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1. 发明授权

US11166705B2 Intra-atrial implants made of non-braided material 有权
公开(公告)号：US11166705B2
公开(公告)日：2021-11-09
申请号：US13471419
申请日：2012-05-14
申请人： Edward McNamara , David Celermajer , Stephen Forcucci , Hiroatsu Sugimoto
发明人： Edward McNamara , David Celermajer , Stephen Forcucci , Hiroatsu Sugimoto
IPC分类号： A61F2/24 , A61B17/02 , A61B17/00 , A61F2/06 , A61M27/00
摘要： Several unique intra-cardiac pressure devices, placement catheters, methods of placement and methods of treating heart failure are presented. The intra-cardiac pressure devices presented allow sufficient flow from the left atrium to the right atrium to enable the relief of elevated left atrial pressure and resulting patient symptoms. The intra-cardiac pressure devices are made of a non-braided material.

2. 发明授权

US08460372B2 Prosthesis for reducing intra-cardiac pressure having an embolic filter 有权
标题翻译：用于降低具有栓塞过滤器的心脏内压力的假体
公开(公告)号：US08460372B2
公开(公告)日：2013-06-11
申请号：US13290295
申请日：2011-11-07
申请人： Edward McNamara , Matthew J. Finch , Stephen Forcucci , Hiroatsu Sugimoto
发明人： Edward McNamara , Matthew J. Finch , Stephen Forcucci , Hiroatsu Sugimoto
IPC分类号： A61F2/24
CPC分类号： A61B17/0057 , A61B6/12 , A61B6/4423 , A61B6/487 , A61B6/503 , A61B8/0841 , A61B8/0883 , A61B2017/00252 , A61B2017/00526 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61B2017/00867 , A61B2560/063 , A61F2/2412
摘要： The present disclosure relates to devices and methods for implanting a prosthesis into a heart of a mammal, such as a person. The disclosure includes a prosthesis that acts as a pressure vent between the left and right atria of the heart. The intracardiac pressure vents disclosed allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms. The devices also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombi or other embolic material from entering arterial circulation.
摘要翻译：本公开涉及用于将假体植入哺乳动物（例如人）的心脏中的装置和方法。该公开内容包括用作心脏左心房和右心房之间的压力通气口的假体。所公开的心内压力通风口允许从左心房到右心房的足够的流动，以缓解升高的左心房压力和导致的患者症状。这些装置还限制从右心房到左心房的流量，以最小化血栓或其他栓塞物质进入动脉循环的可能性。

3. 发明授权

US10413284B2 Atrial pressure regulation with control, sensing, monitoring and therapy delivery 有权
公开(公告)号：US10413284B2
公开(公告)日：2019-09-17
申请号：US13450244
申请日：2012-04-18
申请人： Edward McNamara , Matthew J. Finch , Hiroatsu Sugimoto , Stephen Forcucci , Harith Rajagopalan
发明人： Edward McNamara , Matthew J. Finch , Hiroatsu Sugimoto , Stephen Forcucci , Harith Rajagopalan
IPC分类号： A61F2/82 , A61B17/00 , A61B17/221 , A61F2/24 , A61L31/02 , A61B5/0215 , A61B18/14 , A61B17/22 , A61B18/00 , A61F2/06 , A61F2/966
摘要： The present disclosure relates to improved capabilities for stabilizing and regulating atrial pressure with a shunt in the atrial septum or a stent in the coronary sinus. The disclosure also includes sensing, monitoring, drug therapy and control capabilities to provide improved treatment of patients with heart disease and other cardiac related conditions.

4. 发明申请

US20080039728A1 Catheters and Related Systems and Methods 审中-公开
标题翻译：导管及相关系统和方法
公开(公告)号：US20080039728A1
公开(公告)日：2008-02-14
申请号：US11680772
申请日：2007-03-01
申请人： Dharmendra Pal , Michael Amato , Brian Connor , Douglas Hutchison , Mark A. Hamm , Stephen Forcucci
发明人： Dharmendra Pal , Michael Amato , Brian Connor , Douglas Hutchison , Mark A. Hamm , Stephen Forcucci
IPC分类号： A61B8/14
CPC分类号： A61B8/12 , A61B17/22012 , A61B2017/22014 , A61B2017/22018 , A61B2017/22039 , A61B2090/08021 , A61M2025/0183
摘要： This disclosure relates to catheters and related systems and methods. In some embodiments, a catheter defines a lumen and an aperture extending from an outer surface of the catheter to the lumen, and a waveguide is disposed within the lumen of the catheter.
摘要翻译：本公开涉及导管及相关系统和方法。在一些实施例中，导管限定了从导管的外表面延伸到内腔的内腔和孔，并且波导设置在导管的内腔内。

5. 发明申请

US20050060019A1 Implant and agent delivery device 审中-公开
标题翻译：植入物和药剂输送装置
公开(公告)号：US20050060019A1
公开(公告)日：2005-03-17
申请号：US10951735
申请日：2004-09-28
申请人： Richard Gambale , Stephen Forcucci , Michael Weiser , Sean Forde
发明人： Richard Gambale , Stephen Forcucci , Michael Weiser , Sean Forde
IPC分类号： A61F2/00 , A61F2/02 , A61F2/06 , A61F2/88
CPC分类号： A61F2/88 , A61F2/06 , A61F2/2493 , A61F2220/0016 , A61F2250/0067
摘要： The present invention provides a system (178) for delivering a therapeutic agent in combination with an implantable device (2) to maximize a therapeutic benefit offered by each. Preferably, the therapeutic agent is contained within a solid matrix form such as a pellet or gel to facilitate its handling and to regulate its rate of dissipation into the tissue after delivery. The implant device (2) is specially configured to receive and retain the matrix but permit blood to interact with the matrix so that the agent can be released to the blood in and around the device and the surrounding tissue. A delivery system (178) comprises an implant delivery device having an obturator (180) capable of piercing the tissue and an agent matrix delivery device (210) to place a matrix form, such as a pellet, into the interior of the implant (2) after it has been implanted. Preferably, the implant delivery device (180) and the matrix delivery device (210) are contained in one apparatus to facilitate delivery of the pellet into the embedded implant. The present invention is useful for treating tissue in any area of the body, especially ischemic tissue experiencing reduced blood flow. The present devices and methods are especially useful for treatment of ischemia of the myocardium. In treatment of the myocardium, the present implant device and matrix combination may be delivered surgically through the epicardium of the heart.
摘要翻译：本发明提供了一种用于将治疗剂与可植入装置（2）组合递送以最大化由每个提供的治疗益处的系统（178）。优选地，治疗剂包含在固体基质形式例如丸粒或凝胶中，以促进其处理并调节其在分娩后向组织中的耗散速率。植入装置（2）被特别地构造成接收和保持基质，但允许血液与基质相互作用，使得试剂可以释放到装置周围的组织和周围的组织中和周围。递送系统（178）包括植入物递送装置，其具有能够刺穿组织的闭孔器（180）和药剂矩阵输送装置（210），以将诸如颗粒的矩阵形式放置在植入物（2）的内部）植入后。优选地，植入物递送装置（180）和基质递送装置（210）被包含在一个装置中以便于将颗粒递送到嵌入的植入物中。本发明可用于治疗身体的任何区域中的组织，特别是经历血流减少的缺血组织。本发明的装置和方法对于治疗心肌缺血特别有用。在心肌的治疗中，本发明的植入装置和基质组合可以通过心脏的心外膜手术递送。

6. 发明授权

US06692520B1 Systems and methods for imbedded intramuscular implants 失效
标题翻译：嵌入肌内植入物的系统和方法
公开(公告)号：US06692520B1
公开(公告)日：2004-02-17
申请号：US09211332
申请日：1998-12-15
申请人： Richard A. Gambale , Mike Weiser , Stephen Forcucci , Chirag B. Shah
发明人： Richard A. Gambale , Mike Weiser , Stephen Forcucci , Chirag B. Shah
IPC分类号： A61F206
CPC分类号： A61F2/2493 , A61F2/02 , A61F2/064
摘要： The invention includes systems and methods for stimulating intramuscular angiogenesis by placing a biocompatible device within the tissue of a muscle. The biocompatible device is dimensionally adapted for placement within the tissue of a muscle. Placement of the biocompatible device within the muscle can take place according to the method of the invention by using techniques familiar to those of ordinary skill in the art. Illustrative techniques for placement of the device within the myocardium comprise one practice of the method of the invention.
摘要翻译：本发明包括通过将生物相容性装置放置在肌肉组织内来刺激肌肉内血管发生的系统和方法。生物相容性装置在尺寸上适于放置在肌肉组织内。通过使用本领域普通技术人员熟悉的技术，可以根据本发明的方法将生物相容性装置置于肌肉内。用于将装置放置在心肌内的说明性技术包括本发明方法的一个实践。

7. 发明申请

US20050121081A1 Valve for use with chest drainage system 有权
标题翻译：阀门用于胸腔引流系统
公开(公告)号：US20050121081A1
公开(公告)日：2005-06-09
申请号：US10731549
申请日：2003-12-09
申请人： Scott Corbeil , Theodore Karwoski , Nicholas Want , Stephen Forcucci
发明人： Scott Corbeil , Theodore Karwoski , Nicholas Want , Stephen Forcucci
IPC分类号： A61M1/00 , A61M39/24 , F16K17/18 , F16K17/26
CPC分类号： F16K17/18 , A61M1/0013 , A61M39/24 , Y10T137/7771 , Y10T137/778 , Y10T137/7882
摘要： A valve for use in a chest drainage device is disclosed, the chest drainage device is adapted to receive liquid and air from a patient's chest cavity via an inlet and to permit air to escape through an outlet for air to leave the chest drain, the inlet and outlet define a flow path and the valve is disposed along the flow path. The valve has a valve element that separates an upstream chamber from a downstream chamber and has a first and second sealing surface that are opposed so that when the first and second sealing surfaces are in contact, air pressure below a predetermined value will be prevented from moving from the downstream location to the upstream location. The valve element allows air to move from the upstream chamber to the downstream chamber at a low pressure differential. A pressure relief actuating element is disposed in the valve and located adjacent the valve element such that when the predetermined sub-atmospheric pressure limit between the upstream side and the downstream side is reached or exceeded, the valve element deforms and contacts the pressure relief actuating element such that the post causes the first and second sealing surfaces to partially separate and reduce the pressure differential.
摘要翻译：公开了一种用于胸部引流装置的阀，胸部引流装置适于经由入口从患者的胸腔接收液体和空气，并允许空气通过出口排出空气以离开胸腔排泄物，入口并且出口限定流动路径，并且阀沿着流动路径设置。阀具有将上游室与下游室隔开的阀元件，并且具有相对的第一和第二密封表面，使得当第一和第二密封表面接触时，防止低于预定值的空气压力移动从下游位置到上游位置。阀元件允许空气以低压差从上游室移动到下游室。压力释放致动元件设置在阀中并且位于阀元件附近，使得当达到或超过上游侧和下游侧之间的预定次大气压力极限时，阀元件变形并接触压力释放致动元件使得柱使得第一和第二密封表面部分地分离并降低压力差。

8. 发明申请

US20120290062A1 INTRA-ATRIAL IMPLANTS MADE OF NON-BRAIDED MATERIAL 审中-公开
标题翻译：内衬材料的非拉伸材料
公开(公告)号：US20120290062A1
公开(公告)日：2012-11-15
申请号：US13471419
申请日：2012-05-14
申请人： Edward McNamara , David Celermajer , Stephen Forcucci , Hiroatsu Sugimoto
发明人： Edward McNamara , David Celermajer , Stephen Forcucci , Hiroatsu Sugimoto
IPC分类号： A61F2/24 , A61F2/90
CPC分类号： A61B17/02 , A61B17/0057 , A61B2017/00252 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/0237 , A61F2/06 , A61F2/24 , A61F2/2412 , A61F2/2442 , A61F2/2475 , A61M27/002
摘要： Several unique intra-cardiac pressure devices, placement catheters, methods of placement and methods of treating heart failure are presented. The intra-cardiac pressure devices presented allow sufficient flow from the left atrium to the right atrium to enable the relief of elevated left atrial pressure and resulting patient symptoms. The intra-cardiac pressure devices are made of a non-braided material.
摘要翻译：提出了几种独特的心脏内压力装置，放置导管，放置方法和治疗心力衰竭的方法。提供的心脏内压力装置允许从左心房到右心房的足够的流动，以便缓解升高的左心房压力和导致的患者症状。心脏内压力装置由非编织材料制成。

9. 发明申请

US20120053686A1 PROSTHESIS FOR REDUCING INTRA-CARDIAC PRESSURE HAVING AN EMBOLIC FILTER 有权
标题翻译：用于减少具有嵌体过滤器的内部压力的优点
公开(公告)号：US20120053686A1
公开(公告)日：2012-03-01
申请号：US13290295
申请日：2011-11-07
申请人： Edward McNamara , Matthew J. Finch , Stephen Forcucci , Hiroatsu Sugimoto
发明人： Edward McNamara , Matthew J. Finch , Stephen Forcucci , Hiroatsu Sugimoto
IPC分类号： A61F2/24
CPC分类号： A61B17/0057 , A61B6/12 , A61B6/4423 , A61B6/487 , A61B6/503 , A61B8/0841 , A61B8/0883 , A61B2017/00252 , A61B2017/00526 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61B2017/00867 , A61B2560/063 , A61F2/2412
摘要： The present disclosure relates to devices and methods for implanting a prosthesis into a heart of a mammal, such as a person. The disclosure includes a prosthesis that acts as a pressure vent between the left and right atria of the heart. The intracardiac pressure vents disclosed allow sufficient flow from the left atrium to the right atrium to relieve elevated left atrial pressure and resulting patient symptoms. The devices also limit the amount of flow from the right atrium to the left atrium to minimize the potential for thrombi or other embolic material from entering arterial circulation.
摘要翻译：本公开涉及用于将假体植入哺乳动物（例如人）的心脏中的装置和方法。该公开内容包括用作心脏左心房和右心房之间的压力通气口的假体。所公开的心内压力通风口允许从左心房到右心房的足够的流动，以缓解升高的左心房压力和导致的患者症状。这些装置还限制从右心房到左心房的流量，以最小化血栓或其他栓塞物质进入动脉循环的可能性。

10. 发明申请

US20050004558A1 Flexible vascular inducing implants 审中-公开
标题翻译：柔性血管诱导植入物
公开(公告)号：US20050004558A1
公开(公告)日：2005-01-06
申请号：US10899368
申请日：2004-07-26
申请人： Richard Gambale , Stephen Forcucci , Michael Weiser , Richard Choh , Sean Forde
发明人： Richard Gambale , Stephen Forcucci , Michael Weiser , Richard Choh , Sean Forde
IPC分类号： A61B17/00 , A61F2/00 , A61F2/02 , A61F2/94 , A61K9/22 , A61L27/00 , A61M37/00
CPC分类号： A61F2/94 , A61F2/2493 , A61F2230/0091 , A61F2250/0067
摘要： Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.
摘要翻译：提供了用于促进缺血组织中血管生成的植入物和相关递送系统。植入物可以经皮，胸部或手术递送，并且特别适合于植入心脏的心肌。植入物被构造成具有柔性的，使得它们随着植入其中的周围组织的相应运动而压缩和扩张。血液进入植入物的流动以及血液在植入物中和周围的汇集导致血栓形成和纤维蛋白生长，这是导致植入物周围组织血管生成的愈合过程。此外，植入物可能含有血管生成物质或血栓，预先加载或在植入后注射以帮助起始血管发生。

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