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1. 发明授权

US6020162A Crystal of a protein-ligand complex containing an N-terminal truncated eIF4E, and methods of use thereof 失效
标题翻译：含有N-末端截短的eIF4E的蛋白质 - 配体复合物的晶体及其使用方法
公开(公告)号：US6020162A
公开(公告)日：2000-02-01
申请号：US97233
申请日：1998-06-12
申请人： Stephen K. Burley , Nahum Sonenberg , Joseph Marcotrigiano , Anne-Claude Gingras
发明人： Stephen K. Burley , Nahum Sonenberg , Joseph Marcotrigiano , Anne-Claude Gingras
IPC分类号： C07K14/47 , C12N15/63
CPC分类号： C07K14/4705
摘要： A detailed three-dimensional structure for the least abundant of the general translation initiation factors in eukaryotes, eIF4E, complexed with a ligand is disclosed. The novel N-terminal truncated eIF4Es which were constructed so as to omit a significant portion of the flexible N-terminal tail of the eIF4E are also part of the present invention. In addition, the crystals of the protein-ligand complexes containing the N-terminal truncated eIF4Es are also included. Furthermore, methods of identifying antagonists of the eIF4E protein which can be used to regulate protein synthesis in cells are also disclosed.
摘要翻译：公开了一种与配体络合的真核生物eIF4E中一般翻译起始因子最少量的详细三维结构。被构造为省略eIF4E的柔性N末端尾部的重要部分的新型N-末端截短的eIF4E也是本发明的一部分。此外，还包括含有N-末端截短的eIF4E的蛋白质 - 配体配合物的晶体。此外，还公开了可用于调节细胞中蛋白质合成的eIF4E蛋白质的拮抗剂的方法。

2. 发明授权

US08173793B2 Nucleic acids encoding modulators of body weight 失效
标题翻译：编码体重调节剂的核酸
公开(公告)号：US08173793B2
公开(公告)日：2012-05-08
申请号：US12436773
申请日：2009-05-06
申请人： Jeffrey M. Friedman , Yiying Zhang , Ricardo Proenca , Margherita Maffei , Jeffrey L. Halaas , Ketan Gajiwala , Stephen K. Burley
发明人： Jeffrey M. Friedman , Yiying Zhang , Ricardo Proenca , Margherita Maffei , Jeffrey L. Halaas , Ketan Gajiwala , Stephen K. Burley
IPC分类号： C07H21/04 , C12N15/16 , C12N15/12
CPC分类号： C07K14/5759 , A01K2217/05 , A61K8/64 , A61K38/00 , A61K48/00 , A61Q19/06 , C07K16/18 , C07K2319/00 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , Y10S514/866 , Y10S514/909 , Y10S930/12 , Y10S930/14
摘要： The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to nucleic acids encoding materials identified herein as modulators of weight. In its broadest aspect, the present invention relates to the elucidation and discovery of nucleotide sequences, and proteins putatively expressed by such nucleotides, that demonstrate the ability to participate in the control of mammalian body weight. The nucleotide sequences in object represent the genes corresponding to the murine and human ob gene, that have been postulated to play a critical role in the regulation of body weight and adiposity. Preliminary data, presented herein, suggests that the polypeptide product of the gene in question functions as a hormone. The present invention further provides nucleic acid molecules for use as molecular probes, or as primers for polymerase chain reaction (PCR) amplification, i.e., synthetic or natural oligonucleotides.
摘要翻译：本发明一般涉及包括哺乳动物和人在内的动物的体重控制，更具体地说，涉及编码本文中鉴定的调节剂的核酸。在其最广泛的方面，本发明涉及阐明和发现核苷酸序列和由这些核苷酸推定表达的蛋白质，其表现出参与控制哺乳动物体重的能力。物体中的核苷酸序列代表了对应于鼠和人类ob基因的基因，这些基因被假定在调节体重和肥胖中起关键作用。本文提供的初步数据表明，所讨论的基因的多肽产物作为激素起作用。本发明还提供用作分子探针的核酸分子，或用作聚合酶链反应（PCR）扩增的引物，即合成或天然寡核苷酸。

3. 发明申请

US20110218332A1 Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof 失效
公开(公告)号：US20110218332A1
公开(公告)日：2011-09-08
申请号：US12436773
申请日：2009-05-06
申请人： Jeffrey M. Friedman , Yiying Zhang , Ricardo Proenca , Margherita Maffei , Jeffrey L. Halaas , Ketan Gajiwala , Stephen K. Burley
发明人： Jeffrey M. Friedman , Yiying Zhang , Ricardo Proenca , Margherita Maffei , Jeffrey L. Halaas , Ketan Gajiwala , Stephen K. Burley
IPC分类号： C07H21/04
CPC分类号： C07K14/5759 , A01K2217/05 , A61K8/64 , A61K38/00 , A61K48/00 , A61Q19/06 , C07K16/18 , C07K2319/00 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , Y10S514/866 , Y10S514/909 , Y10S930/12 , Y10S930/14
摘要： The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight, and to the diagnostic and therapeutic uses to which such modulators may be put. In its broadest aspect, the present invention relates to the elucidation and discovery of nucleotide sequences, and proteins putatively expressed by such nucleotides or degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian body weight. The nucleotide sequences in object represent the genes corresponding to the murine and human ob gene, that have been postulated to play a critical role in the regulation of body weight and adiposity. Preliminary data, presented herein, suggests that the polypeptide product of the gene in question function as a hormone. The present invention further provides nucleic acid molecules for use as molecular probes, or as primers for polymerase chain reaction (PCR) amplification, i.e., synthetic or natural oligonucleotides. In further aspects, the present invention provides a cloning vector, which comprises the nucleic acids of the invention; and a bacterial, insect, or a mammalian expression vector, which comprises the nucleic acid molecules of the invention, operatively associated with an expression control sequence. Accordingly, the invention further relates to a bacterial or a mammalian cell transfected or transformed with an appropriate expression vector, and correspondingly, to the use of the above mentioned constructs in the preparation of the modulators of the invention. Also provided are antibodies to the ob polypeptide. Moreover, a method for modulating body weight of a mammal is provided. In specific examples, genes encoding two isoforms of both the murine and human ob polypeptides are provided.

4. 发明授权

US5935810A Mammalian ob polypeptides capable of modulating body weight, corresponding nucleic acids, and diagnostic and therapeutic uses thereof 失效
公开(公告)号：US5935810A
公开(公告)日：1999-08-10
申请号：US347563
申请日：1994-11-30
申请人： Jeffrey M. Friedman , Yiying Zhang , Ricardo Proenca , Margherita Maffei , Jeffrey L. Halaas , Ketan Gajiwala , Stephen K. Burley
发明人： Jeffrey M. Friedman , Yiying Zhang , Ricardo Proenca , Margherita Maffei , Jeffrey L. Halaas , Ketan Gajiwala , Stephen K. Burley
IPC分类号： A61K8/64 , A61K38/00 , A61K38/17 , A61K48/00 , A61Q19/06 , C07K14/47 , C07K14/575 , C07K16/18 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N5/16 , C12N15/12 , C12N15/16 , C12Q1/68 , G01N33/53 , C12N1/15
CPC分类号： C07K14/5759 , A61K8/64 , A61Q19/06 , C07K16/18 , C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00 , C12Q2600/156 , C12Q2600/158 , Y10S514/866 , Y10S514/909 , Y10S930/12 , Y10S930/14
摘要： The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight, and to the diagnostic and therapeutic uses to which such modulators may be put. In its broadest aspect, the present invention relates to the elucidation and discovery of nucleotide sequences, and proteins putatively expressed by such nucleotides or degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian body weight. The nucleotide sequences in object represent the genes corresponding to the murine and human ob gene, that have been postulated to play a critical role in the regulation of body weight and adiposity. Preliminary data, presented herein, suggests that the polypeptide product of the gene in question functions as a hormone. The present invention further provides nucleic acid molecules for use as molecular probes, or as primers for polymerase chain reaction (PCR) amplification, i.e., synthetic or natural oligonucleotides. In further aspects, the present invention provides a cloning vector, which comprises the nucleic acids of the invention; and a bacterial, insect, or a mammalian expression vector, which comprises the nucleic acid molecules of the invention, operatively associated with an expression control sequence. Accordingly, the invention further relates to a bacterial or a mammalian cell transfected or transformed with an appropriate expression vector, and correspondingly, to the use of the above mentioned constructs in the preparation of the modulators of the invention. Also provided are antibodies to the ob polypeptide. Moreover, a method for modulating body weight of a mammal is provided. In specific examples, genes encoding two isoforms of both the murine and human ob polypeptides are provided.

5. 发明授权

US5872011A Crystal of a protein-ligand complex containing an N-terminal truncated eIF4E, and methods of use thereof 失效
公开(公告)号：US5872011A
公开(公告)日：1999-02-16
申请号：US874832
申请日：1997-06-13
申请人： Stephen K. Burley , Nahum Sonenberg , Joseph Marcotrigiano , Anne-Claude Gingras
发明人： Stephen K. Burley , Nahum Sonenberg , Joseph Marcotrigiano , Anne-Claude Gingras
IPC分类号： C07K14/47 , G01N30/50 , C07K14/00
CPC分类号： C07K14/4705
摘要： A detailed three-dimensional structure for the least abundant of the general translation initiation factors in eukaryotes, eIF4E, complexed with a ligand is disclosed. The novel N-terminal truncated eIF4Es which were constructed so as to omit a significant portion of the flexible N-terminal tail of the eIF4E are also part of the present invention. In addition, the crystals of the protein-ligand complexes containing the N-terminal truncated eIF4Es are also included. Furthermore, methods of identifying antagonists of the eIF4E protein which can be used to regulate protein synthesis in cells are also disclosed.

6. 发明授权

US07544492B1 OB polypeptides, modified forms and derivatives 有权
标题翻译： OB多肽，修饰形式和衍生物
公开(公告)号：US07544492B1
公开(公告)日：2009-06-09
申请号：US09635864
申请日：2000-08-10
申请人： Jeffrey M. Friedman , Jeffrey L. Halaas , Ketan Gajiwala , Stephen K. Burley
发明人： Jeffrey M. Friedman , Jeffrey L. Halaas , Ketan Gajiwala , Stephen K. Burley
IPC分类号： C12N1/20 , C12N5/10 , C12N15/16 , C12N15/63
CPC分类号： C07K14/5759 , A01K2217/05 , A61K8/64 , A61K38/00 , A61K48/00 , A61Q19/06 , C07K16/18 , C07K2319/00 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , Y10S514/866 , Y10S514/909 , Y10S930/12 , Y10S930/14
摘要： The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of weight, and to the diagnostic and therapeutic uses to which such modulators may be put. In its broadest aspect, the present invention relates to the elucidation and discovery of nucleotide sequences, and proteins putatively expressed by such nucleotides or degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian body weight. The nucleotide sequences in object represent the genes corresponding to the murine and human ob gene, that have been postulated to play a critical role in the regulation of body weight and adiposity. Preliminary data, presented herein, suggests that the polypeptide product of the gene in question functions as a hormone. The present invention further provides nucleic acid molecules for use as molecular probes, or as primers for polymerase chain reaction (PCR) amplification, i.e., synthetic or natural oligonucleotides. In further aspects, the present invention provides a cloning vector, which comprises the nucleic acids of the invention; and a bacterial, insect, or a mammalian expression vector, which comprises the nucleic acid molecules of the invention, operatively associated with an expression control sequence. Accordingly, the invention further relates to a bacterial or a mammalian cell transfected or transformed with an appropriate expression vector, and correspondingly, to the use of the above mentioned constructs in the preparation of the modulators of the invention. Also provided are antibodies to the ob polypeptide. Moreover, a method for modulating body weight of a mammal is provided. In specific examples, genes encoding two isoforms of both the murine and human ob polypeptides are provided.
摘要翻译：本发明一般涉及包括哺乳动物和人在内的动物的体重控制，更具体地说，涉及本文中鉴定为重量调节剂的材料，以及可以将这些调节剂置于其上的诊断和治疗用途。在其最广泛的方面，本发明涉及阐明和发现核苷酸序列和由这些核苷酸或其简并变异体推测表达的蛋白质，其表现出参与控制哺乳动物体重的能力。物体中的核苷酸序列代表了对应于鼠和人类ob基因的基因，这些基因被假定在调节体重和肥胖中起关键作用。本文提供的初步数据表明，所讨论的基因的多肽产物作为激素起作用。本发明还提供用作分子探针的核酸分子，或用作聚合酶链反应（PCR）扩增的引物，即合成或天然寡核苷酸。在另外的方面，本发明提供了一种克隆载体，其包含本发明的核酸; 和细菌，昆虫或哺乳动物表达载体，其包含与表达调控序列有效连接的本发明的核酸分子。因此，本发明还涉及用合适的表达载体转染或转化的细菌或哺乳动物细胞，并且相应地涉及在制备本发明的调节剂中使用上述构建体。还提供了针对ob多肽的抗体。此外，提供了一种用于调节哺乳动物体重的方法。在具体实例中，提供编码鼠和人类ob多态的两种同种型的基因。

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