsheng Zhu , Steven Girouard
发明人： Imad Libbus , Qingsheng Zhu , Steven Girouard
IPC分类号： A61N1/36 , A61N1/365 , A61N1/362
CPC分类号： A61N1/36117 , A61N1/36135 , A61N1/36564
摘要： An aspect of the present subject matter relates to an implantable medical system. An embodiment of the system comprises a baroreflex stimulator, a cardiac event detector, and communication circuitry. The stimulator includes a pulse generator to apply baroreflex stimulation therapy. The detector includes a sensor to detect electrical signals indicative of cardiac events, and a controller connected to the sensor to determine an occurrence of a cardiac event from the electrical signals using an event detection routine. The communication circuitry communicates between the baroreflex stimulator and the cardiac event detector to account for applied baroreflex stimulation therapy and enable the cardiac event detector to discriminate the electrical signals indicative of the cardiac event from the applied baroreflex stimulation therapy. Other aspects are provided herein.
摘要翻译：本主题的一个方面涉及可植入医疗系统。系统的一个实施例包括压力反射刺激器，心脏事件检测器和通信电路。刺激器包括脉冲发生器以应用压力反射刺激疗法。检测器包括用于检测指示心脏事件的电信号的传感器，以及连接到传感器的控制器，以使用事件检测程序从电信号确定心脏事件的发生。通信电路在压力反射刺激器和心脏事件检测器之间进行通信，以解决所施加的压力反射刺激治疗，并且使得心脏事件检测器能够将指示心脏事件的电信号与施加的压力反射刺激疗法区分开。本文提供了其他方面。

8. 发明申请

US20050137671A1 His bundle mapping, pacing, and injection method and lead 有权
标题翻译：他的束映射，起搏和注射方法和引导
公开(公告)号：US20050137671A1
公开(公告)日：2005-06-23
申请号：US10745302
申请日：2003-12-23
申请人： Lili Liu , Randy Westlund , Steven Girouard
发明人： Lili Liu , Randy Westlund , Steven Girouard
IPC分类号： A61N1/05
CPC分类号： A61N1/0568
摘要： A cardiac rhythm management system includes a lead assembly for intracardiac mapping, pacing, and drug delivery. The lead assembly includes an implantable endocardial lead having a proximal end for connection to an implantable cardiac rhythm management device and a distal end for disposal in an intracardiac region. The lead includes a pacing-sensing electrode and a drug delivery device, both located at or near the distal end. A lumen is within and extends throughout the lead, with an opening at or near the proximal end and another opening at or near the distal end. The lumen provides for access to the intracardiac region by a steerable stylet and a hollow needle, one at a time. The steerable stylet allows for electrophysiological mapping of the intracardiac region. The hollow needle allows for delivery of chemical, biochemical, and/or biological substance to the intracardiac region.
摘要翻译：心律管理系统包括用于心内测绘，起搏和药物递送的导联组件。引线组件包括可植入心内膜引线，其具有用于连接到可植入心律管理装置的近端和用于在心内区域中处置的远端。引线包括起搏感测电极和药物递送装置，两者都位于远端或靠近远端。管腔在整个引线内部并且贯穿整个引线，在近端处或近端处的开口以及在远端处或附近的另一个开口。管腔通过可导向的管心针和中空针头一次一个地进入心脏内区域。可导向的管心针允许心内区域的电生理作图。中空针允许将化学，生物化学和/或生物物质递送至心内区域。

9. 发明申请

US20060178719A1 Method and apparatus for passive cardiac stimulation 审中-公开
标题翻译：被动心脏刺激的方法和装置
公开(公告)号：US20060178719A1
公开(公告)日：2006-08-10
申请号：US11391604
申请日：2006-03-28
申请人： Raymond Ideker , Steven Girouard
发明人： Raymond Ideker , Steven Girouard
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/36114
摘要： A passive conductor assembly for use with an implanted stimulating device having an intracavitarily or transvenously disposed electrode is disclosed. The passive conductor assembly used in combination with the implanted stimulus generator having an intracavitarily or intravenously disposed electrode includes at least one conductive element having a first end and a second end, and/or other contacting sites for contacting a portion of a heart of a subject to be stimulated. The passive conductor is disposed in proximity to the intracavitarily or transvenous electrode which is connected to the implanted stimulus generator such as a pacemaker or defibrillator. Upon discharge of an electrical stimulus or waveform from the implanted stimulus generator, the stimulus is conducted through the myocardial tissue to the conductor assembly where it is passively conducted to a region of the heart in contact with an end or other contacting sites of the conductive element of the passive conductor assembly which have been selected for cardiac stimulation. The passive conductor assembly can include electrical components disposed in electrical communication therewith which provide for the manipulation and/or modification of the electrical stimulus or waveform generated by the implanted stimulus generator which can be designed, for example, to selectively stimulate only neural tissue and not cardiac tissue or vice versa through the same passive conductor assembly.
摘要翻译：公开了一种与植入的刺激装置一起使用的被动导体组件，该植入式刺激装置具有静脉内或经转移设置的电极。与植入的刺激发生器组合使用的被动导体组件具有静脉内或静脉内设置的电极包括至少一个具有第一端和第二端的导电元件，和/或用于接触受试者心脏的一部分的其它接触部位被刺激。被动导体设置在与植入的刺激发生器（例如起搏器或除颤器）连接的静脉内或经静脉电极附近。在从植入的刺激发生器排出电刺激或波形时，将刺激通过心肌组织传导到导体组件，其中被动地传导到与导电元件的端部或其它接触部位接触的心脏区域被选择用于心脏刺激的被动导体组件。无源导体组件可以包括与其通信的电气部件，其提供用于由植入的刺激产生器产生的电刺激或波形的操作和/或修改，所述刺激或波形可被设计为例如仅选择性地仅刺激神经组织心脏组织，反之亦然。

10. 发明申请

US20060015146A1 Method and apparatus for controlled gene or protein delivery 失效
标题翻译：用于控制基因或蛋白质递送的方法和装置
公开(公告)号：US20060015146A1
公开(公告)日：2006-01-19
申请号：US10890825
申请日：2004-07-14
申请人： Steven Girouard , Jeffrey Ross
发明人： Steven Girouard , Jeffrey Ross
IPC分类号： A61N1/18 , A61N1/365 , A61N1/39
CPC分类号： A61N1/306
摘要： An implantable system which includes a gene/protein delivery device and a pulse generator, as well as method of preparing the gene/protein delivery device and using the system, are provided. In one embodiment, the implantable system detects a predetermined condition or event and, in response, delivers gene(s) and/or protein(s) in conjunction with delivering pacing and/or defibrillation pulses.
摘要翻译：提供了包括基因/蛋白质递送装置和脉冲发生器的可植入系统，以及制备基因/蛋白质递送装置和使用该系统的方法。在一个实施方案中，可植入系统检测预定条件或事件，并且作为响应，递送基因和/或蛋白质以及递送起搏和/或除颤脉冲。

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